scholarly journals THE RELATIONSHIP BETWEEN CLINICAL SYMPTOMS AND ULTRASONOGRAPHIC SIGNS IN GOUT

2017 ◽  
Vol 27 (1) ◽  
pp. 70-77
Author(s):  
Eleonora Norkuvienė ◽  
Mykolas Petraitis ◽  
Indrė Apanavičienė ◽  
Dalia Virvičiūtė ◽  
Asta Baranauskaitė
Keyword(s):  
Disease Duration ◽  
Clinical Symptoms ◽  
False Negative ◽  
Joint Damage ◽  
Patient Reported ◽  
Urate Crystal ◽  
Us Findings ◽  
First Time ◽  
The Relationship ◽  
Spearman’S Correlation

For the first time, the new ACR/EULAR gout classification criteria incorporate ultrasound (US) evidence of double contour sign (DC), an articular cartilage abnormality related to the deposition of crystals on the surface of the hyaline cartilage, as a sign specific to gout. US recently has been used as an objective diagnostic tool for detecting urate deposition (tophus (T), DC) or joint damage (erosion) in gout. Objective: Our aim was to investigate the relationship between clinical gout activity and load of US changes, also to examine the concordance between patient reported joint attack (PRGA) and ultrasonographic intraarticular changes. Methods: Sixty monosodium-urate-crystal-confirmed gout patients and 36 healthy controls were prospectively included in one centre. The relationship between clinical symptoms and ultrasonographic gout-related changes investigating 36 joints and 4 tendons (m. triceps and patellar) was evaluated using Spearman’s correlation and agreement analysis (kappa coefficient). Results: moderate, positive correlation was observed between the number of subcutaneous tophi and total US tophus area (rs=0,628), total number of DC (rs=0,612), and erosions (rs=0,526), all p<0, 0001, found per patient on US. Gout attacks and disease duration significantly positively correlated with the load of all investigated US changes (p<0, 01). Investigating 1980 joints in 55 gout patients irrespective of treatment and disease duration, symptoms were reported in 307 (15,5%) joints while ultrasound detected signs of urate deposition and erosions in 416 (20,9%) and 143 (7,2%) joints, respectively. The overall concordance rate with PRGA in the joint was fair for tophus (κ= 0,333), especially in the wrist and ankle, also fair for DC (κ= 0,275) and erosion (κ= 0,217). There was large number of clinically false negative joints with T and/or DC found on US, but also negative intraarticular US in patient-reported arthritis. Better concordance, considered as moderate between PRGA and any sign of urate deposition (US T or DC) was found, investigating 1008 joints in untreated (28) gout subgroup (κ= 0,498) compared to treated (κ= 0,231). The specificity of US T, DC, and erosion was 81% (p<0, 0001), 86% (p<0, 0001), and 70% (p<0, 01), respectively. Conclusions: Ultrasonographic changes positively correlate with disease activity and duration in gout with fair to moderate concordance between patientreported gout attack and intraarticular US findings. Not only symptomatic joints should be used for US gout classification in clinical practice.

scholarly journals Variability of sleep bruxism—findings from consecutive nights of monitoring

2021 ◽  
Author(s):  
Brigitte Ohlmann ◽  
Wolfgang Bömicke ◽  
Rouven Behnisch ◽  
Peter Rammelsberg ◽  
Marc Schmitter
Keyword(s):  
Clinical Trial ◽  
Muscle Activity ◽  
Masseter Muscle ◽  
Clinical Symptoms ◽  
Sleep Time ◽  
Sleep Bruxism ◽  
Descriptive Statistics ◽  
The Relationship ◽  
Reliable Correlation ◽  
Spearman’S Correlation

Abstract Objectives To determine sleep bruxism (SB) behavior during five consecutive nights and to identify correlations between SB episodes per hour (SB index) and sleep-time masseter-muscle activity (sMMA). Material and methods Thirty-one participants were included in the study. Of these, 10 were classified as sleep bruxers (group SB-1) and nine as non-sleep bruxers (group non-SB). The bruxism status of these 19 patients was identified by means of questionnaires, an assessment of clinical symptoms, and electromyographic/electrocardiographic data (Bruxoff® device). The remaining 12 participants were also identified as bruxers, but based exclusively on data from the Bruxoff device (group SB-2). Data analysis included descriptive statistics and Spearman’s correlation to assess the relationship between the SB index and sMMA. Results Participants in group SB-1 showed an overall mean SB index of 3.1 ± 1.6 and a mean total sMMA per night of 62.9 ± 38.3. Participants in group SB-2 had an overall mean SB index of 2.7 ± 1.5 and a mean total sMMA of 56.0 ± 29.3. In the non-SB group, participants showed an overall mean SB index of 0.8 ± 0.5 and a mean total sMMA of 56.8 ± 30.3. Spearman’s correlation yielded values of − 0.27 to 0.71 for the correlation between sMMA and SB index. Conclusions The data revealed variable SB activity and the absence of a reliable correlation between sMMA and the SB index. Clinical relevance The high variation in SB activity and lack of correlation between sMMA and the SB index should be considered when diagnosing SB. Trial registration Clinical Trials [NIH], clinical trial no. NCT03039985.

scholarly journals Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Rita Christiane Baron ◽  
Lorenz Risch ◽  
Myriam Weber ◽  
Sarah Thiel ◽  
Kirsten Grossmann ◽  
...  
Keyword(s):  
Disease Duration ◽  
Validation Cohort ◽  
Clinical Symptoms ◽  
False Negative ◽  
Population Based ◽  
Initial Presentation ◽  
Rt Pcr ◽  
Antibody Testing ◽  
Disease Symptoms

AbstractObjectivesThe sensitivity of molecular and serological methods for COVID-19 testing in an epidemiological setting is not well described. The aim of the study was to determine the frequency of negative RT-PCR results at first clinical presentation as well as negative serological results after a follow-up of at least 3 weeks.MethodsAmong all patients seen for suspected COVID-19 in Liechtenstein (n=1921), we included initially RT-PCR positive index patients (n=85) as well as initially RT-PCR negative (n=66) for follow-up with SARS-CoV-2 antibody testing. Antibodies were detected with seven different commercially available immunoassays. Frequencies of negative RT-PCR and serology results in individuals with COVID-19 were determined and compared to those observed in a validation cohort of Swiss patients (n=211).ResultsAmong COVID-19 patients in Liechtenstein, false-negative RT-PCR at initial presentation was seen in 18% (12/66), whereas negative serology in COVID-19 patients was 4% (3/85). The validation cohort showed similar frequencies: 2/66 (3%) for negative serology, and 16/155 (10%) for false negative RT-PCR. COVID-19 patients with negative follow-up serology tended to have a longer disease duration (p=0.05) and more clinical symptoms than other patients with COVID-19 (p<0.05). The antibody titer from quantitative immunoassays was positively associated with the number of disease symptoms and disease duration (p<0.001).ConclusionsRT-PCR at initial presentation in patients with suspected COVID-19 can miss infected patients. Antibody titers of SARS-CoV-2 assays are linked to the number of disease symptoms and the duration of disease. One in 25 patients with RT-PCR-positive COVID-19 does not develop antibodies detectable with frequently employed and commercially available immunoassays.

scholarly journals Differential detection ofEntamoeba histolytica,Entamoeba disparandEntamoeba moshkovskiiin faecal samples using nested multiplex PCR in west of Iran

2019 ◽  
Vol 147 ◽  
Author(s):  
Fares Bahrami ◽  
Ali Haghighi ◽  
Ghasem Zamini ◽  
Mohammadbagher Khademerfan
Keyword(s):  
Clinical Symptoms ◽  
Gastrointestinal Symptoms ◽  
Stool Examination ◽  
Entamoeba Dispar ◽  
Faecal Samples ◽  
Northwest Of Iran ◽  
Stool Samples ◽  
Species Specific ◽  
First Time ◽  
The Relationship

AbstractThis study aimed to determine the prevalence ofEntamoeba histolytica,Entamoeba disparandEntamoeba moshkovskii(collectively referred to asEntamoebacomplex), using microscopic and molecular methods in Kurdistan Province, northwest of Iran. The relationship between positiveEntamoebaspecies and clinical symptoms was also investigated. Eight positiveEntamoebacomplex, as well as fourEntamoebacomplex-like isolates, were detected by microscopic stool examination. DNA was extracted from all positive and from 55 randomly selected negative stool samples. PCR was performed using species-specific 18S rRNA primers for theEntamoebacomplex. All positive PCR samples were sequenced. In total, 14 (1.01%) out of 1383 isolates, i.e. 12 microscopy-positive andEntamoebacomplex-like isolates and two out of 55 microscopy-negative isolates, were identified via PCR and sequencing. Overall, 0.58% (8/1383) of the isolates wereE.dispar, 0.14% (2/1383)E.histolytica, 0.07% (1/1383)E.moshkovskiiand 0.22% (3/1383) were mixed ofE.histolyticaandE.dispar. Based on our findings, the prevalence ofE. disparis greater than that ofE. histoltyica. On the other hand, a case ofE. moshkovskiiwas reported for the first time in this region. It seems that some gastrointestinal symptoms may be attributed toEntamoebaspecies.

Affirmative Action and Leadership Attitudes in Brazilian Women Managers

2011 ◽  
Vol 10 (3) ◽  
pp. 139-143 ◽  
Author(s):  
Gazi Islam ◽  
Sarah E. S. Zilenovsky
Keyword(s):  
Affirmative Action ◽  
Latin American ◽  
Women Managers ◽  
Psychological Effects ◽  
Preferential Selection ◽  
Justice Perceptions ◽  
First Time ◽  
The Relationship

This note examines the relationship between affirmative action (AA) program perceptions and women’s self-ascribed capacity and desire to become leaders. We propose that women who believe that their organization implements a program of preferential selection toward women will experience negative psychological effects leading to lowered self-expectations for leadership, but that this effect will be moderated by their justice perceptions of AA programs. We test this proposition empirically for the first time with a Latin American female sample. Among Brazilian women managers, desire but not self-ascribed capacity to lead was reduced when they believed an AA policy was in place. Both desire’s and capacity’s relationships with belief in an AA policy were moderated by justice perceptions.

The assessment of vitamin D3 deficiency in patients with Hashimoto's disease and the relationship between the disease duration and 25OHD3 levels

2018 ◽  
Author(s):  
Katarzyna Lizis-Kolus ◽  
Alicja Hubalewska-Dydejczyk ◽  
Anna Sowa-Staszczak ◽  
Anna Skalniak ◽  
Aldona Kowalska ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Disease Duration ◽  
Hashimoto’S Disease ◽  
Hashimoto's Disease ◽  
The Relationship ◽  
Vitamin D3 Deficiency

ЗУБРЫ НА СЕВЕРЕ РОССИИ — НАСТОЯЩЕЕ И БУДУЩЕЕ

2019 ◽  
pp. 42-44
Author(s):  
I.V. GUSAROV ◽  
V.A. OSTAPENKO ◽  
T.V. NOVIKOVА
Keyword(s):  
Biological Diversity ◽  
Climatic Conditions ◽  
Economic Consequences ◽  
European Bison ◽  
Rare And Endangered Species ◽  
The North ◽  
Rare And Endangered ◽  
Relationship Of ◽  
First Time ◽  
The Relationship

Впервые в мире создана популяция зубров на территории 60 градусов северной широты. В новых климатических условиях разведения и сохранения зубров определены и проанализированы факторы существования вида на севере Европейской части РФ. Выявлены признаки, динамика численности, которые являются составной частью системы, предназначенной для управления биоразнообразием. Интродукция, являясь процессом введения в экосистему нехарактерных для нее видов, может усиливать изменения биоценозов как положительно, так и отрицательно. Насколько быстро и успешно проходит процесс адаптации заселенного вида, и усматривается его влияние на окружающую среду зависит дальнейшее существование зубров и в целом биоразнообразия. В статье обсуждаются вопросы взаимоотношения зубров с другими видами копытных и хозяйственной деятельностью человека, а также дальнейшим использованием зубров в сельскохозяйственном производстве. Пластичность зубров, выявление изменений и их анализ при вселении видов в новые условия обитания необходимы не только для определения развития или деградации биоценозов и в целом экосистемы, но и прогноза социально-экономических последствий интродукции как одного из методов сохранения редких и исчезающих видов фауны.For the first time in the world, a bison population has been created in an area of 60 degrees north latitude. In the new climatic conditions of breeding and preservation of bison, the factors of the species existence in the north of the European part of the Russian Federation are identified and analyzed. The signs, dynamics of abundance, which are an integral part of the system designed to manage biodiversity are identified, since the preservation of biological diversity on the planet is one of the main problems of our time. Introduction, being the process of introducing non-typical species into an ecosystem, can enhance changes in biocenoses, both positively and negatively. The question posing sounds especially when it comes to such a large hoofed animal as the European bison. How quickly and successfully the process of adaptation of the universe takes place and its environmental impact is seen depends on the continued existence of bison and biodiversity in general. The article discusses the relationship of bison with other types of ungulates and human activities, as well as the further use of bison in agricultural production. How these issues will be resolved positively depends on the future of these animals. Thus, the plasticity of bison, the identification of changes and their analysis, with the introduction of species into new habitat conditions is necessary not only to determine the development or degradation of biocenoses and the ecosystem as a whole, but also to predict the socio-economic consequences due to the introduction as one of the methods of preserving rare and endangered species of fauna.

Scoring System for the Diagnosis of COVID-19

2020 ◽  
Vol 13 (1) ◽  
pp. 413-414 ◽  
Author(s):  
Mohamed Farouk Allam
Keyword(s):  
Scoring System ◽  
Clinical Symptoms ◽  
False Negative ◽  
Nasopharyngeal Swab ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Negative Results ◽  
False Negative Results ◽  
Symptoms And Signs

Due to the international spread of COVID-19, the difficulty of collecting nasopharyngeal swab specimen from all suspected patients, the costs of RT-PCR and CT, and the false negative results of RT-PCR assay in 41% of COVID-19 patients, a scoring system is needed to classify the suspected patients in order to determine the need for follow-up, home isolation, quarantine or the conduction of further investigations. A scoring system is proposed as a diagnostic tool for suspected patients. It includes Epidemiological Evidence of Exposure, Clinical Symptoms and Signs, and Investigations (if available). This scoring system is simple, could be calculated in a few minutes, and incorporates the main possible data/findings of any patient.

A University Education

2017 ◽  
Author(s):  
David Willetts
Keyword(s):  
Higher Education ◽  
Modern Society ◽  
University Education ◽  
Modern World ◽  
Controversial Issues ◽  
The Us ◽  
The Individual ◽  
The University ◽  
First Time ◽  
The Relationship

Universities have a crucial role in the modern world. In England, entrance to universities is by nation-wide competition which means English universities have an exceptional influence on schools--a striking theme of the book. This important book first investigates the university as an institution and then tracks the individual on their journey to and through university. In A University Education, David Willetts presents a compelling case for the ongoing importance of the university, both as one of the great institutions of modern society and as a transformational experience for the individual. The book also makes illuminating comparisons with higher education in other countries, especially the US and Germany. Drawing on his experience as UK Minister for Universities and Science from 2010 to 2014, the author offers a powerful account of the value of higher education and the case for more expansion. He covers controversial issues in which he was involved from access for disadvantaged students to the introduction of L9,000 fees. The final section addresses some of the big questions for the future, such as the the relationship between universities and business, especially in promoting innovation.. He argues that the two great contemporary trends of globalisation and technological innovation will both change the university significantly. This is an authoritative account of English universities setting them for the first time in their new legal and regulatory framework.

scholarly journals Variation in VKORC1 Is Associated with Vascular Dementia

2021 ◽  
Vol 80 (3) ◽  
pp. 1329-1337
Author(s):  
Jure Mur ◽  
Daniel L. McCartney ◽  
Daniel I. Chasman ◽  
Peter M. Visscher ◽  
Graciela Muniz-Terrera ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vascular Dementia ◽  
Genetic Variant ◽  
Warfarin Dose ◽  
Uk Biobank ◽  
Parental History ◽  
Genome Wide ◽  
History Of ◽  
First Time ◽  
The Relationship

Background: The genetic variant rs9923231 (VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer’s disease in the parents of participants, with suggestive evidence for an association for rs9923231 (p = 1.8×10–7), which was included in the genome-wide significant KAT8 locus. Objective: Our study aimed to investigate whether the relationship between rs9923231 and dementia persists only for certain dementia sub-types, and if those taking warfarin are at greater risk. Methods: We used logistic regression and data from 238,195 participants from UK Biobank to examine the relationship between VKORC1, risk of dementia, and the interplay with warfarin use. Results: Parental history of dementia, APOE variant, atrial fibrillation, diabetes, hypertension, and hypercholesterolemia all had strong associations with vascular dementia (p < 4.6×10–6). The T-allele in rs9923231 was linked to a lower warfarin dose (βperT - allele = –0.29, p < 2×10–16) and risk of vascular dementia (OR = 1.17, p = 0.010), but not other dementia sub-types. However, the risk of vascular dementia was not affected by warfarin use in carriers of the T-allele. Conclusion: Our study reports for the first time an association between rs9923231 and vascular dementia, but further research is warranted to explore potential mechanisms and specify the relationship between rs9923231 and features of vascular dementia.

scholarly journals Nasal Morphology and Its Correlation to Craniofacial Morphology in Lateral Cephalometric Analysis

2021 ◽  
Vol 18 (6) ◽  
pp. 3064
Author(s):  
Agnieszka Jankowska ◽  
Joanna Janiszewska-Olszowska ◽  
Katarzyna Grocholewicz
Keyword(s):  
Soft Tissue ◽  
Nasal Bone ◽  
Correlation Coefficients ◽  
Craniofacial Morphology ◽  
Base Angle ◽  
Nasolabial Angle ◽  
Orthodontic Patients ◽  
Nose Shape ◽  
The Relationship ◽  
Spearman’S Correlation

Nose shape, size, and inclination influence facial appearance, but few studies concern the relationship between the nasal profile and craniofacial structures. The objective of this study was to analyze association of nasal cephalometric variables with skeletal structures, age, and sex. Cephalometric and nasal analysis was performed in 386 Polish orthodontic patients (aged 9–25 years). Student t-test and Mann–Whitney test were used to compare quantitative variables and Pearson’s or Spearman’s correlation coefficients—to find correlations. Soft tissue facial convexity angle correlates to Holdaway ratio, ANB (A-Nasion-B), and Wits appraisal. Nasal dorsum axis, nose length, nose depth (1) and nose depth (2), nose hump, lower dorsum convexity, and columella convexity increase with age. Nasal base angle, nasolabial angle, nasomental angle, soft tissue facial convexity and nasal bone angle decrease with age. Nasal base angle and nasomental angle are smaller in females. Thus, a relationship exists between nasal morphology and sagittal jaw configuration. Nasal parameters significantly change with age. Sexual dimorphism characterizes nasal bone angle and nasomental angle.

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