Clinical Effect and Adverse Reaction Rate of Taohong Siwu Decoction in Treating Early Traumatic Fracture

2021 ◽  
Keyword(s):  
Adverse Reaction ◽  
Reaction Rate ◽  
Clinical Effect ◽  
Taohong Siwu Decoction ◽  
Traumatic Fracture

scholarly journals Are Kidney-Tonifying and Blood-Activating Medicinal Herbs Better than NSAIDs for Knee Osteoarthritis? A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-19
Author(s):  
Hetao Huang ◽  
Jianke Pan ◽  
Weiyi Yang ◽  
Yanhong Han ◽  
Minghui Luo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Reaction ◽  
Knee Osteoarthritis ◽  
Reaction Rate ◽  
Total Effective Rate ◽  
Meta Analysis ◽  
Effective Rate ◽  
Medicinal Herbs ◽  
Vas Scores ◽  
Quality Evidence

Objective. To compare the efficacy and safety of kidney-tonifying and blood-activating medicinal herbs (KTBAMs) and nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of knee osteoarthritis (KOA). Methods. Randomized controlled trials (RCTs) from online databases that compared the efficacy of KTBAMs and NSAIDs in the treatment of KOA were retrieved. The main outcomes included the evaluation of functional outcomes, pain, and adverse effects. The Cochrane risk-of-bias (ROB) tool was used to assess methodological quality. Results. A total of 38 RCTs (3994 participants) were included in our meta-analysis. We found that KTBAMs had a significantly higher total effective rate (P<0.00001, risk ratio (RR) = 1.08, confidence interval (CI) = 1.05 to 1.11, I2 = 4%) and a lower gastrointestinal adverse reaction rate (P<0.00001, RR = 0.36, CI = 0.24 to 0.53, I2 = 33%) than NSAIDs. KTBAMs showed greater improvements in the Knee Society Scale (KSS) scores (mean difference (MD) = 7.17, 95% CI 0.71 to 13.64, P=0.03). Regarding the visual analog scale (VAS) scores, WOMAC scores, and Lequence scores, there were no significant differences between the KTBAM group and the NSAID group. The GRADE quality level of this systematic review indicated that the very low-quality evidence showed that KTBAMs had a higher total effective rate, while the moderate-quality evidence showed that the adverse reactions of KTBAMs were lower and the KSS scores were higher. Low-quality evidence showed no significant differences in improving VAS scores, WOMAC scores, or Lequence scores. Conclusion. KTBAMs were superior to NSAIDs in terms of a higher total effective rate, a lower adverse reaction rate, and a higher KSS score. There were no significant differences between KTBAMs and NSAIDs in improving VAS scores, WOMAC scores, and Lequence scores of patients with KOA. Therefore, KTBAMs may be an alternative effective method for treating KOA. However, high-quality, well-designed RCTs with long-term follow-up are still required.

scholarly journals Dysfunction of the Clinical Effect of Levonorgestrel Treatment of Dysfunctional Uterine Bleeding

2013 ◽  
Vol 2 ◽  
pp. 4
Author(s):  
Xinhui Mi ◽  
Caixia Qin
Keyword(s):  
Adverse Reaction ◽  
Clinical Practice ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Endometrial Thickness ◽  
Hemoglobin Concentration ◽  
Uterine Bleeding ◽  
Dysfunctional Uterine Bleeding ◽  
Curative Effect ◽  
Intrauterine Treatment

<strong>Objective: </strong>Study clinical curative effect of levonorgestrel treatment on perimenopausal dysfunctional uterine bleeding. Method: Selected 126 outpatient of dysfunctional uterine bleeding which hospitalize from December 2010 to December 2012 at department of gynaecology to undergo levonorgestrel treatment on the 5‒7 days of menstruation. The endometrial thickness, hemoglobin, and the PBAC score of before and 3, 6, and 12 months after placement were observed and recorded. To observation the adverse reactions after levonorgestrel treatment. <strong>Results: </strong>After treatment, the thickness of the endometrium, the amount of menstruation and the hemoglobin concentration increased in 126 patients. During the treatment, 21 patients experienced mild dizziness and nausea, but did not affect the drug use and efficacy. <strong>Conclusion: </strong>Effects of levonorgestrel on intrauterine treatment of perimenopausal dysfunctional uterine bleeding can effectively reduce the amount of menstruation and increase hemoglobin levels. It is economic, simple, less adverse reaction, and widely entrenched in clinical practice.

scholarly journals Clinical Effect Observation of Spiral CT in The Etiological Diagnosis of Senile Acute Abdomen

2015 ◽  
Vol 4 (3) ◽  
pp. 16
Author(s):  
Jun Li
Keyword(s):  
Adverse Reaction ◽  
Acute Abdomen ◽  
Clinical Application ◽  
Reaction Rate ◽  
Statistical Significance ◽  
Spiral Ct ◽  
Liver Mri ◽  
Etiological Diagnosis ◽  
Comparison Results ◽  
Diagnosis Rate

<strong>Objective</strong>: To discuss the clinical application value of multi-slice spiral CT in etiological diagnosis of senile acute abdomen. <strong>Methods</strong>: To select 80 cases of elderly patients with acute abdomen received treatment from June 2006 to August 2012 in our hospital. Among them, 40 patients were diagnosed by multi-slice spiral CT technique and considered as CT group; 40 patients were diagnosed by liver MRI technology and considered as MRI group. The diagnostic accuracy and adverse reaction rate of two groups were compared, and the comparison results were analyzed statistically using SPSS statistical software. <strong>Result</strong>: The diagnosis rate of CT group was significantly higher than that of MIR group, while the adverse reaction rate was significantly lower than that of MIR group, <em>p </em>&lt; 0.05, with statistical significance. <strong>Conclusion</strong>: multi-slice spiral CT can accurately diagnose the cause of senile acute abdomen. It has important clinical significance for the treatment of senile acute abdomen, and it has clinical application value.

scholarly journals Efficacy of Zhifei Kangfu Decoction in the Treatment of Infantile Pneumonia in the Recovery Period

2021 ◽  
Vol 271 ◽  
pp. 03031
Author(s):  
Yingying Zhang ◽  
Caihong Cao ◽  
Xin Guo ◽  
Haijun Shan
Keyword(s):  
Adverse Reaction ◽  
Reaction Rate ◽  
Treatment Time ◽  
Recovery Period ◽  
Research Work ◽  
Effective Rate ◽  
Control Group ◽  
Pediatric Pneumonia ◽  
The Difference ◽  
Experimental Group

The objective of this article is to explore the effect of applying Zhifei Kangfu Decoction on the treatment effect of patients during the recovery period of children with pneumonia. The method of this research is to take patients who were treated in our hospital from December 2019 to December 2020 as an example to carry out the research work. The researchers selected all patients in the recovery period of pediatric pneumonia, and the number was selected as 100 cases, who were divided into two groups, and the treatment methods used are conventional western medicine and Zhifei Kangfu Decoction treatment, who were named the control group and the experimental group, and the clinical treatment effects of the two groups of patients are compared and analyzed. The effective rate and adverse reaction rate of children in the experimental group were 96.00% and 4.00%, respectively. The effective rate and adverse reaction rate of children in the control group were 82.00% and 30.00%, respectively. Asthma, cough relieving, and treatment time were shorter than those of the control group, and the difference in the data was P<0.05, which was statistically significant. The experimental group had better results. The treatment of children in the recovery period of pneumonia and the application of Zhifei Kangfu Decoction can promote the improvement of clinical efficacy, reduce the incidence of adverse reactions in children, and have a positive significance in promoting the recovery of children.

scholarly journals Effect of Combining Immersion Therapy with Shengji Ointment on Wound Healing Rate and Adverse Reaction Rate in Patients with Second-Degree Burn

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yun Guo ◽  
Junjie Yu
Keyword(s):  
Wound Healing ◽  
Adverse Reaction ◽  
Treatment Group ◽  
Reaction Rate ◽  
Healing Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Degree Burn ◽  
Wound Healing Rate ◽  
Second Degree

Objective. To explore the effect of combining immersion therapy with Shengji ointment on wound healing rate and adverse reaction rate (ARR) in patients with second-degree burn. Methods. The data of 80 patients with second-degree burn treated in our hospital from February 2019 to February 2020 were retrospectively analyzed by the means of retrospective study, and the patients were equally divided into the treatment group and the control group according to their admission order, with 40 cases each. Immersion therapy was performed to all patients (7 d); after that, patients in the control group received routine medication (7 d), and those in the treatment group were treated with Shengji ointment until the wounds were healed, so as to compare their wound healing condition, ARRs, levels of inflammatory factors, and infection incidence. Results. Compared with the control group after treatment, the treatment group presented significantly shorter wound healing time (12.14 ± 1.26 vs. 15.98 ± 1.20, P  < 0.001), better wound healing rate and quality ( P  < 0.05), and lower levels of inflammatory factors ( P  < 0.001); no significant between-group difference in ARRs was shown ( P  > 0.05); 34 patients in the treatment group (85.0%) and 26 patients in the control group (65.0%) had no infections, so the incidence rate of infections was significantly lower in the treatment group than in the control group (P < 0.05). Conclusion. Combining immersion therapy with Shengji ointment can reduce the levels of inflammatory factors in patients with second-degree burn, lower the incidence rate of infections, provide the conditions for wound healing, and increase the wound healing rate, which shall be promoted and applied in practice.

scholarly journals Clinical Study on the Aerosol Inhalation of Budesonide in Treatment of Acute Exacerbation of COPD

2015 ◽  
Vol 4 (3) ◽  
pp. 40
Author(s):  
Huifeng Duan
Keyword(s):  
Adverse Reaction ◽  
Acute Exacerbation ◽  
Clinical Effect ◽  
Control Group ◽  
Chronic Obstructive ◽  
Observation Group ◽  
Obstructive Pulmonary Disease ◽  
Acute Exacerbation Of Copd ◽  
Aerosol Inhalation ◽  
Exacerbation Of Copd

<p><strong>Objective</strong>: To observe the clinical effect and adverse reaction of aerosol inhalation of budesonide in treatment of acute exacerbation of COPD. 110 cases of patients with acute exacerbation of chronic obstructive pulmonary disease, who were treated in our department from January 2009 to January 2011, were selected as research objects (69 males, 41 females). All the patients were divided into control group and observation group. The two groups were treated routinely, in addition, the control group was treated with vein administration of methylprednisolone, the observation group received aerosol inhalation of budesonide, observed the clinical effect.<strong> Result: </strong>The clinical effect of observation group is better and the adverse reaction rate is clearly lower. <strong>Conclusion: </strong>Comparing with the control group which is treated with vein administration of methylprednisolone on the basis of routine treatment<strong>, </strong>the effect of observation group which is treated with aerosol inhalation of budesonide is extremely precise and its adverse reaction is also relatively less. Meanwhile, it has a higher security and its clinical effect is worth applying.</p>

scholarly journals Discussion on the Effect of Introducing Clinical Pharmacists to Guide Clinical Medication in ICU

2021 ◽  
Vol 10 (1) ◽  
pp. 14
Author(s):  
Dalai Wuyun
Keyword(s):  
Adverse Reaction ◽  
Drug Use ◽  
Infection Rate ◽  
Reaction Rate ◽  
Adverse Reactions ◽  
Control Group ◽  
Observation Group ◽  
Icu Patients ◽  
Clinical Pharmacists ◽  
Previous Medication

<p>Objective: to investigate the effect of clinical pharmacists in ICU. Methods: 108 ICU patients from January 2018 to March 2020 were divided into the control group and the observation group, with 54 cases in each group. The control group used the previous medication route, while the observation group introduced clinical pharmacists to guide clinical medication. The infection rate and adverse reaction rate of the two groups were compared. Results: the infection rate of the observation group was 3.70%, and that of the control group was 14.81%, which was significantly lower than that of the control group (P&lt;0.05). The adverse reaction rate of the observation group was 5.56%, and that of the control group was 18.52%, which was significantly lower than that of the control group (P&lt;0.05). Conclusion: the introduction of clinical pharmacists to guide clinical medication in ICU can effectively control the infection, and reduce various adverse reactions during drug use, so as to realize the scientific and standardized use of drugs, and improve the efficiency and safety of drug use.</p>

Routine Pertussis Immunization

1985 ◽  
Vol 19 (10) ◽  
pp. 729-731 ◽  
Author(s):  
Bev Lorraine True ◽  
Elizabeth A. Burns
Keyword(s):  
Adverse Reaction ◽  
Longitudinal Study ◽  
Reaction Rate ◽  
Whooping Cough ◽  
Smallpox Vaccine ◽  
Morbidity And Mortality ◽  
Vaccination Program ◽  
Health Consequence ◽  
Short Term ◽  
Mortality And Morbidity

The benefits and risks of both the vaccine for pertussis and the disease itself are reviewed in this article. Unlike with the smallpox vaccine, it seems unlikely that a vaccine will be developed to eradicate pertussis completely, since most confer only a short-term immunity. A longitudinal study was undertaken to compare the mortality and morbidity rates of pertussis with the adverse reaction rate of the vaccination program. Risks of the vaccination, such as erythema, drowsiness, and vomiting are well known. However, the issue of neurologic difficulties has surfaced and disagreement exists. Some association does seem to exist between the vaccine and neurologic problems; however, the morbidity and mortality of whooping cough is of a greater health consequence than these rare neurologic reactions.

scholarly journals Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Vincenza Granata ◽  
Marco Cascella ◽  
Roberta Fusco ◽  
Nicoletta dell’Aprovitola ◽  
Orlando Catalano ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adverse Reaction ◽  
Magnetic Resonance ◽  
Contrast Media ◽  
Contrast Agents ◽  
Reaction Rate ◽  
Adverse Reactions ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Mr Contrast Media

Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI.Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist).Results. 32 acute adverse reactions occurred, accounting for 0.3% of all administration. Twelve reactions were associated with Gd-DOTA injection (0.11%), 9 with Gd-BOPTA injection (0.08%), 6 with Gd-BTDO3A (0.056%), 3 with Gd-EOB-DTPA (0.028%), and 2 with Gd-DTPA (0.018%). Twenty-four reactions (75.0%) were mild, four (12.5%) moderate, and four (12.5%) severe. The most severe reactions were seen associated with use of Gd-BOPTA, with 3 severe reactions in 32 total reactions.Conclusion. Acute adverse reactions are generally rare with the overall adverse reaction rate of 0.3%. The most common adverse reactions were not severe, consisting in skin rash and hives.

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