scholarly journals A Clinical Study of Serum Vitamin D Levels in Chronic Tonsillitis among Paediatric Age Group

2020 ◽  
Vol 28 (1) ◽  
pp. 23-29
Author(s):  
Sudhakar Rao M.S. ◽  
Deepak Karade
Keyword(s):  
Vitamin D ◽  
Clinical Study ◽  
Active Form ◽  
Serum Vitamin ◽  
The Body ◽  
Chronic Tonsillitis ◽  
Age Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Paediatric Age

Introduction Infectious diseases of the faucial tonsils are most frequently encountered by Oto-rhino-laryngologists. Vitamin D has got an important role in the production of surface Anti-microbial peptides (AMPs). Overall, the active form of vitamin D plays a vital role in maintaining the immune system of the body. This study aims to evaluate the association of vitamin D deficiency in chronic tonsillitis among paediatric age group. Materials and Methods It is a clinical study carried out in the Department of Oto-rhino-laryngology and Head and Neck surgery at a medical college in Ballari, Karnataka, India from January 2018 to January 2019 for the time period of 12 months. Patients were evaluated with the relevant investigations and digital X-ray nasopharynx along with serum Vitamin D level assessment. Results A total of 60 children with chronic tonsillitis were enrolled in this study. There were 26(43.3%) male children and 34(56.7%) females, ranging in age group from 5 to15 years, mean age is 9.82. The common clinical presentation was recurrent episodes of throat pain seen in all the patients (100%). On serum 25-hydroxyvitamin D assessment, 40(66.7%) patients were found to have deficiency and 20(33.3%) patients were having insufficiency. Mean is 17.99ng/ml and ranging from 9.13-28.58ng/ml.   Conclusion The study concludes that, the serum vitamin D levels in chronic tonsillitis among the paediatric age groups is found to be below normal levels and is unrelated to the socio demographic factors.

Vitamin D and breast cancer

2014 ◽  
Vol 155 (28) ◽  
pp. 1091-1096 ◽  
Author(s):  
Tamás Nagykálnai ◽  
László Landherr ◽  
András Csaba Nagy
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Tumor Suppressor Genes ◽  
Active Form ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Scientific Publications ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The active form of vitamin D, in conjunction with his own receptor, affect a multitude of biological processes in the cell (inter alia it influences the expression of oncogenes and tumor suppressor genes). There is an increasing volume of scientific publications examining the relationships between serum vitamin D levels, vitamin D supplementation and malignant diseases. Some articles suggest inverse relationship between the low serum levels of vitamin D and the breast cancer risk and mortality, whilst other publications do not support this view. Thus the present opinion is conflicted. Vitamin D can exert a beneficial influence on the symptoms and outcomes of a large number of ailments, but its role in affecting cancer is still not completely clear. Orv. Hetil., 2014, 155(28), 1091–1096.

scholarly journals SAT-017 Relationship Between Vitamin D Levels and Signs of Polycystic Ovary Syndrome

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anastasia Smykalova ◽  
Svetlana Kalinchenko ◽  
Aigul Safi ◽  
Mekan Orazov ◽  
Alexander Nizhnik
Keyword(s):  
Vitamin D ◽  
Waist Circumference ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
The Body ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Abstract An analysis of the structure of the causes of infertility shows that up to almost 25% of women of reproductive age ovulation disorders are observed. Hormonal disorders leading to the absence of ovulation, began to play a leading role in the etiology of infertility, special vitamin D deficiency, while today it has been established that its D receptors (VDR) are localized in most organs, including reproductive ones. VDR affect the expression of 1000 genes and play a crucial role in the implementation of sex hormones function. The aim of the study was to assess the vitamin D level in women of reproductive age, depending on the presence of signs of PCOS and waist circumference (WC). 71 women from 19 to 44 years old were examined of these, 41 patients were diagnosed with PCOS and impaired ovulatory function, in 30 patients the ovulatory cycle was preserved, and signs of PCOS were not detected. The level of vitamin 25 (OH) D3 in the serum of the subjects was evaluated by tandem chromato-mass spectrometry at the ArchiMed clinic of new medical technologies, Moscow. In the recommendations of the Canadian “The Vitamin D society”, 40-60 ng/ml the optimal level of serum vitamin D, a concentration of 20-40 ng/ml insufficiency, <20 ng/ml as a deficiency. Vitamin D deficiency was detected in 57% of women in both groups, with a pronounced deficiency (<10 ng/ml) in 17%, insufficiency was observed in 43% of cases, a sufficient level was not detected in any of the subjects. The average level of vitamin D in patients with PCOS was 18.2 (2 to 32.3) ng/ml, the value in patients without signs of PCOS was 18.5 (6.8 to 31) ng/ml. Comparison of the vitamin D value with WC showed that in women with PCOS with an WC <80 cm the value of this indicator was 18.8 ng/ml, and for WC ≥ 80 cm it was statistically significantly lower - 13.3 ng/ml (p<0.05). Conclusion. High prevalence of vitamin D deficiency among patients of reproductive age, with no differences in the magnitude of this indicator depending on the presence of signs of PCOS and persistent ovulation. Difference was established between the levels of vitamin D in patients with PCOS depending on the waist circumference - its insufficiency increases with an increase in WC. The results of the study suggest that the deficiency of vitamin D in the body increases with the aggravation of hormonal dysfunction in PCOS, which should be taken into account by specialists during the management of this category of patients and the treatment of infertility.

scholarly journals A Novel Biosensor and Algorithm to Predict Vitamin D Status by Measuring Skin Impedance

Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 8118
Author(s):  
Jin-Chul Heo ◽  
Doyoon Kim ◽  
Hyunsoo An ◽  
Chang-Sik Son ◽  
Sangwoo Cho ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Impedance Measurement ◽  
Blood Parameters ◽  
The Body ◽  
Skin Impedance ◽  
Fat Percentage ◽  
Health Measurement ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The deficiency and excess of vitamin D cause various diseases, necessitating continuous management; but it is not easy to accurately measure the serum vitamin D level in the body using a non-invasive method. The aim of this study is to investigate the correlation between vitamin D levels, body information obtained by an InBody scan, and blood parameters obtained during health checkups, to determine the optimum frequency of vitamin D quantification in the skin and to propose a vitamin D measurement method based on impedance. We assessed body composition, arm impedance, and blood vitamin D concentrations to determine the correlation between each element using multiple machine learning analyses and an algorithm which predicted the concentration of vitamin D in the body using the impedance value developed. Body fat percentage obtained from the InBody device and blood parameters albumin and lactate dehydrogenase correlated with vitamin D level. An impedance measurement frequency of 21.1 Hz was reflected in the blood vitamin D concentration at optimum levels, and a confidence level of about 75% for vitamin D in the body was confirmed. These data demonstrate that the concentration of vitamin D in the body can be predicted using impedance measurement values. This method can be used for predicting and monitoring vitamin D-related diseases and may be incorporated in wearable health measurement devices.

scholarly journals Genetic Polymorphisms of Vitamin D Metabolism Genes and Serum Level of Vitamin D in Colorectal Cancer

2017 ◽  
Vol 32 (4) ◽  
pp. 441-446 ◽  
Author(s):  
Veronica Marques Vidigal ◽  
Pedro Nazareth Aguiar ◽  
Tiago Donizetti Silva ◽  
Juliana de Oliveira ◽  
Célia Aparecida Marques Pimenta ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Active Form ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Active Vitamin ◽  
Vitamin D Metabolism ◽  
Serum Vitamin D ◽  
Active Vitamin D ◽  
Vitamin D Levels

Background The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. Methods One hundred fifty-two CRC patients and 321 controls were included. DNA was extracted from peripheral blood. Polymorphisms of BsmI and ApaI were identified by PCR-RFLP. Those of CYP24A1 (rs6013897, rs158552 and rs17217119) and CYP27B1 (rs10877012) were determined by gene sequencing. Results The median serum levels of circulating vitamin D were not different between CRC patients and controls; however, the percentage of those with deficient vitamin D was higher in patients with cancer. The active form of the vitamin D was higher in CRC patients. VDR, CYP27B1 and CYP24A1 polymorphic genotypes had no influence on serum levels of circulating vitamin D. The correlation between circulating and active vitamin D forms was lower among patients with CRC, regardless of the presence or absence of any genetic polymorphism. The mean serum levels of active vitamin D were higher among patients with polymorphic genotype variants of Apa1 or Bsm1. Conclusions CRC patients had a higher frequence of insufficient vitamin D and a higher concentration of active vitamin D. These concentration were higher between patients with polymorphic genotypes variants of ApaI and BsmI, CYP24A1 and CYP27B1. Polymorphic genotypes cause a lower correlation between the forms of vitamin D.

scholarly journals The Use of 25-hydroxyvitamin D Saliva Test to Replace Vitamin D Serum Blood Test in Healthy People

2021 ◽  
Vol 9 (T3) ◽  
pp. 40-43
Author(s):  
Dina Keumala Sari ◽  
Liza Meutia Sari ◽  
Lidya Imelda Laksmi ◽  
Farhat Farhat
Keyword(s):  
Vitamin D ◽  
Active Form ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Healthy People ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

BACKGROUND: Routine examination of Vitamin D levels is carried out by checking serum 25-hydroxyvitamin D (25[OH]D) levels which indicate circulating Vitamin D levels. While serum 1.25(OH)D levels are less frequently performed, although serum 1.25(OH)D levels represent the active form of Vitamin D be a substitute for checking Vitamin D levels. AIMS: This study aims to see the correlation between Vitamin D levels, namely, 25(OH)D and 1.25(OH)D saliva, which correlate with serum 25(OH)D and 1.25(OH)D levels so that the examination of salivary Vitamin D levels can be a substitute for checking serum Vitamin D levels. MATERIAL AND METHODS: This study is a cross-sectional study involving healthy men and women, aged 20–50 years, sampling in Lima Puluh Village, Batubara District, North Sumatra Province, Indonesia. The parameters studied were 25(OH)D and 1.25(OH)D levels of saliva and serum. RESULTS: This study involved 56 study subjects, male and female, with a percentage of deficiencies of 78.6% by examining 25(OH)D saliva and 76.8% by examining 25(OH)D serum. As for the 1.25(OH)D examination of saliva and serum, all were within normal limits. The analysis showed that a moderate correlation was obtained for levels of 25(OH)D saliva with serum 25(OH)D (p = 0.424) and a weak correlation for levels of 1.25(OH)D saliva with serum 25(OH)D (p = 0.339). CONCLUSIONS: Salivary 25(OH)D assay can be used to replace serum 25(OH)D assay in healthy people as a non-invasive alternative.

scholarly journals Correlation of Vitamin D Serum Levels with Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community in Mohammad Hoesin General Hospital Palembang

2021 ◽  
Vol 5 (2) ◽  
pp. 332-334
Author(s):  
Noveldy Calzoum Bachry ◽  
Nur Riviati ◽  
Yulianto kusnadi ◽  
Erial Bahar
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Serum Vitamin ◽  
The Elderly ◽  
The Body ◽  
Serum Vitamin D ◽  
Hand Grip ◽  
Vitamin D Levels

A B S T R A C TIntroductionOlder people tend to have decreased activity and intake of macronutrients andmicronutrients that are not in accordance with the body's needs. Research in 2017on elderly men and women at the Center for Family Compensation (PUSAKA) inCentral Jakarta showed that 80.2% of elderly people have vitamin D deficiency. Lowserum levels of vitamin D in the body are the initial risk of decreased muscle massand physical performance in old age. where there is a significant correlation betweenlow serum vitamin D levels in the body with sarcopenia and mortality. The purposeof this study was to determine the correlation of vitamin D levels with muscle mass,muscle strength and physical performance in the elderly community at RSMHPalembang. Methods This research is a study analytic observation with a cross-sectional approach that was carried out at the Integrated Geriatric Clinic InternalMedicine RSMH Palembang from November 2019 to November 2020. A sample of 34people aged> 60 years were examined for muscle mass, muscle strength, physicalperformance and serum vitamin D levels. All processing and analysis The data inthis study used SPSS version 25 for Windows. Results From 34 subjects, it wasfound that there were 29 women (85.3%) and 5 men (14.7%). The mean value ofmuscle mass is38.76 ± 4.1 kg / m2, long runs within 6 meters 6.12± 0.9 m / sec,and hand grip strength 24.9 ± 5.2 kg. It was found that 18 (62.1%) female sampleshad vitamin D deficiency while 11 (37.9%) samples had vitamin D insufficiency.There was a significant correlation between muscle mass and hand grip strengthwith vitamin D with weak correlation strength and length of walking with vitamin Dwith moderate correlation strength.Conclusion There is a significant correlationbetween muscle mass and grip strength and walking time of 6 meters with vitaminD.

scholarly journals VITAMIN-D LEVELS AND LOW BACK PAIN

2018 ◽  
Vol 25 (04) ◽  
pp. 615-619
Author(s):  
Rahman Rasool Akhtar ◽  
Junaid Khan ◽  
Tehreem Zahid ◽  
Riaz Ahmed
Keyword(s):  
Vitamin D ◽  
Low Back Pain ◽  
Back Pain ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
The Body ◽  
Low Back ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels

Objectives: To determine the number of patients with low back pain who havelow serum Vitamin-D levels along with associated risk factors in our local population. StudyDesign: Descriptive Study. Place and Duration: At the Department of Orthopedics, BenazirBhutto Hospital, Rawalpindi, for a duration of 01 year from 20th March 2016 to 19th March 2017.Patients and Methods: 600 patients were included in the study who met the inclusion criteria,i.e. patients presenting to the Out Patient Department (OPD) with low back pain for a duration ofless than six months aged between 15 to 55 years. Venous blood withdrawn and serum levelsof Vitamin-D measured. According to serum Vitamin-D levels, categorized as deficient, sufficientor excess. Results: Mean age of patients included in the study 44.21 ± 11.92 years. Out of thetotal, 337 (56.17%) were males and 263 (43.83%) females. Out of the total, 20.67%, 26.17%and 28.83% had mild, moderate and severe Vitamin-D deficiency, respectively. Predominantlypatients with severe Vitamin-D deficiency presented in winters (October – February) (17.16%)as compared to other seasons. The most pre-dominant risk factor in patients with low Vitamin-Dlevels was smoking (21.33%). Conclusion: Vitamin D plays a crucial role in the musculoskeletalframework of the body. The deficiency is more prevalent in the youth due to sedentary lifestyleand indoor preference.

scholarly journals Evaluation of vitamin D status and depression in thyroid patients referred to Yazd Diabetes Center clinic in 2020

2021 ◽  
Author(s):  
Marzieh Shukohifar ◽  
Ali Dadbinpour ◽  
Zohre Sadat Mozafari ◽  
Mohadeseh Zarei Yazdeli
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Significant Negative Correlation ◽  
The Body ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean ◽  
Diabetes Center

Introduction: Vitamin D is a hormonal precursor that in addition to known roles, may have an important effect on mental disorders such as depression. Therefore, this study was performed to determine the extent of vitamin D deficiency and depression and their relationship in thyroid patients referred to The clinic of Yazd Diabetes Center has been performed. Methods: The present study is a cross-sectional-analytical study that was performed on 150 thyroid patients referred to the Yazd Diabetes Center Clinic. Results: In this study, 150 thyroid patients including 55 men and 11. women with a mean age of 41.40± 7.61years participated. The mean score of Beck depression among these patients was 28.71± 8.34 .The mean level of vitamin D in these patients was 20.58 ± 7.21  ng / ml so that a total of 85% of thyroid patients were in the group of insufficient levels of vitamin D. A significant negative correlation was observed between depression score and serum vitamin D levels (r = -0.79 and p <0.001). Conclusion: The results of this study indicate a high prevalence of depression and vitamin D deficiency in thyroid patients. Another finding of this study was the relationship between vitamin D deficiency and depression, so that the less vitamin D in the body, the lower the rate of depression in The person becomes more. The use of vitamin D supplements in the treatment of thyroid patients with depression, as a clinical trial, can be a good solution in the treatment of patients.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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