scholarly journals Evaluation of Antihyperlipidaemic and Antioxidant Activity of Astercantha longifolia (Linn.) Nees and Pergularia daemia (Forsskal) Chiov

2020 ◽  
pp. 134-138
Author(s):  
T. P. Kumari Pushpa Rani ◽  
A. Doss ◽  
S. P. Anand
Keyword(s):  
Antioxidant Activity ◽  
Biochemical Parameters ◽  
Methanol Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Objective: To evaluate the antioxidant and antihyperlipidaemic effect of methanol extracts of Asteracantha longifolia and Pergularia daemia leaf in alloxan induced diabetic rats. Methods: Swiss albino rats were made diabetic by a single dose of alloxan monohydrate (150 mg/kg i.p.). Blood glucose levels and body weights of rats were measured using on weekly intervals i.e day 0,7,14 and 21 after daily administration of both extracts at dose 200 mg/kg bw. Other biochemical parameters such as serum cholesterol, triglycerides, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, phospholipids and serum protein, albumin, globulin levels were also measured at the end of study. The antioxidant enzymes (CAT, SOD & GSH) were also measured in the diabetic rats. Results: In the acute toxicity study, methanol extract of both plants were non-toxic at 2000 mg/kg in rats. The increased body weight, decreased blood glucose and other biochemical parameters level were observed in diabetic rats treated with methanol extracts of both plants compared to diabetic control rats. The antioxidant activity of both plant extracts were also exhibited significant activity. In diabetic rats, methanol extract of both plants administration, altered lipid profiles were reversed to near normal than diabetic control rats. Conclusions: Methanol extract of both plants (Asteracantha longifolia and Pergularia daemia) leaf possesses significant antioxidant and antihyperlipidaemic activity in diabetic rats.

scholarly journals Blood Lipids and Its Atherogenic Indices in Alloxan Induced Diabetic Male Rats

2020 ◽  
pp. 25-33
Author(s):  
O. D. Chikezie ◽  
S. C. Meludu ◽  
I. S. I. Ogbu ◽  
B. N. Egejuru ◽  
T. Ude ◽  
...  
Keyword(s):  
Blood Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Low Density Lipoprotein Cholesterol ◽  
Atherogenic Indices ◽  
Diabetes Induction

Background: Diabetes mellitus is a group of metabolic disorders which result to excessive accumulation of blood sugar over a prolonged period. Due to higher risk of diabetes mellitus to cardiovascular disease, it is crucial to identify and address these cardiovascular risks. This study assessed the effects of diabetes on levels of some blood lipids and its atherogenic indices in diabetic male rats. Methods: This is an experimental study that involved 40 apparently healthy adult male albino rats (wistar strain) which were randomly assigned to five groups (A, B, C, D and E) of eight (8) animals each. Group A (Normal Control of No intervention for 72 hours), Group B (Diabetic rats of 72 hours post diabetes induction), Group C (metformin treated diabetic rats), Group D (Diabetic Control untreated) and Group E (Normal Control of 3 weeks post diabetes induction). Seven milliliters of fasting blood sample were collected from all the subjects. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) were determined using standard methods. Atherogenic indices, non HDL cholesterol (Non HDL-c), cardio risk ratio (CRR), atherogenic index of plasma (AIP), atherogenic coefficient (AC) and atherosclerosis index (AI) were calculated. It was analyzed statistically using SPSS version 23.0. Results: The mean values of HDL-c was significantly higher in the treated diabetic group when compared with untreated diabetic control (P<0.05) while TC, TG, LDL-c, VLDL-c, Non HDL-c, CRR, AIP, AC and AI were significantly lower in treated diabetics when compared to the untreated diabetic control (P<0.05). Also, blood mean levels of HDL-c were significantly lower in the diabetic groups (treated and untreated) when compared with non diabetic control (P<0.05) while TC, TG, LDL-c, VLDL-c, Non HDL-c, CRR, AIP, AC and AI were significantly higher in the diabetic groups (treated and untreated) when compared with non diabetic control (P<0.05). Conclusion: The study suggests that atherogenic indices can serve as predictive pointer for future cardiovascular event especially, when LDLc value is normal. Also hyperglycemia could cause significant alterations of lipids, but metformin treatment has showed not only hypoglycemic effect, but also anti-hyperlipidemic properties.

Modulation of the Lipid Profile, Hepatic and Renal Antioxidant Activities, and Markers of Hepatic and Renal Dysfunctions in Alloxan-Induced Diabetic Rats by Virgin Coconut Oil

2019 ◽  
Vol 19 (7) ◽  
pp. 1032-1040
Author(s):  
Chinedum Eleazu ◽  
Chima E. Ekeleme ◽  
Ademola Famurewa ◽  
Mahaneem Mohamed ◽  
Gabriel Akunna ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coconut Oil ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Distilled Water ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Virgin Coconut Oil

Background:Research studies that holistically investigated the effect of administration of Virgin Coconut Oil (VCO) on diabetic humans or animals are limited in literature.Objective:To investigate the effect of administration of VCO on lipid profile, markers of hepatic and renal dysfunction, and hepatic and renal antioxidant activities of alloxan induced diabetic rats.Methods:Twenty-four male albino rats were used, and they were divided into four groups of six rats each. Group 1 (Normal Control, NC) received distilled water (1 mL/kg); Group 2 (VCO Control) received VCO (5 mL/kg); Group 3 (Diabetic Control, DC) received distilled water (1 mL/kg); Group 4 (Test Group, TG) received 5 ml/kg of VCO.Results:There were no significant differences in blood glucose, body weights, relative liver weights, relative kidney weights, hepatic and renal Superoxide Dismutase (SOD) activities, Malondialdehyde (MDA), albumin, aspartate Amino Transaminase (AST), alanine Amino Transaminase (ALT), Alkaline Phosphatase (ALP), urea, creatinine, uric acid, total cholesterol, triacylglycerol, Very Low Density Lipoprotein cholesterol (VLDL) and Low Density Lipoprotein cholesterol (LDL) concentrations; significant increases in renal Glutathione (GSH), hepatic catalase, Glutathione Peroxidase (GPx) and GSH but significant reduction in renal GPx and catalase activities of VCO control group compared with NC group. There were significant increases in blood glucose, relative liver and kidney weights, hepatic GPx, hepatic and renal MDA concentration, ALP, AST, ALT, urea, creatinine, uric acid, triacylglycerol, total cholesterol, LDL and VLDL concentrations; and significant decreases in body weight, hepatic SOD and GSH activities and albumin concentration but no significant difference in hepatic catalase activity of DC group compared with NC group. Administration of VCO to diabetic rats positively modulated these parameters compared with the diabetic control.Conclusion:The study showed the potentials of VCO in the management of hyperlipidemia, renal and hepatic dysfunctions imposed by hyperglycemia and by oxidative stress in diabetic rats.

scholarly journals Protein Isolate from Parkia biglobosa Seeds Improves Dyslipidaemia and Cardiac Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Antioxidants ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 481
Author(s):  
Bolajoko Idiat Ogunyinka ◽  
Babatunji Emmanuel Oyinloye ◽  
Foluso Oluwagbemiga Osunsanmi ◽  
Unathi Kolanisi ◽  
Andrew Rowland Opoku ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Protein Isolate ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Parkia Biglobosa ◽  
Low Density Lipoprotein Cholesterol ◽  
Biomarkers Of Oxidative Stress

Reports from previous studies now provide evidence that dyslipidaemia and oxidative stress play crucial roles in the pathogenesis and progression of diabetes and its related complications. This research is aimed to investigate the potential effects of protein isolate from Parkia biglobosa seeds (PBPI) in streptozotocin (STZ)-induced diabetic rats by measuring blood glucose levels, changes in lipid metabolism and biomarkers of oxidative stress. Diabetic rats were treated orally with graded doses of PBPI, 200 mg/kg bw and 400 mg/kg bw, and 5 U/kg, intraperitoneal (i.p.) of insulin once daily for 28 days with the fasting blood glucose (FBG) monitored weekly. The effect of PBPI on the serum lipid profile was measured while the extent of lipid peroxidation (LPO), as well as antioxidant parameters (superoxide dismutase; SOD, catalase; CAT, glutathione-S-transferase; GST and total glutathione; total GSH), was determined in the cardiac homogenates of diabetic rats. At the tested doses, treatment with PBPI was significantly effective in lowering FBG, serum triglyceride, cholesterol, low-density lipoprotein cholesterol (LDL-c) and very low-density lipoprotein cholesterol (VLDL-c), while concurrently increasing high-density lipoprotein cholesterol (HDL-c). PBPI also significantly decreased the elevations witnessed in LPO levels and restored the biomarkers of oxidative stress in the cardiac homogenate of experimental rats. The results from this study demonstrate that PBPI could improve dyslipidaemia and cardiac oxidative stress in the experimental diabetic animal model possibly by reducing and effectively scavenging reactive oxygen species (ROS) production as well as by increasing antioxidant capacity in combating oxidative stress. Therefore, it can be concluded that PBPI could be explored in the development of a potent cardioprotective supplement or adjuvant therapy towards the management of diabetes and its related complications.

In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

Drug Research ◽  
2018 ◽  
Vol 69 (01) ◽  
pp. 46-52 ◽  
Author(s):  
Bijan Oskouei ◽  
Soheil Abbaspour-Ravasjani ◽  
Seyed Jamal Musavinejad ◽  
Seyed Ahmad Salehzadeh ◽  
Alireza Abdolhosseinzadeh ◽  
...  
Keyword(s):  
Liver Function ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Positive Effects ◽  
Liver And Kidney ◽  
Anti Oxidant

Abstract Aim The evaluation of the positive and protective effects thymol as a natural compound on the STZ -induced diabetic rats. Materials and methods In this study, seven groups of the streptozotocin induced diabetic and normal rats (overall 42 males) were tested through various biochemical and histopathological factors such as: serum glucose, insulin, creatinine, lipids, lipoproteins, liver function-related enzymes, and antioxidant status in liver and kidney. Results The obtained results in this work indicated that thymol had a significant anti-hypoglycemic, anti-hypolipidemic activities on the STZ-induced diabetic rats. Further, the assessment different biochemical parameters revealed that the levels of creatinine, low-density lipoprotein cholesterol, very low density lipoprotein cholesterol, and liver function-related enzymes such as aspartate aminotransferase and alanine aminotransferase were decreased in the treated diabetes rats under 20 and 40 mg/kg thymol compared to the control diabetes group. Considerably, the anti-oxidant enzymes status that were achieved from the liver and kidney organs were modulated after treatment with thymol in the diabetic rats. Conclusion The results of this research has brough a new aspect concerning the proteevtive and positive effects of thymol on the diabetic complications in the animal model.

scholarly journals Lipid Profile of Streptozotocin-Induced Diabetic Wistar Albino Rats Treated with Aqueous Extracts of Nauclea latifolia

2019 ◽  
Vol 1 ◽  
pp. 18-24
Author(s):  
D O Ochalefu ◽  
G I Adoga ◽  
L D Luka ◽  
H A Abu ◽  
O B Olaniru
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Aqueous Extracts ◽  
Low Density Lipoprotein Cholesterol ◽  
Nauclea Latifolia

In recent times there has been a steady increase in researches aimed at searching for plant agents that can be used in the management of diabetes mellitus and its complications with minimal side effects compared with the anti-diabetic drugs in the pharmaceutical market. This work is on the effect of aqueous extracts ofNauclea latifolia plant on serum lipid profile in streptozotocin- induced diabetic rats. Thirty mature male Wistar albino rats were divided into six treatment groups of five rats each. Group A was normal control and group B was streptozotocin-induced diabetic control. Groups C, D and E were streptozotocin- induced diabetic rats treated daily with 500mg / kg. body weight of aqueous extracts of stem-bark, leaves and root-bark of Nauclea latifolia respectively. Group F was streptozotocin- induced diabetic rats treated daily with 5mg / kg. body weight of glibenclamide and the treatment was for 28 days. The serum total cholesterol, high density lipoprotein cholesterol and triacylglycerol of the rats were determined using assay kits from Agape Diagnostic, Switzerland while very low density lipoprotein cholesterol was determined by calculation according to the method of Burstein and Samaile (1960). The low density lipoprotein cholesterol was estimated using the method of Friedwald, Levy and Fredrickson (1972) which entails differential subtraction of the sum of the cholesterol fractions from the total cholesterol. The parameters were analyzed using One- way Analysis of Variance with the level of significance determined by least significant difference. The streptozotocin-induced diabetic control rats had their serum levels of total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol and triacylglycerol significantly elevated compared with the normal control. Nauclea latifolia aqueous extracts brought about significant reduction of total cholesterol, low density lipoprotein cholesterol and triacylglycerol levels in the diabetic treated rats. The outcome of this work indicates that Nauclea latifolia aqueous extracts have ameliorating effect on diabetic complications due to high serum lipid profile levels.

Antidyslipidemic Capacity of Cleome arabica (L.) in Streptozotocin-Induced Diabetic Rats

2021 ◽  
Vol 19 ◽  
Author(s):  
Ayoub Amssayef ◽  
Mohamed Eddouks
Keyword(s):  
Diabetes Mellitus ◽  
Risk Index ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Cleome Arabica ◽  
Lipid Abnormalities

Aims: The aim of the study was to assess the effect of Cleome arabica on lipid metabolism. Background: Cleome arabica (L.) is a medicinal plant used traditionally by the population of North Africa for managing diabetes mellitus. Objective: This study was designed to evaluate the antidyslipidemic and antiatherogenic capacities of Cleome arabica (L.) in normal and streptozotocin(STZ)-induced diabetic rats. Methods: The hypolipidemic, antihyperglycemic and antiatherogenic effects of oral administration of the aqueous extract of Cleome arabica (CAAE) (100 mg/kg) were evaluated in normal and diabetic rats. In addition, the quantification of polyphenols, flavonoids and tannins as well as the antioxidant activity were performed. Results : The results showed that the extract (CAAE) revealed an antidyslipidemic action by attenuating plasma levels of Total Cholesterol (TC), Triglycerides (TGs), Low-Density Lipoprotein cholesterol (LDL-c), Very low-density lipoprotein cholesterol (VLDL-c) and glucose. Additionally, CAAE exhibited a potent antiatherogenic activity by reducing Atherogenic Coefficient (AC), Castelli’s Risk index-I (cri-I), and Castelli’s Risk Index-II (CRI-II). Furthermore, the findings indicated that CAAE is abundant with polyphenols, flavonoids and tannins, and exhibited an important antioxidant capacity. Conclusion: The study demonstrates that aqueous Cleome arabica extract was able to ameliorate lipid abnormalities associated with diabetes mellitus. This pharmacological activity might be due to the antioxidant capacities of phytochemical compounds.

scholarly journals Lipid Profile of Streptozotocin-Induced Diabetic Wistar Albino Rats Treated with Aqueous Extracts of Nauclea latifolia

2019 ◽  
Vol 1 ◽  
pp. 18-24
Author(s):  
D O Ochalefu ◽  
G I Adoga ◽  
L D Luka ◽  
H A Abu ◽  
O B Olaniru
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Aqueous Extracts ◽  
Low Density Lipoprotein Cholesterol ◽  
Nauclea Latifolia

In recent times there has been a steady increase in researches aimed at searching for plant agents that can be used in the management of diabetes mellitus and its complications with minimal side effects compared with the anti-diabetic drugs in the pharmaceutical market. This work is on the effect of aqueous extracts ofNauclea latifolia plant on serum lipid profile in streptozotocin- induced diabetic rats. Thirty mature male Wistar albino rats were divided into six treatment groups of five rats each. Group A was normal control and group B was streptozotocin-induced diabetic control. Groups C, D and E were streptozotocin- induced diabetic rats treated daily with 500mg / kg. body weight of aqueous extracts of stem-bark, leaves and root-bark of Nauclea latifolia respectively. Group F was streptozotocin- induced diabetic rats treated daily with 5mg / kg. body weight of glibenclamide and the treatment was for 28 days. The serum total cholesterol, high density lipoprotein cholesterol and triacylglycerol of the rats were determined using assay kits from Agape Diagnostic, Switzerland while very low density lipoprotein cholesterol was determined by calculation according to the method of Burstein and Samaile (1960). The low density lipoprotein cholesterol was estimated using the method of Friedwald, Levy and Fredrickson (1972) which entails differential subtraction of the sum of the cholesterol fractions from the total cholesterol. The parameters were analyzed using One- way Analysis of Variance with the level of significance determined by least significant difference. The streptozotocin-induced diabetic control rats had their serum levels of total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol and triacylglycerol significantly elevated compared with the normal control. Nauclea latifolia aqueous extracts brought about significant reduction of total cholesterol, low density lipoprotein cholesterol and triacylglycerol levels in the diabetic treated rats. The outcome of this work indicates that Nauclea latifolia aqueous extracts have ameliorating effect on diabetic complications due to high serum lipid profile levels.

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