scholarly journals FREQUENCY, DISTRIBUTION AND PRESENTATION OF HYPOCALCEMIA IN BETA THALASSEMIA MAJOR

2018 ◽  
Vol 16 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Salva Shah ◽  
Adeel Basharat ◽  
Maheen Shah ◽  
Muhammad Marwat ◽  
Mohtasim Billah ◽  
...  
Keyword(s):  
Frequency Distribution ◽  
Goodness Of Fit ◽  
Calcium Supplementation ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Goodness Of Fit Test ◽  
Cross Sectional ◽  
Symptomatic Hypocalcemia ◽  
Carpopedal Spasm

Background: Disturbance of calcium hemostasis is common in patients of ß-thalassemia major. The objectives of this study were to determine the frequency, distribution and presentation of hypocalcemia in ß-thalassemia major children. Materials and Methods: This cross-sectional study was conducted in Fatimid Foundation Peshawar, Pakistan from to June 2015 to August 2015. 100 patients of ß-thalassemia major, aged 5-20 years were enrolled. After history and examination, serum calcium levels were determined through semi-automated analyzer Microlab 200. Those having levels less than 8.6 mg/dl were labelled as hypocalcemics. Sex, hypocalcemia in ß-thalassemia major, symptomatic hypocalcemia, presence of paresthesias & numbness, myalgias, hyperpigmentation and carpopedal spasm were variables. Frequency and percentage were calculated for all variables. Observed to expected frequencies of all variables were analyzed by chi-square goodness-of-fit test. Results: The frequency of hypocalcemia in ß-thalassemia major was 49/100 (49%), including 25 boys and 24 girls. The frequency of symptomatic hypocalcemia in ß-thalassemia major was 15/49 (30.61%). Paresthesias & numbness was present in 7/49 (14.29%) cases, hyperpigmentation in 6/49 (12.24%), myalgias in 3/49 (6.12%) and carpopedal spasm in 2/49 (4.08%) cases. The frequency of hypocalcemia in ß-thalassemia major and frequency of symptomatic hypocalcemia were higher in our sample than expected for the population. The frequency of paresthesia & numbness and of carpopedal spasm were similar while that of hyperpigmentation and myalgias were lower than expected. Conclusion: Hypocalcemia in ß-thalassemia major is very prevalent and mostly asymptomatic and chronic, therefore calcium levels of such patients should be periodically assessed and calcium supplementation advised where necessary.

scholarly journals A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

2008 ◽  
Vol 28 (5) ◽  
pp. 361 ◽  
Author(s):  
Farzad Najafipour ◽  
Akbar Aliasgarzadeh ◽  
Naser Aghamohamadzadeh ◽  
Amir Bahrami ◽  
Majid Mobasri ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Endocrine Complications

scholarly journals Serum IGF-1 and short stature in adolescents with beta-thalassemia major

2018 ◽  
Vol 58 (4) ◽  
pp. 151-8 ◽  
Author(s):  
Monalisa Elizabeth ◽  
Eddy Fadlyana ◽  
Lelani Reniarti ◽  
Faisal Faisal ◽  
Hadyana Sukandar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Short Stature ◽  
Family Income ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Growth Chart ◽  
Chi Square ◽  
Cross Sectional ◽  
Beta Thalassemia Major

Background The  prevalence  of  short  stature  in  thalassemia  patients ranges from 39.3 to 65%.  The  cause  of short stature is complex  and  still up for debate.  In  Indonesia, data on the  prevalence  and risk  factors  of  short  stature  in  adolescents  with  thalassemia  have been limited. Objective To assess for the prevalence and risk factors of short stature in adolescents with beta-thalassemia major. Methods This cross-sectional study was done from February to March 2017 at the Thalassemia Clinic at Dr. Hasan Sadikin General Hospital, Bandung. The baseline characteristics data of 80 adolescents with thalassemia aged 10-14 years were recorded. Short stature was assessed by height-for-age, (Z-score <-2SD) based on the 2007 WHO Reference Growth Chart. Mid-upper arm circumference was scored according to age and sex and serum IGF-1 was measured by ELISA method. Data analyses used were Chi-square, Fisher’s, and Mann-Whitney tests. Logistic regression model was used to further analyze for risk factors of short stature. Results Subjects were 40 males and 40 females, 81.2% of whom had short stature. The mean serum IGF-1 level was 32.2 (SD 26.38) ng/mL. The IGF-1 cut-off point by ROC curve was £38.51 ng/mL, with sensitivity of 64.4% and specificity of 86.7%. The risk factors of short stature were IGF-1 level £38.51 ng/mL (PR 40.66; 95%CI 4.37 to 377.58; P<0.001) and low family income (PR 19.76; 95%CI: 1.152 to 256.08; P=0.022). Conclusion IGF-1 level may be useful as a predictor of short stature in adolescent beta-thalassemia major patients.

scholarly journals FREQUENCY, DISTRIBUTION AND DETERMINANTS OF HYPERTENSION IN ADULT STROKE POPULATION OF D.I.KHAN DIVISION, PAKISTAN

2020 ◽  
Vol 17 (3) ◽  
pp. 81-89 ◽  
Author(s):  
Nazafatul Ain ◽  
Saira Khan ◽  
Muhammad Marwat ◽  
Nisar Khan ◽  
Iftikhar Ahmad ◽  
...  
Keyword(s):  
Frequency Distribution ◽  
Goodness Of Fit ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Age Group ◽  
Chi Square ◽  
Cross Sectional ◽  
Medical College ◽  
Stroke Population ◽  
Chi Square Test

Background: Global Health Estimates 2015 has shown the stroke as second leading global cause of death and 3rd leading global cause for DALYs for year 2015. The objectives of this study were to determine the frequency, distribution and determinants of hypertension in adult stroke population of D.I.Khan Division, Pakistan. Materials & Methods: This cross-sectional study was conducted in Department of Community Medicine, Gomal Medical College, D.I.Khan, Pakistan from February 1, 2017 to April 30, 2017. A sample 217 was selected with margin of error 5.59%, 90%CL and 50% prevalence of hypertension in 200,000 adults at risk of stroke population through consecutive sampling. All indoor adult patients of stroke were eligible. Sex, age groups, and residence and presence of hypertension were variables. Frequency and distribution of hypertension were analyzed by count and percentage. Hypotheses for distribution were substantiated by chi-square goodness-of-fit and of association by chi-square test of association. Results: Out of 217 patients with stroke, 123 (56.7%) were men and 94 (43.3%) were women, 86 (39.6%) were≤60 years and 131 (60.4%) were>60 years, and 105 (48.4%) were urban and 112 (51.6%) were rural. Frequency of hypertension was 132/217 (60.83%). Out of 132 patients with hypertension, men were 74 (34.10%), women 58 (26.73%), age group≤60 years 46 (21.20%), >60 years 86 (39.63%), urban 72 (33.18%) and rural 60 (27.65%). Presence of hypertension was associated to residence (p=.023) but not to sex (p=.817) and age groups (p=.072). Conclusion: Frequency of hypertension in adult stroke population of D.I.Khan Division, Pakistan was found to be similar as expected. Frequency was more in men, in older age group (of>60years) and in urban population. The presence of hypertension in adult stroke population of D.I.Khan Division was associated to residence but not to sex and age groups.

scholarly journals Renal damages in patients with major β-thalassemia

2019 ◽  
Vol 9 (1) ◽  
pp. e02-e02
Author(s):  
Malihe Najafpour ◽  
Majid Farshdousti-Hagh ◽  
Ali Akbar Movasagpoor-Akbari ◽  
Abbas-Ali Hosein-Pour Feyzi ◽  
Majid Malaki
Keyword(s):  
Renal Function ◽  
Renal Dysfunction ◽  
Urine Analysis ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Iron Chelators ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Healthy Control

Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.

scholarly journals FREQUENCY OF ABO, RH AND ABO-RH BLOOD GROUPS IN STUDENTS OF GOMAL MEDICAL COLLEGE, D.I.KHAN, PAKISTAN

2020 ◽  
Vol 18 (01) ◽  
pp. 30-36
Author(s):  
Sadiq Amin ◽  
Jawad Ahmad ◽  
Muhammad Suhail Khan ◽  
Amanullah Khan ◽  
Rashid Hassan Khan ◽  
...  
Keyword(s):  
Blood Group ◽  
Goodness Of Fit ◽  
Cross Sectional Study ◽  
Blood Groups ◽  
Goodness Of Fit Test ◽  
Chi Square ◽  
Cross Sectional ◽  
Medical College ◽  
Emergency Situations ◽  
Rh Blood Group

Background: Blood group of an individual is commonly determined by ABO & Rh status. The objectives of the study were to determine the frequency of ABO, Rh and ABO-Rh blood groups in students of Gomal Medical College, D.I.Khan, Pakistan. Materials & Methods: This cross-sectional study was conducted in the Department of Community Medicine, Gomal Medical College, D.I.Khan, Pakistan from April 1 to May 23, 2019. The population being accessible was taken as sample. Sample size was 452. Our research variables (attributes) were ABO (A, B, AB, O), Rh (positive and negative) and ABO-Rh (A+, B+, AB+ O+, A-, B-, AB-, O-) respectively. All variables being nominal were described by count and percentage. The estimated parameters were given as confidence interval for proportion at 95% confidence level. The observed frequency of ABO, Rh and ABO-Rh blood groups was tested against their expected frequency using chi-square goodness of fit test. Results: Out of 452 students, the frequency of ABO blood group was; A 127 (28.12%), B 165 (36.53%), AB 57 (12.62%) & O 103 (22.73%); Rh blood group was; Rh+ 408 (90.33%) & Rh- 44 (9.67%) and ABO-Rh was; A+ 116 (25.60%), B+ 148 (32.05%), AB+ 50 (11.30%), O+ 91 (20.10%), A- 11 (2.40%), B- 17 (03.70%), AB- 7 (1.50%) & O- 12 (2.60%). The observed frequency of ABO & ABO-Rh blood groups was significantly different whereas of Rh blood group was similar to expected prevalence. Conclusion: In our population, most common blood group was B+ and the least common was AB-. The observed frequency of ABO & ABO-Rh blood groups was different while of Rh was same as expected. Awareness of blood groups in populations will help in the effective management of blood banks record in routine as well as during blood related life emergency situations.

scholarly journals FREQUENCY, DISTRIBUTION AND DETERMINANTS OF DIABETES MELLITUS IN ADULT ACUTE CORONARY SYNDROME POPULATION OF D.I.KHAN DIVISION, PAKISTAN

2019 ◽  
Vol 17 (4) ◽  
pp. 131-143 ◽  
Author(s):  
Muhammad Marwat ◽  
Iftikhar Ahmad ◽  
Fariha Ashiq ◽  
Sania Ali ◽  
Sher Zamir ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Frequency Distribution ◽  
Goodness Of Fit ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Age Group ◽  
Chi Square ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Chi Square Test

Background: Global Health Estimates 2015 has shown IHD as second leading global cause of death and 3rd leading global cause for DALYs for 2015. The objectives of this study were to determine frequency, distribution and determinants of DM in adult acute coronary syndrome (ACS) population of D.I.Khan Division, Pakistan. Materials & Methods: This cross-sectional study was conducted in Departments of Ophthalmology & Community Medicine, Gomal Medical College, D.I.Khan, from February 1, 2017 to April 30, 2017. 331 cases were selected with margin of error 4.511%, 90%CL and 25% prevalence of DM in 73,438 adults assumed to have IHD. All indoor adult patients of ACS were eligible. Sex, age groups, and residence and presence of DM were variables. Frequency and distribution were analyzed by count and percentage. Hypotheses for distribution were substantiated by chi-square goodness-of-fit and of association by chi-square test of association. Results: Out of 331 patients with ACS, 225 (68.0%) were men and 106 (32.0%) women, 221 (66.8%) ≤60 years and 110 (33.2%) >60 years, and 210 (63.4%) urban and 121 (35.6%) rural. Frequency of DM was 79/331 (23.87%). Out of 79 patients with DM, men were 44 (13.29%), women 35 (10.57%), age group ≤60 years 57 (17.22%), >60 years 22 (6.65%), urban 53 (16.01%) and rural 60 (7.85%). Our prevalence of DM was lower than expected (p=.00214), our distribution by sex was similar to expected (p=.4993) while our distribution for age groups (p=.01209) and residence (p=.00005) were not similar to expected. Presence of DM was associated to sex (p=.011) but not to age groups (p=.0304) and residence (p=.5241). Conclusion: Prevalence of DM in adult ACS population of D.I.Khan Division, Pakistan was found lower than expected. The prevalence was more in men than women, more in younger age group (≤60 years) than older age group (>60 years) and more in urban than rural population. Our prevalence of DM was lower than expected, our distribution by sex was similar to expected while our distribution for age groups and residence were not similar to expected. The presence of DM was associated to sex but not to age groups and residence.

scholarly journals Chair dimension compatibility with elementary school students anthropometric data in North Jakarta

2021 ◽  
Vol 4 (1) ◽  
pp. 12-18
Author(s):  
Hiromi Hiromi ◽  
Yunisa Astiarani ◽  
Robi Irawan ◽  
Mariani Santosa
Keyword(s):  
Elementary School ◽  
Elementary School Students ◽  
Goodness Of Fit ◽  
Cross Sectional Study ◽  
School Students ◽  
Goodness Of Fit Test ◽  
Chi Square ◽  
Cross Sectional ◽  
Average Size ◽  
School Furniture

BACKGROUND In Indonesia, primary school begins at 6 years old and continues until 12, where most of their growth is experienced at that age. Non-ergonomic school furniture can harm the musculoskeletal system. This study evaluates the suitability of chair dimensions to elementary school student’s anthropometry in North Jakarta. METHODSA cross-sectional study of 98 students in North Jakarta. Chair dimension data and student anthropometry were measured using a tape measure, which was then analyzed using the Chi-Square Goodness of Fit Test to evaluate their suitability. RESULTSThe ages of the students ranged from 5 to 11 years. Anthropometric measurements of students show that the mean Sitting Shoulder Height is 41.81±4.36 cm, Popliteal Height 36.83±3.77 cm, Hip Breadth 25.88±3.47 cm, and Buttock-Popliteal Length 36.56±4.33 cm. While the average size assessed from the seat dimensions is Seat Height 41.71±0.22 cm, Seat Width 37.2±1.26 cm, Seat Depth 37.2±1.42 cm, and Backrest Height Above Seat 35.54±3.19 cm. The results of Goodness of Fit with Kendall's Tau-b critical value for the suitability of chair dimensions to student anthropometry were 0.37, and vice versa 0.672, which stated a discrepancy. CONCLUSIONThere is a mismatch between chair dimension and anthropometry of elementary school students in North Jakarta. Adjustment of chair dimensions needs to be done using a student's average size approach to prevent musculoskeletal disorders.

Prevalence of Malocclusion in Patients with Thalassemia Major: A Cross-sectional Study

2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Parastoo Namdar ◽  
Atena Shiva ◽  
Tahura Etezadi ◽  
Jamshid Yazdani Charati ◽  
Hossein Karami ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Iranian Population ◽  
Beta Thalassemia ◽  
Practical Training ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Adolescents And Adults ◽  
And Gender

Background: Iran lies in the world's thalassemia belt; accordingly, the beta‐thalassemia gene is carried by 4% of the Iranian population. Due to the dearth of research and literature available on the prevalence of malocclusions in the Iranian population with beta-thalassemia major, this study was conducted to determine the prevalence and severity of facial abnormalities among patients who were referred to Bu-Ali Sina Hospital, Sari, Iran. Methods: This descriptive cross-sectional study was conducted on 200 patients with thalassemia major who were referred to the care unit of Bu-Ali Sina teaching and therapeutic Hospital, Sari, Iran, in 2018. The patients were then visited by a trained dentist who had been given the necessary theoretical and practical training. Malocclusion was classified based on Angle's classification. Spacing, overcrowding, overjet, and overbite were measured, and the distances were recorded based on a checklist. Results: The prevalence of malocclusions obtained was 87.5%, which included malocclusions of Class I (34%), Class II (31%), and Classes III (22%) amongst patients. There was no significant relationship between the type of malocclusion and gender (P = 0.77). Moreover, no significant difference was observed among patients with thalassemia major and different classes of malocclusions in terms of age both in males (P = 0.49) and females (P = 0.58). Conclusions: Malocclusions are common among adolescents and adults with thalassemia, which is not associated with age or gender. Therefore, patients should be regularly visited and followed up by a dentist to manage and control their dental problems. In addition, effective and preventive measures, as well as health education should be seriously considered in these patients.

scholarly journals Diagnostic Test Validity of MCV for Determination of Thalassaemia Carrier in Bangladesh

2017 ◽  
Vol 2 (2) ◽  
pp. 94-97
Author(s):  
Nazmul Haque ◽  
Narayan Chandra Saha ◽  
Mohammad Ekhlasur Rahman ◽  
Tahmina Ahmed
Keyword(s):  
Diagnostic Test ◽  
Test Validity ◽  
Area Under The Curve ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
College Hospital ◽  
Cross Sectional ◽  
Sensitivity Specificity

Background: Mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) of red blood cell is the useful diagnostic test which is performed during routine blood examination.Objective: The purpose of the present study was to measure the diagnostic test validity of MCV for the determination of thalassaemia carrier. Methodology: This analytic cross-sectional study was carried out in the Department of Pediatrics and Department of Medicine at MAG Osmani Medical College Hospital, Sylhet, Bangladesh from September 2007 to January 2009 for a period of one year and five months. Siblings and cousins of beta Thalassemia major and Hb- E -beta Thalassemia satisfying the selection criteria were enrolled. The detailed history and thorough physical examination were done meticulously. Five (5) mL blood was drawn from each case and control for determination of MCV and Hb-Electrophoresis. Result: Total 63 were enrolled as cases and total 65 were enrolled as controls. Sensitivity, specificity, positive and negative predictive value of MCV in determination of thalassemic carriers were 92%, 89.2%, 89.2% and 92% respectively. The area under the curve value was 0.094 (0.035 to 0.152). Conclusion: In conclusion the diagnostic test validity of MCH and MCH is high in determination of Thalassemic carrier. Journal of National Institute of Neurosciences Bangladesh, 2016;2(2): 94-97]

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