Discussion on the Effect of Introducing Clinical Pharmacists to Guide Clinical Medication in ICU

Objective: to investigate the effect of clinical pharmacists in ICU. Methods: 108 ICU patients from January 2018 to March 2020 were divided into the control group and the observation group, with 54 cases in each group. The control group used the previous medication route, while the observation group introduced clinical pharmacists to guide clinical medication. The infection rate and adverse reaction rate of the two groups were compared. Results: the infection rate of the observation group was 3.70%, and that of the control group was 14.81%, which was significantly lower than that of the control group (P<0.05). The adverse reaction rate of the observation group was 5.56%, and that of the control group was 18.52%, which was significantly lower than that of the control group (P<0.05). Conclusion: the introduction of clinical pharmacists to guide clinical medication in ICU can effectively control the infection, and reduce various adverse reactions during drug use, so as to realize the scientific and standardized use of drugs, and improve the efficiency and safety of drug use.

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Observation on the Effect of Comfortable Nursing in ICU Patients with Severe Infection

Journal of Nursing ◽

10.18686/jn.v9i2.171 ◽

2020 ◽

Vol 9 (2) ◽

pp. 36

Author(s):

Yexin Li

Keyword(s):

Sleep Quality ◽

Adverse Reactions ◽

Severe Infection ◽

Nursing Intervention ◽

Control Group ◽

Observation Group ◽

Icu Patients ◽

Before And After ◽

The Difference ◽

And Control

Objective: this article aims to explore the effect of comfortable nursing in ICU patients with severe infection. Methods: from January 2018 to January 2019, 44 patients with severe infection were selected as research objects. They were randomly divided into observation group (n=22) and control group (n=22). The control group was given routine nursing, while the observation group was given comfortable nursing on the basis of the control group. Pittsburgh Sleep Quality Index (PSQ1), Self-rating Anxiety Scale (SAS) and the incidence of adverse reactions were observed and compared between the two groups before and after intervention. Results: the PSQI score and SAS score of the patients in the observation group were lower than those in the control group. The incidence of adverse reactions in the observation group was 4.59%, which was significantly lower than that in the control group (27.27%), and the difference between the two groups was statistically significant (P<0.05). Conclusion: comfortable nursing intervention for ICU patients with severe infection can obviously improve their sleep quality and negative emotions, and reduce the incidence of adverse reactions during hospitalization, which has clinical application value.

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Effect of Cefazolin Sodium on Perioperative Prophylactic Anti-Infection in Patients Undergoing Gynecological Surgery

Advanced Emergency Medicine ◽

10.18686/aem.v10i1.184 ◽

2021 ◽

Vol 10 (1) ◽

pp. 11

Author(s):

Na Sai

Keyword(s):

Adverse Reaction ◽

Blood Cells ◽

Adverse Reactions ◽

White Blood Cells ◽

Perioperative Period ◽

Control Group ◽

Gynecological Surgery ◽

Observation Group ◽

Blood Cell Count ◽

Cefazolin Sodium

Purpose: The purpose is to investigate the effect of cefazolin sodium on perioperative prophylactic anti-infection in patients undergoing gynecological surgery. Methods: 112 cases of gynecological surgery from January 2019 to April 2020 were divided into the control group and the observation group, with 56 cases in each group. They were given cefazolin sodium + metronidazole and cefazolin sodium monotherapy respectively. The perioperative white blood cells and the incidence of adverse reactions of the two groups were compared. Results: There was no difference in the normal rate of white blood cell count between the observation group and the control group (P > 0.05), and no adverse reaction in the observation group, which was significantly lower than 7.14% in the control group (P < 0.05). Conclusion: the use of cefazolin sodium in perioperative period of gynecological surgery can prevent infection, with advanced security, less adverse reactions and high value.

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A Prospective Trial of Prophylactic Povidone Iodine in Lacerations of the Hand

Journal of Hand Surgery (European Volume) ◽

10.1016/s0266-7681_85_80064-4 ◽

1985 ◽

Vol 10 (3) ◽

pp. 370-374

Author(s):

A. H. N. ROBERTS ◽

F. E. V. ROBERTS ◽

R. I. HALL ◽

I. H. THOMAS

Keyword(s):

Wound Infection ◽

Infection Rate ◽

Adverse Reactions ◽

Healing Rate ◽

Povidone Iodine ◽

Prospective Trial ◽

Control Group ◽

Iodine Treatment ◽

Pain Patients

A series of 418 patients with lacerations of the hands were allocated randomly to a control group or to a group where the injury was treated with povidone iodine before suture. The incidence of infected and imperfectly healed wounds was determined seven days later. As well as the effect of povidone iodine on infection, thirteen other factors were also analysed. The overall infection rate of 5.0% and the 38.5% imperfect healing rate were not significantly affected by povidone iodine treatment, although both were reduced. The figures of four other trials were combined with this trial and this showed a significant effect of povidone iodine treatment. There were no adverse reactions to povidone iodine. It is therefore recommended that hand lacerations should be treated with povidone iodine prior to suture. Other factors found to be significantly important in wound infection or imperfect healing were the condition of the dressing, the part of the hand injured and pain. Patients should be strongly advised to keep their dressing clean and dry.

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Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.4.1831 ◽

2020 ◽

Vol 36 (4) ◽

Author(s):

Xuewen Wo ◽

Jinyan Han ◽

Jiajia Wang ◽

Xinmin Wang ◽

Xiaoying Liu ◽

...

Keyword(s):

Plasma Level ◽

Cerebral Infarction ◽

Antiplatelet Therapy ◽

Adverse Reactions ◽

Dual Antiplatelet Therapy ◽

Acute Cerebral Infarction ◽

Control Group ◽

Observation Group ◽

Significant Difference ◽

Better Than

Objective: To observe the clinical efficacy of sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of elderly patients with acute cerebral infarction (ACI). Methods: One hundred and twenty-two elderly patients with ACI who were admitted to the department of neurology of our hospital at May 2016-August 2018 were selected grouped into a control group and an observation group by random number table method, 61 in each group. On the basis of conventional treatment, the patients in the control group were given dual antiplatelet therapy (aspirin enteric-coated tablets + clopidogrel bisulfate tablets), while the patients in the observation group were given sequential butylphthalide therapy on the basis of the control group. The clinical effects of the two groups were compared after four weeks of treatment, and the changes of National Institutes of Health Stroke Scale (NIHSS), ADL score, plasma 3-mercaptopyruvate sulphurtransferase (3-MST) and Amyloid β42 (Aβ42) levels and the occurrence of adverse reactions during treatment were recorded. Results: The clinical efficacy of the observation group was better than that of the control group (P<0.05). There was no significant difference in NIHSS and ADL scores between the two groups before treatment (P>0.05). After treatment, the NIHSS and ADL scores of the observation group were better than those of the control group (P<0.05). There was no significant difference in plasma levels of 3-MST and AB42 between the two groups before treatment (P>0.05). The level of plasma 3-MST in the observation group was higher than that in the control group, and the level of plasma Aβ42 was lower than that in the control group (P<0.05). No serious adverse reactions occurred during the treatment period in both groups. Conclusion: Butylphthalide sequential therapy combined with dual antiplatelet therapy is effective in the treatment of elderly ACI. It can effectively improve the plasma level of 3-MST and decrease the plasma level of Aβ42, which is conducive to improving the living ability and neurological function of patients and has high safety. doi: https://doi.org/10.12669/pjms.36.4.1831 How to cite this:Wo X, Han J, Wang J, Wang X, Liu X, Wang Z. Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1831 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Clinical Observation of Zhuang Medicine Crystal Sugar Ye’An Decoction in Treating Senile Skin Pruritus and Its Effects on Serum IgE

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v4i6.1625 ◽

2020 ◽

Vol 4 (6) ◽

Author(s):

Yun Zhang ◽

Yuying Lan

Keyword(s):

Adverse Reactions ◽

Clinical Observation ◽

Skin Lesions ◽

Effective Rate ◽

Inflammatory Factors ◽

Control Group ◽

Observation Group ◽

Serum Ige ◽

The Difference ◽

Lesion Severity

Objective: To discuss the specific application of Zhuang Medicine Crystal Sugar Ye’An Decoction in senile skin pruritus and its effects on serum IgE detection level. Methods: 90 patients with senile skin pruritus admitted to our hospital from February 2019 to April 2020 were randomly grouped. The general treatment effect, itching, secondary skin lesion severity, serum IL-6, IgE level and adverse reactions between 45 patients treated with Chlorcyclizine Hydrochloride Tablets (The control group) and 45 patients treated with Crystal Sugar Ye’An Decoction were compared. Results: The total effective rate of the treatment in the observation group was 93.33%, much higher than that in the control group, 75.56%. The difference was verified and statistically significant (P<0.05). Before the treatment, the itching area, frequency, duration and severity of secondary skin lesions were at the same level (P>0.05). After the treatment, the above data were all reduced, and the reduction of the observation group was more significant than that of the control group, indicating the difference was statistically significant (P<0.05). Before the treatment, there was no difference in serum IL-6 and IgE test data between the two groups (P>0.05). After the treatment, the tendency all declined, and that of the observation group was more obvious, indicating the difference was statistically significant (P<0.05). During the experiment, no obvious adverse reactions were observed in both groups. Conclusion: In the treatment of patients with senile pruritus, the application of Zhuang Medicine Crystal Sugar Ye’An Decoction is not only safe and reliable, but can promote the improvement of patients’ symptoms, adjust the level of inflammatory factors, and enhance clinical efficacy.

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Insulin Glargine and Acarbose in the treatment of elderly patients with diabetes

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.3.86 ◽

2019 ◽

Vol 35 (3) ◽

Author(s):

Jing Li ◽

Jinzhi Ji ◽

Fuyan Liu ◽

Lingling Wang

Keyword(s):

Quality Of Life ◽

Blood Glucose ◽

Elderly Patients ◽

Insulin Glargine ◽

Adverse Reactions ◽

Postprandial Blood Glucose ◽

Control Group ◽

Observation Group ◽

Patients With Diabetes

Objective: To investigate the clinical efficacy of insulin glargine combined with acarbose in the treatment of elderly patients with diabetes. Methods: One hundred and forty-four elderly patients with diabetes who received treatment between December 2016 and December 2017 in Binzhou People’s Hospital, China, were selected and divided into a control group and an observation group, 72 each, using random number table. The control group was treated with insulin glargine, while the observation group was treated with insulin glargine combined with acarbose. The therapeutic effect, improvement of quality of life and adverse reactions were compared between the two groups. Results: After treatment, fasting blood glucose (FBG), 2h postprandial blood glucose (PBG) and glycosylated hemoglobin (Hb Alc) of the two groups were lower than those before treatment, and the decrease degree of the observation group was significantly larger than that of the control group (P<0.05). The time needed for blood glucose reaching the standard level and daily insulin dosage of the observation group were significantly lower than that of the control group, and the differences were statistically significant (P<0.05). SF-36 scale score of the observation group was significantly better than the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of insulin Glargine and Acarbose can significantly control the blood glucose level of elderly patients with diabetes, improve the biochemical indicators, and enhance the quality of life. It is worth promotion in clinical practice. doi: https://doi.org/10.12669/pjms.35.3.86 How to cite this:Li J, Ji J, Liu F, Wang L. Insulin Glargine and Acarbose in the treatment of elderly patients with diabetes. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.86 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect Of Butylphthalide Combined with Ozagrel Sodium on Cerebral Perfusion and Oxidative Stress Indexes in Patients with Transient Ischemic Attack

Tobacco Regulatory Science ◽

10.18001/trs.7.6.111 ◽

2021 ◽

Vol 7 (6) ◽

pp. 6388-6394

Author(s):

Changya Liu ◽

Yun Li ◽

Jianhua Zhou ◽

Chuanxiang Wang ◽

Tao Hu

Keyword(s):

Oxidative Stress ◽

Transient Ischemic Attack ◽

Cerebral Perfusion ◽

Reaction Rate ◽

Effective Rate ◽

Control Group ◽

Observation Group ◽

Plaque Area ◽

Ischemic Attack ◽

And Oxidative Stress

Background The pathogenesis of transient ischemic attack is not clear. Microthrombosis theory is a theory with high clinical recognition. Microthrombosis of carotid artery and vertebral basilar artery wall occurs shedding and vasospasm, resulting in transient cerebral insufficiency. Microembolic decomposition or distal movement, cerebrovascular dilatation, local collateral circulation after the establishment of symptoms relieved or disappeared. Most patients can be relieved in a short time, but recurrent attacks can gradually damage the structure and function of brain tissue, and increase the risk of acute cerebral infarction. The clinical treatment of this disease is mainly based on the comprehensive control of risk factors, anti thrombosis, and anti-platelet aggregation. Objective To observe the effect of butylphthalide combined with ozagrel sodium on cerebral perfusion and oxidative stress indexes in patients with transient ischemic attack. Methods A total of 116 patients diagnosed as transient ischemic attack in our hospital (February 2018 - February 2020) were selected and divided into two groups according to the treatment methods. 58 cases in the control group were treated with ozagrel sodium, 58 cases in the observation group were treated with butylphthalide combined with ozagrel sodium. The CT perfusion imaging parameters, oxidative stress indexes, plaque area, and the levels of platelet activating factor ( PAF ), α-granule membrane protein-140 ( GMP-140 ), fibrinogen ( FIB ), platelet aggregation rate (PAgT), neuron-specific enolase (NSE), oxygend-inducible factor-1α (HIF-1α), and matrix metalloproteinases 9 (MMP-9) in the two groups were recorded, and the total effective rate and adverse reaction rate were counted. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (χ2=4.640, P = 0.031). Compared with before treatment, the average time (MTT) required for the two groups of contrast agents to pass through the local brain tissue and the time (TTP) required to start the injection of contrast agents to reach the peak concentration decreased compared with before treatment. After treatment, the MTT and TTP of the observation group were shorter than those of the control group (P < 0.05). Compared with before treatment, superoxide dismutase ( SOD ) in the two groups was higher than that in the control group, PAF, GMP-140, FIB, PAgT, NSE, HIF-la, MMP-9, malondialdehyde (MDA) and plaque area decreased. After treatment, the levels of related factors in the observation group were better than those in the control group, and the plaque area was less than that in the control group (P < 0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group (χ2 = 0.438, P=0.508). Conclusion Butylphthalide combined with ozagrel sodium in the treatment of transient ischemic attack can improve cerebral perfusion, reduce oxidative stress injury, reduce plaque and improve curative effect.

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Analysis of ticagrelor’s cardio-protective effects on patients with ST-segment elevation acute coronary syndrome accompanied with diabetes

Open Medicine ◽

10.1515/med-2019-0017 ◽

2019 ◽

Vol 14 (1) ◽

pp. 234-240 ◽

Cited By ~ 1

Author(s):

Dong-Tao Li ◽

Shun-Bao Li ◽

Jian-Yong Zheng ◽

Hai-hong Tang ◽

Yi-Gang Qiu ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Adverse Reactions ◽

Left Ventricular ◽

Control Group ◽

Observation Group ◽

Protective Effects ◽

St Segment Elevation ◽

Coronary Syndrome ◽

St Segment ◽

Elevation Acute Coronary Syndrome

AbstractBackgroundTo analyze the cardio-protective effects of ticagrelor in patients with acute coronary syndrome with S-T segment elevation.MethodsThe sample was 200 patients who had been diagnosed with acute coronary syndrome accompanied by diabetes Mellitus type II. Only patients having ST segment elevation before the treatment were included. Then, the subjects were further randomly divided into an observation group and a control group. The control group of 100 patients received clopidogrel; the observation group of 100 patients of ticagrelor. The serous creatine kinase CK-MB, functional cardiac indexes of left ventricular end diastolic diameter (LVDD), cardiac troponin I, ventricular ejection fraction, and relevant major adverse cardiovascular events (MACE) were compared between the two groups.ResultsOne month after a percutaneous coronary intervention (PCI) the observation group showed better results against angina, stent thrombosis, and all-cause mortality compared with those of the control subjects. Six months after treatment, both groups suffered adverse reactions. The number of patients who suffered adverse reactions in respiratory tract in the observation group was higher than in the control group. The inhibition of platelet aggregation IPA of ticagrelor was found to be significantly higher than clopidogrel, having a significant p value.ConclusionTicagrelor can effectively protect myocardial function for patients with ST-segment elevation acute coronary syndrome accompanied by diabetes and can reduce the incidence of adverse reactions..

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Research on the treatment of Pseudomonas aeruginosa pneumonia in children by macrolide antibiotics

Open Medicine ◽

10.1515/med-2015-0082 ◽

2015 ◽

Vol 10 (1) ◽

Author(s):

Xu-qiang Huang ◽

Li Deng ◽

Gen Lu ◽

Chun-hui He ◽

Pei-qiong Wu ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Reaction Rate ◽

Total Effective Rate ◽

Effective Rate ◽

Macrolide Antibiotics ◽

Control Group ◽

Observation Group ◽

Bacterial Clearance ◽

Clinical Method ◽

Combined Application

Abstract To observe a therapeutic effect of macrolide antibiotics in children with Pseudomonas aeruginosa pneumonia. Fifty-four cases of children with Pseudomonas aeruginosa pneumonia were randomly divided into an observation group (n=30) and a control group (n=24). The observation group was treated with macrolide antibiotics and cefoperazone/sulbactam. The control group was treated with cefoperazone/ sulbactam during a course of 10-14 days. The total effective rate was 93.3% in the observation group, and 58.3% in the control group, and results in the observation group were superior to the control group notably (P>0.05). There were no significant differences in bacterial clearance rate, adverse reaction rate between two groups (P>0.05). The combined application of cefoperazone/sulbactam with macrolide antibiotics to treat Pseudomonas aeruginosa pneumonia in children would be a more effective clinical method.

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Analysis of Clinical Effect of Treating Arrhythmia with Stable Heart Granules

Advanced Emergency Medicine ◽

10.18686/aem.v2i1.3 ◽

2013 ◽

Vol 2 ◽

pp. 7

Author(s):

Li Liu

Keyword(s):

Clinical Practice ◽

Adverse Reactions ◽

Clinical Effect ◽

Total Effective Rate ◽

Effective Rate ◽

Control Group ◽

Observation Group ◽

The Difference ◽

And Control ◽

Group Observation

Objective: To study the clinical effect on the treatment of cardiac arrhythmia, and further guide the clinical treatment. Method: From January 2011 to January 2013, 100 patients with arrhythmia were randomly divided into observation group and control group with 50 cases in each group. Observation group patients given oral Stable heart granule treatment, while control group was treated with oral propafenone treatment. The therapeutic effect and adverse reactions of the two groups were observed and compared. Results: The total effective rate of the observation group was higher than control group and incidence of adverse reactions was lower than control group, the difference was statistically significant, p < 0.05. The use of stable heart particles in the treatment of arrhythmia produce significant effect. Conclusion: Clinical effect for Stable heart granule on arrhythmia was significant and should widely entrenched in clinical practice.

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