scholarly journals Efficacy of Shunthi-Lodhra Churna in the Management of Asrigdara (DUB)

2019 ◽  
Vol 10 (1) ◽  
pp. 39-46
Author(s):  
Swatirekha Mohapatra ◽  
Rachana Gupta ◽  
Kalpana Sharma ◽  
Gyanendra Datta Shukla
Keyword(s):  
Marked Improvement ◽  
Cold Water ◽  
Modern Medicine ◽  
Uterine Bleeding ◽  
Drug Formulation ◽  
Bleeding Disorders ◽  
Age Group ◽  
Fibrinolytic Agents ◽  
Dysfunctional Uterine Bleeding ◽  
Mild Improvement

Objectives: The most common bleeding disorders in women are described as Asrigdara in Ayurveda, characterized by Pradirana (excessive excretion) of Raja (menstrual blood). It can be correlated to ‘Dysfunctional Uterine Bleeding’ in modern medicine. In modern medicine hormonal therapy, anti-prostaglandins & anti-fibrinolytic agents have not proven their definitive efficacy in spite of high costs; their side effects have led to hormonal imbalances. Methods: In order to overcome the above abnormalities, we conducted a clinical trial for 90 days on 30 patients of age group 18-45 yrs. We administered Shunthi Churna (2 gms.) and Lodhra Churna (3gms) mixed with Sharkara (5 gms.) i.e. total (10gms) thrice daily with cold water, after food. Two observations were taken, 1st after 45 days of treatment and the 2nd one after completion of treatment on various parameters like amount and duration of blood loss, inter-menstrual period, passage of clots and pain during menstruation. Results: Based on the parameters studied, we observed 60% of patients improved moderately, 36.7% showed mild-improvement, 3.3% showed marked-improvement in different symptoms. The results are highly significant on most parameters. Conclusion: Drug formulation Shunthi Churna and Lodhra Churna with Sharkara, proved to be effective in treating most of the symptoms of Asrigdara..  

A PROSPECTIVE ANALYTICAL STUDY OF PATIENTS WITH DYSFUNTIONAL UTERINE BLEEDING.

2021 ◽  
pp. 1-2
Author(s):  
Mangal Supe ◽  
Anup Arun Gundecha
Keyword(s):  
Social Life ◽  
Analytical Study ◽  
Systemic Disease ◽  
Abnormal Uterine Bleeding ◽  
Study Data ◽  
Uterine Bleeding ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Endometrial Pattern ◽  
Considerable Morbidity

Background: Dysfunctional uterine bleeding is dened as abnormal uterine bleeding not caused by any pelvic pathology, medications, pregnancy related complications or any systemic disease. It is the most common cause of abnormal uterine bleeding. It affects pubertal adolescents and perimenopausal women and is associated with considerable morbidity and affects patient’s family, personal and social life. Patient presents as menorrhagia, polymenorrhea, metrorrhagia or intermenstrual bleeding. It has great variations in endometrial patterns each deciding treatment modality. Objective: To determine frequency of various types of abnormal uterine bleeding and analyze the histopathology of endometrial curettage samples. Method: A prospective analytical study was conducted from Jan 2018 to Dec 2019 on sample of 650 patients between 20-70 years of age with symptoms of dysfunctional uterine bleeding presenting to medical college and hospital, Pimpri. Their endometrial samples were obtained by dilatation and curettage. To have a broader analysis the endometrial histopathology on hysterectomy specimens where the clinical diagnosis was DUB were also included in the study. Data obtained was tabulated and analyzed. Conclusion: The age group 31-40 and 41-50 years was the most common age group presenting with DUB. The predominant pattern of presentation was menorrhagia. The most common endometrial pattern on histopathology was proliferative type.

scholarly journals Transcervical resection of endometrium as a conservative management of dysfunctional uterine bleeding in premenopausal patients

2019 ◽  
Vol 8 (11) ◽  
pp. 4208
Author(s):  
Girish A. Pote ◽  
Namita Nandkumar Raut
Keyword(s):  
Uterine Bleeding ◽  
Reproductive Age ◽  
Response To Treatment ◽  
P Value ◽  
Uterine Perforation ◽  
Efficacy Rate ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Bleeding Score ◽  
Transcervical Resection

Background: Dysfunctional uterine bleeding (DUB) affects 10% to 15% women of reproductive age group. A prospective observational study was performed to study the efficacy, rate of satisfaction and adverse effects of Transcervical resection of endometrium (TCRE) in the treatment of DUB in premenopausal women.Methods: 30 patients with DUB attending the hospital underwent TCRE and patients were followed up after 6 week, 3 months, 6 months up to 1 year and there bleeding score was calculated. Their response to treatment, complications and satisfaction rate were studied.Results: 43.3% of the women in this study were in the age group of 40-44 years. Post TCRE, 43.33% (n=13) had hypomenorrhea. 33.33% (n=10) had regular cycle, 13.33% (n=4) women had amenorrhea and 10% (n=3) had no response and underwent hysterectomy. 86.66% (n=26) women were satisfied with the treatment whereas 13.33% (n=4) were not satisfied. One patient had uterine perforation and serosal bowel injury due to extended cautery injury. Bleeding reduced considerably and a statistically significant (paired t-test, p-value <0.05) difference was observed in pre and post procedure (6 weeks, 3 months, 6 months and 1 year) bleeding scores.Conclusions: Considering advantages like shorter operative time, uterine conservation and early mobility TCRE is a procedure of choice in patients in whom hysterectomy is either technically difficult or medically contraindicated or in those who are not suitable for long term medical management.

scholarly journals Comparative study of ormeloxifene and low dose oral contraceptive pill for the treatment of dysfunctional uterine bleeding in peri-menopausal age group

2021 ◽  
Vol 10 (8) ◽  
pp. 3112
Author(s):  
Maitri Shah ◽  
Chirayu Parmar ◽  
Riddhi Gor
Keyword(s):  
Oral Contraceptive ◽  
Blood Loss ◽  
Uterine Bleeding ◽  
T Test ◽  
Wilcoxon Test ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Oral Contraceptive Pills ◽  
Combined Oral Contraceptive ◽  
Contraceptive Pills

Background: Dysfunctional uterine bleeding (DUB) is the most common menstrual disorder of women in any age group and is a diagnosis of exclusion. Medical management of menorrhagia is a difficult task as there are wide variations in the available drugs and a lot of different regimes are available. Present study evaluates efficacy and safety of ormeloxifene a selective estrogen receptor modulator (SERMs) as compared to combined oral contraceptive pills in treatment of dysfunctional uterine bleeding in perimenopausal women.Methods: Total 60 patients meeting with our inclusion and exclusion criteria were enrolled in the study over a time period of 6 months and were further divided randomly into two groups. One group was given Ormeloxifene and the other group was treated with combined oral contraceptive pills (COCP) over a period of six months. The outcome variables noted were pictorial blood loss assessment chart (PBAC) score, Hb level and combined endometrial thickness (CET). Quantitative variables were compared using independent t test/Mann-Whitney test between the two groups and paired t Test/Wilcoxon test was used for comparison between pre and post within the group.Results: Both ormeloxifene and COCP significantly reduce blood loss in these patients evidenced by decrease of PBAC score, rise in hemoglobin levels and decrease in CET levels. However, ormeloxifene was found to be superior to COCP in reducing the menstrual blood loss. Ormeloxifene was also tolerated better compared to COCP with fewer side effects experienced by patients.

scholarly journals Ormeloxifene in the management of dysfunctional uterine bleeding

2018 ◽  
Vol 7 (5) ◽  
pp. 1885
Author(s):  
L. Thulasi Devi ◽  
Ravi Nimonkar
Keyword(s):  
Side Effects ◽  
Medical Management ◽  
Abnormal Uterine Bleeding ◽  
Cost Effective ◽  
Uterine Bleeding ◽  
Brand Names ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Receptor Modulator ◽  
One Year

Background: Dysfunctional Uterine Bleeding (DUB), is the commonest cause of Abnormal Uterine Bleeding (AUB). It causes morbidity, anaemia, and unnecessary hysterectomies in women of fertile age group. This study attempts to study efficacy of medical management especially Selective Estrogen Receptor Modulator (SERM) namely Ormeloxefine (ORM) (Sevista®) in Perimenopausal women. Ormeloxifene was marketed in India for contraception under brand names Centron, Saheli, Choice-7, Novex and Novex-DS. It’s a benzopyran derivative also known as Centchroman which causes asynchronousity between ovulation and menstrual cycles possibly because of both estrogenic and anti-estrogenic actions. It has been known to cause delay in ovulation in clinical trials; however, majority have been unaffected. It causes delay in proliferation of endometrium thereby causing asynchronous cycles. It also improves motility of ciliary lining of Fallopian tubes thereby reducing the chances of implantation of fertilized egg.  Methods: This study is aimed at evaluation of subjective and objective stastical benefits and side effects in treatment of DUB in perimenopausal age group with ORM and commonly used 19 nortestosterone compound (progesterone); Norethisterone (NET).Results: Primary outcome were analyzed at the end of every 3 months and at the end of one year finally. Secondary outcomes of the study in each arm were also assessed. There was stastically significant increase in Hb and stastically significant decrease in ET. Data analysis was done for variables in each arm by t-test to estimate the mean, median, range P and t value for a conclusion. Differences were taken as significant when P<0.05.Conclusions: ORM is a safe, cost effective, non-steroidal, non-hormonal drug with convenient dosage and better compliance for medical management of perimenopausal DUB with minimum focal pathology. Side effects observed need more evaluation with larger sample size to be statistically significant.

scholarly journals A clinicopathological study of dysfunctional uterine bleeding

2014 ◽  
Vol 4 (8) ◽  
pp. 635-638
Author(s):  
N Katuwal ◽  
G Gurung ◽  
A Rana ◽  
A Jha
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
University Teaching ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Obstetrics And Gynaecology ◽  
Proliferative Endometrium ◽  
One Year ◽  
Complete History

Background: Dysfunctional uterine bleeding is a form of abnormal uterine bleeding when there is absence of organic disease of the genital tract. The objective of this study was to find out the clinical and pathological aspect of women presenting with dysfunctional uterine bleeding.Materials and Methods: A descriptive study was conducted over a period of one year from April 14th 2010 to April 13th 2011 in the Department of Obstetrics and Gynaecology and Department of Pathology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal. A complete history, clinical examination, pelvic scan, hormonal status if required and endometrial biopsy were done to diagnose dysfunctional uterine bleeding.Results: A total of 120 cases were included. The age of the patients diagnosed dysfunctional uterine bleeding were ranging from 24 -63 years. Dysfunctional uterine bleeding was most common in the age group 40-44 yrs (30%) followed by 45-49 yrs (27.5%). Menorrhagia (41.7%) was the most common presenting sign. Majority histopathology of endometrium revealed anovulatory pattern (61.7%) followed by ovulatory (38.3%). Of the cases with an anovulatory pattern 48.6% was proliferative endometrium, 33.8% disordered proliferative endometrium, 6.8%atrophic, 5.4% weakly proliferative and 2.7% each of simple hyperplasia without atypia and complex hyperplasia with atypia. All cases with ovulatory pattern showed secretory endometrium.Conclusion: Dysfunctional uterine bleeding was the most common in the perimenopausal age group and chiefly in the form of an anovulatory endometrium. . Histopathological evaluation of endometrium helps exclude the local causes and establishes the diagnosis of dysfunctional uterine bleeding, its types, and clinical correlation to histopathological findings and finally helps to determine the mode of management.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11500 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 635-638

scholarly journals Histopathological study of endometrium in dysfunctional uterine bleeding

2018 ◽  
Vol 7 (9) ◽  
pp. 3497
Author(s):  
Malarvizhi Loganathan ◽  
Meera Krishnakumar
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Histological Change ◽  
Uterine Bleeding ◽  
Histopathological Study ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Medical College ◽  
Histopathological Studies ◽  
The Right ◽  
Secretory Endometrium

Background: This study was undertaken to study the endometrial histology in patients presenting with abnormal uterine bleeding in the absence of palpable pelvic pathology, which helps in choosing the right modality of treatment in a particular age group with a specific histological change. The study of endometrium in dysfunctional uterine bleeding was undertaken to correlate clinical presentations with histopathological studies and to correlate the distribution of histopathological findings in various age groups.Methods: The present study was conducted in the Department of Obstetrics and Gynaecology at Govt. Dharmapuri Medical College and Hospital during the period 01.07.2017 to 31.05.2018. Patients presenting to Govt. Dharmapuri Medical College and Hospital with abnormal uterine bleeding form the material of this study. Cases have been selected by using purposive sampling technique.Results: An ovulatory cycles were more common than ovulatory cycles in all age group. However, in patients with menorrhagia and polymenorrhagia majority had secretory endometrium (ovulatory cycles).Conclusions: Majority of the patients were found in the reproduction age group with the maximum percentage in multiparous women. Menorrhagia was the commonest mode of presentation in all age group. Most of the patients with proliferative and secretory endometrium had normal sized uterus and normal looking endometrium.

scholarly journals Study on Thyroid Dysfunction in Patients of Dysfunctional Uterine Bleeding

2021 ◽  
pp. 44-49
Author(s):  
Koduru Mounika
Keyword(s):  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Abnormal Uterine Bleeding ◽  
Common Type ◽  
Uterine Bleeding ◽  
Thyroid Disorder ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Medical College ◽  
Hyperthyroid Patients

Aim: The purpose of the study was to detect thyroid dysfunction in women who had abnormal uterine bleeding Study Design: Menorrhagia was the most common type of bleeding (36%). Thyroid dysfunction was discovered in 32% of the patients (Subclinical hypothyroidism in 17%, Hyper thyroid is 11% and hyperthyroidism in 4 % of cases). The researchers looked at 100 cases of Dysfunctional Uterine Bleeding that were clinically identified at Sree Balaji Medical College and Hospital between March 2014 and August 2016. The patients in this study ranged in age from under 20 to 45 years old. The number of instances with DUB who were between the ages of 31 and 40 is 38 %. Methodology: The parity of the patients ranged from unmarried to 0-5, with the parity 2 group accounting for 37% of all DUB patients and the following assessments were made. Results: Thyroid dysfunction was most common in cases of polymenorrhagia (42.8%), menorrhagia (33.3%), polymenorrhea (28.5%), and oligomenorrhea. (26%). Thyroid dysfunction was most common in the age group 31-40 years, accounting for 77.5% of the population. In 17 % of cases, the primary thyroid malfunction was subclinical hypothyroidism. 3% of hyperthyroid patients were also oligomenorrhocic. The most prevalent thyroid disorder in metrorrhagic patients was subclinical hypothyroidism.

Levonorgestrel Releasing Intrauterine System in the Treatment of Dysfunctional Uterine Bleeding

2014 ◽  
Vol 25 (2) ◽  
pp. 60-62
Author(s):  
Rokeya Begum ◽  
Mafruha Khanam
Keyword(s):  
Body Mass Index ◽  
Intrauterine Device ◽  
Uterine Bleeding ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
College Hospital ◽  
Medical College ◽  
Percent Improvement ◽  
Medicine Today

This study was designed to determine progress of women presenting with dysfunctional uterine bleeding (i.e decrease in amount and duration of bleeding in days) due to a cause amenable to treatment. To evaluate improvement in Haemoglobin level (Hb gm%) in patients during treatment. The study was conducted in the Department of Obstetrics & Gynaecology, Chittagong Medical College Hospital, Chittagong, Bangladesh from August 2008 to July 2010. Thirty six patients with Dysfunctional Uterine Bleeding (DUB) in 30-45 years age group with Body Mass Index (BMI) 0f 18-30 during treatment period were included in the study. They were counselled, investigated and had Levonogestrel Intrauterine device inserted. Outcome was measured by Hb improvement and decrease in blood loss both in amount and duration. Record was kept and follow up was done. Ninety percent of the patients were relieved from menorrhagia and one hundred percent improvement was seen in cases with polymenorrhagia. 50% patients had an Hb of >11.1gm% after 3 months of use. Levonogestrel intrauterine system or LNG-IUS is a safe and effective device for the treatment of DUB patients and it is an alternative to hysterectomy. DOI: http://dx.doi.org/10.3329/medtoday.v25i2.17921 Medicine Today 2013 Vol.25(2): 60-62

scholarly journals CLINICAL STUDY OF LAGHUPANCHMOOLA SADHIT COW’S MILK IN COW’S MILK PROTEIN ALLERGY

AYUSHDHARA ◽  
2020 ◽  
pp. 2586-2590
Author(s):  
Sujata Sharma ◽  
Avdesh Dangwal ◽  
Reena Pandey ◽  
N. Sujatha
Keyword(s):  
Marked Improvement ◽  
Milk Protein ◽  
Challenge Test ◽  
Cow Milk ◽  
Cow’S Milk ◽  
Age Group ◽  
Cow's Milk ◽  
Mild Improvement ◽  
Arm Circumference ◽  
Complete History

In Ayurveda classics it is pointed out that cow’s milk have Vamaka, Virechaka, Sarama and Abhisyandi properties. In classics, it has been mentioned that cow milk should always be processed with Laghupanchmoola before it is consumed. Aims and Objectives of the study: To study Aetiopathogensis of cow milk protein allergy and to evaluate the efficacy of Laghupanchmoola sadhit cow milk in CMPA. Material & Methods: To fulfill the above Aims and Objectives: Total 35 patients were selected between the age group of 0-3 years of age with symptoms of CMPA. Hb%, complete history and elimination-challenge test were used for evaluation of the patients. Laghupanchmoola granules dose depend upon age and duration of trial was 60 days. Results: After analyzing the data statistically in 30 patients, statistically highly significant improvements were found in diarrhea, abdominal pain, respiratory difficulty and vomiting. Significant improvements were found in dermatitis. No improvement was found in anemia and nausea. Statistically highly significant improvement was found in weight, height, mid arm circumference, chest circumference and head circumference. After full observation of treatment modules, it was found that: Number of patient with complete improvement was 0, Number of patient unchanged was 2 (6.5%), Mild improvement was observed in 05 patients (16.6%), and Moderate improvement was observed in 21 patients (70%), where marked improvement was observed in 2 patients (6.7%). Conclusion: Laghupanchmoola proved quite effective in managing the patients of CMPA due to its Tridoṣahar, Deepana, Aamdoshanasaka, Balya and Brahmanna properties.

scholarly journals A study of thyroid dysfunction in dysfunctional uterine bleeding

2018 ◽  
Vol 7 (3) ◽  
pp. 1002 ◽  
Author(s):  
Sujata Singh ◽  
Shradhanjali Sahoo ◽  
Pravat Chandra Das
Keyword(s):  
Thyroid Dysfunction ◽  
Uterine Bleeding ◽  
Aetiological Factor ◽  
Obstetrics And Gynecology ◽  
Thyroid Disorder ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Menstrual Disorder ◽  
Menstrual Irregularities ◽  
Menstrual Pattern

Background: The objective of the study was to evaluate the prevalence of thyroid disorder in dysfunctional uterine bleeding and to assess the menstrual pattern in women with thyroid disorders.Methods: The present study was conducted on 104 patients who presented with dysfunctional uterine bleeding in gynecology OPD/IPD Department of Obstetrics and Gynecology, SCBMCH, Cuttack, India.Results: Among the 104 women 16 (15.3%) had hypothyroidism, 3 (2.8%) had hyperthyroidism and 75 (72.1%) were euthyroid and 10(9.6%) subclinical hypothyroidisim. Menorrhagia was the most common menstrual disorder in hypothyroidism and oligomenorrhoea in hyperthyroidism. In the present study the age group of 41-50 year and multyparity (para-2) and commonest are menorrhagic 42 (40.38%). Menorrhagia in hypothyroidisim 15 (72.4%) cases and oligomenorrhoea in hyperthyroidisim 3 (10.3%).Conclusions: Thyroid dysfunction should be considered as an important aetiological factor in menstrual disturbances and thyroid assessment should be done in all patients with menstrual irregularities. Therefore, to conclude any type of menstrual abnormality should be considered as a possible presenting symptom of thyroid dysfunction and it may even indicate subclinical abnormality, evaluation of thyroid would avoid unnecessary surgeries and exposure to hormones.

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