scholarly journals Photo activated disinfection in Restorative Dentistry: A technical review

2014 ◽  
Vol 6 (1) ◽  
pp. 16-18
Author(s):  
BS Deepak ◽  
K Mallikarjun Goud ◽  
P Nishanth
Keyword(s):  
Photodynamic Therapy ◽  
Antimicrobial Therapy ◽  
Clinical Studies ◽  
Current Status ◽  
Restorative Dentistry ◽  
Pertinent Literature ◽  
Technical Review ◽  
Recent Developments ◽  
Current Stage

Abstract The purpose of this review is to summarize the recent developments regarding photodynamic therapy (PDT) in the field of restorative dentistry. A search of pertinent literature was carried out in PubMed to determine the current applications of photo activated disinfection (PAD) in dentistry. This overview will provide the practitioners, the current status and use of PAD. Within the limitations of the present review, it can be concluded that although PAD cannot replace antimicrobial therapy at its current stage, it may be used as an adjunctive tool in restorative dentistry. Further long-term clinical studies are necessary in establishing a more specific place of the technique in the field of dentistry. How to cite this article Deepak BS, Mallikarjun GK, Nishanth P. Photo activated disinfection in Restorative Dentistry: A technical review. CODS J Dent 2014;6;16-18

scholarly journals Osteoarthritis background therapy: current view on the glucosamine and chondroitin therapy

2021 ◽  
Vol 15 (2) ◽  
pp. 112-119
Author(s):  
L. I. Alekseeva ◽  
A. M. Lila
Keyword(s):  
Combination Therapy ◽  
Chondroitin Sulfate ◽  
Mechanism Of Action ◽  
Clinical Studies ◽  
Current Status ◽  
Current View ◽  
Background Therapy ◽  
Therapeutic Doses

The article highlights the current status of symptomatic slow-acting drugs (SYSADOA) in osteoarthritis (OA). Mechanism of action, clinical studies data on the effectiveness of glucosamine (GA) and chondroitin sulfate (CS) and their combinations in OA, their positive symptomatic and structural-modifying effects, are described. The article provides the latest recommendations for the OA treatment with these two drugs and presents an argument for the combination therapy with both drugs as a background therapy in the earliest stages of OA. It is indicated that such therapy should be long-term due to its high safety and possible reduction of cardiovascular accidents risk as well. It is noted that therapeutic doses of CS and GA are ≥1500 and ≥800 mg per day, respectively, and encapsulated forms of SYSADOAs have advantages due to their pharmacokinetic features.

scholarly journals Review of Clinical Studies of the Treatment of Ulcerative Colitis Using Acupuncture and Moxibustion

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Jun Ji ◽  
Yan Huang ◽  
Xia-Fei Wang ◽  
Zhe Ma ◽  
Huan-Gan Wu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Moxibustion Therapy ◽  
Clinical Studies ◽  
Current Status ◽  
Proximal Point ◽  
Acupuncture And Moxibustion ◽  
Diagnostic Standards ◽  
Efficacy Criteria ◽  
Selection Of

Background. Clinical studies suggest that acupuncture and moxibustion therapy in ulcerative colitis (UC) can regulate bowel inflammation, and these treatments have the advantages of low rates of adverse reactions and recurrence as well as good long-term efficacy. We reviewed the current status of clinical studies of the treatment. Methods. Randomized controlled trials (RCTs) using the therapy as the major intervention for treating UC were included from 1995 to 2015. The extracted data mainly included diagnostic standards, treatment methods, selection of acupoints, treatment times and courses, and efficacy determination criteria. Results. The use of diagnostic standards and efficacy criteria lacked unification and standardization. There were two main groups: acupuncture and moxibustion therapy combined with drug treatment and the use of all types of acupuncture and moxibustion therapy alone or in combination. The acupoint compositions included distal-proximal point combinations, back-shu point and front-mu point combinations, and acupuncture through meridians. The treatment courses in all the clinical trials had large variations. Conclusion. The treatment of UC in the examined articles was mainly based on the classical theory. However, many links of the clinical regimen design were still lacking, which affected the repeatability of the clinical studies and the accuracy of the clinical conclusions.

scholarly journals Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations

2020 ◽  
Vol 9 (2) ◽  
pp. 333 ◽  
Author(s):  
Irati Beltrán Hernández ◽  
Yingxin Yu ◽  
Ferry Ossendorp ◽  
Mladen Korbelik ◽  
Sabrina Oliveira
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Clinical Studies ◽  
Growth Control ◽  
Local Inflammatory Response ◽  
Immunological Effects ◽  
Preclinical And Clinical Studies ◽  
Cure Rates ◽  
Treated Site

Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates tumor destruction through the generation of reactive oxygen species and tumor-associated vasculature damage, generally resulting in high tumor cure rates. In addition, a PDT-induced immune response against the tumor has been documented in several studies. However, some contradictory results have been reported as well. With the aim of improving the understanding and awareness of the immunological events triggered by PDT, this review focuses on the immunological effects post-PDT, described in preclinical and clinical studies. The reviewed preclinical evidence indicates that PDT is able to elicit a local inflammatory response in the treated site, which can develop into systemic antitumor immunity, providing long-term tumor growth control. Nevertheless, this aspect of PDT has barely been explored in clinical studies. It is clear that further understanding of these events can impact the design of more potent PDT treatments. Based on the available preclinical knowledge, recommendations are given to guide future clinical research to gain valuable information on the immune response induced by PDT. Such insights directly obtained from cancer patients can only improve the success of PDT treatment, either alone or in combination with immunomodulatory approaches.

The Effect of Long-Term Antioxidant Treatments on Redox Homeostasis in Clinical Studies

2007 ◽  
Vol 1 (1) ◽  
pp. 83-95
Author(s):  
Anna Blázovics ◽  
Ágota Kovács ◽  
Andrea Lugasi
Keyword(s):  
Clinical Studies ◽  
Redox Homeostasis

Physical activity and cognitive function in older persons

2016 ◽  
Vol 64 (2) ◽  
Keyword(s):  
Physical Activity ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Executive Functions ◽  
Cognitive Aging ◽  
Clinical Studies ◽  
Older Persons ◽  
Positive Effects ◽  
Critical Challenge

Strategies to improve cognitive aging are highly needed. Among those, promotion of exercise and physical activity appears as one of the most attractive and beneficial intervention. Indeed, results from basic and clinical studies suggest that exercise and physical activity have positive effects on cognition in older persons without cognitive impairment, as well as in those with dementia. Despite inconsistent results, aerobic exercise appears to have the strongest potential to enhance cognition. However, even limited periods of walking (45 minutes, three times a week, over a 6-month period) have also been shown to enhance cognition, particularly executive functions. Changing long-term lifestyle habits in these older persons remains a critical challenge and attractive programs susceptible to gain adherence are needed to succeed in achieving improved cognitive aging.

The mechanistic role of thymoquinone in Parkinson's disease: focus on neuroprotection in pre-clinical studies

2021 ◽  
Vol 14 ◽  
Author(s):  
Mohammad Najim Uddin ◽  
Mohammad Injamul Hoq ◽  
Israt Jahan ◽  
Shafayet Ahmed Siddiqui ◽  
Chayan Dhar Clinton ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Studies ◽  
Nigella Sativa ◽  
Biological Effects ◽  
Neuroprotective Activity ◽  
Substantia Nigra Pars Compacta ◽  
Movement Difficulties

: Thymoquinone (TQ) is one of the leading phytochemicals, which is abundantly found in Nigella sativa L. seeds. TQ exhibited various biological effects such as antioxidant, anti-inflammatory, antimicrobial, and anti-tumoral in several pre-clinical studies. Parkinson's disease (PD) is a long-term neurodegenerative disease with movement difficulties, and the common feature of neurodegeneration in PD patients is caused by dopaminergic neural damage in the substantia nigra pars compacta. The neuroprotective activity of TQ has been studied in various neurological disorders. TQ-mediated neuroprotection against PD yet to be reported in a single frame; therefore, this review is intended to narrate the potentiality of TQ in the therapy of PD. TQ has been shown to protect against neurotoxins via amelioration of neuroinflammation, oxidative stress, apoptosis, thereby protects neurodegeneration in PD models. TQ could be an emerging therapeutic intervention in PD management, but mechanistic studies have been remained to be investigated to clarify its neuroprotective role.

Recent Developments in the Downstream Processing of Phycobiliproteins from Algae: A Review

2021 ◽  
Vol 06 ◽  
Author(s):  
Ayekpam Chandralekha Devi ◽  
G. K. Hamsavi ◽  
Simran Sahota ◽  
Rochak Mittal ◽  
Hrishikesh A. Tavanandi ◽  
...  
Keyword(s):  
Cell Wall ◽  
Large Scale ◽  
Downstream Processing ◽  
Review Article ◽  
Current Status ◽  
Wall Structure ◽  
Scale Production ◽  
Cell Wall Disruption ◽  
Recent Developments ◽  
Macro Algae

Abstract: Algae (both micro and macro) have gained huge attention in the recent past for their high commercial value products. They are the source of various biomolecules of commercial applications ranging from nutraceuticals to fuels. Phycobiliproteins are one such high value low volume compounds which are mainly obtained from micro and macro algae. In order to tap the bioresource, a significant amount of work has been carried out for large scale production of algal biomass. However, work on downstream processing aspects of phycobiliproteins (PBPs) from algae is scarce, especially in case of macroalgae. There are several difficulties in cell wall disruption of both micro and macro algae because of their cell wall structure and compositions. At the same time, there are several challenges in the purification of phycobiliproteins. The current review article focuses on the recent developments in downstream processing of phycobiliproteins (mainly phycocyanins and phycoerythrins) from micro and macroalgae. The current status, the recent advancements and potential technologies (that are under development) are summarised in this review article besides providing future directions for the present research area.

scholarly journals Long-term Outcomes of Small Pigmented Choroidal Melanoma Treated with Primary Photodynamic Therapy

2020 ◽  
Author(s):  
Kelsey A. Roelofs ◽  
Ido Didi Fabian ◽  
Amit K. Arora ◽  
Victoria M.L. Cohen ◽  
Mandeep S. Sagoo
Keyword(s):  
Photodynamic Therapy ◽  
Choroidal Melanoma ◽  
Long Term Outcomes
Sign in / Sign up

Export Citation Format

Share Document