Licorice a Supernatural Herb for Healthy Life: Bioactive Phytochemicals and Biological activities – A Review

2019 ◽  
pp. 34-40
Author(s):  
Rozina Aslam ◽  
Misbah Aslam ◽  
Shawana Abdullah ◽  
Muhammad Sarwar Yaqub
Keyword(s):  
Phenolic Compounds ◽  
Biological Activities ◽  
Chewing Gum ◽  
Biological Functions ◽  
Bioactive Constituents ◽  
Healthy Life ◽  
Chemopreventive Agents ◽  
Anti Cancer ◽  
Bioactive Phytochemicals ◽  
Anti Inflammation

Licorice, a medicinal herb, has been found to contain various phytochemicals including flavonoids, phenolic compounds, saponins, sapogenins, pterocarpenes, coumestan derivatives, 2-arylobenzofuran derivatives, chemopreventive agents, acidic constituents and glycyrrhizin having different biological activities. Licorice is used in medical for treatment of various diseases like atherosclerosis, osteoporosis and Alzheimer’s disease. It is used as anti-inflammation, anti-ulcer, anti-cancer, anti-virus and in many other problems. It is also used as additive for flavoring candies, chewing gum and toothpaste. The roots of this plant are majorly used for extracting different phytochemicals. Various licorice species: Glycyrrhiza glabra, G. uralensis, G. inflata, G. lepidota, and G. pallidiflora contain various phytochemicals with different type of biological activities. This paper provides a brief of the bioactive constituents and biological functions of different licorice species in details.

Effects of Minor Compounds of Edible Oils on Human Health

2020 ◽  
Vol 16 (8) ◽  
pp. 1196-1208
Author(s):  
Ramin Ghodsi ◽  
Rahmat Nosrati
Keyword(s):  
Human Health ◽  
Food Industry ◽  
Edible Oils ◽  
Food Groups ◽  
Bioactive Constituents ◽  
Beneficial Effects ◽  
Anti Cancer ◽  
Prevention And Treatment ◽  
Minor Compounds ◽  
Anti Inflammation

Background: Oils and fats are the densest sources of food energy among food groups. Vegetable oils are constituted predominantly of triglycerides. Due to the importance of edible oils in nutrition, food industry and human health, great attention has been paid to them in recent years. Some minor bioactive constituents in oils include phospholipids, tocols, sterols, carotenoid, chlorophyll, phenols, phylokynon and terpenes. Objective: The aim of the present study was to examine beneficial effects of minor compounds in edible oils on human health. Results: Minor compounds of edible oils that we use daily can produce remarkable results in the prevention and treatment of various diseases like diabetes, inflammation, hypertension, cancer, allergy and central nervous system disorders due to their antimicrobial, anti-cancer, anti-viral, anti-oxidative, anti-inflammation, anti-mutagenic, hypolipidemic, and hypoglycemic properties, among others. Conclusion: The results of this study showed that the presence of beneficial minor compounds in oils could have significant impact on the prevention and treatment of various diseases. Therefore, the type of consumed oil can play an important role in human health.

scholarly journals Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties

2019 ◽  
Vol 20 (17) ◽  
pp. 4238 ◽  
Author(s):  
Yaqi Ren ◽  
Chunlan Wang ◽  
Jiakun Xu ◽  
Shuaiyu Wang
Keyword(s):  
Furan Ring ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coffee Beans ◽  
Anti Cancer ◽  
Underlying Mechanisms ◽  
Target Alternative ◽  
Anti Inflammation

Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the two diterpenes demonstrate multiple potential pharmacological actions such as anti-inflammation, hepatoprotective, anti-cancer, anti-diabetic, and anti-osteoclastogenesis activities. The most relevant mechanisms involved are down-regulating inflammation mediators, increasing glutathione (GSH), inducing apoptosis of tumor cells and anti-angiogenesis. Cafestol and kahweol show similar biological activities but not exactly the same, which might due to the presence of one conjugated double bond on the furan ring of the latter. This review aims to summarize the pharmacological properties and the underlying mechanisms of cafestol-type diterpenoids, which show their potential as functional food and multi-target alternative medicine.

scholarly journals The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Yi Wang ◽  
Jingyu Yang ◽  
Xian Li ◽  
Jinhui Wang
Keyword(s):  
Biological Activities ◽  
Bioactive Constituents ◽  
Scutellariae Radix ◽  
First Time ◽  
Plausible Scheme ◽  
Anti Inflammation

Baicalin is one of the major bioactive constituents of Scutellariae Radix, but the biotransformation of it is poorly understood. In this paper, the metabolism of baicalin in rat was studied. Nine metabolites including one new compound were isolated and identified structurally. The plausible scheme for the biotransformation pathways of baicalin in the rats was deduced. And the main metabolites were evaluated for their antioxidation and anti-inflammation biological activities for the first time.

scholarly journals Synthesis of Daidzein Glycosides, α-Tocopherol Glycosides, Hesperetin Glycosides by Bioconversion and Their Potential for Anti-Allergic Functional-Foods and Cosmetics

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2975
Author(s):  
Yuya Fujitaka ◽  
Hiroki Hamada ◽  
Daisuke Uesugi ◽  
Atsuhito Kuboki ◽  
Kei Shimoda ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Water Solubility ◽  
Biological Activities ◽  
Biological Effects ◽  
Physicochemical Stability ◽  
Peritoneal Mast Cells ◽  
Anti Cancer ◽  
New Compounds ◽  
Poor Absorption ◽  
Anti Inflammation

Daidzein is a common isoflavone, having multiple biological effects such as anti-inflammation, anti-allergy, and anti-aging. α-Tocopherol is the tocopherol isoform with the highest vitamin E activity including anti-allergic activity and anti-cancer activity. Hesperetin is a flavone, which shows potent anti-inflammatory effects. These compounds have shortcomings, i.e., water-insolubility and poor absorption after oral administration. The glycosylation of bioactive compounds can enhance their water-solubility, physicochemical stability, intestinal absorption, and biological half-life, and improve their bio- and pharmacological properties. They were transformed by cultured Nicotiana tabacum cells to 7-β-glucoside and 7-β-gentiobioside of daidzein, and 3′- and 7-β-glucosides, 3′,7-β-diglucoside, and 7-β-gentiobioside of hesperetin. Daidzein and α-tocopherol were glycosylated by galactosylation with β-glucosidase to give 4′- and 7-β-galactosides of daidzein, which were new compounds, and α-tocopherol 6-β-galactoside. These nine glycosides showed higher anti-allergic activity, i.e., inhibitory activity toward histamine release from rat peritoneal mast cells, than their respective aglycones. In addition, these glycosides showed higher tyrosinase inhibitory activity than the corresponding aglycones. Glycosylation of daidzein, α-tocopherol, and hesperetin greatly improved their biological activities.

scholarly journals Absorption of polymethoxyflavones and their derivatives

2018 ◽  
Vol 2 ◽  
Author(s):  
Ruolin L.Y. Wang ◽  
Shiming Li ◽  
Chi-Tang Ho
Keyword(s):  
Water Solubility ◽  
Transport Model ◽  
Biological Activities ◽  
Cell Monolayer ◽  
Aqueous Solubility ◽  
High Permeability ◽  
Anti Cancer ◽  
Antioxidant Effects ◽  
Anti Inflammation ◽  
Nutraceutical Products

Polymethoxyflavones (PMFs) are a group of flavonoids found exclusively in citrus genus that have been identified with many potent biological activities, including anti-inflammation, anti-cancer, anti-atherosclerosis, and antioxidant effects. However, the bioavailability of PMFs is seldom studied. Evaluating by aqueous solubility and permeability, absorption is the first indicator of bioavailability. In this research, we systemically investigated permeability and solubility of six PMFs and their derivatives, namely, sinensetin (SIN), 5-demethylsinensetin (5-OHSIN), 5-acetylsinensetin (5-AcSIN), 3,5,6,7,8,3′,4′-heptamethoxyflavone (HeptaMF), 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5-OHHeptaMF), and 5-acetyl-3,6,7,8,3′,4′-hexamethoxyflavone (5-AcHeptaMF). From octanol/water solubility test, we found that PMFs and their derivatives had very low aqueous solubility. Permeability experiment via Caco-2 cell monolayer transport model indicated high permeability of all the tested compounds. Furthermore, PMFs had the greatest permeability, followed by 5-acetyl PMFs and 5-hydroxylated PMFs. Considering permeability and solubility together, PMFs and their derivatives are expected to have good absorption. This study provides indicative information on the bioavailability of PMFs and their derivatives, which offers clues on the application of PMFs in functional food or nutraceutical products.

scholarly journals Characterisation and Bioactivity Analysis of Peridinin-Chlorophyll a-Protein (PCP) Isolated from Symbiodinium tridacnidorum CS-73

2021 ◽  
Vol 9 (12) ◽  
pp. 1387
Author(s):  
Kanoknate M. Supasri ◽  
Manoj Kumar ◽  
Anna Segečová ◽  
Janice I. McCauley ◽  
Andrei Herdean ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chlorophyll A ◽  
Rna Binding ◽  
Biological Activities ◽  
Metastatic Breast ◽  
Spectroscopic Properties ◽  
Breast Adenocarcinoma ◽  
Pharmaceutical Applications ◽  
Anti Cancer ◽  
Anti Inflammation

Peridinin-Chlorophyll a-Proteins (PCP) are the major light harvesting proteins in photosynthetic dinoflagellates. PCP shows great variation in protein length, pigment ratio, sequence, and spectroscopic properties. PCP conjugates (PerCP) are widely used as fluorescent probes for cellular and tissue analysis in the biomedical field. PCP consists of a peridinin carotenoid; thereby, it can potentially be used as a bioactive compound in pharmaceutical applications. However, the biological activities of PCP are yet to be explored. In this study, we extracted, purified, and partially characterised the PCP from Symbiodinium tridacnidorum (CS-73) and explored its antioxidant, anti-cancer and anti-inflammation bioactivities. The PCP was purified using an ÄKTA™ PURE system and predicted to be of 17.3 kDa molecular weight (confirmed as a single band on SDS-PAGE) with an isoelectric point (pI) 5.6. LC-MS/MS and bioinformatic analysis of purified PCP digested with trypsin indicated it was 164 amino acids long with >90% sequence similarity to PCP of SymA3.s6014_g3 (belonging to clade A of Symbiodinium sp.) confirmed with 59 peptide combinations matched across its protein sequence. The spectroscopic properties of purified PCP showed a slight shift in absorption and emission spectra to previously documented analysis in Symbiodinium species possibly due to variation in amino acid sequences that interact with chl a and peridinin. Purified PCP consisted of a 19-amino-acid-long signal peptide at its N terminal and nine helixes in its secondary structure, with several protein binding sites and no DNA/RNA binding site. Furthermore, purified PCP exhibited antioxidant and in vitro anti-inflammation bioactivities, and anti-cancer activities against human metastatic breast adenocarcinoma (MDA-MB-231) and human colorectal (HTC-15) cancer cell lines. Together, all these findings present PCP as a promising candidate for continued investigations for pharmaceutical applications to cure chronic diseases, apart from its existing application as a fluorescent-probe.

Alchornea floribunda (Müll. Arg.), Phytochemistry and Biological Activities: A Review

2018 ◽  
Author(s):  
Matthias Onyebuchi Agbo ◽  
Festus Basden Chiedu Okoye ◽  
Godwin Chukwu Ebi ◽  
Patience Ogoamaka Osadebe
Keyword(s):  
Antibacterial Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Bioactive Constituents ◽  
Anti Cancer ◽  
The Family ◽  
Anti Inflammatory

Alchornea floribunda is a small evergreen plant that grows up to 32 feet tall. It belongs to the family of Euphorbiaceae and is found mainly in African forest undergrowth. In Nigeria it’s leaves, stems and roots are widely used in folkloric medicine in the management of many ailments and diseases. The pharmacological activity of A. floribunda depends mainly on the part used. The leaves have been documented to possess anti-inflammatory, antimicrobial, antioxidant and anti-cancer activities while the roots and stems have been reported to possess antibacterial activity. Thus, this review summarizes all the findings and information about the phytochemistry, biological activities and various isolated bioactive constituents from the leaves, roots and stems of Alchornea floribunda.

scholarly journals Alchornea floribunda (Müll. Arg.) - A review of its phytochemistry and biological activities

2020 ◽  
Vol 19 (5) ◽  
pp. 1113-1120
Author(s):  
Matthias O Agbo ◽  
Festus B.C. Okoye ◽  
Godwin C. Ebi ◽  
Patience O. Osadebe
Keyword(s):  
Antibacterial Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Bioactive Constituents ◽  
Anti Cancer ◽  
The Family

Alchornea floribunda is an evergreen plant that grows up to 32 feet tall and belongs to the family of Euphorbiaceae. It is found mainly in African forest undergrowth. In Nigeria, its leaves, stems and roots are widely used in folkloric medicine to manage ailments and diseases. The pharmacological activity of A. floribunda depends mainly on the part used. A previous study showed that the leaves have antiinflammatory, antimicrobial, antioxidant and anti-cancer activities, while its roots and stem possess antibacterial activity. Thus, this review takes a critical look at previously reported findings and information about the phytochemistry, biological activities and various isolated bioactive constituents from the leaf, root and stem of Alchornea floribunda. Keywords: Alchornea floribunda, Phytochemistry, Inflammatory, Antimicrobial, Antioxidant, Anti-cancer

scholarly journals A review on Medicago sativa: A potential medicinal plant

2021 ◽  
Vol 1 (2) ◽  
pp. 022-033
Author(s):  
Ali Esmail Al-Snafi ◽  
Hanaa Salman Khadem ◽  
Hussein Ali Al-Saedy ◽  
Ali M. Alqahtani ◽  
Gaber El-Saber Batiha ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Medicago Sativa ◽  
Nutritional Supplement ◽  
Phytochemical Analysis ◽  
Health Food ◽  
Bioactive Constituents ◽  
Food Stores ◽  
Anti Cancer ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

Medicago sativa (Family: Fabaceae) was used traditionally for the treatment of arthritis, kidney problems, fever, as diuretic, anti-cancer, anti-rheumatic, cardiotonic, depurative, lactagogue, emmenagogue, antiscorbutic and in the treatment of boils. Leaves and sprouts were also consumed as vegetable salad. The leaves or seeds were sold as bulk powdered herb, capsules, and tablets for nutritional supplement in health food stores. The phytochemical analysis of Medicago sativashowed the presence of proteins, carbohydrates, saponins, lignin, phenolic compounds, tannins, alkaloids triterpene glycosides, carotenoids, sterols, phytoestrogens, flavones, isoflavonoids and phenolic compounds. The previous pharmacological investigation showed that the plant possessed antioxidant, antidiabetic, reproductive, anti-inflammatory, antimicrobial, dermatological, anxiolytic, hepatoprotective, neuroprotective, immunological, cardioprotective, cytotoxic, anti-scorbutic, anti-anemic, xanthine oxidase inhibition and many other pharmacological effects. The current review discussed the bioactive constituents and pharmacological activities of Medicago sativa.

scholarly journals Anti-Cancer Activity of Andrographolide: A Review

2021 ◽  
pp. 1-9
Author(s):  
Vishwanadham Yerragunta ◽  
Kavita Waghray ◽  
. Shivraj ◽  
N. J. P. Subhashini
Keyword(s):  
Biological Activities ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Cytotoxic Effects ◽  
Research Activities ◽  
Anti Cancer ◽  
Research Findings ◽  
Anti Oxidant ◽  
Anti Inflammation

Andrographolide, is a chemical compound obtained from the Andrographis paniculata (Family- Acanthaceae), maybe a diterpene lactone ring is responsible for various biological activities like anti-inflammation, anti-microbial anti-cancer, anti-obesity, anti-diabetes, anti-oxidant immunomodulatory, antiseptic, hypolipidemic, cardioprotective, hepatoprotective, neuroprotective effects and other biological activities. In Current research activities worldwide to exhibit the beneficial role of Andrographolide are continuously enriching the therapeutic arsenal of this important Phyto molecule. For this purpose, several databases were accustomed explore for the anticancer/cytotoxic effects of the andrographolide in pre-clinical and clinical studies. During this report, an attempt has been given to spotlight the research findings, related to therapeutic potentials and up-to-date development within the pharmacological activities of andrographolide. Andrographolide is often one of the potential agents within the treatment of cancer.

Sign in / Sign up

Export Citation Format

Share Document