scholarly journals Investigation and Management of COVID-19

2021 ◽  
Author(s):  
Jovana Momic ◽  
Eric Di Gravio ◽  
Thulasie Manokaran ◽  
Ruchi Sharan ◽  
Meera Shah
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Diagnostic Tests ◽  
Clinical Presentation ◽  
Management Strategies ◽  
Hubei Province ◽  
Medical Community ◽  
Unknown Etiology ◽  
Infection Rates ◽  
Test And Treat ◽  
Global Pandemic

In December 2019, an outbreak of viral pneumonia of unknown etiology arose in Wuhan, Hubei Province, China. Eventually isolated and named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), this virus has caused a global pandemic of the pneumonia-like Coronavirus Disease (COVID-19). With global infection rates and deaths mounting, the medical community has been forced to recognize, test, and treat these patients within a rapidly evolving situation and a shortage of resources. In this article, we summarize the most recent data pertaining to the clinical presentation, diagnostic tests, imaging, and management strategies for COVID-19. This article concludes with a discussion of ongoing efforts to develop critically needed therapeutics and vaccines, which may subsequently shape our responses to future pandemics.

scholarly journals Dilated Cardiomyopathy Compatible With Sarcoidosis Presenting with Syncope Due to Torsades de Pointes: a Case Report

2021 ◽  
Vol 34 (1) ◽  
pp. 32-37
Author(s):  
Carollina Fernandes Tinoco ◽  
Nathalia Rodrigues Perrenoud Branca ◽  
Gabriela Domingues Carvalho ◽  
Lívia Silva de Paula Faria ◽  
Erivelton Alessandro do Nascimento
Keyword(s):  
Case Report ◽  
Natural History ◽  
Dilated Cardiomyopathy ◽  
Female Patient ◽  
Diagnostic Tests ◽  
Clinical Presentation ◽  
Cardiac Sarcoidosis ◽  
Torsades De Pointes ◽  
Unknown Etiology ◽  
Granulomatous Disease

Sarcoidosis is a multisystemic noncaseating granulomatous disease of unknown etiology. Cardiac sarcoidosis clinical presentation is diverse, and syncope is one of the possible primary events. Due to its variable natural history and initial presentation associated with lacking sensitive and specific diagnostic tests, it still represents a challenging diagnosis. This article presents the case of a 51-year-old female patient with intermittent syncope events associated with torsades de pointes and dilated cardiomyopathy compatible with sarcoidosis.

COVID-19, the Ubiquitous National Security Threat: Lessons Learned Around the Globe

2021 ◽  
Vol 49 (2) ◽  
pp. 66-79
Author(s):  
Shannon Havlicak Grondel
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
National Security ◽  
Hubei Province ◽  
Lessons Learned ◽  
Small Cluster ◽  
Security Threat ◽  
Global Pandemic

Today is October 1, 2020. In this moment, over 34 million bodies—that we know of—have hosted a deadly virus and more than one million of those bodies have succumbed to the strain of their unwelcome, malignant guest. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—genetically related to, yet different from the coronavirus responsible for the 2003 SARS outbreak—is the virus that causes coronavirus disease 2019 (COVID-19). The virus first materialized in Wuhan, Hubei province, China as early as November 17, 2019, and quickly escalated from a small cluster of cases of what appeared to be pneumonia to a global pandemic by March 11, 2020.

scholarly journals Why the SARS-CoV-2 antibody test results may be misleading: insights from a longitudinal analysis of COVID-19

2020 ◽  
Author(s):  
Jorg Taubel ◽  
Samuel Thomas Cole ◽  
Christopher S. Spencer ◽  
Anne Freier ◽  
Dorothée Camilleri ◽  
...  
Keyword(s):  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Longitudinal Analysis ◽  
Diagnostic Tests ◽  
Antibody Test ◽  
Test Results ◽  
Infection Rates ◽  
Chemiluminescent Microparticle Immunoassay ◽  
Antibody Levels ◽  
Over Time

AbstractTo estimate the effectiveness of vaccines in development, a robust mechanism is required to understand immunity, risks of reinfection and measure the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and how this may change over time. This study is a longitudinal analysis of COVID-19 infection rates using PCR, membrane immunoassay and chemiluminescent microparticle immunoassay (CMIA) diagnostic tests. Our data confirm that antibody levels wane in the three months after symptom onset. Comparison of the three methods used suggests that quantitative CMIA testing may exaggerate numbers of COVID-19 negative individuals.

scholarly journals Focus on the Potential Role of Lung Ultrasound in COVID-19 Pandemic: What More to Do?

2020 ◽  
Vol 17 (22) ◽  
pp. 8398
Author(s):  
Beatrice Ragnoli ◽  
Mario Malerba
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Potential Role ◽  
Lung Ultrasound ◽  
Hubei Province ◽  
Global Pandemic ◽  
The World

COVID-19, a novel severe acute respiratory syndrome (SARS) emerging in China’s Hubei province in late 2019, due to a new coronavirus (SARS-CoV-2), is causing a global pandemic involving many areas of the world, which so far counts more than 43 million cases and more than 1,155,000 deaths worldwide [...]

COVID-19 and our DNA

2020 ◽  
Vol 4 (2) ◽  
pp. 55-58
Author(s):  
Muhammad Aslamkhan
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Hubei Province ◽  
World Health ◽  
Unknown Etiology ◽  
Wuhan City ◽  
Animal Reservoir ◽  
Health Authorities ◽  
Health Organization ◽  
Respiratory Droplets

On December 31st 2019, Chinese Health Authorities in Wuhan city of their Hubei province, diagnosed 29 pneumonia cases of unknown etiology and informed WHO (World Health Organization). The unknown virus resembled SARS (severe acute respiratory syndrome), that occurred in China in November 2002, caused by a novel corona virus spilling over from an animal reservoir and transmitted by respiratory droplets. More than 8000 cases and 774 deaths were caused by SARS and circa US$20 billion coasted for its control.

scholarly journals SARS-Cov-2 and COVID-19, Basic and Clinical Aspects of the Human Pandemic: A Review

2021 ◽  
Author(s):  
Mahdi Zavva ◽  
Hamid Emadi Kochak ◽  
Kamal Abdolmohammadi ◽  
Nesa Rashidi ◽  
Majid Mokhtari ◽  
...  
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Human Disease ◽  
Middle Eastern ◽  
Disease Status ◽  
Medical Community ◽  
Clinical Aspects ◽  
Multidimensional Approach ◽  
Laboratory Methods ◽  
Global Pandemic

In the last two decades, we have witnessed three major epidemics of the coronavirus human disease namely, severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome, and more recently an ongoing global pandemic of coronavirus disease 2019 (COVID-19). Iran, a country of nearly 84 million, in the Middle East, severely involved with the COVID-19 disease. A documented multidimensional approach to COVID-19 disease is therefore mandatory to provide a well-balanced platform for the concerned medical community in our county and beyond. In this review, we highlight the disease status in Iran and attempt to provide a multilateral view of the fundamental and clinical aspects of the disease including the clinical features of the confirmed cases, virology, pathogenesis, epidemiology, and laboratory methods needed for diagnosis.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Clinical Epidemiology of Coronavirus Disease 2019:Defined on Current Research

2020 ◽  
pp. 54-72 ◽  
Author(s):  
Fengyu Zhang ◽  
Claude Hughes
Keyword(s):  
Clinical Presentation ◽  
Population Distribution ◽  
Clinical Epidemiology ◽  
Case Fatality ◽  
Immunological Response ◽  
Prevention Strategies ◽  
Clinical Type ◽  
Global Pandemic ◽  
Potential Therapeutics

Coronavirus disease 2019 (COVID-19) is a new infectious respiratory disease that has caused the ongoing global pandemic. The primary purpose of this article is to describe evolving clinical epidemiology of COVID-19, including 1) infection and testing, 2) clinical spectrum including classification of clinical type, asymptomatic cases, severe cases and comorbidity, and clinical and immunological response, 3) regional variation in clinical presentation, 4) population distribution by age, sex, and occupation, and finally, 5) case-fatality. This content may provide important information on detailed clinical type and presentation of the disease, in which appropriate clinical outcomes can be derived for developing prevention strategies and clinical studies or trials that aim to test potential therapeutics or products for different patient populations.

The Unparalleled Growth of COVID-19 Publications (Preprint)

2020 ◽  
Author(s):  
Paul Fontelo ◽  
Mrigendra Bastola ◽  
Craig Locatis ◽  
Fang Liu
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Evidence Base ◽  
Research Papers ◽  
Global Pandemic ◽  
The Us ◽  
International Collaborative ◽  
Number Of Publications ◽  
Collaborative Publishing

UNSTRUCTURED The global pandemic of COVID-19 has generated an unprecedented number of research papers from clinicians and scientists worldwide. We searched PubMed for articles on coronaviruses from 1970 to June 2020. Surges of publications occurred in 2003 from SARS and, again in 2012 from MERS. Although the name COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was only announced by WHO in February 2020, the number of publications has already exceeded 16000 by June this year. China and the US lead in publications, but a significant number also come from countries hardest hit by the illness. International collaborative publishing is significant. Since these publications are generally free to access worldwide, it provides a rich evidence base for clinicians and scientists combatting the COVID-19 pandemic.

scholarly journals KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients

2021 ◽  
Vol 9 (6) ◽  
pp. 1259
Author(s):  
Carla Prezioso ◽  
Ugo Moens ◽  
Giuseppe Oliveto ◽  
Gabriele Brazzini ◽  
Francesca Piacentini ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthcare Workers ◽  
Respiratory Pathogens ◽  
Threshold Values ◽  
Cycle Threshold ◽  
Viral Interference ◽  
Disease Outcomes ◽  
Global Pandemic ◽  
Wu Polyomavirus ◽  
Washington University

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 healthcare workers not infected by SARS-CoV-2, were collected from March 2020 through May 2020 and tested for KIPyV and WUPyV DNA presence. Of the 112 SARS-CoV-2 positive patients, 27 (24.1%) were co-infected with KIPyV, 5 (4.5%) were positive for WUPyV, and 3 (2.7%) were infected simultaneously by KIPyV and WUPyV. Neither KIPyV nor WUPyV DNA was detected in samples of healthcare workers. Significant correlations were found in patients co-infected with SARS-CoV-2 and KIPyV (p < 0.05) and between SARS-CoV-2 cycle threshold values and KIPyV, WUPyV and KIPyV and WUPyV concurrently detected (p < 0.05). These results suggest that KIPyV and WUPyV may behave as opportunistic respiratory pathogens. Additional investigations are needed to understand the epidemiology and the prevalence of respiratory polyomavirus in COVID-19 patients and whether KIPyV and WUPyV could potentially drive viral interference or influence disease outcomes by upregulating SARS-CoV-2 replicative potential.

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