scholarly journals Status of organochlorine pesticides in the drinking water well-field located in the Delhi region of the flood plains of river Yamuna

2011 ◽  
Vol 4 (1) ◽  
pp. 51-60 ◽  
Author(s):  
P. K. Mutiyar ◽  
A. K. Mittal ◽  
A. Pekdeger
Keyword(s):  
Organochlorine Pesticides ◽  
Monsoon Season ◽  
Local Population ◽  
World Health Organisation ◽  
Flood Plain ◽  
Quality Parameters ◽  
World Health ◽  
Human Populations ◽  
Low Doses ◽  
Well Field

Abstract. This study presents the occurrence of pesticides in a well-field located in Yamuna flood plain of Delhi region. Ground water sampling campaigns were carried out during pre-monsoon and post-monsoon periods covering 21 borewells and 5 Ranney wells. Major 17 organochlorine pesticides (OCP's) along with other water quality parameters were monitored during this period. Pesticide concentrations were determined using GC-ECD, while GC-MS was used for confirmatory purposes. OCP's groups like ∑HCH, ∑DDT, endosulfan and aldrin were observed in this well-field. Concentration of OCPs from Ranney well exceeded the limit (1 μg l−1) prescribed by the Bureau of Indian Standards (BIS) in pre-monsoon season, though OCP levels in borewells were within BIS limits. However, these levels were very close to the World Health Organisation (WHO) and European Union (EU) limit of for pesticides (0.5 μg l−1) in many samples. Borewell produced better quality water compared to the water from Ranney wells. Although, the level of OCP's was slightly lower than prescribed limit of national regulatory agency but such low doses may cause long-term damage to human populations if such water is consumed for longer durations. At low doses OCP's acts as endocrine disrupting agent and cause metabolic disorders in local population.

scholarly journals Status of organochlorine pesticides in the drinking water well-field located in the Delhi region of the flood plains of river Yamuna

2011 ◽  
Vol 4 (1) ◽  
pp. 85-115 ◽  
Author(s):  
P. K. Mutiyar ◽  
A. K. Mittal ◽  
A. Pekdeger
Keyword(s):  
Organochlorine Pesticides ◽  
Monsoon Season ◽  
Local Population ◽  
World Health Organisation ◽  
Flood Plain ◽  
Quality Parameters ◽  
World Health ◽  
Human Populations ◽  
Low Doses ◽  
Well Field

Abstract. This study presents the occurrence of pesticides in a well-field located in Yamuna flood plain of Delhi region. Ground water sampling campaigns were carried out during pre-monsoon and post-monsoon periods covering 21 bore-wells and 5 Ranney wells. Major 17 organochlorine pesticides (OCP's) along with other water quality parameters were monitored during this period. Pesticide concentrations were determined using GC- ECD, while GC-MS was used for confirmatory purposes. OCP's groups like ∑HCH, ∑DDT, endosulfan and aldrin were observed in this well-field. Concentration of OCPs from Ranney wells exceeded the limit (1 μg l−1) prescribed by the Bureau of Indian Standards (BIS) in pre-monsoon season, though OCP levels in bore wells were within BIS limits. However, these levels were very close to the World Health Organisation (WHO) and European Union (EU) limit of for pesticides (0.5 μg l−1) in many samples. Bore well produced better quality water compared to the water from Ranney wells. Although, the level of OCP's was slightly lower than prescribed limit of national regulatory agency but such low doses may cause long-term damage to human populations if such water is consumed for longer durations. At low doses OCP's acts as endocrine disrupting agent and cause metabolic disorders in local population.

scholarly journals A Comparison of International and National References to the Prevalence of Stunting in Pakistani School-age Girls

2020 ◽  
Author(s):  
Asima Karim ◽  
Rizwan Qaisar
Keyword(s):  
Local Population ◽  
Age Groups ◽  
World Health Organisation ◽  
Cross Sectional Study ◽  
World Health ◽  
Kappa Statistics ◽  
School Age ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

Abstract Background: Epidemiology of stunting in <5 years old is well characterized, however its prevalence in adolescence is inconsistent in different geographical locations. We aimed to estimate the prevalence of stunting in schoolgirls of Punjab, Pakistan according to international and national references, to standardize references and devise strategies to combat stunting in adolescent girls of Punjab, Pakistan.Methods: In this population wide cross-sectional study, 10,050 schoolgirls aged 8-16 years from 12 different districts of northern, central and southern Punjab were analysed. Prevalence of stunting was calculated by applying Centres for Disease Control and Prevention (CDC) and World Health Organisation (WHO) height-for-age references and the national reference for study population. We used Cohen’s kappa statistics to analyse agreement of our data with reference values and chi square test was used as the test of trend.Results: Marked overestimation of prevalence of stunting was observed (22.72% and 17.49% according to CDC and WHO respectively) in comparison to local reference (4.94%). There was an increasing trend of prevalence of stunting with higher age according to CDC and WHO references; however, data was comparable across all the age groups when local references were applied.Conclusion: We recommend that prevalence of stunting in school-age girls should be determined by applying local height reference rather than international ones to plan health strategies and treatments in local population.

The effectiveness of adolescent-specific prenatal interventions on improving attendance and reducing harm during and after birth: a systematic review

2016 ◽  
Vol 30 (3) ◽  
Author(s):  
Brenda Tibingana-Ahimbisibwe ◽  
Catherine Katabira ◽  
Lena Mpalampa ◽  
Roger A Harrison
Keyword(s):  
Prenatal Care ◽  
Cohort Studies ◽  
Perinatal Death ◽  
Local Population ◽  
Intervention Group ◽  
World Health Organisation ◽  
World Health ◽  
Low Middle Income Countries ◽  
Prenatal Interventions ◽  
The Impact

Abstract Background: Adolescent pregnancy has been associated with poor pregnancy outcomes including pre-term birth (PTB), low birth weight (LBW) and perinatal death. Objective: To systematically review the effect of adolescent-specific interventions on reducing PTB, LBW, and perinatal death and increasing prenatal care attendance. Search strategy: Possible studies for inclusion were identified by a comprehensive search of OvidSP MEDLINE (limits: humans, 1990–present), EMBASE (limits: humans, 1990–2015), Popline and Global Health Database from the World Health Organisation (WHO) and PubMed International scientific databases, and references of identified articles were searched from 1990 to present. Selection criteria: All types of controlled studies of prenatal interventions were exclusive to adolescents and at least one of the outcomes of interest. Data collection and analysis: Investigators identified relevant studies and entered the data in a pro forma. Data were summarised as forest plots and narrative synthesis. Main results: Twenty-two studies (three randomised controlled trials (RCTs), four prospective cohort studies, nine retrospective cohort studies, five case controls and one natural experiment) were included with all but one study being carried out in higher-income countries. Seven of the 16 studies reporting on PTB found a statistically significant reduction in PTB rates between adolescent-specific prenatal care (intervention) and non-age specific prenatal care odds ratio (OR) and 95% confidence intervals (CIs) ranged from OR: 0.15 (95% CI: 0.03–0.83) to OR: 0.59 (95% CI: 0.45–0.78). Nine of the 12 studies reported statistically significant higher mean prenatal attendance rates among the intervention group compared to controls (ranging from a mean number of visits of 14.3 vs. 10.7 p<0.001 to 10.8 vs. 7.6 visits p<0.001). The type and construct of the interventions, their implementation and local population differed sufficiently that a statistical synthesis was deemed inappropriate. Conclusion: There is some evidence that adolescent-specific programs can increase prenatal attendance and reduce the risk of PTB and low birth rate but their effect on perinatal death is uncertain. There is a distinct lack of evidence of the effectiveness of these interventions for adolescents living in low-middle income countries, despite having the majority of adolescent pregnancies, and associated risk of harm. No high-quality intervention studies were identified. Robust, cluster-based RCTs are an urgent necessity to quantify the impact of these interventions and to identify factors contributing to their success.

scholarly journals Variation of Water Quality of Four Micro Watersheds Outlets in Upstream of Mahaweli River during Maha Cropping Season

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
N.S. Abeysingha ◽  
M.I. Madusanka ◽  
B. Rotawewa ◽  
N. Gunasena
Keyword(s):  
Water Quality ◽  
Drinking Water ◽  
Water Samples ◽  
Water Quality Index ◽  
Quality Index ◽  
World Health Organisation ◽  
Management Plan ◽  
Quality Parameters ◽  
Drinking Water Quality ◽  
World Health

Non-point source, agriculture based pollutants have been identified as one of the main cause for water pollution in Sri Lanka. Naranhinna, Pambadeniya Kappeti-Ela, and Rajamale micro watersheds located in the Kandy district have been identified by the project on Rehabilitation of degraded agricultural lands in the Central Highlands implemented by Food and Agricultural Organisation (FAO) to rehabilitate through watershed management plan. This study assessed the baseline water quality status of these micro watersheds by obtaining water samples at the outlet of each watersheds during the Maha cropping seasons 2018/2019. Three replicates water samples from each outlets were collected six times and analysed for EC , pH, TDS, CO32-, HCO3-, NO3-, NH4+, available P, total K, Na, Ca, Mg, Fe, Al, As, Cd, Cr, Mn, and Pb using standard methods. Most of the tested drinking water quality parameters in all four micro watersheds were within the permissible limits of World Health Organisation (WHO) standard except Fe and NH4+. Observed Fe contents exceeded the WHO limits (0.3 mg/L) of all watersheds and was in the range of 1.2-1.5 mg/L. Concentration of NH4+ at Kappeti Ela, Rajamale, and Pambadeniya was in the range of 0.5 to 0.7 mg/L which exceeded the WHO standard (0.5 mg/L). Using the tested parameters, study calculated drinking water quality index (DWQI) and also irrigation water quality index (IWQI) for all investigated micro watersheds for each of the sampling date. According to the guideline, mean DWQI (19 to 48.1) graded the water of all micro watersheds as excellent while IWQI (8.7-9.2) characterised them as excellent for any crops during the study period.

A Collaborative Study to Establish the Second International Standard for Streptokinase

1990 ◽  
Vol 64 (02) ◽  
pp. 267-269 ◽  
Author(s):  
A B Heath ◽  
P J Gaffney
Keyword(s):  
High Purity ◽  
Collaborative Study ◽  
World Health Organisation ◽  
World Health ◽  
Clot Lysis ◽  
Current Standard ◽  
International Standard ◽  
Accelerated Degradation ◽  
The World ◽  
International Collaborative Study

SummaryAn International Standard for Streptokinase - Streptodomase (62/7) has been used to calibrate high purity clinical batches of SK since 1965. An international collaborative study, involving six laboratories, was undertaken to replace this standard with a high purity standard for SK. Two candidate preparations (88/826 and 88/824) were compared by a clot lysis assay with the current standard (62/7). Potencies of 671 i.u. and 461 i.u. were established for preparations A (88/826) and B (88/824), respectively.Either preparation appeared suitable to serve as a standard for SK. However, each ampoule of preparation A (88/826) contains a more appropriate amount of SK activity for potency testing, and is therefore preferred. Accelerated degradation tests indicate that preparation A (88/826) is very stable.The high purity streptokinase preparation, coded 88/826, has been established by the World Health Organisation as the 2nd International Standard for Streptokinase, with an assigned potency of 700 i.u. per ampoule.

A Collaborative Study to Establish an International Standard for Alpha-Thrombin

1992 ◽  
Vol 67 (04) ◽  
pp. 424-427 ◽  
Author(s):  
P J Gaffney ◽  
A B Heath ◽  
J W Fenton II
Keyword(s):  
Elevated Temperatures ◽  
Collaborative Study ◽  
World Health Organisation ◽  
Significant Loss ◽  
Thrombin Inhibitors ◽  
World Health ◽  
Expert Committee ◽  
International Standard ◽  
Assay Procedure ◽  
And Control

SummarySince 1975 an International Standard for Thrombin of low purity has been used. While this standard was stable and of value for calibrating thrombins of unknown potency the need for a pure a-thrombin standard arose both for accurate calibration and for precise measurement of thrombin inhibitors, notably hirudin. An international collaborative study was undertaken to establish the potency and stability of an ampouled pure a-thrombin preparation. A potency of 97.5 international units (95% confidence limits 86.5-98.5) was established for the new a-thrombin standard (89/ 588) using a clotting-assay procedure. Stability data at various elevated temperatures indicated that the standard could be transported and stored with no significant loss of potency.Ampoules of lyophilised a-thrombin (coded 89/588) have been recommended as an International Standard for a-thrombin with an assigned potency of 100 international units per ampoule by the International Society for Thrombosis and Haemostasis (Thrombin and its Inhibitors Sub-Committee) in Barcelona, Spain in July 1990 while the Expert Committee on Biological Standardisation and Control of the World Health Organisation will consider its status at its next meeting in Geneva in 1991.

ANTARA SUNNAH DAN TRADISI (Khitan Muallaf Perempuan Baligh di Jayapura, Papua)

1970 ◽  
Vol 9 (2) ◽  
pp. 271-284
Author(s):  
Hendra Yulia Rahman
Keyword(s):  
World Health Organisation ◽  
World Health

Masyarakat Indonesia pada umumnya khususnya yang bergama Islam, memiliki kebiasaan mengkhitankan anak perempuannya dan memandang ini sebagai sunnah, hal ini juga dilakukan masyarakat di negara-negara lain yang memiliki penduduk pemeluk agama Islam. Pada umumnya masyarakat megkhitankan anak perempuannya, ketika masih bayi dan meyakininya sebagai bentuk kewajiban dari perintah agama. Badan kesehatan dunia World Health Organisation (WHO) melakukan pelarangan segala bentuk khitan pada perempuan, karena dianggap sebagai bentuk kekerasan pada perempuan dengan menyakiti dan merusak alat reproduksi perempuan. Khitan perempuan dianggap sebagai tradisi yang sudah lama ada tengah-tengah masyarakat baik yang muslim maupun yang non muslim, yang dalam pelaksanaannya lebih dimaksudkan sebagai upaya pengontrolan seksualitas perempuan. Muallaf perempuan baligh khususnya di wilayah kota Jayapura, Papua rata-rata melakukan khitan, yang menurut mereka merupakan bagian dari perintah agama. Bahwasanya khitan muallaf perempuan baligh di kota Jayapaura merupakan sebuah tradisi yang terus berlangsung, dan tradisi tersebut sejalan dengan sunnah.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Leishmanicidal Activity of Plant Extracts from Sefrou, a Moroccan Focus of Leishmaniasis, against Various Leishmania Parasites in the Promastigote Stage

2018 ◽  
Vol 17 (2) ◽  
pp. 83-89 ◽  
Author(s):  
I. Zeouk ◽  
A. Et-Touys ◽  
M. Balouiri ◽  
H. Fellah ◽  
A. El Ouali Lalami ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Plant Extracts ◽  
Leishmania Infantum ◽  
Leishmania Major ◽  
Local Population ◽  
Public Health Problem ◽  
World Health ◽  
Total Phenolic ◽  
Leishmania Tropica ◽  
Cistus Salviifolius

According to the World Health Organization, leishmaniasis remains a major worldwide public health problem. The province of Sefrou located in the center of Morocco is a focus of cutaneous leishmaniasis. The present study aims at evaluating the antileishmanial potential of Berberis sp.,Crataegus oxyacantha, Cistus salviifolius, Ephedra altissima and Lavandula dentatafrequently used by the local population. Methanolic extracts were tested against the promastigote form ofLeishmania tropica, Leishmania majorandLeishmania infantumusing tetrazolium-based colorimetric (MTT) assay. The total phenol and flavonoids content of all extracts were determined using the Folin–Ciocalteu reagent, aluminum chloride, and potassium acetate solutions respectively. The plant extracts exhibited antileishmanial activity with variability depending on the tested strain and the plant species compared to Glucantime® used as control (IC50 (the half maximal inhibitory concentration) > 1,000 μg/mL). The best inhibition was observed with Berberis sp., againstLeishmania major(IC50 = 394.40 ± 3.02 μg/ml), andEphedra altissima(reported for the first time) againstLeishmania infantum(IC50 = 490.84 ± 3.15 μg/mL).Leishmania tropicahas shown the same sensitivity behavior toward the five extracts (in average IC50 = 540 ± 11.20 μg/mL). The total phenolic content was higher forCrataegus oxyacanthaandCistus salviifolius(140.67 ± 3.17 μg eq Gallic Acid (GA)/ mg of Extract (E) and 133.83 ± 9.03 μg eq GA/mg of E respectively), while flavonoid was higher forCistus salviifoliusandLavandula dentata(57.92 ± 2.46 μg eq Quercetin (Que)/ mg of Extract (E) and 41.53 ± 1.74 μg eq Que/mg of E). All the tested extracts present some promising aspects that may cure cutaneous leishmaniasis in the center of Morocco; further bioguided assays are needed to isolate the fractions and the bioactive molecule.

Osseointegrated Implants: A Comprehensive Review

2021 ◽  
Vol 2 (1) ◽  
pp. 24-30
Author(s):  
Matheus Marquez Cruvinel Santos ◽  
◽  
Flávio Barros da Silva ◽  
Idiberto José Zotarelli-Filho ◽  
Elias Naim Kassis ◽  
...  
Keyword(s):  
Dental Implants ◽  
Pharmacological Action ◽  
World Health Organisation ◽  
World Health ◽  
Density Level ◽  
Mineral Density ◽  
Osseointegrated Implants ◽  
Bone Mineral Density Level ◽  
The Mean ◽  
Normal Women

The most common bone disorder found by implant dentists is osteoporosis, which is a systemic skeletal disorder associated with aging, which is characterized by loss of bone mass, making bones fragile and more susceptible to fractures. The World Health Organisation has defined osteoporosis as a bone mineral density level greater than 2.5 standard deviations below the mean of young normal women. After 60 years of age, a third of the population have this disorder, it occurs twice as often in women than in men. It is estimated that 1.3 million fractures and 133,000 all hip fractures occur every year as a result of osteoporosis. This study aimed to discuss aspects of the pharmacological action of Bisphosphonates (BP) and their influence on the bone tissue when associated with treatment with dental implants. There are several types of treatments that prevent or prevent the progression of osteoporosis. So, BP, such as alendronate, are inhibitors of bone resorption. Act as controlling the development of osteoporosis by increasing the process of bone density and decrease its reabsorption, often acting as supporting the process of osseointegration of dental implants.

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