Hypothesizing Synergy between Acupuncture/ Auriculotherapy and Natural Activation of Mesolimbic Dopaminergic Pathways: Putative Natural Treatment Modalities for the Reduction of Drug Hunger and Relapse

Acupuncture is a very ancient form of healing which predates recorded history. The philosophy is rooted in the Taoist tradition which goes back over 8000 years. To date this practice although used world-wide to treat addictive behaviors has not been generally accepted or scientifically proven. There are however many positive reports in the literature in its effectiveness in reducing symptoms of withdrawal from alcohol, heroin and cocaine. In addition, due to known neuro-chemical mechanisms associated with acupuncture, especially its role in pain relief and endogenous opioid function, clinical benefits in reward dependence behaviors seem parsimonious. In this review article we are hypothesizing synergy between acupuncture/auriculotherapy and natural activation of mesolimbic dopaminergic pathways to reduce drug hunger and prevent relapse. Following a review of the literature involving both of these modalities the scientific and clinical community is encouraged to carry out translational research in large randomized double-blinded placebo controlled investigations coupling these two anti-craving treatment modalities.

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Is Atherothromboaspiration a Possible Solution for the Prevention of No-Reflow Phenomenon in Acute Coronary Syndromes? Single Centre Experience and Review of the Literature

Current Vascular Pharmacology ◽

10.2174/1570161116666180101150956 ◽

2019 ◽

Vol 17 (2) ◽

pp. 164-179

Author(s):

Antonis S. Manolis

Keyword(s):

Coronary Intervention ◽

Covered Stent ◽

Current Status ◽

Extensive Literature ◽

Review Of The Literature ◽

Single Centre ◽

Total N ◽

No Reflow ◽

Clinical Benefits ◽

Meta Analyses

Background: Intracoronary thrombus in acute Myocardial Infarction (MI) confers higher rates of no-reflow with attendant adverse consequences. Earlier Randomized-Controlled-Trials (RCTs) of routine thromboaspiration during Percutaneous Coronary Intervention (PCI) indicated a clinical benefit, but more recent RCTs were negative. However, data of selective use of this adjunctive approach remain scarce. Objective: The aim of this single-centre prospective study was to report the results of selective thromboaspiration during PCI in patients with intracoronary thrombi, and also to provide an extensive literature review on current status of thromboaspiration. Methods: The study included 90 patients (77 men; aged 59.3±12.7 years) presenting with acute MI (STElevation MI (STEMI) in 74, non-STEMI in 16) who had intracoronary thrombi and were submitted to thromboaspiration. Results: Total (n=67) or subtotal (n=18) vessel occlusions were present in 85 (94%) patients. Thromboaspiration and subsequent PCI were successful in 89/90 (98.9%) patients, with coronary stenting in 86 (96.6%). In 4 patients with residual thrombus, a mesh-covered stent was implanted. IIb/IIIa-inhibitors were administered in 57 (63.3%) patients. No-reflow occurred in only 1 (1.1%) patient. The postprocedural course was uneventful. Review of the literature revealed several early observational and RCTs and meta-analyses favouring manual, not mechanical, thrombectomy. However, newer RCTs and meta-analyses significantly curtailed the initial enthusiasm for the clinical benefits of routine use of thromboaspiration. Conclusion: Selective thromboaspiration for angiographically visible thrombi in MI patients undergoing PCI, as an adjunct to mechanical reperfusion and to IIb/IIIa-inhibitors, may be an option since this manoeuvre may improve procedural and clinical outcome.

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Clinical benefits and risks associated with epoetin and darbepoetin in patients with chemotherapy-induced anemia: A systematic review of the literature

Clinical Therapeutics ◽

10.1016/j.clinthera.2006.06.003 ◽

2006 ◽

Vol 28 (6) ◽

pp. 801-831 ◽

Cited By ~ 95

Author(s):

Susan D. Ross ◽

I. Elaine Allen ◽

David H. Henry ◽

Christopher Seaman ◽

Brian Sercus ◽

...

Keyword(s):

Systematic Review ◽

Review Of The Literature ◽

Clinical Benefits

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Shigella Vaginitis: Report of 38 Patients and Review of the Literature

PEDIATRICS ◽

10.1542/peds.63.4.511 ◽

1979 ◽

Vol 63 (4) ◽

pp. 511-516

Author(s):

Trudy V. Murphy ◽

John D. Nelson

Keyword(s):

Antibiotic Therapy ◽

Retrospective Review ◽

Vaginal Discharge ◽

Treatment Modalities ◽

Adult Women ◽

Review Of The Literature ◽

Systemic Antibiotic ◽

The Past ◽

Systemic Antibiotic Therapy ◽

Topical Antimicrobials

Thirty-eight cases of Shigella vaginitis were identified in a retrospective review of records kept over the past 14 years. The cases of vaginitis were due to three subgroups of Shigella. Vaginitis varied in severity and duration, persisting for several months in some instances. In 47% of the cases, there was associated bloody vaginal discharge. Only two children had diarrhea temporally associated with vaginitis, but six others had had diarrhea. Many treatment modalities were used. Systemic antibiotic therapy appeared more effective than topical antimicrobials in the few patients who could be evaluated. Review of the literature revealed 32 additional cases, including four in adult women.

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61. Can Melatonin Improve Adaptation To Night Shift? A Pilot Study Using an Urban EMS System

Prehospital and Disaster Medicine ◽

10.1017/s1049023x0004574x ◽

1996 ◽

Vol 11 (S2) ◽

pp. S34-S34

Author(s):

Michael Tremea ◽

Mark James ◽

Jeffrey Jones ◽

Jon Krohmer

Keyword(s):

Job Performance ◽

Night Shift ◽

Biological Clock ◽

Consecutive Night ◽

Sleep Diaries ◽

Visual Analog Scales ◽

Significant Difference ◽

Clinical Benefits ◽

Double Blinded ◽

Night Shifts

Purpose: To determine whether melatonin (N-acetyl-5-methoxytryptamine) is effective in helping prehospital personnel working consecutive night shifts reset their biological clock and minimize circadian rhythm disruption.Methods: A double-blinded, randomized, cross-over study was performed using 12 paramedic volunteers. Paramedics were working a span of consecutive night (2300-0700) shifts and received either a melatonin capsule (6 mg) or placebo to be taken prior to each of the consecutive day sleeps. Each participants completed a total of four spans of consecutive night shifts (2-melatonin, 2-placebo). Collected data included daily sleep diaries, quantification of alcohol/caffeine consumed, and possible drug side-effects. Assessment of job performance, mood and alertness were measured every day using 10-cm visual analog scales (VAS).Results: Analysis of sleep diaries demonstrated no significant difference (p >0.05) between the two treatments in respect to mean sleep latency (melatonin = 15.4 min. vs. placebo = 14.6 min), mean sleep duration (melatonin = 6.7 hrs. vs. placebo = 6.9 hrs), or subjectively rated sleep quality (melatonin = 5.8 VAS vs placebo = 5.6 VAS). Similarly, no significant benefits were noted between the mean VAS scores for daily job performance, mood and alertness. Adverse effects were rare, one patient taking melatonin reported a prolonged sedative effect.Conclusion: Despite widespread belief in the benefits of melatonin as a hypnotic agent, no clinical benefits were noted in terms of daytime sleep or job performance in paramedics working consecutive night shifts.

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An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

SAGE Open Medical Case Reports ◽

10.1177/2050313x20953114 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2095311

Author(s):

Kelsey Hinther ◽

Jihane Henni ◽

Rachel N Asiniwasis

Keyword(s):

Excisional Biopsy ◽

Treatment Modalities ◽

Review Of The Literature ◽

Micrographic Surgery ◽

Unique Case ◽

Clinical Recurrence ◽

Microcystic Adnexal Carcinoma ◽

History Of ◽

Ongoing Assessment ◽

To Receive

Microcystic adnexal carcinoma is a rare cutaneous neoplasm believed to arise from pluripotent keratinocytes capable of adnexal differentiation. Due to its insidious growth and appearance, diagnosis is often delayed. A deep incisional or excisional biopsy for histopathology is the gold standard for diagnosis. Different treatment modalities have been described in the literature, including the Mohs micrographic surgery, standard excision, radiation, chemotherapy, and observation. Currently, Mohs remains the treatment of choice. We present a unique case of a 12-month history of an extensive progressive centrofacial cutaneous induration diagnosed as microcystic adnexal carcinoma in an 83-year-old female. Due to the extensive nature of the tumor, she received radiation therapy and continues to receive ongoing assessment with no evidence of clinical recurrence at 2-year post-treatment including negative scouting biopsies. To date, there is no consensus on the optimal treatment for microcystic adnexal carcinoma.

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An Unusual Case of an Odontogenic Keratocyst Associated With an Ungrafted Alveolar Cleft: A Case Report and Review of the Literature

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665618770053 ◽

2018 ◽

Vol 56 (1) ◽

pp. 110-115 ◽

Cited By ~ 1

Author(s):

Sapna Radia ◽

Alexander C. Cash ◽

Kanwalraj Moar

Keyword(s):

Case Report ◽

Male Patient ◽

Bone Grafting ◽

Unusual Case ◽

Odontogenic Keratocyst ◽

Permanent Teeth ◽

Treatment Modalities ◽

Review Of The Literature ◽

Alveolar Cleft

We describe an unusual case of an odontogenic keratocyst (OKC) associated with an ungrafted left-sided alveolar cleft in a 10-year-old male patient. There is no previous report in the literature of OKC or other dental cysts associated with an alveolar cleft. We discuss the management of the OKC prior to secondary bone grafting and present this case to highlight the difficulty in the management of OKC concurrent with grafting of the alveolar cleft site, the proximity of unerupted permanent teeth, and possible treatment modalities.

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Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

International Journal of Molecular Sciences ◽

10.3390/ijms21186752 ◽

2020 ◽

Vol 21 (18) ◽

pp. 6752

Author(s):

Sathish Sundar Dhilip Kumar ◽

Heidi Abrahamse

Keyword(s):

Tissue Engineering ◽

Engineering Application ◽

Natural Compounds ◽

Treatment Modalities ◽

Tissue Engineering Application ◽

Engineering Applications ◽

Synthetic Drugs ◽

Medicinal Compounds ◽

Wide Range ◽

Clinical Benefits

Recent advancement in nanotechnology has provided a wide range of benefits in the biological sciences, especially in the field of tissue engineering and wound healing. Nanotechnology provides an easy process for designing nanocarrier-based biomaterials for the purpose and specific needs of tissue engineering applications. Naturally available medicinal compounds have unique clinical benefits, which can be incorporated into nanobiomaterials and enhance their applications in tissue engineering. The choice of using natural compounds in tissue engineering improves treatment modalities and can deal with side effects associated with synthetic drugs. In this review article, we focus on advances in the use of nanobiomaterials to deliver naturally available medicinal compounds for tissue engineering application, including the types of biomaterials, the potential role of nanocarriers, and the various effects of naturally available medicinal compounds incorporated scaffolds in tissue engineering.

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Management of Pearly Penile Papules: A Review of the Literature

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475419887730 ◽

2019 ◽

Vol 24 (1) ◽

pp. 79-85 ◽

Cited By ~ 1

Author(s):

Anthony D. Honigman ◽

Danielle P. Dubin ◽

Justin Chu ◽

Matthew J. Lin

Keyword(s):

Psychological Distress ◽

Long Term Results ◽

Treatment Modalities ◽

Line Treatment ◽

Review Of The Literature ◽

First Line ◽

Cosmetic Outcomes ◽

First Line Treatment ◽

Ablative Laser

Pearly penile papules (PPPs) are benign, dome-shaped lesions found around the corona of the penis. Despite being asymptomatic and benign in nature, the appearance of PPPs may cause a great deal of psychological distress to both the patient and their sexual partner. While patient reassurance may be the first-line treatment, several other treatment modalities including cryotherapy, electrodessication and curettage, and laser therapy have all been used to treat PPPs in order to achieve a cosmetic outcome that satisfies the patient. Based on the evaluation of the existing literature, ablative laser therapies offer satisfactory cosmetic outcomes with good long-term results.

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Eruption Disturbances of the Maxillary Incisors:A Literature Review

Journal of Clinical Pediatric Dentistry ◽

10.17796/jcpd.32.3.m175g328l100x745 ◽

2008 ◽

Vol 32 (3) ◽

pp. 221-230 ◽

Cited By ~ 17

Author(s):

Kristin Huber ◽

Lokesh Suri ◽

Parul Taneja

Keyword(s):

Systematic Review ◽

Literature Review ◽

Root Development ◽

Time Frame ◽

Treatment Modalities ◽

Chronological Age ◽

Review Of The Literature ◽

Expected Time ◽

Ectopic Eruption ◽

Delayed Eruption

Eruption disturbances can be broadly classified as disturbances related to time and disturbances related to position. Time related disturbances include premature eruption, delayed eruption or impactions. A common feature of these is a significant deviation in eruption time within the established norms for a particular age,sex, race or ethnicity. Although root development represents the fundamental biologic parameter for tooth eruption, chronological age at presentation is used as the first criteria in the establishment of the diagnosis of prematurity or a delay in eruption. Eruption disturbances related to position include ectopic eruption and transpositions. Positional deviations too can cause a delay in eruption time, however, more commonly the involved tooth erupts within the expected time frame with an abnormality in position. The focus of this paper is to present a systematic review of the literature including classification, etiology and treatment modalities available for eruption disturbances of the maxillary incisors.

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