Experimental Investigation on the Mechanical Behavior of Polyurethane PICCs after Long-Term Conservation in in Vivo-Like Conditions

2017 ◽  
Vol 18 (6) ◽  
pp. 522-529 ◽  
Author(s):  
Francesca Di Puccio ◽  
Giuseppe Gallone ◽  
Andrea Baù ◽  
Emanuele M. Calabrò ◽  
Simona Mainardi ◽  
...  
Keyword(s):  
Mechanical Behavior ◽  
Mechanical Response ◽  
Tensile Tests ◽  
Ethanol Solution ◽  
Uniaxial Tensile ◽  
Research Activity ◽  
Two Fluids ◽  
Weight Variation

Introduction In a previous paper, the authors investigated the mechanical behavior of several commercial polyurethane peripherally inserted central venous catheters (PICCs) in their ‘brand new’ condition. The present study represents a second step of the research activity and aims to investigate possible modifications of the PICC mechanical response, induced by long-term conservation in in vivo-like conditions, particularly when used to introduce oncologic drugs. Methods Eight 5 Fr single-lumen catheters from as many different vendors, were examined. Several specimens were cut from each of them and kept in a bath at 37°C for 1, 2, 3 and 6 months. Two fluids were used to simulate in vivo-like conditions, i.e. ethanol and Ringer-lactate solutions, the first being chosen in order to reproduce a typical chemical environment of oncologic drugs. The test plan included swelling analyses, uniaxial tensile tests and dynamic mechanical thermal analysis (DMTA). Results and conclusions All tested samples were chemically and mechanically stable in the studied conditions, as no significant weight variation was observed even after six months of immersion in ethanol solution. Uniaxial tensile tests confirmed such a response. For each PICC, very similar curves were obtained from samples tested after different immersion durations in the two fluid solutions, particularly for strains lower than 10%.

Dependence of Mechanical Behavior of the Murine Tail Disc on Regional Material Properties: A Parametric Finite Element Study

2005 ◽  
Vol 127 (7) ◽  
pp. 1158-1167 ◽  
Author(s):  
Adam H. Hsieh ◽  
Diane R. Wagner ◽  
Louis Y. Cheng ◽  
Jeffrey C. Lotz
Keyword(s):  
Finite Element ◽  
Mechanical Behavior ◽  
Nucleus Pulposus ◽  
Material Properties ◽  
Mechanical Response ◽  
Swelling Pressure ◽  
Transient Behavior ◽  
Sensitivity Analyses ◽  
Intact Mouse

In vivo rodent tail models are becoming more widely used for exploring the role of mechanical loading on the initiation and progression of intervertebral disc degeneration. Historically, finite element models (FEMs) have been useful for predicting disc mechanics in humans. However, differences in geometry and tissue properties may limit the predictive utility of these models for rodent discs. Clearly, models that are specific for rodent tail discs and accurately simulate the disc’s transient mechanical behavior would serve as important tools for clarifying disc mechanics in these animal models. An FEM was developed based on the structure, geometry, and scale of the mouse tail disc. Importantly, two sources of time-dependent mechanical behavior were incorporated: viscoelasticity of the matrix, and fluid permeation. In addition, a novel strain-dependent swelling pressure was implemented through the introduction of a dilatational stress in nuclear elements. The model was then validated against data from quasi-static tension-compression and compressive creep experiments performed previously using mouse tail discs. Finally, sensitivity analyses were performed in which material parameters of each disc subregion were individually varied. During disc compression, matrix consolidation was observed to occur preferentially at the periphery of the nucleus pulposus. Sensitivity analyses revealed that disc mechanics was greatly influenced by changes in nucleus pulposus material properties, but rather insensitive to variations in any of the endplate properties. Moreover, three key features of the model—nuclear swelling pressure, lamellar collagen viscoelasticity, and interstitial fluid permeation—were found to be critical for accurate simulation of disc mechanics. In particular, collagen viscoelasticity dominated the transient behavior of the disc during the initial 2200s of creep loading, while fluid permeation governed disc deformation thereafter. The FEM developed in this study exhibited excellent agreement with transient creep behavior of intact mouse tail motion segments. Notably, the model was able to produce spatial variations in nucleus pulposus matrix consolidation that are consistent with previous observations in nuclear cell morphology made in mouse discs using confocal microscopy. Results of this study emphasize the need for including nucleus swelling pressure, collagen viscoelasticity, and fluid permeation when simulating transient changes in matrix and fluid stress/strain. Sensitivity analyses suggest that further characterization of nucleus pulposus material properties should be pursued, due to its significance in steady-state and transient disc mechanical response.

scholarly journals In Silico Performance of a Recellularized Tissue-Engineered Transcatheter Aortic Valve

2019 ◽  
Vol 141 (6) ◽  
Author(s):  
Christopher Noble ◽  
Joshua Choe ◽  
Susheil Uthamaraj ◽  
Milton Deherrera ◽  
Amir Lerman ◽  
...  
Keyword(s):  
Mechanical Behavior ◽  
Heart Valves ◽  
Mechanical Response ◽  
Mechanical Performance ◽  
Fe Analysis ◽  
Model Parameters ◽  
Biaxial Testing ◽  
Principal Stresses

Commercially available heart valves have many limitations, such as a lack of remodeling, risk of calcification, and thromboembolic problems. Many state-of-the-art tissue-engineered heart valves (TEHV) rely on recellularization to allow remodeling and transition to mechanical behavior of native tissues. Current in vitro testing is insufficient in characterizing a soon-to-be living valve due to this change in mechanical response; thus, it is imperative to understand the performance of an in situ valve. However, due to the complex in vivo environment, this is difficult to accomplish. Finite element (FE) analysis has become a standard tool for modeling mechanical behavior of heart valves; yet, research to date has mostly focused on commercial valves. The purpose of this study has been to evaluate the mechanical behavior of a TEHV material before and after 6 months of implantation in a rat subdermis model. This model allows the recellularization and remodeling potential of the material to be assessed via a simple and inexpensive means prior to more complex ovine orthotropic studies. Biaxial testing was utilized to evaluate the mechanical properties, and subsequently, constitutive model parameters were fit to the data to allow mechanical performance to be evaluated via FE analysis of a full cardiac cycle. Maximum principal stresses and strains from the leaflets and commissures were then analyzed. The results of this study demonstrate that the explanted tissues had reduced mechanical strength compared to the implants but were similar to the native tissues. For the FE models, this trend was continued with similar mechanical behavior in explant and native tissue groups and less compliant behavior in implant tissues. Histology demonstrated recellularization and remodeling although remodeled collagen had no clear directionality. In conclusion, we observed successful recellularization and remodeling of the tissue giving confidence to our TEHV material; however, the mechanical response indicates the additional remodeling would likely occur in the aortic/pulmonary position.

scholarly journals Anisotropic mechanical behaviour of calendered nonwoven fabrics: Strain-rate dependency

2020 ◽  
pp. 002199832097679
Author(s):  
V Cucumazzo ◽  
E Demirci ◽  
B Pourdeyhimi ◽  
VV Silberschmidt
Keyword(s):  
Strain Rate ◽  
Mechanical Behaviour ◽  
Mechanical Response ◽  
Tensile Tests ◽  
Elastic Response ◽  
Uniaxial Tensile ◽  
Rate Dependency ◽  
Fibrous Matrix ◽  
Nonwoven Fabrics ◽  
Linear Elastic

Calendered nonwovens, formed by polymeric fibres, are three-phase heterogeneous materials, comprising a fibrous matrix, bond-areas and interface regions. As a result, two main factors of anisotropy can be identified. The first one is ascribable to a random fibrous microstructure, with the second one related to orientation of a bond pattern. This paper focuses on the first type of anisotropy in thin and thick nonwovens under uniaxial tensile loading. Individual and combined effects of anisotropy and strain rate were studied by conducting uniaxial tensile tests in various loading directions (0°, 30°, 45°, 60° and 90° with regard to the main fabric’s direction) and strain rate (0.01, 0.1 and 0.5 s−1). Fabrics exhibited an initial linear elastic response, followed by nonlinear strain hardening up to necking and final softening. The studied allowed assessment of the extent the effects of loading direction (anisotropy), planar density and strain rate on the mechanical response of the calendered fabrics. The evidence supported the conclusion that anisotropy is the most crucial factor, also delineating the balance between the fabric’s load-bearing capacity and extension level along various directions. The strain rate produced a marked effect on the fibre’s response, with increased stress at higher strain rate while this effect in the fabric was small. The results demonstrated the differences of the mechanical behaviour of fabrics from that of their constituent fibres.

scholarly journals Mechanical Behavior and Failure Analysis of Prosthetic Retaining Screws after Long-term Use In Vivo. Part 3: Preload and Tensile Fracture Load Testing

2008 ◽  
Vol 17 (3) ◽  
pp. 192-200 ◽  
Author(s):  
Youssef S. Al Jabbari ◽  
Raymond Fournelle ◽  
Gerald Ziebert ◽  
Jeffrey Toth ◽  
Anthony M. Iacopino
Keyword(s):  
Failure Analysis ◽  
Mechanical Behavior ◽  
Fracture Load ◽  
Tensile Fracture ◽  
Load Testing

Numerical Evaluation of Crack in Polyvinylidene Fluoride (PVDF)

2020 ◽  
Author(s):  
Ingrid Cristina S. Pereira ◽  
Celio A. da Costa Neto ◽  
José Renato M. Sousa ◽  
Erica G. Chaves ◽  
Sylvia Teixeira
Keyword(s):  
Numerical Model ◽  
Mechanical Behavior ◽  
Polyvinylidene Fluoride ◽  
Numerical Data ◽  
Tensile Tests ◽  
Plastic Behavior ◽  
Razor Blade ◽  
Material Parameters ◽  
High Degree

Abstract Polyvinylidene fluoride (PVDF) is an engineering thermoplastic having a high degree of sensibility to crack, which affects long-term mechanical behavior. This study evaluates the crack-sensitive of PVDF for one commercial-grade through the development of a numerical model. Firstly, tensile tests using DIC were performed on both uncrack and pre-crack specimens to get experimental tensile as DIC-displacement, displacement-control, and load data. For pre-crack specimens, it was proposed two values of depth: 1.0 and 1.5 mm, opened by razor blade. All specimens were uniaxial tests at 23°C under 5 mm/min. Secondly, tensile tests using extensometer were implemented for uncrack samples to determine material parameters for calibration of the numerical model and comparison with DIC-displacement. Finally, a numerical model based on the FE was implemented using ANSYS-student that inputs PVDF’s material properties, which considered the elastic-plastic behavior in simulation tests. The PVDF demonstrated significant crack sensitivity, as it can be seen in experimental and numerical data. And, the numerical model developed based on MKHP was successfully agreement against experimental data obtained by Blue Hill 3 software. Therefore, the results allowed us to observe that pre-crack acts as a stress concentration and the numerical model got well simulates this influence on the PVDF mechanical behavior.

Using Inverse Finite Element Analysis to Obtain Passive Mechanical Behavior of Abdominal Wall

1970 ◽  
Vol 3 ◽  
pp. 17-18
Author(s):  
Raquel Simón-Allué ◽  
Assad Oberai ◽  
Begoña Calvo
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Mechanical Behavior ◽  
Inverse Analysis ◽  
Mechanical Response ◽  
Abdominal Muscle ◽  
Hernia Surgery ◽  
Element Analysis ◽  
Inverse Finite Element Analysis

In this work we develop a methodology to characterize in vivo the passive mechanical behavior of abdominal muscle, using for that finite element simulations combined with inverse analysis and optimization algorithms. The knowledge of the mechanical response of the muscle is needed to determine the features of the mesh in cases of hernia surgery.

The Mechanical Response of a Structural Epoxy Adhesive Reinforced with Carbon Black Nanoparticles

2018 ◽  
Vol 25 (1) ◽  
pp. 187-191 ◽  
Author(s):  
Ricardo J. C. Carbas ◽  
Lucas F. M. da Silva ◽  
Luís F. S. Andrés
Keyword(s):  
Carbon Black ◽  
Mechanical Behavior ◽  
Mechanical Response ◽  
Tensile Tests ◽  
Epoxy Adhesive ◽  
Carbon Black Nanoparticles ◽  
Electron Microscopy Analysis ◽  
Microscopy Analysis ◽  
Strength And Deformation ◽  
Structural Adhesive

AbstractThe influence of the concentration of carbon black nanoparticles on the mechanical behavior of a structural adhesive was studied to evaluate and understand the stiffness, strength, and deformation behavior of a reinforced epoxy adhesive. Two carbon black nanoparticles with different dielectric properties and sizes (Monarch® 120 and Vulcan® XC72R) were studied. A bi-component structural epoxy adhesive was selected. Specimens with different concentrations of carbon black were manufactured (0, 5, 10, and 20% on volume of resin) for each type of nanoparticle. The specimens were cured in a hydraulic hot-plates press machine. The mechanical behavior of the adhesives was found not to vary significantly as a function of carbon black nanoparticles amount. A scanning electron microscopy analysis was performed to evaluate the fracture surface. The fracture surfaces of specimens were correlated with the mechanical response obtained through tensile tests.

scholarly journals Determination of Long-Term Creep Properties for 316H Steel Using Short-Term Tests on Pre-strained Material

2021 ◽  
Author(s):  
H. Zhou ◽  
A. Mehmanparast ◽  
K. Nikbin
Keyword(s):  
Mechanical Response ◽  
Tensile Tests ◽  
Primary Objective ◽  
Creep Rupture ◽  
Creep Ductility ◽  
Creep Properties ◽  
Material State ◽  
Term Creep

AbstractDetermination of long-term creep rupture properties for 316H steel is both costly and time-consuming and given the level of scatter in the data would need substantial number of tests to be performed. The primary objective of this study is to estimate the long-term creep properties of cross-weld (XW) and as-received (AR) 316H stainless steel by performing accelerated tests on pre-compressed (PC) material. In this work, uniaxial creep rupture tests have been performed on XW specimens and the results have been used to establish a correlation with accelerated test results on the PC material. Moreover, tensile tests have been performed on XW specimens at room temperature and 550 °C to examine the pre-conditioning effects on the mechanical response of the material. Similar power-law creep properties have been found for the creep strain rate and rupture time behaviour of the XW and PC specimens. It also has been found that the creep ductility data points obtained from XW and PC specimens fall upon the estimated trend for the AR material at 550 °C when the data are correlated with the applied stress normalised by 0.2% proof stress. The results show that the long-term creep properties of the XW and AR material can be estimated in much shorter time scales simply by performing tests on the PC material state.

scholarly journals Study on Retrofitted Masonry Elements under Shear Using Digital Image Correlation

Sensors ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 2122 ◽  
Author(s):  
Benjamín Torres ◽  
Francisco B. Varona ◽  
F. Javier Baeza ◽  
David Bru ◽  
Salvador Ivorra
Keyword(s):  
Digital Image Correlation ◽  
Mechanical Behavior ◽  
Digital Image ◽  
Tensile Tests ◽  
Shear Behavior ◽  
Wind Pressure ◽  
Image Correlation ◽  
Uniaxial Tensile ◽  
Tension Tests ◽  
Reinforced Masonry

Architectural heritage is usually built with masonry structures, which present problems under lateral in-plane loading conditions, such as wind pressure or earthquakes. In order to improve the shear behavior of masonry, the use of a fabric-reinforced cementitious matrix (FRCM) has become an interesting solution because of its synergy of mechanical properties and compatibility with masonry substrates. For a proper structural evaluation, the mechanical behavior of reinforced masonry and the FRCM itself needs to be characterized. Hence, a numerical model to evaluate the FRCM reinforcement requires some mechanical parameters that may be difficult to obtain. In this sense, the shear behavior of masonry can be evaluated by means of diagonal tension tests on small specimens (71 × 71 cm). In this work, a digital image correlation (DIC) monitoring system was used to control displacements and cracking patterns of masonry specimens under shear stress (induced by diagonal tension with FRCM layers) applied to one or two sides. In addition, the mechanical behavior of FRCM coupons under uniaxial tensile tests was also registered with DIC. The displacement measurements obtained by DIC were validated with the measurements registered with LVDT. Unlike LVDT-based techniques, DIC monitoring allowed us to measure deformations in masonry during the full test, detecting crack initiation even before it was visible to the eye.

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