scholarly journals Chronic tick-borne encephalitis

2021 ◽  
Author(s):  
Е.Г. Демьяновская ◽  
В.В. Погодина ◽  
Н.Г. Бочкова ◽  
Е.И. Наумов ◽  
Т.А. Снитур ◽  
...  
Keyword(s):  
Immune Response ◽  
Neurological Status ◽  
High Antibody ◽  
Unique Case ◽  
Antibody Avidity ◽  
Cortical Motor ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype ◽  
Chronic Course

Статья посвящена эпилепсии Кожевникова, одному из наиболее распространенных и по сути патогномоничных проявлений хронического течения клещевого энцефалита. Описаны стадийность в ее развитии, типы течения сформировавшейся кожевниковской эпилепсии, подходы к терапии. В статье представлен уникальный по продолжительности наблюдения случай хронического клещевого энцефалита (ХКЭ) (47 лет от начала заболевания и свыше 30 лет после вакцинотерапии). Показано, что замедленное развитие тяжелой неврологической симптоматики, прогрессирование болезни происходят на фоне дисиммуноглобулинемии. Штамм, выделенный от пациентки, обладал высокой нейровирулентностью для белых мышей, был высоконейроинвазивным, показал принадлежность к сибирскому подтипу вируса клещевого энцефалита. По мере прогрессирования ХКЭ развивался полиштаммовый иммунный ответ и напряженный иммунитет с высокой авидностью антител (через 30-32 года после вакцинотерапии). В неврологическом статусе – характерные постэнцефалитические изменения с элементами кортикальной моторной эпилепсии. Существенного когнитивного дефекта не было выявлено. The article is devoted to Kozhevnikov's epilepsy, one of the most common and, in fact, pathognomonic manifestations of the chronic course of tick-borne encephalitis. The stages in its development, the types of the course of the formed Kozhevnikovskaya epilepsy, and approaches to therapy are described. This material presents a unique case of chronic tick-borne encephalitis (TBE) (47 years from the beginning of the disease and more than 30 years after vaccination). It is shown that the delayed development of severe neurological symptoms and disease progression occur against the background of dysimmunoglobulinemia. The strain isolated from the patient had high neurovirulence for white mice, was highly neuroinvasive, and belong to the Siberian subtype of tick-borne encephalitis virus (TBEV). As TBE progressed, a polystrain immune response and a stressed immune response with high antibody avidity developed (30-32 years after vaccination). In the neurological status – pecular postencephalitic changes with elements of cortical motor epilepsy. No significant cognitive defect was detected.

scholarly journals The elected questions of condition of cellular factors of resistance during tick-borne mixed-infections

2006 ◽  
Vol 5 ◽  
pp. 144-150
Author(s):  
N. P. Pirogova ◽  
M. R. Karpova ◽  
V. V. Novitsky ◽  
A. P. Zima ◽  
O. V. Voronkova ◽  
...  
Keyword(s):  
Immune Response ◽  
Borrelia Burgdorferi ◽  
Inflammatory Cytokines ◽  
Mixed Infection ◽  
Immune Cells ◽  
Peripheral Blood ◽  
Mixed Infections ◽  
Tick Borne Encephalitis ◽  
Cellular Factors ◽  
Tick Borne Encephalitis Virus

The authors of the article are trying to generalize the literary data that characterizing proinflammatory and anti-inflammatory cytokines production of peripheral blood immune cells during tick-borne neuroinfections: Lyme borreliosis, associated with tick- borne encephalitis. The immune response development to antigens of a tick-borne encephalitis virus and Borrelia burgdorferi in pa- tients with a mixed-infection essentially differs from those during monoinfections.

scholarly journals Impact of Co-Infections in Lyme Disease

2016 ◽  
Vol 10 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Giuseppe Stinco ◽  
Serena Bergamo
Keyword(s):  
Lyme Disease ◽  
Clinical Features ◽  
Disease Process ◽  
Babesia Species ◽  
Bartonella Species ◽  
Disease Spectrum ◽  
Tick Borne Encephalitis ◽  
Occupationally Exposed ◽  
Tick Borne Encephalitis Virus ◽  
Chronic Course

Lyme disease is one of the most frequent tick-borne diseases worldwide, it can be multi-systemic and insidious, in particular when it shows a chronic course.In recent years co-infections represent an emerging issue in Lyme disease spectrum because in addition toBorrelia burgdorferi slmany other potential pathogens may be transmitted by hard ticks Ixodes species. The main co-infections found in Lyme disease described in this review are represented byAnaplasma phagocytophilum, Babesia species, Bartonella species, Rickettsiae species and tick-borne encephalitis virus. For each single co-infecting micro-organism, clinical features, diagnostic issues and therapeutical approaches are discussed.Co-infections represent an emerging problem because they might exacerbate Lyme disease clinical features, they can also mimic Lyme borreliosis sharing common manifestations, and eventually they can change the course of the disease itself.The presence of one or more co-infecting agent during the course of Lyme disease may represent an issue especially in endemic areas for tick-borne diseases and in people occupationally exposed.The aim of this review is to summarize the more important co-infections in patients with Lyme disease and to discuss their importance in the disease process.

scholarly journals Humoral and Cellular Immune Response to RNA Immunization with Flavivirus Replicons Derived from Tick-Borne Encephalitis Virus

2005 ◽  
Vol 79 (24) ◽  
pp. 15107-15113 ◽  
Author(s):  
Judith H. Aberle ◽  
Stephan W. Aberle ◽  
Regina M. Kofler ◽  
Christian W. Mandl
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Response ◽  
Cellular Immune Response ◽  
T Cell Response ◽  
The Self ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Cellular Immune ◽  
Rna Vaccine

ABSTRACT A new vaccination principle against flaviviruses, based on a tick-borne encephalitis virus (TBEV) self-replicating noninfectious RNA vaccine that produces subviral particles, has recently been introduced (R. M. Kofler, J. H. Aberle, S. W. Aberle, S. L. Allison, F. X. Heinz, and C. W. Mandl, Proc. Natl. Acad. Sci. USA 7:1951-1956, 2004). In this study, we evaluated the potential of the self-replicating RNA vaccine in mice in comparison to those of live, attenuated vaccines and a formalin-inactivated whole-virus vaccine (ImmunInject). For this purpose, mice were immunized using gene gun-mediated application of the RNA vaccine and tested for CD8+ T-cell responses, long-term duration, neutralizing capacity, and isotype profile of specific antibodies and protection against lethal virus challenge. We demonstrate that the self-replicating RNA vaccine induced a broad-based, humoral and cellular (Th1 and CD8+ T-cell response) immune response comparable to that induced by live vaccines and that it protected mice from challenge. Even a single immunization with 1 μg of the replicon induced a long-lasting antibody response, characterized by high neutralizing antibody titers, which were sustained for at least 1 year. Nevertheless, it was possible to boost this response further by a second injection with the RNA vaccine, even in the presence of a concomitant CD8+ T-cell response. In this way it was possible to induce a balanced humoral and cellular immune response, similar to infection-induced immunity but without the safety hazards of infectious agents. The results also demonstrate the value of TBEV replicon RNA for inducing protective long-lasting antiviral responses.

Siberian subtype tick-borne encephalitis virus in Ixodes ricinus in a newly emerged focus, Finland

2016 ◽  
Vol 7 (1) ◽  
pp. 216-223 ◽  
Author(s):  
Anu Jääskeläinen ◽  
Elina Tonteri ◽  
Ilkka Pieninkeroinen ◽  
Tarja Sironen ◽  
Liina Voutilainen ◽  
...  
Keyword(s):  
Ixodes Ricinus ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype

Genetic diversity and geographical distribution of the Siberian subtype of the tick-borne encephalitis virus

2020 ◽  
Vol 11 (2) ◽  
pp. 101327 ◽  
Author(s):  
S.E. Tkachev ◽  
I.V. Babkin ◽  
G.S. Chicherina ◽  
I.V. Kozlova ◽  
M.M. Verkhozina ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Geographical Distribution ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype

scholarly journals Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Petra Pokorna Formanova ◽  
Martin Palus ◽  
Jiri Salat ◽  
Vaclav Hönig ◽  
Michal Stefanik ◽  
...  
Keyword(s):  
Immune Response ◽  
Brain Tissue ◽  
Inflammatory Cytokines ◽  
Mouse Serum ◽  
Neural Cells ◽  
Tick Borne Encephalitis ◽  
Human Neural Cells ◽  
Tick Borne Encephalitis Virus ◽  
Tbev Infection ◽  
Pro Inflammatory Cytokines

Abstract Background Tick-borne encephalitis (TBE) is a severe neuropathological disorder caused by tick-borne encephalitis virus (TBEV). Brain TBEV infection is characterized by extensive pathological neuroinflammation. The mechanism by which TBEV causes CNS destruction remains unclear, but growing evidence suggests that it involves both direct neuronal damage by the virus infection and indirect damage caused by the immune response. Here, we aimed to examine the TBEV-infection-induced innate immune response in mice and in human neural cells. We also compared cytokine/chemokine communication between naïve and infected neuronal cells and astrocytes. Methods We used a multiplexed Luminex system to measure multiple cytokines/chemokines and growth factors in mouse serum samples and brain tissue, and in human neuroblastoma cells (SK-N-SH) and primary cortical astrocytes (HBCA), which were infected with the highly pathogenic TBEV strain Hypr. We also investigated changes in cytokine/chemokine production in naïve HBCA cells treated with virus-free supernatants from TBEV-infected SK-N-SH cells and in naïve SK-N-SH cells treated with virus-free supernatants from TBEV-infected HBCA cells. Additionally, a plaque assay was performed to assess how cytokine/chemokine treatment influenced viral growth following TBEV infection. Results TBEV-infected mice exhibited time-dependent increases in serum and brain tissue concentrations of multiple cytokines/chemokines (mainly CXCL10/IP-10, and also CXCL1, G-CSF, IL-6, and others). TBEV-infected SK-N-SH cells exhibited increased production of IL-8 and RANTES and downregulated MCP-1 and HGF. TBEV infection of HBCA cells activated production of a broad spectrum of pro-inflammatory cytokines, chemokines, and growth factors (mainly IL-6, IL-8, CXCL10, RANTES, and G-CSF) and downregulated the expression of VEGF. Treatment of SK-N-SH with supernatants from infected HBCA induced expression of a variety of chemokines and pro-inflammatory cytokines, reduced SK-N-SH mortality after TBEV infection, and decreased virus growth in these cells. Treatment of HBCA with supernatants from infected SK-N-SH had little effect on cytokine/chemokine/growth factor expression but reduced TBEV growth in these cells after infection. Conclusions Our results indicated that both neurons and astrocytes are potential sources of pro-inflammatory cytokines in TBEV-infected brain tissue. Infected/activated astrocytes produce cytokines/chemokines that stimulate the innate neuronal immune response, limiting virus replication, and increasing survival of infected neurons.

scholarly journals Origin and distribution of tick-borne encephalitis virus strains of the Siberian subtype in the Middle Urals, the north-west of Russia and the Baltic countries

2009 ◽  
Vol 90 (12) ◽  
pp. 2884-2892 ◽  
Author(s):  
S. Yu. Kovalev ◽  
D. N. Chernykh ◽  
V. S. Kokorev ◽  
T. E. Snitkovskaya ◽  
V. V. Romanenko
Keyword(s):  
European Part ◽  
Middle Urals ◽  
Glycoprotein E ◽  
The Middle Urals ◽  
Baltic Countries ◽  
Tick Borne Encephalitis ◽  
European Part Of Russia ◽  
Tick Borne Encephalitis Virus ◽  
The Baltic ◽  
Siberian Subtype

Tick-borne encephalitis virus (TBEV) plays an important role in infectious human morbidity, particularly in Russia and the Middle Urals. The Siberian subtype of TBEV (S-TBEV) is dominant in the Middle Urals. Determining the origin of S-TBEV strains in this territory and also in the European part of Russia and the Baltic countries is very important for understanding the cause of its distribution. The surface glycoprotein E gene was partially sequenced in 165 S-TBEV isolates collected in the Middle Urals between 1966 and 2008. Nucleotide and amino acid sequence identity of the studied isolates is 94 and 97.4 %, respectively. Eighty per cent of them are represented by six clusters with identical amino acid sequences in the glycoprotein E fragment analysed. We have determined four types of isolate distribution in the explored territory: local, split, corridor and diffuse. The average rate of nucleotide substitutions per site year−1 is estimated to be 1.56×10−4. The age of the S-TBEV population was evaluated to be slightly less than 400 years. Phylogenetic analysis of the data and comparison with historical events indicate that the distribution of S-TBEV strains in the Middle Urals and the European part of Russia originated twice from different foci in western Siberia. This is related to the first land road into Siberia and the Trans-Siberian Way, which functioned at different times. The main reason for such rapid distribution of S-TBEV strains is the anthropogenic factor, i.e. human economic activity during the colonization of new territories in Siberia in the recent past.

Sign in / Sign up

Export Citation Format

Share Document