Variation in VKORC1 Is Associated with Vascular Dementia

Background: The genetic variant rs9923231 (VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer’s disease in the parents of participants, with suggestive evidence for an association for rs9923231 (p = 1.8×10–7), which was included in the genome-wide significant KAT8 locus. Objective: Our study aimed to investigate whether the relationship between rs9923231 and dementia persists only for certain dementia sub-types, and if those taking warfarin are at greater risk. Methods: We used logistic regression and data from 238,195 participants from UK Biobank to examine the relationship between VKORC1, risk of dementia, and the interplay with warfarin use. Results: Parental history of dementia, APOE variant, atrial fibrillation, diabetes, hypertension, and hypercholesterolemia all had strong associations with vascular dementia (p < 4.6×10–6). The T-allele in rs9923231 was linked to a lower warfarin dose (βperT - allele = –0.29, p < 2×10–16) and risk of vascular dementia (OR = 1.17, p = 0.010), but not other dementia sub-types. However, the risk of vascular dementia was not affected by warfarin use in carriers of the T-allele. Conclusion: Our study reports for the first time an association between rs9923231 and vascular dementia, but further research is warranted to explore potential mechanisms and specify the relationship between rs9923231 and features of vascular dementia.

Download Full-text

Variation in VKORC1 is associated with vascular dementia

10.1101/2020.07.31.231126 ◽

2020 ◽

Author(s):

Jure Mur ◽

Daniel L. McCartney ◽

Daniel I. Chasman ◽

Peter M. Visscher ◽

Graciela Muniz-Terrera ◽

...

Keyword(s):

Genetic Variation ◽

Vascular Dementia ◽

Uk Biobank ◽

Alzheimer Dementia ◽

First Time ◽

The Relationship

AbstractGenetic variation in VKORC1 is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has also been linked to parental dementia. However, it is unclear whether the relationship persists for the diagnosis in patients themselves, whether the association holds only for certain forms of dementia, and if those taking warfarin are at greater risk. Here, we use data from 211,423 participants from UK Biobank to examine the relationship between VKORC1, risk of dementia, and the interplay with warfarin use. We find that the T-allele in rs9923231 confers a greater risk for vascular dementia (OR=1.28, p=0.0069), but not for general dementia (OR=1.04, p=0.21) or Alzheimer dementia (OR=1.05, p=0.35), and that the risk of vascular dementia is not affected by warfarin use in carriers of the T-allele. Our study reports for the first time an association between rs9923231 and vascular dementia, but further research is warranted to explore potential mechanisms and specify the relationship between rs9923231 and features of vascular dementia.

Download Full-text

Die Bundeswehr und die Belgischen Streitkräfte in Deutschland

10.5771/9783748928393 ◽

2021 ◽

Author(s):

Jonas Springer

Keyword(s):

Local Level ◽

Military Training ◽

Armed Forces ◽

History Of ◽

Military Training Areas ◽

The Military ◽

First Time ◽

The Relationship ◽

Peak Phase ◽

East West

This study is dedicated to the regional history of the East-West conflict on the basis of the relationship between the Germany military and the Belgian armed forces stationed in Germany. The central question it addresses is which factors were largely responsible for the interdependence between actors and institutions of both armies. In addition to analysing the limited time of the peak phase of Belgian military deployment in the Federal Republic 1946–1990, the book concentrates regionally on the military training areas of Vogelsang in the Eifel and the Wahner Heide near Cologne as military contact zones. For this purpose, the author evaluates unpublished archival sources at the local level for the first time.

Download Full-text

M.E. Levberg’s Play “Danton” as Perceived by А. Blok

Literary Fact ◽

10.22455/2541-8297-2021-20-115-130 ◽

2021 ◽

pp. 115-130

Author(s):

Veronika B. Zuseva-Özkan

Keyword(s):

Russian Literature ◽

State Archive ◽

Silver Age ◽

Saint Petersburg ◽

Critical Attitude ◽

Russian State ◽

History Of ◽

Aleksandr Blok ◽

First Time ◽

The Relationship

The article considers the unpublished play by Maria Levberg, a little known female writer of the Silver Age. Aleksandr Blok praised this drama entitled Danton; thanks to his efforts, it was performed in the Bolshoi Drama Theater in 1919. Danton is discussed in several articles by Blok (Bolshoi Drama Theater in the Next Season, of 19 May 1919, Tribune (Tiberius Sempronius Gracchus)) and in his correspondence; it is also mentioned in Blok’s notebooks. The author of the article analyzes all these mentions, reconstructs the history of interactions between Blok and Levberg. Some of her letters to the poet are published here for the first time. Blok’s notes on the typed copy of Danton, preserved at the Manuscript Department of the Institute of Russian Literature in Saint Petersburg, are described. The relationship between this version of the play and the version, preserved at the Russian State Archive of Literature and Arts in Moscow, is revealed. The author analyzes the plot and the system of characters, characterizes the concept of history expressed in Danton, and proposes the hypothesis why this play turned out to be so dear to Blok. Blok’s reviews on Danton are compared to those written by A.M. Remizov (who also welcomed the play, as well as other dramas by Levberg — Stones of Death and The Chevalier’s Epee) and by M.A. Kuzmin who displayed a more critical attitude. Finally, the place of this drama among Levberg’s works and her main themes and ideas are considered.

Download Full-text

Food Relations of Ukraine and the RSFSR in 1918 − the first half of 1919

Roxolania Historĭca = Historical Roxolania ◽

10.15421/30190215 ◽

2019 ◽

Vol 2 ◽

pp. 237

Author(s):

Dmytro Arkhireyskyi

Keyword(s):

Communist Regime ◽

Food Crisis ◽

Agricultural Resources ◽

Trade Relations ◽

Self Help ◽

Economic Methods ◽

History Of ◽

Soviet Russia ◽

First Time ◽

The Relationship

The purpose of the article is to establish and investigate the dependence of the population of Soviet Russia, which in 1918 − the first half of 1919 was suffering from the food crisis caused by the policy of the Bolsheviks, as well as the communist regime itself on Ukrainian food, also, to review the plans of the RSFSR leadership on Ukrainian agricultural resources in the context of the actual conquest of Russia by Ukraine in early 1919.Methods of research: chronological, structural-system, logical-historical.The main results. The reasons for the birth in Russia in 1918 of the traffic of bagmen and the peculiarities of the penetration of Russian private suppliers into the territory of Ukraine were researched; the reaction of the Ukrainian State to the appearance of Russian bagmen in the country was studied; the level of efficiency of trade relations of independent Ukraine and RSFSR is analyzed; the relationship between the food situation in Russia and the attempts of the Bolsheviks to overcome it by establishing control over Ukrainian bread in the first half of 1919 was established; it has been proved that the establishment of the Bolshevik authorities in Ukraine and the introduction of the policy of the War Communism here meant the use of force, non-economic methods of influencing Ukrainian peasants for the purpose of actually extracting food resources from them.Practical significance. The results of the article are recommended for use in synthetic works on the history of Ukraine and Russia during the revolution period of 1917−1921, as well as for the development of special courses on the history of Ukraine, Russia and Eastern Europe. These materials can also be used to promote historical knowledge.Originality. The article is completely original, performed on the basis of the generalization of the experience of a number of domestic and foreign researchers with the involvement of archival and narrative sources.Scientific novelty. For the first time in the national historiography, the data revealing the reasons and the peculiarities of the food crisis in Soviet Russia in 1918, and also the doom of a significant part of the Russians to self-help, were synthesized and investigated; the dependence of the starving population of Russia and its authorities on Ukrainian food was first shown; the ways of obtaining Ukrainian bread by Russian bagmen and the Bolshevik regime in the context of the events of the end of 1918 − the first half of 1919 were highlighted.Type of article: anlytical.

Download Full-text

Hypertension Burden and the Risk of New-Onset Atrial Fibrillation

Hypertension ◽

10.1161/hypertensionaha.120.16659 ◽

2021 ◽

Vol 77 (3) ◽

pp. 919-928

Author(s):

So-Ryoung Lee ◽

Chan Soon Park ◽

Eue-Keun Choi ◽

Hyo-Jeong Ahn ◽

Kyung-Do Han ◽

...

Keyword(s):

Atrial Fibrillation ◽

Total Study Population ◽

Increased Risk ◽

Burden Scale ◽

History Of ◽

Study Population ◽

Korean National Health Insurance ◽

Stage 1 ◽

The Relationship

The association between the cumulative hypertension burden and the development of atrial fibrillation (AF) is unclear. We aimed to investigate the relationship between hypertension burden and the development of incident AF. Using the Korean National Health Insurance Service database, we identified 3 726 172 subjects who underwent 4 consecutive annual health checkups between 2009 and 2013, with no history of AF. During the median follow-up of 5.2 years, AF was newly diagnosed in 22 012 patients (0.59% of the total study population; 1.168 per 1000 person-years). Using the blood pressure (BP) values at each health checkup, we determined the burden of hypertension (systolic BP ≥130 mm Hg or diastolic BP ≥80 mm Hg), stratified as 0 to 4 per the hypertension criteria. The subjects were grouped according to hypertension burden scale 1 to 4: 20% (n=742 806), 19% (n=704 623), 19% (n=713 258), 21% (n=766 204), and 21% (n=799 281). Compared with normal people, subjects with hypertension burdens of 1, 2, 3, and 4 were associated with an 8%, 18%, 26%, and 27% increased risk of incident AF, respectively. On semiquantitative analyses with further stratification of stage 1 (systolic BP of 130–139 mm Hg or diastolic BP of 80–89 mm Hg) and stage 2 (systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg) hypertension, the risk of AF increased with the hypertension burden by up to 71%. In this study, both a sustained exposure and the degree of increased BP were associated with an increased risk of incident AF. Tailored BP management should be emphasized to reduce the risk of AF.

Download Full-text

Alla ricerca di una storia dell'ambientalismo italiano: il contributo di Giorgio Nebbia e Franco Pedrotti

SOCIETÀ E STORIA ◽

10.3280/ss2009-124004 ◽

2009 ◽

pp. 303-317

Author(s):

Luigi Piccioni

Keyword(s):

Protected Areas ◽

Environmental History ◽

Scientific Production ◽

Historical Research ◽

World War ◽

Considerable Part ◽

Italian Studies ◽

History Of ◽

First Time ◽

The Relationship

- The birth of Italian environmental history in the late 80s is due to the works and research of professional and non-professional historians. Its recent growth, fed for the first time by young researchers, and its gradual institutionalization could take place neglecting or even ignoring the numerous and sometimes excellent studies published by non-professionals. The cases of the merceologist Giorgio Nebbia and the botanist Franco Pedrotti appear exemplary in this regard. Both of them being eminent scholars in their own fields and pioneers of the italian environmentalist movement, they dedicated a considerable part of their scientific production to historical research. Nebbia has devoted himself to the history of the relationship between society, commodities and natural resources and to the story of "ecological contestation" while Pedrotti has re- searched mainly in the fields of protected areas and in post 2nd World War Italian environmentalism. This essay aims to highlight the contribution given by Nebbia and Pedrotti to Italian studies in the field of environmental history and to the spread of interest in this subject.Parole chiave: Italia; storiografia; storia ambientale; ambientalismo; aree protette; archivi.Key words: Italy; historiography; environmental history; environmentalism; protected areas; archives.

Download Full-text

Human, not too Human: Technology, Rites, and Identity

Open Information Science ◽

10.1515/opis-2018-0015 ◽

2018 ◽

Vol 2 (1) ◽

pp. 189-202

Author(s):

Stefania Operto

Keyword(s):

Social Sciences ◽

Technological Progress ◽

New Technologies ◽

Cultural Models ◽

Conceptual Category ◽

Human Behaviors ◽

The Social ◽

History Of ◽

First Time ◽

The Relationship

Abstract In the social sciences, the term “rite” identifies a set of practices and knowledge that contribute to forming the cultural models of a given society and has the aim of transmitting values and norms, institutionalization of roles, recognition of identity and social cohesion. This article examines the relationship between technology and ritual and the transformations in society resulting from the diffusion of new technologies. Technological progress is not a novelty in human development; though it is the first time in the history of humanity that technology has pervaded the lives of individuals and their relationships. The analyses conducted seem to show that the ritual is not intended to disappear but to change; to change forms and places. Postmodern societies have undergone profound modifications, but the conceptual category of ritual continues to be applicable to many human behaviors and it would be a mistake to support the idea that rituals are weakening.

Download Full-text

Graves’ Hyperthyroidism-Induced Psychosis Treated With Aripiprazole—A Case Report

Journal of Pharmacy Practice ◽

10.1177/0897190012451934 ◽

2012 ◽

Vol 26 (1) ◽

pp. 59-61 ◽

Cited By ~ 4

Author(s):

Livia R. Macedo ◽

Jehan Marino ◽

Brady Bradshaw ◽

Joseph Henry

Keyword(s):

Atrial Fibrillation ◽

Psychiatric Symptoms ◽

Thyroid Stimulating Hormone ◽

Graves Disease ◽

Long Term Effects ◽

Free T4 ◽

History Of ◽

Antithyroid Peroxidase Antibody ◽

First Time

Graves’ disease is an autoimmune syndrome with symptoms such as tachycardia, atrial fibrillation, and psychiatric symptoms. Limited evidence exists for the treatment of Graves’ hyperthyroidism-induced psychosis with atypical antipsychotics. A 47-year-old female with a psychiatric history of bipolar disorder presented for the first time to the psychiatric hospital. She was agitated and grossly psychotic with delusions. Electrocardiogram showed atrial fibrillation and tachycardia. Drug screen urinalysis was negative. Endocrine workup resulted in a diagnosis of Graves’ disease (thyroid-stimulating hormone [TSH]: 0.005 μIU/mL, triiodothyronine [T3]: 537 ng/dL, thyroxine [T4]: 24 mcg/dL, free T4: 4.5 ng/dL, positive antithyroid peroxidase antibody, and antinuclear antibody). Aripiprazole 10 mg daily was initiated and titrated to 15 mg daily on day 4. On day 16, her suspicious behavior, judgment, and insight improved. Other medications given included aspirin 325 mg daily, metoprolol 25 mg twice daily, titrated to 12.5 mg twice daily, and methimazole 30 mg daily, titrated to 20 mg twice daily, and discontinued on day 29. The patient received radioiodine I-131 treatment 1 week later. We report the first known case on the use of aripriprazole to treat Graves’ hyperthyroidism-induced psychosis. Further studies examining the long-term effects and appropriate dose and duration of aripiprazole in this patient population are needed.

Download Full-text

Ulisse Aldrovandi’s Color Sensibility: Natural History, Language and the Lay Color Practices of Renaissance Virtuosi

Early Science and Medicine ◽

10.1163/15733823-02046p04 ◽

2015 ◽

Vol 20 (4-6) ◽

pp. 358-396 ◽

Cited By ~ 2

Author(s):

Valentina Pugliano

Keyword(s):

Natural History ◽

Cultural History ◽

Correct Identification ◽

Unpublished Manuscript ◽

Standard Nomenclature ◽

Natural Knowledge ◽

History Of ◽

Artistic Patronage ◽

First Time ◽

The Relationship

Famed for his collection of drawings of naturalia and his thoughts on the relationship between painting and natural knowledge, it now appears that the Bolognese naturalist Ulisse Aldrovandi (1522–1605) also pondered specifically color and pigments, compiling not only lists and diagrams of color terms but also a full-length unpublished manuscript entitled De coloribus or Trattato dei colori. Introducing these writings for the first time, this article portrays a scholar not so much interested in the materiality of pigment production, as in the cultural history of hues. It argues that these writings constituted an effort to build a language of color, in the sense both of a standard nomenclature of hues and of a lexicon, a dictionary of their denotations and connotations as documented in the literature of ancients and moderns. This language would serve the naturalist in his artistic patronage and his natural historical studies, where color was considered one of the most reliable signs for the correct identification of specimens, and a guarantee of accuracy in their illustration. Far from being an exception, Aldrovandi’s ‘color sensibility’ spoke of that of his university-educated nature-loving peers. 

Download Full-text

12-Month Single-Procedure Outcomes after Atrial Fibrillation Catheter Ablation in Phramongkutklao Hospital: A Single Center 10-Year Experience

Siriraj Medical Journal ◽

10.33192/smj.2021.16 ◽

2021 ◽

Vol 72 (2) ◽

pp. 114-120

Author(s):

Sarawuth Limprasert

Keyword(s):

Atrial Fibrillation ◽

Catheter Ablation ◽

Posterior Wall ◽

Efficacy And Safety ◽

Related Complication ◽

Single Procedure ◽

History Of ◽

Artery Disease ◽

Ischemic Attack ◽

First Time

Objective: This study aimed to report the efficacy and safety of 1-year outcome for single-procedure radiofrequency catheter ablation (RFCA) at Phramongkutklao Hospital. Methods: Review of medical records was carried out on consecutive patients with symptomatic atrial fibrillation (AF) who had undergone first-time RFCA in Phramongkutklao Hospital between January 2009 and December 2018. The efficacy and safety of outcomes after 1 year of RFCA were collected, analyzed, and validated using descriptive data. Results: 61 patients underwent RFCA for the first time. 77.05% were male, with a mean age of 58.31 ± 10.83 years. Paroxysmal AF presented in 65.57%. 49.18% had hypertension, 9.84% had a history of ischemic stroke or transient ischemic attack, 6.56% had diabetes, 6.56% had coronary artery disease, and 4.92% had heart failure. 96.72% of RFCA procedures were performed under local anesthesia and conscious sedation. Pulmonary vein isolation was performed in all patients. Roofline, mitral isthmus line, and posterior wall isolation were created in 27.87%, 13.11%, and 3.28%, respectively. Additional complex fractionated atrial electrograms (CFAEs) were targeted in 19.67%. After 12 months, 45.45% remained in sinus rhythm, with only one patient experiencing a procedure-related complication with cardiac tamponade. Conclusion: The 1-year results of single-procedure RFCA for treating AF at our center, while not highly successful in our first decade, were comparable to other series. Notably, there was a relatively low rate of complications.

Download Full-text