scholarly journals Carotid Artery Intimal Medial thickness in Diabetic and Non-Diabetic Subjects in Central Kerala

2020 ◽  
Vol 8 (2) ◽  
pp. 99-105
Author(s):  
Sholy K Vareed ◽  
Don Paul Mathew ◽  
P Suresh
Keyword(s):  
Blood Pressure ◽  
Carotid Artery ◽  
Total Cholesterol ◽  
Linear Regression Analysis ◽  
Organ Damage ◽  
Diabetic Patients ◽  
Multivariate Linear Regression Analysis ◽  
Atherosclerotic Vascular Disease ◽  
Intimal Medial Thickness ◽  
Linear Probe

Background: Increase in intimal medial thickness (IMT) of the carotid arteries is contemplated as a guide to atherosclerotic vascular disease and subclinical organ damage and foretell cardiovascular disease. The study aimed to analyse IMT in non-diabetic and diabetic subjects. Subjects and Methods: There were 105 diabetic and 95 non-diabetic subjects in this study. Common carotid artery (CCA) IMT was calculated using a linear probe of a high-resolution ultrasound medical system. Results: Diabetic subjects (0.95 mm) showed significantly higher mean intimal medial thickness (IMT) when compared non-diabetic subjects (0.85 mm) (p <0.05). Correlation of IMT was seen with age, total cholesterol, triglycerides, HDL & LDL cholesterol and systolic blood pressure (SBP) in diabetic subjects. Total cholesterol, SBP and diastolic blood pressure (DBP) showed a correlation with IMT in the non-diabetic subjects. Age, total cholesterol, SBP, and diabetes were independent risk factors for intimal medial thickness in multivariate linear regression analysis. Conclusion: Higher intimal medial thickness was seen in diabetic subjects when compared to non-diabetic subjects. We conclude that age, total cholesterol, SBP and duration of diabetes showed a significant correlation with IMT. IMT can be considered as a screening tool in diabetic patients for the early detection of atherosclerosis.

scholarly journals Circadian blood pressure rhythm and intimal media thickness changes in non-dipper normotensives patients

2017 ◽  
Vol 11 ◽  
Author(s):  
Massimiliano Rocchietti March ◽  
Claudia Maggiore ◽  
Gerardo Salerno ◽  
Agostino De Venanzi ◽  
Elena Scaramucci ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Measurement ◽  
Target Organ Damage ◽  
Pressure Profile ◽  
Organ Damage ◽  
Profile Measurement ◽  
Circadian Blood Pressure ◽  
Intimal Medial Thickness ◽  
Carotid Intimal Medial Thickness ◽  
Increased Risk

<p>We investigated 25 <em>non-dipper</em> normotensive <em>vs </em>25 <em>dipper </em>normotensive patients. The aim of our study was to evaluate carotid intimal-medial thickness (IMT) in the two groups. At the admission patients underwent anamnesis and general examination, blood sampling for lipid profile measurement, glycemia, homocysteine, ambulatory blood pressure measurement to assess the circadian blood pressure profile, and Doppler ultrasound to measure carotid intimal-medial thickness (IMT). Our results showed that IMT is significantly higher in the <em>non-dipper </em>group (P&lt;0.006) <em>vs dippers</em>. <em>Non-dipper </em>status has been recognized in several studies a condition with increased risk for target organ damage in hypertensive and normotensive subjects. However, to our knowledge, a possible relationship between IMT and normotensive <em>non-dipper </em>patients has not yet clearly investigated. Our study instead has clearly demonstrated a significant relationship between IMT and the <em>non-dipper status</em>.</p>

scholarly journals Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Lin Xu ◽  
Bo Zhou ◽  
Huixia Li ◽  
Jiali Liu ◽  
Junhui Du ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Microvascular Complications ◽  
Linear Regression Analysis ◽  
Serum Levels ◽  
Diabetic Microangiopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Objective. Progranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway. This study aimed to investigate the correlation between PGRN and type 2 diabetics with microvascular complications.Methods. PGRN serum levels and glucose metabolism related substance were measured in 84 type 2 diabetic patients with or without microangiopathies and 12 health persons. Further analyses of serum PGRN in different stages of diabetic microangiopathies were conducted.Results. Serum levels of PGRN were markedly higher in type 2 diabetic patients with microangiopathies. PGRN serum levels increased with the progress of diabetic microangiopathies with significantly highest values detectable in clinical diabetic nephropathy (CDN) and proliferative diabetic retinopathy (PDR) groups. Serum PGRN concentrations in all individuals positively and markedly correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triglyceride (TG), urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), creatinine (CRE), white blood cell (WBC), disease duration, IL-6, and TNF-α, while correlating negatively and significantly with eGFR. Multiple linear regression analysis showed that only UAER and CRE were independently associated with serum PGRN.Conclusion. PGRN might be considered as a marker for diabetic microangiopathy and its severity.

scholarly journals Determinants of the Morning-Evening Home Blood Pressure Difference in Treated Hypertensives: The HIBA-Home Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lucas S. Aparicio ◽  
Jessica Barochiner ◽  
Paula E. Cuffaro ◽  
José Alfie ◽  
Marcelo A. Rada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Calcium Channel ◽  
Total Cholesterol ◽  
Calcium Channel Blockers ◽  
Target Organ Damage ◽  
Linear Regression Analysis ◽  
Home Blood Pressure ◽  
Channel Blockers ◽  
Analysis Model ◽  
Home Based

Background. The morning home blood pressure (BP) rise is a significant asymptomatic target organ damage predictor in hypertensives. Our aim was to evaluate determinants of home-based morning-evening difference (MEdiff) in Argentine patients.Methods. Treated hypertensive patients aged≥18 years participated in a cross-sectional study, after performing home morning and evening BP measurement. MEdiff was morning minus evening home average results. Variables identified as relevant predictors were entered into a multivariable linear regression analysis model.Results. Three hundred sixty-seven medicated hypertensives were included. Mean age was 66.2 (14.5), BMI 28.1 (4.5), total cholesterol 4.89 (1.0) mmol/L, 65.9% women, 11.7% smokers, and 10.6% diabetics. Mean MEdiff was 1.1 (12.5) mmHg systolic and 2.3 (6.1) mmHg diastolic, respectively. Mean self-recorded BP was 131.5 (14.1) mmHg systolic and 73.8 (7.6) mmHg diastolic, respectively. Mean morning and evening home BPs were 133.1 (16.5) versus 132 (15.7) systolic and 75.8 (8.4) versus 73.5 (8.2) diastolic, respectively. Significant beta-coefficient values were found in systolic MEdiff for age and smoking and in diastolic MEdiff for age, smoking, total cholesterol, and calcium-channel blockers.Conclusions. In a cohort of Argentine medicated patients, older age, smoking, total cholesterol, and use of calcium channel blockers were independent determinants of home-based MEdiff.

scholarly journals Increased glucose-dependent insulinotropic polypeptide (GIP) secretion in acromegaly

2001 ◽  
pp. R1-R4 ◽  
Author(s):  
M Peracchi ◽  
S Porretti ◽  
C Gebbia ◽  
C Pagliari ◽  
P Bucciarelli ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Linear Regression Analysis ◽  
Diabetic Patients ◽  
Multivariate Linear Regression Analysis ◽  
Newly Diagnosed ◽  
Blood Samples ◽  
Liquid Meal ◽  
Postprandial Plasma Glucose ◽  
Solid Liquid ◽  
Design And Methods

OBJECTIVE: Acromegaly is often associated with fasting and postprandial hyperinsulinemia, and the mechanisms involved are only partly understood. Hypersecretion of incretins such as glucose-dependent insulinotropic polypeptide (GIP) could play a role in determining hyperinsulinemia in acromegaly, but the available data are inconsistent. The aim of this study was to characterize the fasting and postprandial pattern of plasma GIP and insulin in a group of acromegalic patients. DESIGN AND METHODS: Eleven non-diabetic patients with newly diagnosed acromegaly and 11 sex- and age-matched healthy subjects were studied. Blood samples were taken at regular intervals in fasting conditions and for 3 h after a standard solid-liquid meal for growth hormone (GH), GIP and insulin measurements. RESULTS: Not only insulin, but also fasting and postprandial GIP levels were significantly higher in the patients with acromegaly than the healthy subjects (P<0.01). In the former group fasting GIP levels and the integrated GIP response to the meal correlated significantly with GH basal levels (r=0.83, P<0.01 and r=0.65, P<0.05, respectively). Moreover, multivariate linear regression analysis showed that the presence of acromegalic status was associated with higher fasting and postprandial GIP levels independently of sex, age, fasting and postprandial plasma glucose and insulin levels, and the occurrence of normal or impaired glucose tolerance. CONCLUSION: This study provides evidence that in patients with acromegaly fasting and postprandial GIP levels are abnormally high. GIP hypersecretion in turn might play a role in the pathogenesis of hyperinsulinemia that characterizes acromegaly.

scholarly journals Prevention and treatment of diabetic microangiopathy: A lecture

1995 ◽  
Vol 41 (6) ◽  
pp. 29-34
Author(s):  
A. K. Dreval
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Diabetic Microangiopathy ◽  
Diabetic Patients ◽  
Atherosclerotic Vascular Disease ◽  
Diabetic Macroangiopathy ◽  
Prevention And Treatment ◽  
Patients With Diabetes

One of the main complications leading to high disability and mortality in patients with diabetes mellitus is atherosclerotic vascular disease (diabetic macroangiopathy). At the same time, the frequency of atherosclerosis among patients with diabetes mellitus is significantly affected by the so-called risk factors for atherosclerosis. In particular, the incidence of atherosclerosis among the general population and among diabetics increases with increased levels of cholesterol (cholesterol) in the blood, blood pressure, smoking and obesity. However, in patients with diabetes mellitus, mortality, for example, from coronary heart disease increases by 3 times against any of the known risk factors. But even without risk factors, the frequency of atherosclerotic vascular damage in patients with diabetes is much higher than in non-diabetic patients, i.e. diabetes in itself is a risk factor for atherosclerosis.

scholarly journals Parameters Associated with Elevated Systolic Blood Pressure Levels in Greek Military Pilots

2014 ◽  
Vol 6 (1) ◽  
pp. 27-31
Author(s):  
G. Platsas ◽  
G. Kourianidis ◽  
P. Toutouzas ◽  
C. Stefanadis ◽  
G. Vyssoulis
Keyword(s):  
Blood Pressure ◽  
Dietary Habits ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Multivariate Linear Regression Analysis ◽  
Medical Monitoring ◽  
Cross Sectional ◽  
Elevated Systolic Blood Pressure ◽  
Life Style Changes ◽  
Military Pilots

Background: Elevated blood pressure levels (BP) continue to comprise one of the most important public health problems worldwide. Hypertension is among the most serious risk factors that relates to myocardial infarction, stroke and kidney failure. The purpose of the study was to examine factors that may contribute to presentation of hypertension in military jet pilots. Methods: This is a cross-sectional study of 300 jet pilots of Greek Air-Force. Several data were retrieved from medical files. Participants filled in a questionnaire about demographics, dietary habits and lifestyle factors. Arterial BP was also measured. Spearman’s r was used for correlations. Also, multivariate linear regression analysis was performed. Results: All pilots presented systolic and diastolic BP within normal range (mean: 117.5 mmHg and 77.0 mmHg, respectively). 200 pilots presented optimal BP, 80 normal BP and 20 had marginally normal BP. Most pilots were exercising up to two times weekly (66.9%), however, some reported they didn’t exercise at all (12%) and mentioned exercising for a mean period of 12.0 (±7.6) years, mainly (62.1%) outdoors with aerobic (52.4%), anaerobic exercises (5.6%) or both (42%). Factors that influenced systolic BP levels were body mass index, flight hours, HDL values and exercise intensity. Conclusion: Pilots’ medical monitoring seems adequate since there weren’t any abnormal BP values. Emphasis should be placed on the continuation of programs already in place with further refinement according to specific needs. Smoking cessation interventions are needed as well as promotion of measures that can effectively lead to long standing life-style changes and dietary modifications.

SO085CIRCULATING PCSK9 LEVEL PREDICTS RISK OF CARDIOVASCULAR EVENTS AND DEATH IN HEMODIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Hyeon Seok Hwang ◽  
Jin Sug Kim ◽  
Yang-Gyun Kim ◽  
So-Young Lee ◽  
Shin Young Ahn ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Total Cholesterol ◽  
Cox Regression ◽  
Linear Regression Analysis ◽  
High Sensitivity ◽  
Statin Treatment ◽  
Multivariate Linear Regression Analysis ◽  
Cox Regression Analysis ◽  
Composite Events ◽  
Multiple Variables

Abstract Background and Aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for prevention of cardiovascular (CV) events. However, the clinical significance of circulating PCSK9 is unclear in hemodialysis (HD) patients. Method A total of 353 HD patients were prospectively enrolled from June 2016 to May 2018 in a K-cohort. Plasma PCSK9 level was measured at the time of study enrollment. Patients were classified into three groups based on PCSK9 tertile. The primary endpoint was defined as composite of CV event and death from any cause. Results Plasma PCSK9 level was positively correlated with total cholesterol level in patients with statin treatment. However, PCSK9 was not related to plasma inflammatory (high-sensitivity C-reactive peptide, monocyte chemoattractant protein-1, interleukin-6) or calcification-related markers (osteoprotegerin and receptor activator of nuclear factor kappa-Β ligand). Multivariate linear regression analysis revealed that baseline statin treatment and serum glucose, albumin, and total cholesterol were independent determinants of circulating PCSK9 levels. In Cox-regression analysis, PCSK9 tertile 3 was associated with a 1.99-fold risk for composite events (95% CI, 1.08–3.66), and it was associated with a 2.26-fold risk for CV events (95% CI, 1.11–4.62) after adjustment for multiple variables. PCSK9 tertile 3 provides additional prognostic power to predict composite events in subgroups with higher levels of high-sensitivity C-reactive peptide and LDL. Conclusion In conclusion, higher circulating PCSK9 level independently predicted CV events and death in HD patients. These results suggest the importance of future studies regarding the effect of PCSK9 inhibition on reduction of CV events.

Abstract MP68: The Correlation Between Left Atrial-left Ventricular-arterial Coupling And Circadian Rhythm Of Blood Pressure In Hypertension

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Yan Liu ◽  
Qiaobing Sun ◽  
Yixiao Zhao ◽  
Yinong Jiang
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Circadian Rhythm ◽  
Linear Regression ◽  
Left Atrial ◽  
Linear Regression Analysis ◽  
Left Ventricular ◽  
Multivariate Linear Regression ◽  
Multivariate Linear Regression Analysis ◽  
Left Ventricular Arterial Coupling

The Correlation between Left Atrial-Left Ventricular-Arterial Coupling and Circadian Rhythm of Blood Pressure in Hypertension Objective: Hypertension induces left atrial (LA) and left ventricular (LV) dysfunction, and arterial stiffness increased. In this study, we further investigated the association between LA-LV-arterial coupling and circadian rhythm of blood pressure (BP) in essential hypertension (HT). Design and Methods: We enrolled 289 HT patients which were evaluated by 2 dimensional speckle tracking echocardiography (2D-STE), ambulatory 24-hour BP monitoring (ABPM) and carotid-femoral pulse wave velocity (PWV). According to BP patterns, these patients were divided into two groups, which included dippers (n=109), patients with a >10% reduction in BP at nighttime; non-dippers (n=180), patients with a <10% reduction in BP at nighttime. 2D-STE based LA and LV strains were studied and the following parameters were measured, LV global longitudinal strain (GLS), LA reservoir strain (LA S-S ), LA conduit strain (LA S-E ), and LA booster pump strain (LA S-A ). LA stiffness index (LASI) defined as the ratio of E/e' to LA S-S , and PWV-to-GLS ratio (PWV/GLS) were calculated to reflect LA-LV-arterial coupling. Furthermore, we also explored the correlation between LASI (or PWV/GLS) and ambulatory blood pressure indexes. The related factors were evaluated by multivariate linear regression analysis to find the independent factors. Results: LASI was significantly higher in non-dippers (0.35±0.24) than dippers (0.29±0.12) ( p <0.05). PWV/GLS was significantly higher in non-dippers (-90.30±34.13) than dippers (-79.62±25.84) ( p <0.05). LA S-S , LA S-A and LV GLS were significantly lower in non-dippers than dippers ( p <0.05). Multivariate linear regression analysis revealed that LV mass index (LVMI), PWV/GLS, nighttime mean SBP (n-SBP) and nighttime mean DBP (n-DBP) were independently correlated with LASI; LASI and n-SBP were independently correlated with PWV/GLS. Conclusions: LA and LV myocardial mechanics, and LA-LV-arterial coupling were associated with circadian rhythm of BP. Nocturnal systolic BP was the independent risk factor of abnormal LA-LV-arterial coupling in HT.

P6198Lipoprotein(a) as a potential residual risk associated with coronary lipid-rich atheroma in type2 diabetic subjects with coronary artery disease who achieved lowdense lipoprotein cholesterol<1.7mmol/l

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Nakamura ◽  
Y K Kataoka ◽  
H H Hosoda ◽  
T N Nakashima ◽  
S H Honda ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Regression Analysis ◽  
Coronary Artery ◽  
Linear Regression Analysis ◽  
Diabetic Patients ◽  
Multivariate Linear Regression Analysis ◽  
Type 2 Diabetic Patients ◽  
Artery Disease ◽  
Type 2 Diabetic

Abstract Background Type 2 diabetic patients with coronary artery disease (CAD) is a high-risk subjects who require intensive secondary preventive management. The current guideline recommends lowering LDL-C with a statin as a first-line therapy in diabetic patients with CAD. However, its anti-atherosclerotic efficacy is diminished compared to non-diabetic subjects. These suggest the need to further identify additional therapeutic target associated with diabetic atherosclerosis. Lipoprotein (a) [Lp (a)] is a plasma lipoprotein which consists of an LDL-like particle with apolipoprotein (a). While Lp (a) has been shown to associate with ASCVD, whether this lipoprotein promotes diabetic coronary atherosclerosis under LDL-C control with a statin remains to be fully elucidated. Purpose To investigate the relationship between Lp (a) and coronary lipidic atheroma by near-infrared spectroscopy (NIRS), which quantitatively measures lipidic burden in vivo. Methods Culprit lesions in 127 type 2 diabetic patients with CAD who already received a statin were evaluated by NIRS imaging. Maximum 4-mm lipid core burden index at culprit lesion (MaxLCBI4mm) was measured. Results High-intensity statin and ezetimibe were used in 13 and 14% of study subjects, respectively. Their on-treatment LDL-C level and Lp (a) were 2.0±0.7 mmol/l and 22.1±26.7 mg/dl. Despite these lipid lowering therapy, average MaxLCBI4mm was 419.6±248.2 and MaxLCBI4mm≥400 was observed in 49% of study subjects. Multivariate linear regression analysis demonstrated LDL-C and Lp (a) as independent determinants associated with MaxLCBI4mm (Table). Of note, in subjects who achieved LDL-C<1.8 mmol/l, an elevated Lp (a) level but not LDL-C predicts MaxLCBI4mmat culprit lesions (Table). Multivariate linear regression analysis t p-value Entire subjects (n=127)   LDL-C 2.04 0.04   Lp (a) 2.88 <0.01 LDL-C <1.8 mmol/l (n=47)   LDL-C 0.45 0.66   Lp (a) 2.74 0.01 Conclusions The association of Lp (a) with coronary lipid-rich atheroma even under guideline-recommended LDL-C control indictaes Lp (a) as an additional therapeutic target to further stabilize diabetic atherosclerosis.

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