ANALISA DRUG RELATED PROBLEMS (DRPs) PADA PASIEN CHRONIC KIDNEY DISEASE (CKD) DI INSTALASI RAWAT INAP KLINIK SARI MEDIKA KABUPATEN SEMARANG

Drug Related Problems (DRPs) merupakan kejadian yang tidak diinginkan yang dialami oleh pasien dan berkaitan dengan pengobatan sehingga berpotensi mengganggu keberhasilan terapi. Penelitian ini bertujuan untuk mengetahui dan menganalisa DRPs yang terjadi pada pasien Chronic Kidney Disease (CKD) di instalasi rawat inap klinik Sari Medika kabupaten Semarang. Penelitian ini merupakan penelitian deskriptif dengan pengumpulan data secara retrospektif pada pasien CKD yang diperoleh dari data rekam medis. Pengambilan sampel menggunakan teknik purposive sampling. Acuan yang digunakan pada penelitian ini adalah Pharmacotherapy Handbook 9th edition 2015, Kidney Disease Improving Global Outcomes (KDIGO), The Renal Drug Handbook 3rd edition 2009, Panduan Praktik Klinis & Clinical Pathway Penyakit Jantung, Pembuluh Darah 2016, dan Henry Ford Health System 6th edition 2011. Hasil penelitian yang dilakukan pada 84 pasien CKD menunjukkan bahwa terdapat DRPs pada 66 pasien dengan kategori yaitu indikasi tanpa terapi (30.86%), terapi tanpa indikasi (6.17%), dosis sub terapi (1.23%), dosis obat berlebih (13.58%), pemilihan obat tidak tepat (45.68%), dan penderita gagal menerima obat (2.47%).

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Drug-related problems among chronic kidney disease patients: a clinical pharmacist led study

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.04.017 ◽

2020 ◽

Vol 12 (04) ◽

Cited By ~ 1

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Clinical Pharmacist ◽

Drug Related Problems

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MP403PREVALENCE OF HYPERURICAEMIA WITHIN THE IRISH HEALTH SYSTEM AND RELATIONSHIPS WITH CHRONIC KIDNEY DISEASE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx170.mp403 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii576-iii577

Author(s):

Arunkumar Udayakumar ◽

David Ryan ◽

Xia Li ◽

Fahd Adeeb ◽

Alexander Fraser ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Health System

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HUBUNGAN JENIS KANKER DENGAN FATIGUE PADA PASIEN KEMOTERAPI DI RSUD. ABDUL WAHAB SJAHRANIE SAMARINDA

Jurnal Keperawatan Dirgahayu (JKD) ◽

10.52841/jkd.v2i1.132 ◽

2020 ◽

Vol 2 (1) ◽

pp. 1-8

Author(s):

Bonifasius Hat ◽

Rufina Hurai

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Self Care ◽

P Value ◽

Test Design ◽

Purposive Sampling ◽

Post Test

Chronic Kidney Disease merupakan gangguan fungsi ginjal yang progresif dan ireversibel, salah satu penanganannya dengan hemodialisa, keluhan yang sering pada pasien hemodialisa adalah kelelahan. Tujuan penelitian ini melihat pengaruh edukasi berbasis self care terhadap perubahan tingkat kelelahan pada pasien hemodialisa, merupakan penelitian kuantitatif dengan metode kuasi eksperimen pre post test design di RSUD A. Wahab Sjahranie periode Mei-Juni 2017, pengambilan sampel dilakukan dengan cara purposive sampling melibatkan 111 responden yang dibagi menjadi 2 kelompok intervensi edukasi berbasis self care 83 orang dan kelompok kontrol 28 orang. Hasil penelitian ini didapatkan setelah dilakukan intervensi selama 6 minggu, Uji Beda Berpasangan Non Parametrik Independent menunjukan bahwa nilai Asymp Sig (2 tailed) = 0,000 atau p-value < 0,05 ada pebedaan tingkat kelelahan antara kelompok intervensi terhadap kelompok kontrol, nilai OR menunjukkan kelompok intervensi edukasi berbasis self care memiliki kecenderungan mengalami perubahan tingkat kelelahan 1,22 kali lebih besar dibandingkan dengan kelompok kontrol. Pada analisis uji logistik ordinal hasil menunjukkan nilai p = 0,00 atau p-value <0,05 ada pengaruh yang signifikan intervensi edukasi berbasis self care yang diberikan terhadap perubahan tingkat kelelahan. Simpulan penelitian edukasi berbasis self care mempunyai pengaruh terhadap perubahan tingkat kelelahan dan direkomendasikan intervensi ini dapat diaplikasikan sebagai salah satu edukasi yang diberikan pada pasien menjalani hemodialisa

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SO081LITHIUM EXPOSURE AND OCCURENCE OF CHRONIC KIDNEY DISEASE IN THE IRISH HEALTH SYSTEM: A COHORT STUDY

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa139.so081 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Mark Behan ◽

Leonard Browne ◽

Stack Austin

Keyword(s):

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Linear Regression ◽

Health System ◽

Multiple Linear Regression ◽

Kidney Function ◽

Ckd Progression ◽

Duration Of Treatment

Abstract Background and Aims Lithium is implicated as a causative factor in the development and progression of chronic kidney disease (CKD). Few studies have assessed the independent impact of plasma levels and duration of lithium therapy on CKD progression. We examined the influence of lithium on CKD progression in the Irish health system. Method We utilised data from the Irish Kidney Disease Surveillance System (IKDSS) to explore associations of lithium levels and duration of exposure with kidney function in a regional cohort. A retrospective cohort study was conducted between 1999 to 2014 from the Midwest Region. All adult patients with lithium levels were identified and followed longitudinally. Kidney function was assessed at baseline and longitudinally using serum creatinine and estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI. Patients with < 2 lithium values, missing data on creatinine were excluded. The index date was the date of the first lithium blood test. Toxicity from lithium was defined as levels >1.2mmol/L as per NICE guidelines while duration of treatment was calculated based on patient –years of exposure as determined by positive blood lithium levels. Relationships between baseline kidney function, lithium levels, duration of exposure and each patients most recent eGFR value on follow up were assessed using multiple linear regression Results We identified 1,978 patients exposed to lithium from 1999-2014, mean age was 47.4 (15.6), 45.1% were men, eGFR [median (IQR)] at baseline was 84.4 (32.1) ml/min1.73m and the median duration of exposure was 3.0 years (IQR=4 years). Frequency of lithium testing increased from 1.77 in 1999 to 2.66 in 2014. In multiple linear regression, the final eGFR on follow-up was significantly lower in older patients (-0.48 ml/min/1.73m per year increase in age), P<0.001; in patients with elevated baseline lithium levels (-2.18 ml/min1.73m lower per unit increase), P<0.05, with long duration of exposure (-1.42 ml/min/1.73m lower for each year on lithium), P<0.001, and for patients with low GFR at baseline (P<0.001). Together these variables explained 58% of the variation in the final model. Conclusion Both the magnitude of and the duration of lithium exposure are both independently associated with CKD progression among lithium users in the Irish health system. Higher baseline lithium values had a more deleterious impact on kidney function. Continued efforts should be expended in minimising the risks of lithium induced nephrotoxicity through switching to alternatives and dose reduction when over possible. Funding This study is funded by the Health Research Board and the Midwest Research and Education Foundation (MKid).

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Pharmacotherapy assessment in chronic kidney disease: validation of the pair instrument for use in Brazil

Brazilian Journal of Nephrology ◽

10.1590/2175-8239-jbn-2019-0205 ◽

2020 ◽

Author(s):

Alessandra Batista Marquito ◽

Hélady Sanders Pinheiro ◽

Natália Maria da Silva Fernandes ◽

Rogério Baumgratz de Paula

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Clinical Judgment ◽

Medical Records ◽

Chronic Renal Disease ◽

Drug Related Problems ◽

Longitudinal Observational Study ◽

Clinically Significant ◽

Validated Instrument ◽

Level Of Agreement

Abstract Individuals with chronic kidney disease (CKD) use polypharmacy, which, in combination with renal impairment, exposes them to the risk of drug-related problems (DRPs). There are no available tools in Brazil to systematically assess the pharmacotherapy and management of DRPs in this population. Therefore, the objective of this work was to validate the PAIR instrument (Pharmacotherapy Assessment in Chronic Renal Disease) for use in Brazilian Portuguese. This is a retrospective longitudinal observational study. Medical records from 100 CKD patients under conservative treatment, between 2016 and 2017, in a nephrology clinic, were analyzed. PAIR was applied by pharmacists in two consultations of the same patient, with an interval of 6 months. Reliability, conceptual validity, responsiveness of the instrument and prevalence of DRPs in the studied sample were assessed. A mean of 1.26 ± 0.96 DRPs/patient was identified. Inter-rater reliability coefficients (k) ranged from 0.58 to 0.94 and from 0.79 to 1.00 for test-retest, revealing moderate to perfect level of agreement. In conceptual validity, a mean of 1.60 ± 1.24 DRPs/patient was identified by the nephrologist through clinical judgment, compared to 1.33±0.76 DRPs/patient identified by the pharmacist using PAIR (p = 0.07). Therefore PAIR allowed the identification of clinically significant DRPs. In responsiveness, a mean of 1.26 ± 0.96 DRPs/patient was identified at the first consultation and 1.11 ± 1.02 DRPs/patient at the subsequent consultation (p = 0.17) by the pharmacist using PAIR. The number of DRPs between the periods did not change. As a conclusion, the PAIR allowed the identification of clinically significant DRPs in CKD, constituting a new validated instrument to be used in Brazil.

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HUBUNGAN LAMANYA MENJALANI HEMODIALISIS DENGAN TINGKAT KECEMASAN PADA PASANGAN HIDUP PASIEN YANG MENDERITA PENYAKIT GINJAL KRONIK DI RSUP PROF. Dr. R. D. KANDOU MANADO

e-CliniC ◽

10.35790/ecl.3.1.2015.6825 ◽

2015 ◽

Vol 3 (1) ◽

Author(s):

Ainivi F. Tangian ◽

L. F. J. Kandou ◽

Herdy Munayang

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Severe Disease ◽

Anxiety Level ◽

Chi Square ◽

Cognitive Changes ◽

Cross Sectional ◽

Probability Sampling ◽

Purposive Sampling ◽

Life Threatening

Abstract: Anxiety is defined as a prolonged response to unexpected threats, which include physiological responses, affective, and cognitive changes. Anxiety will appear in families where one member of the family is ill and requires hospitalization. Severe disease especially life threatening can cause anxiety, rejection and anger. The purpose of this research is to know the relationship between the duration of having hemodialysis and the anxiety level of partners ofpatients who suffer from chronic kidney disease at the Prof. dr. R.D. Kandou Manado Hospital. This research has descriptive analytic type with cross-sectional approach. Samples in this study were 34 spouses. This study used Non Probability Sampling with Purposive Sampling. The results showed that anxiety did not occur at 19 respondents (55%). The result of Chi-square correlation test was a value of Sig. 0.064 (P > 0.05) which meant there was no siginificant relationship. Therefore, H0 was approved and H1 was rejected. Conclusion: There was no relationship between the duration of having hemodialysis and the anxiety level of partners of the patients who suffered from chronic kidney disease at the Prof. dr. R.D. Kandou Manado Hospital.Keywords: anxiety, partners of hemodialysis patients, chronic kidney disease, hemodialysisAbstrak: Kecemasan didefinisikan sebagai respon yang berkepanjangan terhadap ancaman yang tak terduga, responyang meliputi fisiologis, afektif, dan perubahan kognitif. Kecemasan akan muncul pada keluarga yang salah satu anggota keluarganya sedang sakit dan memerlukan perawatan di rumah sakit. Penyakit yang berat terutama yang mengancam kehidupan, dapat menimbulkan kecemasan, penolakan, dan marah.Penelitian ini bertujuan untuk mengetahui hubungan lamanya menjalani hemodialisis dengan tingkat kecemasan pada pasangan hidup pasien yang menderita penyakit ginjal kronik di RSUP Prof dr. R. D. Kandou Manado. Penelitian ini bersifat deskriptif analitik dengan pendekatan potong lintang.Jumlah sampel dalam penelitian ini sebanyak 34 pasangan hidup.Sampling yang digunakan adalah Non Probability Sampling dengan metode purposive sampling. Hasil penelitian sebagian besar yaitu 19 responden (55,9%) tidak mengalami kecemasan. Hasil uji korelasi Chi-square adalah nilai Sig. sebesar 0,064. Penggunaan signifikansi α = 5% (0,05), maka nilai p = 0,064 > 0,05 yang berarti tidak ada hubungan yang bermakna. Dapat disimpulkan H0 diterima dan H1 ditolak yang berarti tidak ada hubungan lamanya menjalani hemodialisis dengan tingkat kecemasan pada pasangan hidup pasien yang menderita penyakit ginjal kronik di RSUP Prof dr. R. D. Kandou Manado.Kata kunci: kecemasan, pasangan hidup, penyakit ginjal kronik, hemodialisis

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Efikasi Diri Dan Dukungan Sosial Pasien Hemodialisa Dalam Meningkatkan Kepatuhan Pembatasan Cairan

Faletehan Health Journal ◽

10.33746/fhj.v5i1.7 ◽

2018 ◽

Vol 5 (1) ◽

pp. 39-48

Author(s):

Ela Susilawati ◽

Kamaluddin Latief ◽

K Khomarudin

Keyword(s):

Social Support ◽

Chronic Kidney Disease ◽

Mixed Methods ◽

Kidney Disease ◽

Self Efficacy ◽

Perceived Social Support ◽

Purposive Sampling ◽

Sequential Explanatory

Peningkatan berat badan intradialitik akibat ketidakpatuhan asupan cairan pasien yang menjalani hemodialisa berdampak pada terjadinya penumpukan cairan secara kronis dan berisiko terhadap gangguan pada kardiovaskuler dan hipertensi, serta meningkatkan mortalitas dan morbiditas pada pasien dengan gagal ginjal kronik. Dukungan sosial menjadi salah satu faktor yang mendukung kepatuhan pasien dalam menjalankan terapi. Penelitian ini menggunakan rancangan mixed methods dengan desain sequential explanatory. Populasi dalam penelitian ini adalah seluruh pasien gagal ginjal kronik yang menjalani hemodialisa di RSU Kabupaten Tangerang. Jumlah sampel kuantitatif dipilih menggunakan tehnik total sampling sebanyak 76 orang dan jumlah sampel kualitatif diambil secara purposive sampling sebanyak 6 orang. Pengumpulan data dilakukan dengan Chronic Kidney Disease Self-Efficacy Instrument dan Multidimentional Scale Perceived Social Support, serta wawancara. Analisis data kuantitatif dengan analisis deskriptif dan korelasi pearson. Analisis data kualitatif menggunakan teknik analisis model Miles dan Huberman. Hasil Uji korelasi Pearson, ada hubungan antara efikasi dan dukungan sosial dengan kepatuhan pembatasan cairan (r=0.476 p= 0.001) dan (r=0.308 p= 0.007). Berdasarkan hasil wawancara mendalam didapatkan bahwa rasa haus menjadi penyebab ketidakpatuhan menjalankan program pembatasan asupan cairan. Diharapkan rumah sakit memberikan ruang khusus kepada keluarga pasien dan perawat memberi motivasi yang tinggi kepada pasien dalam menjalankan regimen terapinya.

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