scholarly journals Blood Transfusion Service and Hospital Blood Rotation: The Implications on Transfusion Safety in Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 19-24
Author(s):  
O D Damulak ◽  
E D Jatau ◽  
E Ekam ◽  
E Rumji ◽  
R Yakubu ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Hospital ◽  
Sub Saharan Africa ◽  
High Rate ◽  
Blood Transfusion Service ◽  
First Time

Blood donation is not readily an altruistic sacrifice in sub-Saharan Africa where microbial infections, maternal haemorrhages, malaria and other tropical diseases that frequently require blood transfusion are daily diagnoses. Blood transfusion safety is hindered by the combined prevailing high rate of Transfusion-Transmissible Infections (TTIs) and poor screening techniques. This study determined the rate of Enzyme-Linked Immuno-Sorbent Assay (ELISA) positive reactions to transfusion-transmissible infections in rapid diagnostic test negative family replacement blood units, compared to the first time voluntarily donated blood. We studied records of blood units collected in a tertiary hospital from donors who scaled pre-donation Rapid diagnostic test (RDT) screening for the human immunodeficiency virus, hepatitis B and hepatitis C viruses and syphilis and rescreened by ELISA techniques at the National Blood Transfusion Service Centre in Jos, along with units from first-time voluntary blood donors. A total of 19562 blood units; 5945 (30.39%) rapid diagnostic tests negative from a linkage hospital and 13617 (69.61%) from first time voluntary donors were screened by ELISA methods for HIV, HBV, HCV, and syphilis. The overall TTIs detected by ELISA was 16.08%, significantly lower among pre-donation rapid screened family replacement blood donors [495(8.32%)] compared to 2651 (19.47%) among first-time voluntary donors; P=0.0001. Fifty-seven (0.96%) HIV, 166 (2.79%) HBV, 137 (2.31%) HCV and 137 (2.31%) syphilis were still detected respectively by ELISA in the pre-screened negative family replacement blood units. The outcome of ELISA screenings of blood collected from first-time volunteer donors were; 143 (1.05%) HIV, 1,486 (10.91%) HBV, 683 (5.02%) HCV, and 339 (2.49%) syphilis. Blood for transfusion should be screened negative at least with ELISA.

scholarly journals Blood Transfusion Service and Hospital Blood Rotation: The Implications on Transfusion Safety in Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 19-24
Author(s):  
O D Damulak ◽  
E D Jatau ◽  
E Ekam ◽  
E Rumji ◽  
R Yakubu ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Hospital ◽  
Sub Saharan Africa ◽  
High Rate ◽  
Blood Transfusion Service ◽  
First Time

Blood donation is not readily an altruistic sacrifice in sub-Saharan Africa where microbial infections, maternal haemorrhages, malaria and other tropical diseases that frequently require blood transfusion are daily diagnoses. Blood transfusion safety is hindered by the combined prevailing high rate of Transfusion-Transmissible Infections (TTIs) and poor screening techniques. This study determined the rate of Enzyme-Linked Immuno-Sorbent Assay (ELISA) positive reactions to transfusion-transmissible infections in rapid diagnostic test negative family replacement blood units, compared to the first time voluntarily donated blood. We studied records of blood units collected in a tertiary hospital from donors who scaled pre-donation Rapid diagnostic test (RDT) screening for the human immunodeficiency virus, hepatitis B and hepatitis C viruses and syphilis and rescreened by ELISA techniques at the National Blood Transfusion Service Centre in Jos, along with units from first-time voluntary blood donors. A total of 19562 blood units; 5945 (30.39%) rapid diagnostic tests negative from a linkage hospital and 13617 (69.61%) from first time voluntary donors were screened by ELISA methods for HIV, HBV, HCV, and syphilis. The overall TTIs detected by ELISA was 16.08%, significantly lower among pre-donation rapid screened family replacement blood donors [495(8.32%)] compared to 2651 (19.47%) among first-time voluntary donors; P=0.0001. Fifty-seven (0.96%) HIV, 166 (2.79%) HBV, 137 (2.31%) HCV and 137 (2.31%) syphilis were still detected respectively by ELISA in the pre-screened negative family replacement blood units. The outcome of ELISA screenings of blood collected from first-time volunteer donors were; 143 (1.05%) HIV, 1,486 (10.91%) HBV, 683 (5.02%) HCV, and 339 (2.49%) syphilis. Blood for transfusion should be screened negative at least with ELISA.

Blood Transfusion Service and Hospital Blood Rotation: The Implications on Transfusion Safety in Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 19-24
Author(s):  
O D Damulak ◽  
E D Jatau ◽  
E Ekam ◽  
E Rumji ◽  
R Yakubu ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Hospital ◽  
Sub Saharan Africa ◽  
High Rate ◽  
Blood Transfusion Service ◽  
First Time

Blood donation is not readily an altruistic sacrifice in sub-Saharan Africa where microbial infections, maternal haemorrhages, malaria and other tropical diseases that frequently require blood transfusion are daily diagnoses. Blood transfusion safety is hindered by the combined prevailing high rate of Transfusion-Transmissible Infections (TTIs) and poor screening techniques. This study determined the rate of Enzyme-Linked Immuno-Sorbent Assay (ELISA) positive reactions to transfusion-transmissible infections in rapid diagnostic test negative family replacement blood units, compared to the first time voluntarily donated blood. We studied records of blood units collected in a tertiary hospital from donors who scaled pre-donation Rapid diagnostic test (RDT) screening for the human immunodeficiency virus, hepatitis B and hepatitis C viruses and syphilis and rescreened by ELISA techniques at the National Blood Transfusion Service Centre in Jos, along with units from first-time voluntary blood donors. A total of 19562 blood units; 5945 (30.39%) rapid diagnostic tests negative from a linkage hospital and 13617 (69.61%) from first time voluntary donors were screened by ELISA methods for HIV, HBV, HCV, and syphilis. The overall TTIs detected by ELISA was 16.08%, significantly lower among pre-donation rapid screened family replacement blood donors [495(8.32%)] compared to 2651 (19.47%) among first-time voluntary donors; P=0.0001. Fifty-seven (0.96%) HIV, 166 (2.79%) HBV, 137 (2.31%) HCV and 137 (2.31%) syphilis were still detected respectively by ELISA in the pre-screened negative family replacement blood units. The outcome of ELISA screenings of blood collected from first-time volunteer donors were; 143 (1.05%) HIV, 1,486 (10.91%) HBV, 683 (5.02%) HCV, and 339 (2.49%) syphilis. Blood for transfusion should be screened negative at least with ELISA.

scholarly journals Prévalence de la syphilis chez les donneurs de sang à la Banque du Sang d’Abéché au Tchad

2020 ◽  
Vol 14 (3) ◽  
pp. 1085-1092
Author(s):  
Djamalladine Mahamat Doungous ◽  
Abdelsalam Adoum Doutoum ◽  
Adawaye Chatte ◽  
Richard Laougangta Dounbe ◽  
Elysée Gondimo Gabdibe ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Blood Donation ◽  
Treponema Pallidum ◽  
Blood Bank ◽  
Sub Saharan Africa ◽  
Prise En Charge ◽  
Afrique Subsaharienne ◽  
Cross Sectional ◽  
Transfusion Sanguine

En Afrique subsaharienne, les infections transmissibles par la transfusion sanguine comme la syphilis sont très répandues, avec une prévalence pouvant atteindre 25% chez les donneurs de sang. La présente étude avait pour objectif de déterminer la prévalence de la syphilis chez les donneurs de sang au niveau de la Banque du Sang d’Abéché. Nous avons mené une étude transversale à visée descriptive, qui s’est déroulée de mai à août 2017. Les échantillons de sang des donneurs ont été testés par immunochromatographie pour la détection des anticorps anti-tréponémiques (Biomnis®). Sur 789 donneurs de sang inclus dans l’étude, la prévalence de la syphilis était de 4,9 %. Les donneurs étaient à 96,1% de sexe masculin et 3,9% de sexe féminin. Cette prévalence était plus élevée chez les sujets âgés de [21-30] ans, chez les femmes, les donneurs non scolarisés, divorcés et les domestiques/ménagères habitant la zone d’Abéché urbaine. Ces résultats montrent qu’il est nécessaire de mettre en place une politique de suivi et de prise en charge médicale des donneurs de sang atteints de la syphilis.Mots clés: Transfusion sanguine, receveurs, Treponema pallidum, don de sang.   English Title: Prevalence of syphilis in blood donors at Abéché blood bank in ChadIn sub-Saharan Africa, infections transmitted by blood transfusion such as syphilis are widespread, with prevalence up to 25% in blood donors. The purpose of this study was to determine the prevalence of syphilis in blood donors at the Blood Bank of Abéché. It was a descriptive cross-sectional study, which ran from May to August 2017. Donor blood samples were tested by immunochromatography for the detection of anti-treponemal antibodies (Biomnis®). Of the 789 blood donors included in the study, the prevalence of syphilis was 4.9%. Donors were 96.1% male and 3.9% female. This prevalence was higher in subjects aged [21-30] years, women, out-of-school, divorced and domestic / household donors living in the urban Abéché area. These results shows that it is necessary to set up a policy of monitoring and medical care of blood donors with syphilis.Keywords: Blood transfusion, recipients, Treponema pallidum, blood donation.

scholarly journals Potential risk of induced malaria by blood transfusion in South-eastern Nigeria

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Chigozie Jesse Uneke ◽  
Ogbonnaya Ogbu ◽  
Vincent Nwojiji
Keyword(s):  
Blood Transfusion ◽  
Thick Film ◽  
Blood Donors ◽  
Blood Donation ◽  
Health Hazard ◽  
Sub Saharan Africa ◽  
Wet Season ◽  
Potential Health ◽  
South Eastern ◽  
Significant Difference

Induced malaria by blood transfusion is a potential health hazard but is often neglected in many malaria endemic areas. Standard parasitological technique was used to determine the prevalence of malaria among blood donors in the South-eastern Nigeria. Of the total 325 blood donors (310 males and 15 females) screened, 133 (40.9%, CI 95%: 35.6-46.2%) were infected with malaria parasite, 78 (58.6%) had 1-10 parasites per 100 thick film fields ('+' or 4-40 parasites per mm3) while 55 (41.4%) had 11-100 parasites per 100 thick film fields ('++' or 41-400 parasites per mm3). P. falciparum was identified in all the infected cases, however 3 (2.3%) persons had mixed infection with P. malariae. Males were more infected (41.3%, CI 95%: 35.8-46.8%) than females (33.3%, CI 95%: 9.4-57.2%). The infection decreased with age with highest prevalence of 48.5% among those aged 20-25 years. The infection significantly varied with age but not with sex (P<0.05). Individuals with blood group B were slightly more infected (42.1%, 95%CI., 19.6-64.6%) than those of groups O (41.0%,CI 95%: 35.3-46.7%) and A (40.0%, CI 95%: 20.8-59.2%) but there was no significant difference (P < 0.05). Highest prevalence of infection was recorded in the month of April corresponding to the onset of the wet season. An overhaul of existing blood donation policies in many health facilities in the sub-Saharan Africa to incorporate malaria screening is advocated. Curative antimalarial drugs followed by prophylactic drugs should be given to all recipients of Parasitized blood.

scholarly journals Prevalence of HIV in Blood Donors

1970 ◽  
Vol 6 (2) ◽  
pp. 93-97 ◽  
Author(s):  
B R Tiwari ◽  
S Karki ◽  
P. Ghimire ◽  
P. Yadav ◽  
M Rajkarnikar
Keyword(s):  
Blood Transfusion ◽  
Blood Supply ◽  
Blood Donors ◽  
Blood Donation ◽  
Cumulative Effect ◽  
Serum Samples ◽  
Total Blood ◽  
Hiv Seroprevalence ◽  
Blood Transfusion Service ◽  
Safe Blood

Background: Nepal is categorized as a country with ‘concentrated' epidemic of HIV Nepal Red Cross Society, Blood Transfusion Service has implemented considerable efforts to supply the safe blood and blood products according to the increasing demand. A trend analysis might prove valuable to understand the outcome and appropriately plan for further  improvements in providing safe blood supply. The study aimed to assess the trends of HIV seroprevalence over the six years in nationwide and in urbanized setting of Kathmandu Valley.Methods: This is a retrospective study conducted among Nepalese blood donors through the years 2001-2007. Serum samples were tested using third generation ELISA tests, strictly following the instructions of manufacturers. The donors' information was collected through the donor record register through the respective Blood Transfusion Services.Results: The overall seroprevalence of HIV among the total blood donors in nation wide and in Central Blood Transfusion Service (CBTS), Kathmandu through the six years of review (from 2001-2007) was 0.33% and 0.4% respectively. A significant decreasing trend in HIV seroprevalence was observed both in nationwide and in Central Blood Transfusion Service, Kathmandu (P< 0.001).Conclusion: The analysis of trends in HIV seroprevalence among blood donors through the year 2001- 2007 showed a significantly decreasing trend, probably due to the cumulative effect of increasing awareness of HIV and improved screening system for safe blood donation. However, an abrupt increase in demand of blood supply was associated with significant increase in seroprevalence in the year 2005/2006. Key words: Nepalese blood donors; Seroprevalence; Trends.doi: 10.3126/jnhrc.v6i2.2203Journal of  Nepal Health Research Council 2008 Oct;6(13): Page: 93-97 

scholarly journals Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services

2021 ◽  
pp. 33-42
Author(s):  
Idayat Adenike Durotoye ◽  
Adekunle Ganiyu Salaudeen ◽  
Emmanuel Oladipo Sanni ◽  
Abiola Samuel Babatunde ◽  
Adekunle Kabir Durowade ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Blood Donation ◽  
Sub Saharan Africa ◽  
World Health ◽  
P Value ◽  
Cross Sectional ◽  
Variant Hemoglobin ◽  
Hemoglobin Variants

Background: Voluntary non-remunerated blood donation is a strategy adopted by World Health Organization aimed at ensuring safety and adequacy of blood supply. Sub-Saharan Africa has a high prevalence of hemoglobin disorders and therefore needs to adopt stringent measures in donor selection to ensure safety for the recipient of blood transfusion. This study aimed to analyze normal and variant hemoglobin among voluntary blood donors. Methods: In this descriptive cross-sectional study, 100 prospective blood donors including 55 (55%) males and 45 (45%) females, aged 18–34 years were recruited. Capillary electrophoresis using the Minicap system was used for determining the hemoglobin variants in alkaline buffer (PH 9.4). Data analysis was done using SPSS version 20 and p-value < 0.05 was considered as the level of significance Results: The mean age of the participants was 22.23 ± 3.3 SD years. The proportion of participants with genotype AA was 67 (67%), those with AS were 17 (22 %), while those with AC were 11 (11 %). While Hb A ≥ 90% was noted in 67 (67%) blood donors, Hb S was seen in 22 (22%) and Hb A2 > 3.5% in 57 (57%). Hb F > 2% was observed in 3% of the studied participants Conclusion: Variant hemoglobin is common among blood donors and this should be taken into consideration whenever blood is being crossmatched for recipients of blood transfusion. Data from this study will be useful in raising awareness and genetic counseling. Keywords: prevalence, hemoglobin variants, capillary electrophoresis

A study of blood donor motivation in South Africa

2018 ◽  
pp. 158-163
Author(s):  
Richard M. Titmuss
Keyword(s):  
South Africa ◽  
Blood Transfusion ◽  
Blood Donor ◽  
Blood Donors ◽  
Blood Donation ◽  
Interview Data ◽  
Donor Motivation ◽  
Manual Worker ◽  
Blood Transfusion Service ◽  
Bantu Population

This chapter looks at a study of blood donor motivation in South Africa, which was commissioned by the Natal Blood Transfusion Service and carried out in Durban. Much of the fieldwork was done by six trained Bantu graduates which helps to explain the perceptive nature of some of the interview data elicited from poor and semi-literate Bantu workers. The study shows that the Bantu donor is statistically rare. They come mainly from institutional groups such as factories and schools and tend to be younger, better educated, and with higher incomes than the average Bantu adult in Durban. The concepts of blood held by the average manual worker Bantu closely link blood with health and are unfavourable to blood donation. Moreover, in the Bantu population at large there is widespread ignorance about, and fear of, blood donation. A marked characteristic of the Bantu blood donors is that they tend to give blood only once or twice.

scholarly journals Clinical overlap between malaria and pneumonia: can malaria rapid diagnostic test play a role?

2011 ◽  
Vol 5 (03) ◽  
pp. 199-203 ◽  
Author(s):  
Kingsley Nnanna Ukwaja ◽  
Olufemi B Aina ◽  
Ademola A Talabi
Keyword(s):  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Diagnostic Tests ◽  
Health Centre ◽  
Rapid Diagnostic Tests ◽  
Case Definition ◽  
Sub Saharan Africa ◽  
Malaria Rapid Diagnostic Test ◽  
Chi Square ◽  
Symptom Overlap

Introduction: Malaria and pneumonia account for 40% of mortality among children under five years of age in sub-Saharan Africa. Due to lack of diagnostic facilities, their management is based on the integrated management of childhood illnesses (IMCI) strategy. Symptoms of malaria and pneumonia overlap in African children, necessitating dual IMCI classifications at health centres and treatment with both antibiotics and antimalarials. This study determined the prevalence of malaria-pneumonia symptom overlap and confirmed the diagnosis of malaria in these cases using a rapid diagnostic test. Methodology: Consecutive consultations of 1,216 children (two months to five years old) were documented over a three-month period in a comprehensive health centre. Malaria rapid diagnostic tests were conducted only for children who had symptom overlap. Results: Of the 1,216 children enrolled, 1,090 (90%) reported cough or fever. Among the children fulfilling the malaria case definition, 284 (30%) also met the pneumonia case definition. Twenty-three percent (284) of all children enrolled met the criteria for both malaria and pneumonia. However, only 130 (46%) of them had a positive result for malaria using a malaria rapid diagnostic test. During a malaria-pneumonia overlap, female children (chi-square 5.9, P = 0.01) and children ≥ one year (chi-square 4.8, P = 0.003) were more likely to seek care within two days of fever. Conclusion: Dual treatment with antimalarials and antibiotics in children with malaria-pneumonia overlap may result in unnecessary over-prescription of antimalarial medications. Use of rapid diagnostic tests in their management can potentially avoid over-prescribing of malaria medications.

scholarly journals Transfusion-Transmitted Malaria: A Systematic Review and Meta-analysis

2019 ◽  
Vol 6 (7) ◽  
Author(s):  
Ehsan Ahmadpour ◽  
Masoud Foroutan-Rad ◽  
Hamidreza Majidiani ◽  
Sirous Mehrani Moghaddam ◽  
Kareem Hatam-Nahavandi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Meta Analysis ◽  
Plasmodium Species ◽  
Diagnostic Methods ◽  
Sub Saharan Africa ◽  
Screening Methods ◽  
Original Research ◽  
Malaria Parasitemia

Abstract Background Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature. Methods PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran’s Q test. Publication and population bias was assessed with funnel plots and Egger’s regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2). Results Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum. Conclusions This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.

scholarly journals Donor awareness: key to successful voluntary blood donation

F1000Research ◽  
2012 ◽  
Vol 1 ◽  
pp. 29 ◽  
Author(s):  
Rateesh Sareen ◽  
Gajendra N Gupta ◽  
Akanksha Dutt
Keyword(s):  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Tertiary Hospital ◽  
Statistical Technique ◽  
Study Data ◽  
Blood Bank ◽  
Western India ◽  
Care Hospital ◽  
Proactive Measures

Context: The current regulatory requirements for donor eligibility pose a challenge to blood centers in recruitment of voluntary blood donors, particularly in a developing country like India where awareness of the general population is low and myths about blood donation are prevalent. This study evaluates the reasons and rates of donor deferral in a tertiary hospital-based blood bank in western India.Aim: To find rates and reasons for deferral of voluntary blood donors in a city in western India.Settings and design: A retrospective study was done on blood donors during a 3-month period. Data collection was done by electronic records of blood donors.Materials and Methods: The study was conducted retrospectively at a tertiary care hospital in western India. All those who donated whole blood between 1st January 2011 and 31st March 2011 were included in the study. Data was collected using local blood bank software.Statistical analysis used: No statistical technique used as it is a data article.Results: 60.5% of donors were young, below 30 years of age. Donors were predominantly male (91.6%). Voluntary donors comprised 88% of the donors. Total deferral rate was 22.36%, with 17.29% permanent deferrals and 82.71% temporary deferrals. Main reasons for deferral were anemia 39.42%, low body weight 14.29%, hypertension 10.73%, age below 18 years 10.73% and history of medication 6.09%. The common causes of deferral between our study and other similar studies are the same.Conclusion: We concluded that majority of the donor population belongs to 18–30-year-old age group. This is encouraging with a voluntary blood donation initiative. Donor self exclusion and strict donor selection criteria application should be addressed by more proactive measures to make blood donation a safe and pleasurable experience.

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