scholarly journals Significance of endometrial dysfunction markers in the pathogenesis of chronic endometritis in women with reproductive losses

2021 ◽  
Vol 20 (5) ◽  
pp. 82-89
Author(s):  
A. E. Esedova ◽  
M. A. Idrisova ◽  
A. M. Gadzhieva
Keyword(s):  
Immune System ◽  
Reproductive Function ◽  
Infectious Agent ◽  
Modern Society ◽  
Diagnostic Methods ◽  
Social Significance ◽  
Scientific Publications ◽  
Chronic Endometritis ◽  
Reproductive Losses ◽  
High Level

Introduction. A review of the literature considering the problem of reproductive health against the background of chronic endometritis is presented. According to the literature, in the etiology and pathogenesis of infertility and habitual miscarriage, the main cause is the «uterine factor» (24-62%). Chronic inflammation in the uterine mucosa can lead to infertility, which increases the significance of this pathology. It is proved that most often the causative agents of this disease are representatives of conditionally pathogenic microflora. Chronic endometritis is an unexplored pathology associated with unfavorable reproductive outcomes, such as unsuccessful implantation and repeated miscarriage. Most scientists assume that inflammation develops against the background of a long-term persistence of an infectious agent. According to other scientists, the cause of the occurrence and development of chronic endometritis is an autoimmune process that contributes to the progression of inflammation. The article describes the mechanisms of impaired receptivity, endometrial microcirculation and changes in the ratio of cells of the immune system. In this article, we aim to give an overview of the diagnosis, etiology, pathophysiology and treatment of chronic endometritis, its effect on endometrial receptivity and its relationship with reproductive dysfunction.The aim of the study is to identify the main discussed aspects of the management of patients with chronic endometritis, to determine promising diagnostic methods.Materials and methods. The analysis and systematization of the data were carried out on the basis of scientific publications in the common database of Cyberleninka and PubMed.Results and Discussions. The article discusses the methods of laboratory, ultrasound and instrumental diagnostics used in Russia and abroad. The» gold standard « of diagnostics is a histological examination of the endometrial tissue material on the 7th10th day of the menstrual cycle. The article describes the mechanisms of impaired receptivity, endometrial microcirculation and changes in the ratio of cells of the immune system.Conclusion. Chronic endometritis remains an important problem in modern society, as it has a social significance: the frequency of reproductive losses is at a high level. There is a need to further study the features of the etiology and pathogenesis of chronic endometritis in order to improve the presentation of the course of the inflammatory process and improve the methods of therapy and prevention of this disease for the realization of reproductive function.

COMMUNITY-ACQUIRED PNEUMONIA AS AN URGENT PROBLEM OF MODERN SOCIETY

2021 ◽  
pp. 57-70
Author(s):  
V.A. Serov ◽  
V.V. Gnoevykh ◽  
D.V. Serova ◽  
E.R. Sakaeva
Keyword(s):  
Respiratory Diseases ◽  
Kidney Injury ◽  
Modern Society ◽  
Community Acquired Pneumonia ◽  
Preventive Health ◽  
Health Messages ◽  
Diagnostic Methods ◽  
Economic Significance ◽  
Treatment And Prevention ◽  
High Level

Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality worldwide. However, there are still many unresolved issues in prevention, diagnosis and treatment of the disease despite its enormous social and economic significance. Mortality associated with CAP in elderly patients is increasing, as the proportion of people over 65 is growing every year. The purpose of this review is to consider the most significant issues in CAP diagnostics and treatment, that will improve the quality of medical care and prognosis of CAP patients. Data from Pubmed, eLIBRARY, and other sources were used to collect the information. The lack of an adequate etiological diagnosis of bacterial CAP has led to unjustified antibacterial therapy, which contributes to the spread of antibiotic-resistant strains of microorganisms and increase in side effects of antibiotics. During COVID-19 pandemic, it has become even more difficult etiologically to diagnose infectious respiratory diseases. The lack of knowledge about the peculiarities of managing patients with comorbid pathology has become more evident. Everyone has understood that the severity of bronchopulmonary diseases was underestimated by the population. Acute kidney injury (AKI) is one of the most formidable CAP complications. The authors describe pathogenetic mechanisms of renal dysfunction, diagnostic methods, AKI treatment and prevention in patients with CAP. Underestimation of the forecast severity, both medium-term and long-term, in patiemts with CAP leads to an insufficiently high level of immunization against influenza and pneumococcus. The authors declare that it is desirable to pay much attention to preventive health messages not only relating to cardiovascular or oncological diseases, but also infectious respiratory diseases. Keywords: community-acquired pneumonia, microbiological diagnostics, comorbidity, preventive health messages. Внебольничная пневмония (ВП) является одной из главных причин заболеваемости и смертности населения во всем мире. Однако несмотря на огромную социально-экономическую значимость этой патологии остается большое количество нерешенных вопросов по профилактике, диагностике и лечению данного заболевания. Особую тревогу вызывает увеличение смертности от ВП у пациентов пожилого возраста, так как во всех развитых странах удельный вес лиц старше 65 лет с каждым годом растет. Целью настоящего обзора является рассмотрение наиболее значимых проблем диагностики и лечения ВП, решение которых позволит повысить качество оказания медицинской помощи и улучшить прогноз пациентов с ВП. В качестве источников информации использовались данные электронных библиотек Pubmed, eLIBRARY и др. Отсутствие адекватной этиологической диагностики бактериальной ВП привело к серьезной опасности необоснованной антибактериальной терапии, которая способствует распространению антибиотикорезистентных штаммов микроорганизмов и росту частоты побочного действия антибиотиков. В период коронавирусной пандемии особенно ярко проявились трудности этиологической диагностики инфекционных заболеваний дыхательных путей, недостаточность знаний об особенностях ведения больных с коморбидной патологией, недооценка населением серьезности бронхолегочных заболеваний. Одним из наиболее грозных осложнений ВП является острое повреждение почек (ОПП). Авторы описывают патогенетические механизмы нарушения функции почек, методы диагностики, тактику лечения и профилактики ОПП при ВП. Недооценка серьезности прогноза, в т.ч. средне- и долгосрочного, при ВП ведет к недостаточно высокому уровню использования вакцин против гриппа и пневмококка. Обращает на себя внимание необходимость усиления санитарно-просветительской работы с населением в отношении не только сердечно-сосудистых или онкологических заболеваний, но и инфекционных заболеваний дыхательных путей. Ключевые слова: внебольничная пневмония, микробиологическая диагностика, коморбидность, санитарное просвещение.

Rehabilitation of reproductive function in women with chronic endometritis

2015 ◽  
Vol 98 (2) ◽  
pp. 94-96
Author(s):  
V.I. Pirogova ◽  
◽  
I.V. Kozlowski ◽  
Keyword(s):  
Reproductive Function ◽  
Chronic Endometritis

scholarly journals METHODS OF FORMING MATHEMATICAL MOBILITY OF FUTURE ENGINEERS IN HIGHER MATHEMATICS CLASSES

2021 ◽  
Vol 1 ◽  
pp. 270-281
Author(s):  
Irina Khomyuk ◽  
Svetlana Kyrylashchuk ◽  
Victor Khomyuk ◽  
Zlata Bondarenkо ◽  
Iryna Klieopa
Keyword(s):  
Higher Education ◽  
Readiness To Change ◽  
Modern Society ◽  
Educational Activity ◽  
Interactive Methods ◽  
Professional Activity ◽  
Professional Mobility ◽  
Education Today ◽  
High Level ◽  
Education Process

Continuous education today is a major feature of modern society. In order to ensure the competitiveness of future professionals who obtain higher education within the walls of the Institutions of Higher Education, the education process should be aimed at ensuring a high level of professional knowledge as well as the formation of graduates' adaptability to changeable modern production.  Since for a future engineer knowledge of higher mathematics is the basis for solving complex problems of a production nature, it can be argued that they are part of professional mobility. The implementation of technologies for the formation of professional mobility in higher mathematics has made it possible to note that the readiness to change activities can be considered not only in the context of changing professional activity, but also in the process of students’ educational activity. And this, in turn, made it possible to determine the «mathematical mobility». The purpose of the article is to theoretically substantiate and practically test the methods of forming mathematical mobility of future engineers in higher mathematics classes. The experiment used competency-oriented tasks, test tasks in higher mathematics, built on the basis of Bloom's taxonomy, developed interactive methods for conducting practical classes in the process of studying higher mathematics. The results of the experiment showed the effectiveness of the proposed innovative technologies in the process of fundamental training of future engineers.  

scholarly journals Features of the histological structure of the placenta in women with recurrent miscarriage depending on polymorphic variants of the metalloproteinase and hemostasis systems

2020 ◽  
Vol 17 (2) ◽  
pp. 158-169
Author(s):  
T. N. Grinevich ◽  
S. A. Lyalikov ◽  
V. A. Basinsky ◽  
T. T. Shtabinskaya ◽  
C. M. Butolina ◽  
...  
Keyword(s):  
Comparison Group ◽  
Recurrent Miscarriage ◽  
Morphological Characteristics ◽  
Reproductive Function ◽  
Placental Tissue ◽  
Histological Structure ◽  
Chorionic Villi ◽  
Intervillous Space ◽  
Reproductive Losses ◽  
Polymorphic Variants

The article is devoted to the analysis of the morphological characteristics of placental tissue in women with early reproductive losses with recurrent miscarriage, depending on the presence of polymorphic variants of metalloproteinases and hemostasis. It was established that in women with recurrent miscarriage, the area of the trophoblast of the placenta is significantly larger (р < 0.003), the area of the chorionic villi is smaller (р < 0.04) than in the group of women with implemented reproductive function. Thrombosis of the chorionic vessels, necrosis and calcinates in the placenta with PNF were detected in 80.0 % (р = 0.001), 93.3 % (р = 0.001), and 30.0 % (р = 0.049) of cases, respectively, which is significantly higher than in the comparison group. In patients with PNP with the T/T genotype of the 735 C/T polymorphism of the MMP-2 gene, the trophoblast area is significant (р < 0.05) more than with the C/C genotype, acute full-back (р = 0.02) and intervillous hemorrhage (р = 0.02). In women with the C/T genotype of the polymorphism 735 C/T of the MMP-2 gene, edema and dystrophic changes in the chorionic villi, placental necrosis are determined more often (р = 0.02) than with the C/C genotype. In carriers of the T allele of the polymorphism 735 C/T of the MMP-2 gene in the placenta, necrosis is significantly more common than in the CC genotype; the carriage of the T allele is also associated with large values of the relative area of the trophoblast and the stromal-intervillous relation, as well as with a smaller value of the ratio of the intervillous space area to the total area of the photograph.

scholarly journals Features of the use of additive technologies in operative orthopaedics

TRAUMA ◽  
2021 ◽  
Vol 22 (3) ◽  
pp. 12-19
Author(s):  
A.N. Kosiakov ◽  
A.Ye. Loskutov ◽  
K.A. Hrebennikov ◽  
A.V. Miloserdov ◽  
Ye.M. Fedin ◽  
...  
Keyword(s):  
Diagnostic Procedures ◽  
Physical Object ◽  
Additive Technologies ◽  
Diagnostic Methods ◽  
High Tech ◽  
Current State ◽  
Wide Range ◽  
Standard Tool ◽  
Level Of Training ◽  
High Level

Background. Additive technologies are increasingly making their way from university laboratories and high-tech industries into routine clinical practice and even into our everyday lives. Any enthusiast, having a PC and a 3D printer at his or her disposal, can create any physical object — from children’s toys to works of art. The presence on the market of a wide range of software pro-ducts, equipment, and consumables along with the data from mo-dern diagnostic methods, a high level of training and cooperation between doctors and engineers provide practical medicine with unprecedented opportunities. We are finally able to fully customize our treatment and diagnostic procedures: to perform precise preoperative planning; to draw up a detailed plan of the operation; to rehearse the intervention on full-scale anatomical prototypes using a standard tool; to conduct the surgery as quickly and atraumatically as possible; to minimize risks; to ensure the optimal functional result and to manufacture and install customized implants in the most difficult cases. The purpose was to draw the attention of our distinguished colleagues to the aspects of application of additive technologies in modern orthopaedic practice, to introduce them into the history and current state of medical prototyping, as well as to share technological nuances with them. Materials and methods. While writing this article, we incorporated the data of recent publications in specialized domestic and foreign periodicals, several monographs, materials from thematic conferences, the results of informal conversations with colleagues in the operating rooms, at the computer and production site, as well as our own experience (over 200 cases of prototyping). Conclusions. The availability of equipment, software, and consumables allows for the introduction of additive technology into the everyday practice of nearly every modern orthopaedic and trauma clinic.

scholarly journals ACADEMIC SUCCESS IN THE CONTEXT OF COMPETENCE APPROACH

1970 ◽  
Vol 15 (1) ◽  
Author(s):  
Liudmyla M. Dybkova
Keyword(s):  
Academic Success ◽  
Modern Society ◽  
Innovative Approach ◽  
Educational Activity ◽  
Educational Achievements ◽  
Methods Of Evaluation ◽  
Cultural Processes ◽  
On Line ◽  
High Level ◽  
Political Economic

The article is devoted the problem of evaluation of results of students educational activity in the context of competence approach. Research actuality is conditioned by socio-political, economic and cultural processes which take place in modern society under act of globalization. These processes require from the system of education an innovative approach in preparation of future specialists. Students acquisition of high level competences, selected in the on-line training in preparation for the proper speciality, will provide them with permanent update of knowledges, succesful finding of decisions for problem tasks, independence, selfefficiency while implementation of their professional duties. Existent forms and methods of evaluation of educational achievements are complemented and approved within the framework of the competence approach.

scholarly journals SCREENING INVESTIGATION OF DISTRIBUTION OF MOOD DISORDERS IN ADOLESCENCE AND PECULIARITIES OF THEIR CURRENCY

2019 ◽  
Vol 72 (9) ◽  
pp. 1795-1801
Author(s):  
Larysa V. Pypa ◽  
Yulia N. Lysytsia ◽  
Ruslan V. Svistilnik ◽  
Maryna M. Murhina
Keyword(s):  
Aggressive Behavior ◽  
Mood Disorders ◽  
Depressive Disorders ◽  
Severe Depression ◽  
Self Esteem ◽  
Social Adaptation ◽  
Educational Institutions ◽  
Social Significance ◽  
Personal Anxiety ◽  
High Level

Introduction:. The problem of mood disorders in adolescents has recently become acute due to the high frequency of encounter and social significance. The aim: To investigate the screening of anxiety and depressive disorders and their manifestations in adolescent children to determine risk factors and to develop measures for their prevention. Materials and methods: The study was attended by 189 students aged 16-17 years of the educational institutions of the Khmelnytskyi region. For study it was used: Spielberger questionnaire in adaptation A. Andreeva and questionnaire for child depression M. Kovacs, 1992. Results: A high level of personal anxiety was detected in 44 adolescents (23,3%) and situational in 76 (40,2%) adolescents. In 48 (25,4%) adolescents there were signs of depression, in 11 (5,8%) - severe depression. The level of depression in girls was significantly higher compared to boys (95% CI, 2,6-8,8) (p<0,0004), which was manifested in the form of aggressive behavior (95% CI, 3,3-9,4) (p<0,0001) and anhedonia (95% CI, 1,7-7,0) (p<0,001). Signs of depression more often were appeared in adolescents who had an incomplete family (95% CI, 0,7-8,5) (p<0,02) and manifested in the form of aggressive behavior (95% CI, 0,6 (p<0,02), anhedonia (95% CI, 0,7-7,3) (p<0,01) and negative self-esteem with the presence of suicidal thoughts (95% CI, 0,3-7,5) (p<0,03). Conclusions: Mood disorders are quite common among adolescents and require timely detection and correction in order to improve their social adaptation and prevent suicidal behavior. The main factors of mood disorders in adolescents can be an incomplete family and a female.

scholarly journals Letterpress Reproduction——Information Visualization Design

2021 ◽  
Vol 236 ◽  
pp. 05079
Author(s):  
Li AnDong ◽  
Fang JianJun
Keyword(s):  
New Media ◽  
Digital Media ◽  
Information Visualization ◽  
Rapid Development ◽  
Modern Society ◽  
Letterpress Printing ◽  
Visualization Design ◽  
Modern Application ◽  
High Level ◽  
Visual Reading

At present, with the rapid development of society, digital media has become the mainstream of vision. Digital vision makes people form a new reading form of “Super-Attention”. The visual performance of letterpress printing conforms to this new form of visual reading very well. It is different from the tactile feeling of ordinary printing that further packages and shapes the original information and improves the expectation of information interpretation and experience to a high level. At the same time, the manual culture highlighted by letterpress printing is also one of the best means to cushion the tension of inconsistent technology and culture in modern society. We don't know the result of the confrontation between paper and digital media, but letterpress printing in digital society has shown its unique “Paper-Based” feelings. Through detailed analysis of the historical evolution of letterpress printing, the comparison between traditional letterpress printing and modern letterpress printing, this paper presents clearly the development of letterpress printing for readers, so that readers can truly understand this unique traditional process; and then it elaborates on the application of modern letterpress in creative products and the development status quo of modern letterpress at home and abroad. This paper probes into how to popularize the new nirvana letterpress once again, thus providing a set of modern application attempt of letterpress printing - Rejuvenation of Letterpress information visualization design, and from practice, looking for letterpress regeneration after integrating new design ideas in the new media era.

scholarly journals A look at the problem of exposure of the population caused by X-ray diagnostics: approaches to analysis and forecasting

2021 ◽  
Vol 26 (4) ◽  
pp. 166-173
Author(s):  
A.I.  Sevalnev ◽  
A.V. Kutsak ◽  
L.P. Sharavara ◽  
Yu.V. Volkova
Keyword(s):  
Practical Interest ◽  
The State ◽  
Diagnostic Methods ◽  
Model Data ◽  
Scientific Publications ◽  
Dose Load ◽  
X Ray ◽  
Different Types ◽  
Medical Exposure ◽  
Radiological Studies

The article is devoted to the analysis of limitation of dose load on the population as a result of radiological researches. It is especially actual and represents rather high scientific and practical interest. In this regard, it is very important to have information about the state of the dose load of the population in separate regions and to rank types of diagnostics by the amount of their contribution to the total dose of medical exposure. The aim of the work was to study the state of dose load of the population of Zaporizhzhia region due to X-ray diagnostics, to develop approaches to analysis and forecasting regarding its limitation. Analytical, statistical calculation and logical generalization methods were used in the course of the work. We used the results of studies carried out in accordance with the regional “Program for the Protection of the Population of Zaporizhzhia Region from the Effect of Ionizing Radiation. The authors analyzed scientific publications (15 sources), including 9 Ukrainian and 6 foreign on the relevance of the problem of exposure of the population caused by X-ray diagnostics. The analysis of the results allowed to determine that in 2010-2014 the radiation dose of the population of Zaporizhzhia region due to X-ray diagnostics averaged 0.92 mSv year-1, in 2015-2016 the dose increased and amounted to 0.96 mSv year-1. The proposed approach to the analysis makes it possible to summarize and model data on radiological studies of the population over a long period of time, to identify persistent trends in the contribution of different types of radiation diagnostics to the dose of medical radiation. All this is necessary for the development, first of all, of measures to reduce the frequency of radiography, its replacement by other diagnostic methods. Priority tasks aimed at reducing the dose load of the population due to X-ray examinations are proposed.

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