scholarly journals Role of Loop Ileostomy in the Management of Ulcerative Colitis Patients

2020 ◽  
Vol 15 (2) ◽  
pp. 62-68
Author(s):  
Ahmed N. Hussein
Keyword(s):  
Ulcerative Colitis ◽  
Erythrocyte Sedimentation Rate ◽  
Medical Therapy ◽  
Sedimentation Rate ◽  
Blood Count ◽  
Complete Blood Count ◽  
Loop Ileostomy ◽  
Erythrocyte Sedimentation ◽  
Fulminant Ulcerative Colitis

Background: Ulcerative colitis is a chronic inflammatory condition characterized by relapsing and remitting episodes of inflammation limited to the mucosal layer of the colon.Loop ileostomy might be helpful in the management of the disease. Objective: To evaluate the role of loop ileostomy in the management of ulcerative colitis.  Methods: Between Januarys 2008 and January 2018, patients with fulminant ulcerative colitis resistant to medical therapy had been referred to our surgical unit and were included in our study. Assessment of the patients’ medical status (serum electrolytes, total serum protein, complete blood count, erythrocyte sedimentation rate, general stool exam,and abdominal ultrasound and x-rays) and psychological statuswere done and then preoperative status correction followed by defunctioning loop ileostomy operated upon them and followed postoperatively in hospital for the response fortwo weeks of hospitalization. Results: Twenty patients were included in the study, two patients died postoperatively due to comorbidities and pulmonary embolism. Eighteen of twenty patients had a gradual improvement clinically (mucus diarrhea with/without blood, weight gain, fever, psychological and edema) and in hematological and biochemicalvalues (complete blood count, serum albumin protein, erythrocyte sedimentation rate and electrolytes) within two weeks. Conclusion: Defunctioning loop ileostomy is a simple,less morbidprocedure if compared to other medical treatments which can change the complication features of fulminant ulcerative colitis towards either continue in medical therapy or towards definitive curative surgery and cost effective as it decrease the need for expensive medications.

Comparison of K2 and K3 EDTA Anticoagulant on Complete Blood Count and Erythrocyte Sedimentation Rate

2021 ◽  
Vol 28 (1) ◽  
pp. 75
Author(s):  
Harida Zahraini ◽  
Yulia Nadar Indrasari ◽  
Hartono Kahar
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Blood Count ◽  
Complete Blood Count ◽  
Rank Test ◽  
Cross Sectional ◽  
Erythrocyte Sedimentation ◽  
Significant Difference ◽  
The Difference ◽  
Cross Sectional Design

The use of anticoagulants is one of the important pre-analytic factors in hematological tests. Both dipotassium (K2) andtripotassium (K3) Ethylene Diamine Tetraacetic Acid (EDTA) are widely used anticoagulants. International CouncilStandardization of Hematology (ICSH) and several researchers recommend the use of K2 EDTA due to its less hyperosmolareffect on blood cells compared to K3 EDTA. This study aimed to compare the results of Complete Blood Count (CBC) andErythrocyte Sedimentation Rate (ESR) using anticoagulant K2 EDTA and K3 EDTA. This study was an analytic observationalstudy with a cross-sectional design conducted from April to December 2018. The subject of the study were 103 healthyadults selected by consecutive sampling. Blood samples were collected in both anticoagulant tubes with a volume of 3 mLeach. Samples were tested twice, in the first 0 hours and the next 6 hours using Sysmex XN 1000 and Alifax Roller 20 LC.Kolmogorov-Smirnov test, paired T-test and Wilcoxon rank test were used for statistical analysis. The agreement testbetween both anticoagulants was carried out using the Bland Altman plot for parameters with a significant difference. Therewas a significant difference between both anticoagulants for the parameters of hemoglobin, hematocrit MCV, MCHC, RDW,PDW, MPV, PLC-R, and erythrocyte sedimentation rate in both the first and second tests. The agreement test using the BlandAltman plot showed that the difference in these parameters was within the Limit of Agreement (LOA) range of 95%. Thisstudy showed that there were differences in some parameters of complete blood count and erythrocyte sedimentation ratebetween the two anticoagulants (K2 K3 EDTA), but these differences were within the LOA range.

scholarly journals The role of laboratory biomarkers in monitoring of rituximab biosimilar therapy (Acellbia, “BIOCAD”) in patients with rheumatoid arthritis

2019 ◽  
Vol 91 (5) ◽  
pp. 26-33
Author(s):  
A S Avdeeva ◽  
M V Cherkasova ◽  
D A Kusevich ◽  
V V Rybakova ◽  
A S Artyuhov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Total Dose ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Disease Duration ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Laboratory Biomarkers

Aim: to evaluate the role of laboratory biomarkers in monitoring effectiveness of rituximab (RTM) biosimilar therapy in a total dose of 1200 mg. Materials and methods. 20 patients (pts) with rheumatoid arthritis (RA) (18 woman, mean age 61.5(54-66.5) years, mean disease duration 39.5(20-84) months, mean DAS28 5.6(4.9-6.8)) received two intravenous RTM biosimilar infusions (600 mg №2) in combination with DMARDs and glucocorticoids. Laboratory biomarkers were assessed at baseline and weeks 12 and 24 after the first infusion of RTX. Results. RTM biosimilar induced decreases in DAS28, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) at week 12 and 24, p

scholarly journals THE ROLE OF GASTRIC ASPIRATES CYTOLOGY AND MICRO-ERYTHROCYTE SEDIMENTATION RATE IN PREDICTING THE EARLY SEPTICEMIA IN NEWBORN BABIES

2018 ◽  
Vol 5 (10) ◽  
pp. 640-643 ◽  
Author(s):  
Meetu Yadav ◽  
Raksha Gupta ◽  
Jasbir Singh ◽  
Sameer Saraswath ◽  
Niranjan Nagaraj ◽  
...  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Erythrocyte Sedimentation

scholarly journals The Canine Erythrocyte Sedimentation Rate (ESR): Evaluation of a Point-of-Care Testing Device (MINIPET DIESSE)

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Carlo Militello ◽  
Anna Pasquini ◽  
Anyela Andrea Medina Valentin ◽  
Petra Simčič ◽  
Giulia De Feo ◽  
...  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Blood Count ◽  
Point Of Care ◽  
Pearson Correlation ◽  
Analytical Sensitivity ◽  
Predictive Values ◽  
Blood Samples ◽  
Percentile Method ◽  
Erythrocyte Sedimentation

The erythrocyte sedimentation rate (ESR) in canine medicine has been replaced by the evaluation of a few sensitive markers of the acute-phase proteins. The aim of the study was to evaluate the ESR using a point-of-care (MINIPET, DIESSE Diagnostica Senese S.p.A.) device (ESR-MP) and to compare the results with the gold standard Westergren method (ESR-W) in dogs. One hundred and nineteen K3-EDTA blood samples for complete blood count were randomly selected and assayed for ESR. The reference interval (RI) was established using the percentile method. The coefficient of variation (CV) in intra-assay and interassay precision of ESR-MP was calculated. The analytical sensitivity (Se), specificity (Sp), positive predictive values (PPVs), and negative predictive values (NPVs) were calculated. Agreement between ESR-MP and ESR-W was assessed with Pearson correlation coefficient (r), Cohen concordance test (K), Passing-Bablok regression, and Bland–Altman plots. Ten canine samples (8.4%) were ruled out because of flag-error by the MINIPET instrument (4.2%) or because they showed the diphasic pattern in ESR-W (4.2%). The canine RI of ESR-MP was 0–10 mm/h. Precision was excellent in intra-assay (CV = 0.02) and interassay (CV = 0.32). The analytical characteristics of ESR-MP in nonanemic samples were as follows: Se = 0.82, Sp = 0.95, PPV = 0.82, and NPV = 0.95. The accuracy of ESR-MP was better than ESR-W in nonanemic samples (r = 0.87; K = 0.77) and lower in anemic subjects (Hct <37%) (r = 0.76; K = 0.69). The Passing-Bablok regression showed the presence of systematic error and the absence of proportional error only in nonanemic blood samples. The Bland–Altman plots gave negative average values due to the difference in RIs and an agreement in both ESRs. The ESR-MP results can be obtained with the same K3-EDTA tubes used for the blood count, in shortcut time, and at reduced costs using the MINIPET device. These investigations highlight that ESR-MP could be useful in canine clinical settings.

scholarly journals A Descriptive Study on Hematological Changes in Brucellosis Infected Individuals

2021 ◽  
pp. 390-395
Author(s):  
Hameedullah Safi ◽  
Waheedullah Noori
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Rural Areas ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Salmonella Typhi ◽  
Presenting Symptoms ◽  
Human Contact ◽  
Erythrocyte Sedimentation ◽  
Hematological Changes

Background: Brucellosis is a zoonotic organism that causes diseases in both animals and humans. Human contact with infected domestic animals is often a transmission route of Brucellosis infection. This infection affects hematological parameters of the patients. We carried this study to determine the changes in various hematological parameters in our study subjects. Patients and Methodology: This study was carried out in Nangarhar regional hospital and safi medical complex on 45 Afghani people from December 2018 up to December 2020. The study design was prospective. A total of 45 patients (Cases) with confirmed diagnosis of Brucellosis on the basis of serology enrolled in the study. Complete blood count and Erythrocyte sedimentation rate studies are also performed. Considered hematological parameters includes Hemoglobin (Hb), White Blood Cell count (WBC), Platelet count (PLT) and ESR.  As well interview was done with each patient and a questionnaire was used. The collected data was analyzed with Microsoft excel program Autosum statistics. Results. A total of 45 patients were enrolled. The mean age±SD of the patients under the study were (28.74±15.22) years. The most common hematological changes observed were; anemia (57.7%), thrombocytopenia (24%), leucocytosis (13.3%), pancytopenia (24.4%), lymphocytopenia (31.1%), lymphocytosis (55.5%) & leucopenia (40%). Erythrocyte sedimentation rate were elevated in about 66% of patients. Fever and headache were the most common presenting symptoms (73%) and (82%) respectively. Night sweats in (40%), joint pain (53%), muscle pain (53%) and lymphadenopathy in 46% of patients. Conclusion: This result of this study shows that Brucellosis commonly affects people of low socioeconomical states, female sex, uneducated, those consuming contaminated dairy products, peoples living in rural areas and those having consuming or contact with animal. Salmonella typhi causes changes in the hematological parameters due to involvement of bone marrow.

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