scholarly journals Synthesis of new 6-substituent 2-phenyl and 2-(furan-2-yl)-3-phenyl-quinoline-4-carboxylic acid derivatives

2019 ◽  
Vol 10 (1) ◽  
pp. 57-63
Author(s):  
Tawassl Tajelsir Hassan Hajalsiddig ◽  
Ahmed Elsadig Mohammed Saeed
Keyword(s):  
Melting Point ◽  
Carboxylic Acid ◽  
Thin Layer ◽  
Spectroscopic Data ◽  
Condensation Reaction ◽  
Phenyl Hydrazine ◽  
Substituted Quinolines ◽  
Unsaturated Carbonyls ◽  
Semicarbazide Hydrochloride ◽  
Layer Chromatography

A synthesis of substituted quinolines has been achieved by the Doebner reaction which is a three component coupling of arylaldehyde, p-amino-acetophenone and phenyl pyruvic acid. The products of 2,3-diary-6-acetyl-quinoline-4-carboxylic acids were obtained by Claisen Schmidt condensation reaction with aldehydes in the presence of sodium hydroxide in order to give the corresponding α,β-unsaturated carbonyls. The substituted α,β-unsaturated carbonyls were condensed with urea, thiourea, hydrazine, phenyl hydrazine, semicarbazide hydrochloride and ethanolamine to synthesized 2-pyrimidinone, 2-pyrimidinethion, pyrazoline-1-phenyl, pyrazoline, pyrazoline-1-carboxamide and 1,4-oxazepines derivatives, respectively, with good yields. The purity and identities of products were elucidated through thin layer chromatography (TLC), melting point and spectroscopic data (IR, 1H NMR, 13C NMR and LC-Mass).

Synthetic hydroxymethyl-porphyrins for protection of carboxy group

2007 ◽  
Vol 11 (06) ◽  
pp. 434-441 ◽  
Author(s):  
Hitoshi Tamiaki ◽  
Kouji Kumon ◽  
Reiko Shibata
Keyword(s):  
Liquid Phase ◽  
Carboxylic Acid ◽  
Thin Layer ◽  
Peptide Synthesis ◽  
Phenyl Group ◽  
Coupling Reagents ◽  
Protective Groups ◽  
Simple Filtration ◽  
Meso Position ◽  
Layer Chromatography

Hydroxymethyl-porphyrins were prepared by modifying tetraarylporphyrin possessing a p-(methoxycarbonyl)phenyl group at the meso-position and octaethylporphyrin. The synthetic alcohols reacted with carboxylic acids by the use of coupling reagents, to give the corresponding esters quantitatively. Due to the porphyrin dye moiety, the esterification was easily monitored on thin layer chromatography, and the resulting esters were highly soluble in most organic solvents and easily handled. The esters were readily cleaved by the action of an acid to give the original carboxylic acid and hydroxymethyl-porphyrin. Separation of the two species was performed by simple filtration: the carboxylic acid was soluble (filtrate) and the porphyrins were precipitates in methanol. These protective groups for carboxy groups were useful for peptide synthesis in the liquid phase.

scholarly journals SINTESIS CALKON ((E)-1,3-DI(NAPHTHALEN-2-YL)PROP-2-EN-1-ONE) DAN AKTIVITASNYA SEBAGAI ANTIOKSIDAN

2012 ◽  
Vol 3 (1) ◽  
pp. 7-14
Author(s):  
Rahmiwati Hilma ◽  
Jasril ◽  
Hilwan Yuda Teruna
Keyword(s):  
Free Radical ◽  
Melting Point ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Room Temperature ◽  
Intermediate Compound ◽  
Alkaline Condition ◽  
Point Measurement ◽  
Anti Inflammatory ◽  
Layer Chromatography

Study on chalcone calkon (E)-1,3-di(naphthalen-2-yl)prop-2-en-1-one synthesis have been carried out with stirrer methode. These compounds can be used as intermediate compound to synthesize others compounds which was reported having antimicrobial, anti-inflammatory, anti-depressant, anti-tumour. The of chalcones synthesis vatives were reported in acid and alkali condition. In this study, chalcone and its derivates were synthesized by using stirrer method in alkaline condition in room temperature. the compounds subjected to somes analyses including melting point measurement, thin layer chromatography and HPLC. Scavenging free radical by using DPPH methode showed Scavenging free radical with LC50 >80 μg/ml min potent activity while the ascorbat acid LC50 89,79 μg/ml.

Notizen: Improved 2,4-Dinitrophenylhydrazine, Thin Layer Chromatography Methods for the Determination of Micro- and Macroamounts of Ascorbic Acid

1974 ◽  
Vol 29 (11-12) ◽  
pp. 777-780 ◽  
Author(s):  
A. Navon ◽  
H. Z. Levinson
Keyword(s):  
Acetic Acid ◽  
Vitamin C ◽  
Thin Layer ◽  
Condensation Reaction ◽  
Dehydroascorbic Acid ◽  
Previous Method ◽  
Aqueous Acetic Acid ◽  
Tlc Plates ◽  
Layer Chromatography

Microamounts of vitamin C could be readily determined in 20 μl-samples using the 2,4-dinitrophenylhydrazine method together with separation by thin layer chromato­graphy. The condensation reaction was carried out for 5 min at 100 °C on a glass fibre disc. Purification of vitamin C hydrazones was accomplished by repeated separation on TLC plates. An aqueous solution of 65% acetic acid was em­ployed to dissolve the vitamin C hydrazones, providing maxi­mal absorbance at 500 nm. The minimum amount detectable by this method is 0.4 μg of dehydroascorbic acid. The macrodetermination of vitamin C was improved by simpli­fying a previous method and employing 65% aqueous acetic acid as a solvent for the hydrazones.

A PRACTICAL METHOD FOR ESTIMATION OF URINARY PREGNANEDIOL AND ALLOPREGNANEDIOL USING THIN LAYER CHROMATOGRAPHY

1965 ◽  
Vol 49 (1) ◽  
pp. 97-106 ◽  
Author(s):  
S. Sulimovici ◽  
B. Lunenfeld ◽  
M. C. Shelesnyak
Keyword(s):  
Melting Point ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Practical Method ◽  
Melting Point Determination ◽  
Uv Absorption Spectra ◽  
Infra Red ◽  
Point Determination ◽  
Layer Chromatography ◽  
Hydrolysis Of

ABSTRACT A method is described for the assay of urinary pregnanediol and allopregnanediol which employs acid hydrolysis of pregnanediol glucuronide, ascending thin-layer chromatography and spectrophotometric quantitation of the eluted pregnanediol and allopregnanediol. The reliability of the method was established by analysis of infra-red and UV absorption spectra, melting point determination, recovery experiments, duplicate assays and comparison with the Klopper method. The method has advantages in that it is rapid and requires small urine samples.

scholarly journals Synthesis of different α, β- unsaturated oxazolone derivatives

2019 ◽  
Vol 9 (1) ◽  
pp. 124-127
Author(s):  
Pallavi L Phalke
Keyword(s):  
Antibacterial Activity ◽  
Infrared Spectroscopy ◽  
Melting Point ◽  
Acetic Anhydride ◽  
Thin Layer ◽  
Sodium Acetate ◽  
E Coli ◽  
Nucleophilic Reagents ◽  
Formed Product ◽  
Layer Chromatography

Acetyl glycine were prepared from glycine acetic anhydride and then 2, 4-disubstituted Oxazol-5-one were prepared from acetyl glycine, substituted aldehydes, acetic anhydride, and sodium acetate as a catalyst. The formed product is evaluated and characterized by thin layer chromatography, infrared spectroscopy and melting point. The, β- unsaturated shows ability to react with various nucleophilic reagents for synthesis of new fused oxazole compounds. Keywords: glycine, acetic anhydride, aldehyde Sodium acetate, Oxazolone, E. coli, Antibacterial Activity.

Sterols produced by Cryptotnonas ovata var. palustris

1968 ◽  
Vol 14 (8) ◽  
pp. 837-839 ◽  
Author(s):  
R. P. Collins ◽  
K. Kalnins
Keyword(s):  
Infrared Spectroscopy ◽  
Melting Point ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Mass Spectroscopy ◽  
Layer Chromatography

Cholesterol and stigmasterol were isolated from C. ovata var. palustris. The compounds were identified by thin-layer chromatography, mass spectroscopy, infrared spectroscopy, derivative formation, and melting point determinations.

Carbonyl Compounds in Salted Cod.: II. Separation and Identification of Volatile Monocarbonyl Compounds from Heavily Salted Cod

1965 ◽  
Vol 22 (1) ◽  
pp. 27-32 ◽  
Author(s):  
M. Yurkowski ◽  
M.A. Bordeleau
Keyword(s):  
Melting Point ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Chain Length ◽  
Carbonyl Compounds ◽  
Gadus Morhua ◽  
Unknown Compound ◽  
Layer Chromatography

Volatile monocarbonyl compounds were isolated from heavily salted cod (Gadus morhua) as the 2,4-dinitrophenylhydrazones. These compounds were separated by thin-layer chromatography first into classes and then according to chain length. n-Alkanals C1–5 and n-alk-2-enals C5–6 were conclusively identified. n-Alkanals C8,10 and n-alk-2-enals C4,7,8 were tentatively identified. An unknown compound corresponding to n-hexanal, except in the melting point, was isolated. Formaldehyde, and to a lesser extent, acetaldehyde and propanal, were the major monocarbonyls present in salted cod.

Isolation and Characterization of Metabolites fromPseudomonas syringae-strain 3366 and their Phytotoxicity Against Certain Weed and Crop Species

Weed Science ◽  
1996 ◽  
Vol 44 (2) ◽  
pp. 383-392 ◽  
Author(s):  
David R. Gealy ◽  
S. Gurusiddaiah ◽  
Alex G. Ogg
Keyword(s):  
Organic Matter ◽  
Carboxylic Acid ◽  
Thin Layer ◽  
Ethyl Acetate ◽  
Shoot Growth ◽  
Silt Loam ◽  
Downy Brome ◽  
Crop Species ◽  
Layer Chromatography ◽  
Ethyl Acetate Extracts

Phytotoxic effects of metabolites from a naturally occurring rhizobacterial isolate,Pseudomonas syringaestrain 3366, were determined on downy brome and ‘Hill 81’ winter wheat, along with 10 other weed and crop species. Centrifuged supernatant and concentrated ethyl acetate extracts from aerobic shake cultures of strain 3366 suppressed germination of seeds and reduced root and shoot growth in agar diffusion assays, soil assays, and under field conditions. Generally, root growth was inhibited more than shoot growth. Strain 3366 metabolites applied in soil inhibited all species tested. Crude ethyl acetate extracts in soil inhibited downy brome at concentrations that had little effect on winter wheat. Inhibitory activity was greater in Palouse silt loam (pH 5.8, 3.6% organic matter) than in Shano silt loam (pH 9.0, 0.8% organic matter). Activity of extracted metabolites decreased rapidly in wet soil but remained high in dry soil. Active metabolites were isolated and purified from the ethyl acetate extract using column chromatography, thin-layer chromatography, and crystallization. Chemical analysis revealed the presence of phenazine-1-carboxylic acid, 2-amino phenoxazone, and 2-amino phenol. Activity of these metabolites against downy brome was confirmed in agar assays. Phenazine-1-carboxylic acid, the major identifiable metabolite present in ethyl acetate extracts (20% by weight), inhibited downy brome root growth by 99% at concentrations of 5.7 mg L−1. Production of these metabolites in field soil by live bacteria of strain 3366 was confirmed with thin-layer chromatography.

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