scholarly journals Hypothyroidism – An Underestimated Complication After Hemithyroidectomy: A Preliminary Study Report

2017 ◽  
Vol 25 (1) ◽  
pp. 19-26
Author(s):  
Neeraj Aggarwal ◽  
Sirshak Dutta ◽  
Tanaya Panja ◽  
Mainak Dutta ◽  
Sanjoy Kumar Ghosh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Thyroid Function ◽  
Tertiary Care ◽  
Thyroid Function Test ◽  
Lymphocytic Infiltration ◽  
Care Hospital ◽  
Function Test ◽  
Preliminary Study ◽  
Serum Tsh

Introduction Hypothyroidism is a significant but an under-appreciated complication of hemithyroidectomy. The focus of this study was to assess the incidence of hypothyroidism occurring after hemithyroidectomy, identify the risk factors and to suggest a possible follow-up guideline for diagnosis. Materials and Methods An institution based preliminary study was conducted in the Department of Otorhinolaryngology, in a tertiary care hospital, from August 2014 to December 2015 on 25 patients. The patients were regularly followed up in 1st month, 3rd month, 6thmonth, 9th month and 1 year period with the thyroid function test. Results Incidence of hypothyroidism occurring after hemithyroidectomy including transient and permanent cases is 32%. Increased age of presentation, longer duration of thyroid swelling, pre-operative serum TSH level >2.5 mIU/ml, lymphocytic infiltration in histopathology and right sided hemithyroidectomy were found to be the possible risk factors. Conclusion It is indicated from this preliminary report that there should be a serial thyroid function monitoring in every post-operative hemithyroidectomy patient, and special attention should be given to the risk group

scholarly journals Thyroid disorder in pregnancy and postpartum with neonatal outcome a study in tertiary care centre

2019 ◽  
Vol 8 (5) ◽  
pp. 1795
Author(s):  
Bharati Das ◽  
Puspanjali Khuntia
Keyword(s):  
Thyroid Function ◽  
Post Partum ◽  
Tertiary Care ◽  
Thyroid Function Test ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
New Born ◽  
Pregnancy And Postpartum ◽  
Function Test ◽  
In Pregnancy

Background: Thyroid disorders are well known entity in pregnancy. Both mother and baby have to suffer from the consequences.  Lot of works has been done and many guidelines too came out over the years but what is actual understanding of the disease process by the mothers about themselves and for their babies especially in developing country like India remained uncovered. This has been analysed in present study.Methods: It is a prospective observational study done in the post-partum programmed department of SCB medical college and hospital, a tertiary care center in eastern part of India for 3 years period. Thyroid dysfunction of the mothers and new born screening of thyroid function of their babies has been assessed.Results: During this period total no of the babies along with their mothers were evaluated were 3762. Total no of thyroid disorders detected in 85 (2.25%) of mothers, among which hypothyroidism in 79 (2.09%) and hyperthyroidism in 6 (0.16%) were found. From total 85 cases, 79 (93%) mothers were hypothyroid   and 6 (7%) were hyperthyroid. Among the hypothyroid mothers 32 (40.5%) were diagnosed before present pregnancy and (59.5%) were diagnosed during pregnancy. In the babies of hypothyroid mother, new born screening for thyroid function was done only in 14 (17.7%) cases between 5-10 days.Conclusions: Thyroid screening should be done in pregnancy as universal screening instead of high-risk cases. Documentation and interdepartmental coordination are very much essential in thyroid disorders for further decision by the physician for necessity of continuation of treatment and thyroid function test in the post-partum period for the mothers and its long-term consequences. It also guides the neonatologist or pediatrician doing thyroid function test of their babies. Ideally All newborns should be screened for congenital hypothyroidism as a part of new born screening (NBS) programmed. Effective communication with the mother and the family is very much essential for monitoring and treatment of both mother and the baby.

scholarly journals Clinical Finding and Thyroid Function in Women with Struma Ovarii

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Ali Hosseini ◽  
Aida Moeini
Keyword(s):  
Thyroid Function ◽  
Final Analysis ◽  
Thyroid Function Test ◽  
Struma Ovarii ◽  
Presenting Symptoms ◽  
Function Test ◽  
Average Patient ◽  
The Mean ◽  
Serum Tsh ◽  
Hormonal Levels

Background. Struma ovarii (SO) is a variant of dermoid tumors which completely or mainly composed of thyroid tissues. Objective. We report our experience in the diagnosis and thyroid function of patients with SO in our hospital and also review the management and treatment option of this tumor. Materials and Methods. Between 2000 and 2012, 15 consecutive females with SO who were presented to our hospital were fully assessed. All women had histologically confirmed struma ovarii. The medical records of all patients including presenting symptoms, CT scan finding, and hormonal levels were collected for final analysis. Results. Average patient age was 36.6 years (ranging from 21 to 69). The mean ± SDs of serum TSH, T4, and T3 were  mUI/mL,  ng/dL, and  ng/dL, respectively. The value of TSH was lower than normal value in 26.7%. Also, antithyroglobulin and anti-TPO were positive in 2 and one cases, respectively. Conclusion. Based on our data, it is more likely to see a disturbance in serum values of thyroid function test in women with SO.

scholarly journals Prevalence Of Hepatotoxicity In HIV-Positive, Tuberculosis And HIV+TB Co Infected Patients In Tertiary Care Hospitals , Sindh

2020 ◽  
Vol 7 (08) ◽  
pp. 4900-4907
Author(s):  
Arsalan Ahmed Uqaili ◽  
Marvi Gurbakhshani ◽  
Zahid Ali Shaikh ◽  
Imdad Ali Ansari ◽  
Keenjhar Gurbakhshani
Keyword(s):  
Risk Factors ◽  
Confidence Interval ◽  
Incidence Rate ◽  
Cumulative Incidence ◽  
Tertiary Care ◽  
Hiv Positive ◽  
Care Hospital ◽  
Study Population ◽  
Hiv Aids

Hepatotoxicity is historically the 3rd most common reason for drug withdrawal and toxicity-related discontinuation of treatment. This study was aimed at determining the incidence and the onset of hepatotoxicity and at evaluating the relationship of some risk factors for hepatotoxicity among Human Immunodeficiency Virus- (HIV-) positive, tuberculosis (TB), and HIV/TB patients on treatment. This was a prospective follow-up study involving 125 participants from the HIV/AIDS and TB treatment centres in Tertiary Care hospital of Larkana and Sukkur, Sindh. These TB and HIV patients were initiated on RHEZ (R = Rifampicin, H = Isoniazid, E = Ethambutol, and P = Pyrazinamide) and TELE (efavirenz/tenofovir/lamivudine), respectively, and followed up for 12 weeks between September 2018 and November 2019. The levels of liver enzymes (transaminases, gamma- glutamyltransferase, alkaline phosphatase, and unconjugated/total bilirubin) were measured spectrophotometrically using serum. The Chi-squared (χ2) test was used to assess the association between risk factors and hepatotoxicity, while the Kaplan-Meier survival analysis with the log-rank test was used to determine the occurrence of hepatotoxicity in the different groups. We followed the general study population for a total person time of 6580 person-days, with an incidence rate and cumulative incidence of 8 cases per 1000 person-days (53/6580 person-days) and 42.4% (53/125), respectively (95% confidence interval), recorded after 12 weeks of follow-up of all the participants. The onset of hepatotoxicity in the total study population was statistically significant (χ2 = 9:5334; p = 0:022979; CI = 95%), with the majority observed at week eight of follow-up. Also, the incidence rate and cumulative incidence of hepatotoxicity with respect to HIV/AIDS, TB, and HIV/TB patients, respectively, at 95% confidence interval were: 8 cases per 1000 person-days (32/3843 person-days) and 32/76 (42.1%), 6 cases per 1000 person- days (12/1932 person-days) and 12/32 (37.5%), and 11 cases per 1000 person-days (9/805 person-days) and 9/17 (52.9%). This study shows that the incidence rate and cumulative incidence of hepatotoxicity in HIV/AIDS, TB, and HIV/TB patients on treatment were high . Also, it is very important to check these patients’ liver function especially within the first 12 weeks of treatment.

scholarly journals Prevalence and complications of Hypothyroidism during pregnancy in western Nepal

2014 ◽  
Vol 3 (1) ◽  
pp. 48-50 ◽  
Author(s):  
TL Upadhyaya ◽  
A KC ◽  
S Paudel
Keyword(s):  
Thyroid Function ◽  
Care Center ◽  
Tertiary Care ◽  
College Teaching ◽  
Thyroid Function Test ◽  
Overt Hypothyroidism ◽  
Medical College ◽  
Study Results ◽  
Function Test ◽  
Entire Pregnancy

Background: This study was designed to know the prevalence of hypothyroidism during pregnancy in western part of Nepal and its potential complications. Methods: One Hundred seven pregnant cases from Gandaki Medical college teaching hospital and Diabetes thyroid and Endocrinology care center, two of the tertiary care centers in Pokhara were enrolled in the study from the year 2011 January to 2012 December. Detailed history and physical examination was done. Thyroid Function test (FT3, FT4 andTSH) were performed after the confirmation of pregnancy. Patients were followed up during entire pregnancy. Seven patients dropped out from the study. Results: Out of 107 patients 56 patients had TSH below 6 mIU/L,31patients had TSH between 6mIU/L - 10 mIU/L and 13 patients had TSH more than 10 mIU/L. Seven patients dropped out from the study. There was1 miscarriage, 1 still birth from hypothyroid mother and 11 hypothyroid and subclinical hypothyroid mothers had preterm delivery. Conclusion: Prevalence of overt hypothyroidism is around 13% and subclinical hypothyroidism is around 31% in pregnant ladies in western Nepal. Also complications like stillbirth should be prevented by detecting and treating hypothyroidism early. So we recommend all patients with pregnancy to perform thyroid function test at the start of pregnancy. Nepal Journal of Medical Sciences | Volume 03 | Number 01 | January-June 2014 | Page 48-50 DOI: http://dx.doi.org/10.3126/njms.v3i1.10358

scholarly journals Cytomorphological Spectrum of Thyroiditis: A Review of 110 Cases

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Shirish S. Chandanwale ◽  
Rahul Nair ◽  
Anushree Gambhir ◽  
Supreet Kaur ◽  
Aditi Pandey ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Thyroid Function Test ◽  
Lymphocytic Infiltration ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Peroxidase ◽  
Thyroid Follicular Cell ◽  
Cell Clusters ◽  
Thyroid Peroxidase Antibodies ◽  
Function Test

Introduction. Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality. Aim. Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Materials and Methods. The study included consecutive 110 cases of thyroiditis. Detailed cytomorphological features were studied and correlated with ultrasonography findings, thyroid function test, anti-thyroid peroxidase antibodies (anti-TPO) and histopathological features where thyroidectomy specimens were received for histopathological examination. Results. The majority were Hashimoto’s thyroiditis (n=100) and females (n=103). Other forms of thyroiditis were Hashimoto’s thyroiditis with colloid goiter (n=5), De Quervain’s thyroiditis (n=3), and one case each of postpartum thyroiditis and Hashimoto’s thyroiditis with associated malignancy. The majority of patients were in the age group of 21–40 (n=70) and the majority (n=73) had diffuse enlargement of thyroid. The majority of patients were hypothyroid (n=52). The serum anti-TPO antibodies were elevated in 47 patients out of 71 patients. In the 48 patients who underwent ultrasonography, 38 were diagnosed as having thyroiditis. The most consistent cytomorphological features seen in fine-needle aspiration smears of Hashimoto’s thyroiditis were increased background lymphocytes, lymphocytic infiltration of thyroid follicular cell clusters, and Hurthle cells. Conclusion. The diagnostic cytological features in Hashimoto’s thyroiditis are increased background lymphocytes, lymphocytic infiltration of thyroid follicular cell clusters, and Hurthle cells. FNAC remains the “Gold Standard” for diagnosing Hashimoto’s thyroiditis. Clinical history, thyroid function, and biochemical parameters are the key for diagnosis of other forms of thyroiditis.

Thyroid antibodies in blood donors: prevalence and clinical significance

1984 ◽  
Vol 105 (3) ◽  
pp. 324-329 ◽  
Author(s):  
T. Bjøro ◽  
P. I. Gaarder ◽  
E. B. Smeland ◽  
L. Kornstad
Keyword(s):  
Thyroid Function ◽  
Blood Donors ◽  
Thyroid Function Test ◽  
Thyroid Antibodies ◽  
Nodular Goitre ◽  
Thyroglobulin Antibodies ◽  
Function Test ◽  
Toxic Nodular Goitre ◽  
Thyroid Microsomal Antibodies

Abstract. In sera from 1643 randomly selected blood donors examined in 1979 thyroglobulin antibodies (TGA) were found in 3.4% and thyroid microsomal antibodies (TMA) in 7.0%. TMA, but not TGA, showed significant sex and age relationships. Eighty-two donors with TMA titres ≥ 1600 and/or TGA titres ≥ 128 were available for a follow-up study in 1982. In 69 of these with TMA there was a significantly increased incidence of pathological thyroid function-test values (T4, T3 and TSH) as compared to age- and sexmatched donors without thyroid antibodies. In this group 9 individuals had overt and three latent hypothyroidism, two individuals were found with symptomless autoimmune thyroiditis and one with a non-toxic nodular goitre. Only 2 of these had been diagnosed before 1982, and none recognized before 1979. In addition, the group contained 9 individuals who had been treated because of hyperthyroidism, all except one before 1979. The likelihood of detecting a previously unrecognized hypothyroidism increased with increasing TMA titre. In contrast, the 24 donors with TGA did not show an increased frequency of pathological thyroid function-test- values in 1982.

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