The Influence of Various Type of Long Term Physical Activity on the Physical Fitness and Blood Lipid Level in Middle Aged Adult Male

Background: Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. Objective: To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing home residents. We also aimed to ascertain the effect of an exercise program on myostatin levels. Methods: We obtained study data on 112 participants from long-term nursing homes. Participants were randomly assigned to a control or an intervention group and performed a 6-month multicomponent exercise program. Serum myostatin levels were analyzed by ELISA. Assessments also included body composition (anthropometry and bioelectrical impedance), physical fitness (Senior Fitness Test), physical activity level (accelerometry), and frailty (Fried frailty criteria, Clinical Frailty Scale, and Tilburg frailty indicator). Results: The concentration of myostatin at baseline was positively correlated with: a leaner body composition (p < 0.05), and a higher number of steps per day and light and moderate-vigorous physical activity in women (p < 0.005); greater upper and lower limb strength, endurance, and poorer flexibility (p < 0.05) in men; and better performance (less time) in the 8-ft timed up-and-go test in both women (p < 0.01) and men (p < 0.005). We observed higher concentrations of serum myostatin in non-frail than in frail participants (p < 0.05). Additionally, we found that the implemented physical exercise intervention, which was effective to improve physical fitness, increased myostatin concentration in men (p < 0.05) but not in women. The improvements in physical condition were related with increases in serum myostatin only in men (p < 0.05–0.01). Conclusions: Higher serum levels of myostatin were found to be associated with better physical fitness. The improvements in physical fitness after the intervention were positively related to increases in myostatin concentrations in men. These results seem to rule out the idea that high serum myostatin levels are indicative of frailty in long-term nursing home residents. However, although the direction of association was opposite to that expected for the function of myostatin, the use of this protein as a biomarker for physical fitness, rather than frailty, merits further study.

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Long-Term and Transfer Effects of an Action Control Intervention in Overweight Couples: A Randomized Controlled Trial Using Text Messages

Frontiers in Psychology ◽

10.3389/fpsyg.2021.754488 ◽

2021 ◽

Vol 12 ◽

Author(s):

Corina Berli ◽

Urte Scholz

Keyword(s):

Physical Activity ◽

Physical Fitness ◽

Text Messaging ◽

Vigorous Physical Activity ◽

Action Control ◽

Text Messages ◽

Control Group ◽

Transfer Effects ◽

Control Intervention

Keeping a physically active lifestyle requires consistent self-regulatory effort such as action control (e.g., continuously monitoring and evaluating a behavior in terms of one’s goals). Involving the romantic partner in interventions might be particularly effective in the long run. The present study examined the long-term and transfer effects of an action control intervention in couples using text messaging for promoting target persons’ and partners’ physical activity, anthropometric measures and physical fitness 6 months post baseline. A total of 121 overweight and obese romantic couples, randomly allocated to an intervention (n = 60; information + action control text messages) or a control group (n = 61; information only) and to participating as target person or partner, completed baseline assessments (T1). 100 couples (82.6%) completed the 6-month follow-up (T3) assessment. Primary outcomes included self-reported moderate-to-vigorous physical activity (MVPA) and objective MVPA and MVPA adherence using triaxial accelerometers across a diary period of 14 days after T3. Secondary outcomes included BMI, waist-to-hip circumference and physical fitness (target persons only) using a submaximal aerobic cycle test. At T3, there were no significant between-group differences between target persons and partners with regard to their objective MVPA, self-reported MVPA, BMI, waist-hip ratio or physical fitness. No significant changes in outcomes were observed from T1 to T3; however, changes in BMI from T1 to T3 between target persons and partners in the intervention group were associated. Overall, the brief 14-days action control intervention was not effective in improving target person’s physical activity, body measures and physical fitness in the long-term. Moreover, no long-term benefits for partners emerged. While brief ecological momentary interventions might be a promising tool for short-term effects, future studies are needed to test features enhancing long-term effectiveness. Associations in romantic partners’ changes suggest that dyadic interventions can be a promising approach, as changes induced in one partner may then transfer over to the other (controlled-trials.com ISRCTN15705531).

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Effect of cold and warm Juglans nigra L. walnut leaves extract on fat in rats infected with high blood lipid level with hydrogen peroxide and cholesterol

JOURNAL OF EDUCATION AND SCIENCE ◽

10.33899/edusj.2013.89774 ◽

2013 ◽

Vol 26 (2) ◽

pp. 69-84

Author(s):

Khalid Hammadi Hameed Sharaf ◽

Jian Salam Hasan Ali

Keyword(s):

Hydrogen Peroxide ◽

Lipid Level ◽

Blood Lipid ◽

Juglans Nigra ◽

Blood Lipid Level ◽

Walnut Leaves

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PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN DISLIPIDEMIA DAN NORMOLIPIDEMIA DI RSUP PROF. DR. R. D. KANDOU MANADO

Jurnal e-Biomedik ◽

10.35790/ebm.2.1.2014.4189 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Ivan Ch. Sulamanda

Keyword(s):

Platelet Aggregation ◽

Analytical Study ◽

Platelet Reactivity ◽

Hypothesis Test ◽

Lipid Level ◽

Blood Lipid ◽

Normal Blood ◽

Blood Lipid Level ◽

Diabetes Melitus

Abstract: Insulin resistance that occurs in patients with type 2 diabetes mellitus (T2DM), stimulates lipolysis in adipose tissue resulting in increasing of free fatty acid and dyslipidemia. Dyslipidemia is associated with platelet reactivity and thrombogenic potency. Examination of platelet aggregation aims to detect abnormalities of platelet function. This study aimed to obtain the comparison of platelet aggregation values in T2DM patients with dyslipidemia and with normal blood lipid level. This was an observational analytical study, using comparative hypothesis test. This study were conducted on 30 T2DM patients, in which 15 of them have dyslipidemia and the other 15 has normal lipid level. These patients were registered as outpatients of Endocrine and Metabolic Clinic of Prof. Dr. R. D. Kandou Hospital, Manado. Blood samples of patients were processed in Prokita Laboratory, Manado. Platelet aggregation was tested by using 1 set agregometer Chrono - Log model 490, Chrono - Log recorder model 707, and Computer Windows based PC. The T test showed that there were significant differences of the platelet aggregation values with ADP 10 µm agonist between T2DM patients with dyslipidemia and with normal blood lipid level (P = 0.019). Mann-Whitney test showed that there were significant differences of the platelet aggregation values with ADP 5 µm agonist between T2DM patients with dyslipidemia and with normal blood lipid level (P = 0.006). Most patients in this study were elderly (86.7%), with an equal number of men and women. Conclusion: There were significant differences of the platelet aggregation values between T2DM patients with dyslipidemia and with normal blood lipid level, whether using ADP 10 µm agonist or ADP 5 µm agonist. Keywords: platelet aggregation, T2DM, dyslipidemiaAbstrak: Pada pasien diabetes melitus tipe 2 (DMT2), resistensi insulin merangsang lipolisis di jaringan adiposa yang meningkatkan asam lemak bebas sehingga terjadi dislipidemia. Dislipidemia sering dikaitkan dengan peningkatan aktivitas platelet dan potensi trombogenik. Pemeriksaan agregasi trombosit bertujuan untuk mendeteksi abnormalitas fungsi trombosit. Penelitian ini bertujuan untuk melihat perbandingan nilai agregasi trombosit pada pasien DMT2 dengan dislipidemia dan normolipidemia. Penelitian ini bersifat observasional analitik dengan menggunakan metode uji hipotesis komparatif. Subjek penelitian berjumlah 30 orang, terdiri dari 15 pasien DMT2 dengan dislipidemia dan 15 pasien DMT2 dengan normolipidemia yang berobat ke Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Pemeriksaan sampel darah pasien dilakukan di Laboratorium Prokita Manado. Pemeriksaan agregasi trombosit menggunakan 1 set agregometer Chrono - Log model 490, Chrono - Log recorder model 707, Computer Windows based PC. Karakteristik terbanyak pada pasien DMT2 terdapat pada usia tua (86,7%) dengan jenis kelamin laki - laki dan perempuan sama banyak (50%). Hasil uji T menunjukkan terdapat perbedaan bermakna antara nilai agregasi trombosit menggunakan agonis ADP 10 µm pada pasien DMT2 dengan dislipidemia dan normolipidemia (P = 0,019). Uji Mann-Whitney juga menunjukkan terdapat perbedaan bermakna antara nilai agregasi trombosit dengan agonis ADP 5 µm pada pasien DMT2 dengan dislipidemia dan normolipidemia (P = 0,006). Simpulan: Terdapat perbedaan bermakna antara nilai agregasi trombosit pada pasien DMT2 dengan dislipidemia dan normolipidemia baik menggunakan agonis ADP 10 µm maupun ADP 5 µm. Kata kunci: agregasi trombosit, DMT2, dislipidemia

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