scholarly journals Climate indices in historical climate reconstructions: a global state of the art

2021 ◽  
Vol 17 (3) ◽  
pp. 1273-1314
Author(s):  
David J. Nash ◽  
George C. D. Adamson ◽  
Linden Ashcroft ◽  
Martin Bauch ◽  
Chantal Camenisch ◽  
...  

Abstract. Narrative evidence contained within historical documents and inscriptions provides an important record of climate variability for periods prior to the onset of systematic meteorological data collection. A common approach used by historical climatologists to convert such qualitative information into continuous quantitative proxy data is through the generation of ordinal-scale climate indices. There is, however, considerable variability in the types of phenomena reconstructed using an index approach and the practice of index development in different parts of the world. This review, written by members of the PAGES (Past Global Changes) CRIAS working group – a collective of climate historians and historical climatologists researching Climate Reconstructions and Impacts from the Archives of Societies – provides the first global synthesis of the use of the index approach in climate reconstruction. We begin by summarising the range of studies that have used indices for climate reconstruction across six continents (Europe, Asia, Africa, the Americas, and Australia) as well as the world's oceans. We then outline the different methods by which indices are developed in each of these regions, including a discussion of the processes adopted to verify and calibrate index series, and the measures used to express confidence and uncertainty. We conclude with a series of recommendations to guide the development of future index-based climate reconstructions to maximise their effectiveness for use by climate modellers and in multiproxy climate reconstructions.

2020 ◽  
Author(s):  
David J. Nash ◽  
George C. D. Adamson ◽  
Linden Ashcroft ◽  
Martin Bauch ◽  
Chantal Camenisch ◽  
...  

Abstract. Evidence contained within historical documents and inscriptions provides an important record of climate variability for periods prior to the onset of systematic meteorological data collection. A common approach used by historical climatologists to convert such qualitative documentary evidence into continuous quantitative proxy data is through the generation of ordinal-scale climate indices. There is, however, considerable variability in the types of phenomena reconstructed using an index approach and the practice of index development in different parts of the world. This review, written by members of the PAGES CRIAS Working Group – a collective of climate historians and historical climatologists researching Climate Reconstructions and Impacts from the Archives of Societies – provides the first global synthesis of the use of the index approach in climate reconstruction. We begin by summarising the range of studies that have used indices for climate reconstruction across six continents (Europe, Asia, Africa, the Americas, Australia) plus the world's oceans. We then outline the different methods by which indices are developed in each of these regions, including a discussion of the processes adopted to verify and calibrate index series, and the measures used to express confidence and uncertainty. We conclude with a series of recommendations to guide the development of future index-based climate reconstructions to maximise their effectiveness for use by climate modellers and in multiproxy climate reconstructions.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ryosuke Nakamura ◽  
Shigeyuki Mukudai ◽  
Renjie Bing ◽  
Michael J. Garabedian ◽  
Ryan C. Branski

AbstractSimilar to the hypertrophic scar and keloids, the efficacy of glucorticoids (GC) for vocal fold injury is highly variable. We previously reported dexamethasone enhanced the pro-fibrotic effects of transforming growth factor (TGF)-β as a potential mechanism for inconsistent clinical outcomes. In the current study, we sought to determine the mechanism(s) whereby GCs influence the fibrotic response and mechanisms underlying these effects with an emphasis on TGF-β and nuclear receptor subfamily 4 group A member 1 (NR4A1) signaling. Human VF fibroblasts (HVOX) were treated with three commonly-employed GCs+ /-TGF-β1. Phosphorylation of the glucocorticoid receptor (GR:NR3C1) and activation of NR4A1 was analyzed by western blotting. Genes involved in the fibrotic response, including ACTA2, TGFBR1, and TGFBR2 were analyzed by qPCR. RNA-seq was performed to identify global changes in gene expression induced by dexamethasone. GCs enhanced phosphorylation of GR at Ser211 and TGF-β-induced ACTA2 expression. Dexamethasone upregulated TGFBR1, and TGFBR2 in the presence of TGF-β1 and increased active NR4A1. RNA-seq results confirmed numerous pathways, including TGF-β signaling, affected by dexamethasone. Synergistic pro-fibrotic effects of TGF-β were observed across GCs and appeared to be mediated, at least partially, via upregulation of TGF-β receptors. Dexamethasone exhibited diverse regulation of gene expression including NR4A1 upregulation consistent with the anti-fibrotic potential of GCs.


Erdkunde ◽  
2021 ◽  
Vol 75 (2) ◽  
pp. 87-104
Author(s):  
Nicola Di Cosmo ◽  
Sebastian Wagner ◽  
Ulf Büntgen

After a successful conquest of large parts of Syria in 1258 and 1259 CE, the Mongol army lost the battle of 'Ayn Jālūt against Mamluks on September 3, 1260 CE. Recognized as a turning point in world history, their sudden defeat triggered the reconfiguration of strategic alliances and geopolitical power not only in the Middle East, but also across much of Eurasia. Despite decades of research, scholars have not yet reached consensus over the causes of the Mongol reverse. Here, we revisit previous arguments in light of climate and environmental changes in the aftermath of one the largest volcanic forcings in the past 2500 years, the Samalas eruption ~1257 CE. Regional tree ring-based climate reconstructions and state-of-the-art Earth System Model simulations reveal cooler and wetter conditions from spring 1258 to autumn 1259 CE for the eastern Mediterranean/Arabian region. We therefore hypothesize that the post-Samalas climate anomaly and associated environmental variability affected an estimated 120,000 Mongol soldiers and up to half a million of their horses during the conquest. More specifically, we argue that colder and wetter climates in 1258 and 1259 CE, while complicating and slowing the campaign in certain areas, such as the mountainous regions in the Caucasus and Anatolia, also facilitated the assault on Syria between January and March 1260. A return to warmer and dryer conditions in the summer of 1260 CE, however, likely reduced the regional carrying capacity and may therefore have forced a mass withdrawal of the Mongols from the region that contributed to the Mamluks’ victory. In pointing to a distinct environmental dependency of the Mongols, we offer a new explanation of their defeat at 'Ayn Jālūt, which effectively halted the further expansion of the largest ever land-based empire.


2021 ◽  
Author(s):  
Manuel Chevalier

Abstract. Statistical climate reconstruction techniques are practical tools to study past climate variability from fossil proxy data. In particular, the methods based on probability density functions (PDFs) are powerful at producing robust results from various environments and proxies. However, accessing and curating the necessary calibration data, as well as the complexity of interpreting probabilistic results, often limit their use in palaeoclimatological studies. To address these problems, I present a new R package (crestr) to apply the CREST method (Climate REconstruction SofTware) on diverse palaeoecological datasets. crestr includes a globally curated calibration dataset for six common climate proxies (i.e. plants, beetles, chironomids, rodents, foraminifera, and dinoflagellate cysts) that enables its use in most terrestrial and marine regions. The package can also be used with private data collections instead of, or in combination with, the provided dataset. It also includes a suite of graphical diagnostic tools to represent the data at each step of the reconstruction process and provide insights into the effect of the different modelling assumptions and external factors that underlie a reconstruction. With this R package, the CREST method can now be used in a scriptable environment, thus simplifying its use and integration in existing workflows. It is hoped that crestr will contribute to producing the much-needed quantified records from the many regions where climate reconstructions are currently lacking, despite the existence of suitable fossil records.


1997 ◽  
Vol 17 (2) ◽  
pp. 72-78 ◽  
Author(s):  
JM Clochesy ◽  
SM Burns ◽  
ME Shekleton ◽  
SK Hanneman ◽  
AR Knebel ◽  
...  

The survey results of the VIPs membership described in this article add qualitative information to the growing body of scientific knowledge on weaning patients off ventilators. Clearly, quantitative studies exploring the efficacy of different weaning practices across the continuum must be done if we are to accurately compare practices and prescribe the "when" and "how" of weaning. To this end, the Third National Study Group is revising the proposed weaning model and model in order to further elucidate the state of the art and science of weaning.


Entropy ◽  
2020 ◽  
Vol 22 (11) ◽  
pp. 1291
Author(s):  
María Navarro-Cáceres ◽  
Marcelo Caetano ◽  
Gilberto Bernardes ◽  
Mercedes Sánchez-Barba ◽  
Javier Merchán Sánchez-Jara

In tonal music, musical tension is strongly associated with musical expression, particularly with expectations and emotions. Most listeners are able to perceive musical tension subjectively, yet musical tension is difficult to be measured objectively, as it is connected with musical parameters such as rhythm, dynamics, melody, harmony, and timbre. Musical tension specifically associated with melodic and harmonic motion is called tonal tension. In this article, we are interested in perceived changes of tonal tension over time for chord progressions, dubbed tonal tension profiles. We propose an objective measure capable of capturing tension profile according to different tonal music parameters, namely, tonal distance, dissonance, voice leading, and hierarchical tension. We performed two experiments to validate the proposed model of tonal tension profile and compared against Lerdahl’s model and MorpheuS across 12 chord progressions. Our results show that the considered four tonal parameters contribute differently to the perception of tonal tension. In our model, their relative importance adopts the following weights, summing to unity: dissonance (0.402), hierarchical tension (0.246), tonal distance (0.202), and voice leading (0.193). The assumption that listeners perceive global changes in tonal tension as prototypical profiles is strongly suggested in our results, which outperform the state-of-the-art models.


Author(s):  
Sharon E. Nicholson

Environmental constraints have large impacts on populations, especially in semi-arid regions such as Africa. Climate and weather have long affected African societies, but unfortunately the traditional climatic record for the continent is relatively short. For that reason, historical information has often been used to reconstruct climate of the past. Sources of historical information include reports and diaries of explorers, settlers, and missionaries; government records; reports of scientific expeditions; and historical geographical and meteorological journals. Local oral tradition is also useful. It is reported in the form of historical chronicles compiled centuries later. References to famine and drought, economic conditions, floods, agriculture, weather events, and the season cycle are examples of useful types of information. Some of the records also include meteorological measurements. More recently chemical and biological information, generally derived from lake cores, has been applied to historical climate reconstruction. Early works provided in most cases qualitative, discontinuous information, such as drought chronologies. However, a statistical method of climate reconstruction applied to a vast collection of historical information and meteorological data allowed for the creation of a two-century, semi-quantitative “precipitation” data set. It consists of annual indices related to rainfall since 1800 for ninety regions of the African continent. This data set has served to illustrate several 19th-century periods of anomalous rainfall conditions that affected nearly the entire continent. An example is widespread aridity during several decades early in that century.


Biosensors ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 130 ◽  
Author(s):  
Honeychurch

The benzodiazepine class of drugs are characterised by a readily electrochemically reducible azomethine group. A number are also substituted by other electrochemically active nitro, N-oxide, and carbonyl groups, making them readily accessible to electrochemical determination. Techniques such as polarography, voltammetry, and potentiometry have been employed for pharmaceutical and biomedical samples, requiring little sample preparation. This review describes current developments in the design and applications of electrochemical-based approaches for the determination of the benzodiazepine class of drugs form their introduction in the early 1960s to 2019. Throughout this period, state-of-the-art electroanalytical techniques have been reported for their determination. Polarography was first employed focused on mechanistic investigations. Subsequent studies showed the adsorption of many the benzodiazepines at Hg electrodes allowed for the highly sensitive technique of adsorptive stripping voltammetry to be employed. The development and introduction of other working electrode materials such as carbon led to techniques such as voltammetry to become commonly reported, and the modification of these electrodes has now become the most commonly employed approach using molecularly imprinting and nanotechnology.


2017 ◽  
Vol 27 (1) ◽  
pp. 48-52 ◽  
Author(s):  
Kuniko Hagiwara ◽  
Natsuko Seto ◽  
Yasuko Shimizu ◽  
Shiro Takahara

Context: Transplant recipients require long-term immunosuppressive therapy, so continued medical follow-up is necessary for long-term survival. Objective: To investigate the current role of recipient transplant coordinators (RTCs) in the outpatient care of organ transplant recipients in Japan. Methods: We sent a questionnaire survey to doctors in transplant facilities affiliated with the Japan Society for Transplantation probing attitudes on the role of RTCs in outpatient clinics. The questionnaire assessed responses using an ordinal scale of 5 ranks. Results: In total, 139 responses were obtained from 233 transplant facilities. Respondents were divided into 2 groups, doctors currently working with RTCs (group A) and doctors not currently working with RTCs (group B). Differences in response rates between groups were analyzed using the Mann-Whitney U test. The overall attendance rate of RTCs in outpatient clinics was only 45%. Of all items on transplant outpatient clinics, group A exhibited a significantly higher response rate of “strongly agree” for “The involvement of an RTC in outpatient work can be expected to help prevent complications in transplant patients” ( P < .01) and “The involvement of an RTC in outpatient work can be expected to help prevent or reduce drug-related side effects in transplant patients” ( P < .01). Those with the highest rate of “strongly agree” were “It is necessary for RTCs to provide outpatient follow-up for transplant patients alongside doctors” (82.1% vs 67.3%, P < .07). Conclusion: We suggest that Japanese RTCs must participate more frequently in posttransplant outpatient care.


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