Influence Analysis of Acute Pressure Ulcer Nursing Intervention on Long-term Lateral Decubitus Operation Patients with Pressure Ulcer Formation and Adverse Reactions

2021 ◽  
Keyword(s):  
Pressure Ulcer ◽  
Adverse Reactions ◽  
Nursing Intervention ◽  
Ulcer Formation ◽  
Influence Analysis ◽  
Lateral Decubitus

scholarly journals Selective A2A adenosine receptor activation reduces skin pressure ulcer formation and inflammation

2001 ◽  
Vol 281 (1) ◽  
pp. H67-H74 ◽  
Author(s):  
Shayn M. Peirce ◽  
Thomas C. Skalak ◽  
Jayson M. Rieger ◽  
Timothy L. Macdonald ◽  
Joel Linden
Keyword(s):  
Blood Flow ◽  
Pressure Ulcer ◽  
Cell Activation ◽  
Ischemia Reperfusion ◽  
Clinical Problem ◽  
Receptor Activation ◽  
Metal Plate ◽  
Vehicle Group ◽  
Ulcer Formation ◽  
A2a Adenosine Receptor

Activation of A2A adenosine receptors (A2A-AR) by ATL-146e (formerly DWH-146e) prevents inflammatory cell activation and adhesion. Recurrent ischemia-reperfusion (I/R) of the skin results in pressure ulcer formation, a major clinical problem. ATL-146e was evaluated in a novel reproducible rat model of pressure ulcer. A 9-cm2 region of dorsal rat skin was cyclically compressed at 50 mmHg using a surgically implanted metal plate and an overlying magnet to generate reproducible tissue necrosis. Osmotic minipumps were implanted into 24 rats divided into four equal groups to infuse vehicle (control), ATL-146e (0.004 μg · kg−1 · min−1), ATL-146e plus an equimolar concentration of A2A antagonist, ZM-241385, or ZM-241385 alone. Each group received 10 I/R cycles. In non-I/R-treated skin, ATL-146e has no effect on blood flow. I/R-treated skin of the ATL-146e group compared with the vehicle group had 65% less necrotic area, 31% less inhibition of average skin blood flow, and fewer extravasated leukocytes (23 ± 3 vs. 49 ± 6 per 500 μm2). These data suggest that ATL-146e, acting via an A2A-AR, reduces leukocyte infiltration and is a potent prophylactic for I/R injury in skin.

A Case of Gastric Cancer in Which Long-Term Administration of 5′-Deoxy-5-Fluorouridine Proved Effective

1989 ◽  
Vol 17 (2) ◽  
pp. 179-184
Author(s):  
T. Koda ◽  
T. Kurahori ◽  
N. Iwao ◽  
S. Sumi ◽  
T. Sonoda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adverse Reactions ◽  
Substantial Improvement ◽  
Term Treatment ◽  
Borrmann Type ◽  
Long Term Treatment ◽  
Term Administration ◽  
Stopping Treatment ◽  
Lesser Curvature

A patient diagnosed with Borrmann type 4 gastric cancer (mucinous adenocarcinoma), who had refused surgery, was treated by oral administration of 1200 mg/day 5′-deoxy-5-fluorouridine for about 23 weeks. This resulted in substantial improvement of her condition, i.e. the tumour almost completely disappeared, distensibility improved between the central region of the corpus ventriculi and the angulus, and only small protrusions remained on the anterior and posterior walls and the pars pylorica of the lesser curvature. Mild anorexia and diarrhoea were noted as adverse reactions although these symptoms subsided by reducing the dose or temporarily stopping treatment, thereby allowing long-term treatment. Long-term use of 5′-deoxy-5-fluorouridine proved temporarily effective in this patient. The patient died about 3 years and 7 months after starting therapy. Examination showed that the cancer had been mainly in the stomach and that it had metastasized to the colon and pancreas. The liver was free of metastasis.

ADVERSE REACTIONS TO TETRACYCLINE, PENICILLIN AND AN OLEANDOMYCIN-PENICILLIN MIXTURE USED IN THE LONG-TERM THERAPY OF CHRONIC PULMONARY DISEASE

1962 ◽  
Vol 243 (3) ◽  
pp. 341-353 ◽  
Author(s):  
Solomon Sobel ◽  
Edward A. Lichter ◽  
J Calvin Davis ◽  
Harry F. Dowling ◽  
Mark H. Lepper ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Adverse Reactions ◽  
Term Therapy ◽  
Chronic Pulmonary Disease ◽  
Long Term Therapy

Methenamine Hippurate (‘Hiprex’)† in the Treatment of Chronic Urinary Tract Infections: A Trial in a Geriatric Hospital

1976 ◽  
Vol 4 (2) ◽  
pp. 111-114 ◽  
Author(s):  
Salme Parvio
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Adverse Reactions ◽  
Bacterial Resistance ◽  
Term Treatment ◽  
Chronic Urinary Tract Infection ◽  
Long Term Treatment ◽  
Geriatric Hospital ◽  
Tract Infections

Fifty-two patients, all of whom were more than 66 years-old and who were hospitalized for periods in excess of two years were treated for chronic urinary tract infection. All patients received a course of antibiotic treatment for seven to ten days and were then put onto treatment with methenamine hippurate 1 g twice daily for six months. Of the original fifty-two patients, twelve did not complete the six month course. During the six month period with ‘Hiprex’ there were far fewer re-infections than in the previous six months during which time they had received intermittent antibiotic therapy and other long-term treatment. There were no adverse reactions and bacterial resistance did not occur.

scholarly journals The effect of the main active substances of antihypertensive eye drops on condition of the eyes of glaucoma patients

2020 ◽  
pp. 5-10
Author(s):  
O. N. Onufriichuk ◽  
I. R. Gazizova ◽  
A. V. Kuroyedov ◽  
A. V. Seleznev
Keyword(s):  
Quality Of Life ◽  
Adverse Reactions ◽  
Hypotensive Effect ◽  
Eye Drops ◽  
Common Cause ◽  
Treatment Regimens ◽  
Active Substances ◽  
Lifetime Treatment

Today, glaucoma is considered to be the most common cause of irreversible blindness. The treatment of this disease is aimed at reducing intraocular tension in order to slow down the deterioration of visual functions and to maintain accept‑ able quality of life. Most ophthalmologists prefer local medicamentous therapy. Despite a significant expansion of the range of antihypertensive medicines, a significant increase in the hypotensive effect is not always achieved in each certain case, at the same time, at long-term (sometimes lifetime) treatment local and systemic adverse reactions arise and intensify. The findings of recent clinical trials presented in this overview demonstrate an adverse effect of active compounds, preservatives and ad‑ ditives of ophthalmic medicines not only on the eye surface but also on the structure of anterior and posterior eye segments. Taking into account possible side effects of each component of medicines used in glaucoma therapy, ophthalmologists will be able to reasonably approach the choice of optimal treatment regimens with the lowest risk for patients.

scholarly journals Antibiotic Therapy Associated Cardiotoxicity

2021 ◽  
Vol 4 (10) ◽  
pp. RV18-RV21
Author(s):  
Manisha Jha ◽  
Akram Khan
Keyword(s):  
Antibiotic Therapy ◽  
Health Risks ◽  
Adverse Reactions ◽  
Therapeutic Agents ◽  
Qt Prolongation ◽  
Aortic Aneurysms ◽  
Drug Reactions ◽  
Frequent Use ◽  
High Concern

The improper and frequent use of antibiotics has been on a rise. Empirical use for unapproved indications leads to development of resistant pathogens. Many other adverse drug reactions are associated with the use of antibiotics. These may be due to the direct effect of these drugs or due to their interactions with other therapeutic agents. Cardiac toxicities like QT prolongation, aortic aneurysms and dissections are of high concern and may result in long-term health risks. To prevent these adverse reactions, antibiotics should be used as per the manufacturer’s and physician’s instructions. The use of interacting drugs should be avoided wherever possible. Polypharmacy practice should be done after considering all the patient’s health aspects. This review summarizes the cardiac toxicities of commonly prescribed antibiotics and their interactions with other drugs.

scholarly journals Fabrication of A Shear Force Sensor for The Evaluation of The Effects of Skin Deformation on Pressure Ulcer Formation

2000 ◽  
Vol 120 (8-9) ◽  
pp. 1092-1097
Author(s):  
Seiichi Suzuki ◽  
Fukuko Ohnuma ◽  
Chikako Yanami ◽  
Tomoko Murayama ◽  
Makoto Akiyoshi
Keyword(s):  
Pressure Ulcer ◽  
Shear Force ◽  
Force Sensor ◽  
Ulcer Formation ◽  
Skin Deformation

Skin Care Using Heparinoid Creams for Long-Term Treatment with Oxybutynin Transdermal Patches without Skin Irritation in Elderly OAB Patients

2018 ◽  
Vol 2 (1) ◽  
pp. 01-03
Author(s):  
Luke Jackson ◽  
Jonathan Noah ◽  
Miguel Seth ◽  
Collin Jared
Keyword(s):  
Overactive Bladder ◽  
Adverse Reactions ◽  
Skin Irritation ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Transdermal Patch ◽  
Transdermal Patches ◽  
Bladder Symptom ◽  
Overactive Bladder Symptom Score

Background: Overactive bladder is an age-related urologic disease. An oxybutynin transdermal patch is used to treat overactive bladder; however, long-term use is not advised because of potential adverse reactions at the site of application. The present study aimed to investigate the advantages of administering a combination of heparinoid cream and oxybutynin transdermal patch treatment for overactive bladder in elderly patients. Methods: Eight patients (>65 years of age) with overactive bladder were included. The heparinoid cream was applied topically for 1 week, and skin hydration and transepidermal water loss were quantified before and after application. Thereafter, patients were treated with a combination of an oxybutynin transdermal patch and a heparinoid cream for 12 weeks, and the sites of application were monitored for adverse reactions. Clinical effects of the combinatorial treatment were assessed based on the overactive bladder symptom score. Results: Application of the heparinoid cream did not decrease transepidermal water loss, but increased skin hydration and improved dryness. Oxybutynin transdermal patch therapy was not interrupted because no skin irritation was observed at the site of application for 12 weeks, and the overactive bladder symptom score decreased significantly (p<0.05). Conclusions: Combination treatment with an oxybutynin transdermal patch and a heparinoid cream improved treatment outcomes, suggesting that skin hydration with heparinoid cream is a promising treatment method to ensure appropriate use of oxybutynin transdermal patches in elderly patients with overactive bladders.

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