scholarly journals The Effects of Subacute Exposure of Peracetic Acid on Lipid Peroxidation and Hepatic Enzymes in Wistar Rats

2010 ◽  
Author(s):  
Abdoljalal Marjani
Keyword(s):  
Lipid Peroxidation ◽  
Peracetic Acid ◽  
Wistar Rats ◽  
Hepatic Enzymes ◽  
Subacute Exposure

The Effects of Subacute Exposure of Peracetic Acid on Hematological Indices in Wistar Rats

2008 ◽  
Vol 4 (3) ◽  
pp. 176-180
Author(s):  
Mohammad Jafar Golalipour ◽  
Anneh Mohammad Gharravi ◽  
Abbas Ali Keshtkar ◽  
Abdoljalal Marjani
Keyword(s):  
Peracetic Acid ◽  
Wistar Rats ◽  
Hematological Indices ◽  
Subacute Exposure

Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

2020 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Nasiri ◽  
Saja Ahmadizad ◽  
Mehdi Hedayati ◽  
Tayebe Zarekar ◽  
Mehdi Seydyousefi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Wistar Rats ◽  
Enzymatic Antioxidants ◽  
Acute Response ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Exercise Induced ◽  
And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

scholarly journals The subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain

2014 ◽  
Vol 66 (3) ◽  
pp. 1075-1081
Author(s):  
Ivan Simic ◽  
Violeta Iric-Cupic ◽  
Rada Vucic ◽  
Marina Petrovic ◽  
Violeta Mladenovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Rat Brain ◽  
Wistar Rats ◽  
Superoxide Radical ◽  
Reduced Glutathione ◽  
Oxidative Stress Markers ◽  
Sod Activity ◽  
Stress Markers ◽  
Male Wistar Rats

The aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain.

scholarly journals Lipid Peroxidation, Lipid Profile Changes and Antioxidant Properties of the Combination of Vernonia amygdalina and Ficus exasperata on the Blood, Liver and Kidney of Alloxan-Induced Diabetic Rats

2021 ◽  
pp. 37-47
Author(s):  
Ukperoro Uyoyo Jeremiah ◽  
Awarota Ruth Oghogho ◽  
Oroye Otsuko ◽  
Udeze Maria Chizoba
Keyword(s):  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Catalase Activity ◽  
Risk Index ◽  
Antioxidant Properties ◽  
Diabetic Rats ◽  
Atherogenic Index ◽  
Hepatic Enzymes ◽  
Vernonia Amygdalina ◽  
Control Serum

Background: The use of plants known to possess significant antioxidant activities have been widely recommended in the complementary and alternate system of medicine in the treatment of diabetes mellitus. Among the many plant used in Nigeria for the management of DM are Vernonia amygdalina and Ficus exasperata. This study was designed to assess the effect of the combination of the aqueous extract of Vernonia amygdalina and Ficus exasperata on blood glucose level, lipid profile, hepatic enzymes, lipid peroxidation and antioxidant status in alloxan-induced diabetes in rats. Method: Twenty five rats were divided into five groups. Four groups were made diabetic by the intra-peritoneal administration of alloxan monohydrate (150mg/kg body weight) while the fifth group served as normal control. Serum, hepatic and renal concentrations of reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) as well as the catalase activity were determined. The blood lipid profile and some hepatic enzymes were also studied. Result: The combined extract lowered lipid peroxidation, increase glutathione concentration and catalase activity in all the tissues of diabetic rats. The individual extract lowered the total cholesterol LDL-Cholesterol, coronary risk index (CRI), and atherogenic index (AI) while increasing the concentration of HDL cholesterol in alloxan-induced diabetic rats. Diabetes lowered hepatic enzymes’ activities but the leaf extract significantly increased it. Conclusion: It can be concluded that combination of the extracts showed additive effect on each other and it is highly recommended for the management of diabetes.

The Development of Kinetic Parameters of Hepatic Drug-Metabolizing Enzymes in Perinatal Rats

1975 ◽  
Vol 53 (4) ◽  
pp. 433-437 ◽  
Author(s):  
J. U. Bell ◽  
D. J. Ecobichon
Keyword(s):  
Kinetic Parameters ◽  
Wistar Rats ◽  
Drug Metabolizing Enzymes ◽  
Hepatic Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug ◽  
Apparent Kinetic Parameters ◽  
Quantitative Changes ◽  
Functionally Diverse ◽  
Conjugating Enzyme

The development of the apparent kinetic parameters Km and Vmax was studied in perinatal Wistar rats for three functionally diverse, hepatic enzymes (p-nitroanisole O-demethylase, carboxylesterase and bromosulphophthalein–glutathione conjugating enzyme), the period studied being from 3 days prepartum to 35 days postpartum. The kinetic parameters underwent marked quantitative changes during development, which appeared to be independent of sex for the first 5 weeks postpartum.

Alcohol extract of Bauhinia forficata link reduces lipid peroxidation in the testis and epididymis of adult Wistar rats

2018 ◽  
Vol 82 (4) ◽  
pp. 345-351 ◽  
Author(s):  
Carolina Ferreira Sampaio ◽  
Nicla Renata Lucchetta ◽  
Ana Paula Franco Punhagui ◽  
Philippe Rodrigues Banedetti ◽  
Nilton Syogo Arakawa ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Wistar Rats ◽  
Alcohol Extract ◽  
Bauhinia Forficata

Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats

2015 ◽  
Vol 25 (8) ◽  
pp. 7223-7230 ◽  
Author(s):  
Vesna Milovanovic ◽  
Aleksandra Buha ◽  
Vesna Matovic ◽  
Marijana Curcic ◽  
Slavica Vucinic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Renal Toxicity ◽  
Diphenyl Ether ◽  
Subacute Exposure

scholarly journals Features of cellular and molecular inflammatory mechanisms involvement in hormone-mediated myocardial experimental injury

2013 ◽  
Vol 94 (5) ◽  
pp. 723-726
Author(s):  
N N Mayanskaya ◽  
L D Hidirova ◽  
S D Mayanskaya
Keyword(s):  
Myocardial Infarction ◽  
Lipid Peroxidation ◽  
Tumor Necrosis ◽  
Wistar Rats ◽  
Biocidal Activity ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Tetrazolium Test ◽  
Pro Inflammatory Cytokines

Aim. To study the features of inflammatory effector mechanisms variation in Wistar rats with metabolic non-coronary myocardial infarction. Methods. Metabolic myocardial infarction was reproduced in Wistar rats by adrenalin injection. Metabolic myocardial infarction was verified by electrocardiography and histological examination. Biocidal activity of blood neutrophils was determined by nitro blue tetrazolium test and chemiluminescence, cytokine serum levels (interleukin-1β, interleukin 6 and tumor necrosis factor alpha) were determined by ELISA. Lipid peroxidation was assessed by measuring malondialdehyde, diene conjugates and diketones blood concentrations. Catalase activity and reduced glutathione level were determined in erythrocyte hemolysate, serum activity of superoxide dismutase was also measured. Intact animals were examined as a control group. Results. In rats with metabolic myocardial infarction, oxygen-dependent leukocyte biocidity (determined by nitro blue tetrazolium test and chemiluminescence) increased dramatically from the first day of the adrenalin administration and continued to increase until the end of the experiment (day 14). Accordingly, the production of active oxygen metabolites, which intensified the lipid peroxidation, was increasing. Simultaneously an imbalance between pro-and antioxidant system parameters was detected. Serum concentration of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1β, interleukin-6) increased. Conclusion. Long-term administration of adrenalin to experimental animals causes an increase in the neutrophils biocidal activity, accompanied by release of reactive oxygen species, pro-inflammatory cytokines, lipid peroxidation intensifying and decreased compensation by antioxidant defense system, which together can be a powerful trigger of myocardial damage.

scholarly journals Effect of vitamin C on liver regeneration after partial hepatectomy and acetaminophen-induced liver injury in Wistar rats

2021 ◽  
Vol 8 (2) ◽  
pp. 489
Author(s):  
Reno Rudiman ◽  
Handy Wing ◽  
Nurhayat Usman
Keyword(s):  
Lipid Peroxidation ◽  
Liver Injury ◽  
Vitamin C ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Wistar Rats ◽  
Liver Weight ◽  
Potential Effect ◽  
Regeneration Rate ◽  
Male Wistar Rats

Background: The aim of this study is to evaluate the potential effect of vitamin C as an antioxidant on liver regeneration after partial hepatectomy and acetaminophen-induced liver injury in Wistar rats.Methods: A total of 24 male Wistar rats were divided into four groups, each group consisted of 6 rats: group A (control, partial hepatectomy/PHx alone), group B (PHx and vitamin C 250 mg/kg BW), group C (acetaminophen 500 mg/kg BW and PHx), and group D (acetaminophen 500 mg/kg BW with PHx and vitamin C 250 mg/kg BW). Subtoxic dose of acetaminophen was given 24 hours before partial hepatectomy. Vitamin C was given orally via oral gavage for 6 consecutive days after partial hepatectomy. POD 7, all animals were terminated and performed laparotomy to obtain liver tissue for measurement of liver weight and regeneration rate, blood samples for malondialdehyde (MDA) as a lipid peroxidation measurement and histopathological investigation.Results: The means of regeneration rate in vitamin C groups were significantly higher compared to non-vitamin C group (p<0.05). Similar result, the means of MDA values in vitamin C groups were significantly lower compared to non-vitamin C group (p<0.05). This result suggests a protective effect of vitamin C against lipid peroxidation. Histopathological changes in liver cells were statistically difference between vitamin C groups and non-vitamin C groups (p<0.05).Conclusions: Our results indicate that vitamin C administration promotes liver regeneration and inhibits lipid peroxidation after partial hepatectomy and acetaminophen-induced liver injury in Wistar rats.

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