scholarly journals Effects of using cannabidiol on a patient with difficult- tocontrol epilepsy

2021 ◽  
Author(s):  
Maria Eduarda Moreira ◽  
Ana Carolina Soares de Lira ◽  
Bárbara Letícia Barreto Ramos Aragão ◽  
Amuriama Suassuna ◽  
Kelly Farias

Introduction: Epilepsies are chronic neurological syndromes, characterized by spontaneous and recurrent crises. It is estimated that there is a worldwide prevalence of 1.0% and that around 30% of patients remain refractory to drug treatment. The active Cannabis plant has been used for medicinal purposes. Extracts with a high CBD content have been shown to be effective in reducing the frequency and severity of epileptic seizures. Objective: To expose the therapeutic effects of CBD and its consequences in a patient with crises that are difficult to control. Methodology: Case study. Results: Male patient, 18 years old, has epileptic seizures that are difficult to control since he was 7 months old. Progressively, he presented loss of motor functions, social and environmental interaction, and even with the combination of antiepileptic drugs, the crises remained uncontrolled. Magnetic resonance examinations indicate hypogenesis of the corpus callosum, volumetric reduction of the cerebellar vermis, increase of the cerebrospinal fluid space, posteriorly displaced brain stem, with volumetric loss. The diagnosis suggests Dandy-Walker and West syndrome. In 2017, it started using CBD and currently has an 85% reduction in crises. There was an increase in personal and environmental interaction, improved levels of concentration and bimanual skills, and began to express emotions and feelings more clearly. Conclusion: CBD represents a promising alternative for epileptic refractory patients to drug treatment, which can prevent the occurrence of brain damage and modify the natural history of the disease and the quality of life.

2021 ◽  
Vol 6 (2) ◽  
pp. 244-262
Author(s):  
Fatma Laili Khoirun Nida

The phenomenon of the poor quality of parental care for children with disabilities makes resilience one of the psychological capital that contributes to improving the quality of care. This study describes how through a muhasabah intervention in Blimbingrejo Village, Nalumsari District, Jepara Regency. The purpose of this study was to provide information for parents of children with special needs about muhasabah interventions in developing the resilience abilities of parents when carrying out their care. The urgency of this research is to reduce parenting stress experienced by parents because of the developmental barriers of their children. This research is qualitative with a case study approach through in-depth interviews and observation techniques. The study results explain that the condition of children with special needs is often a stressor for their parents. However, parents can live with complete steadfastness as a form of their resilience. The pattern of resilience formed is supported mainly by thinking about what they are trying to do. There are indications of the meaning of resilience factors in the practice of muhasabah in the form of the ability to regulate emotions, develop optimism and empathy, control impulses and causal analysis, good self-efficacy and take wisdom as an indication of aspects of the reaching out process. The results of this study are helpful information in developing the concept and practice of caring for children with special needs.


2018 ◽  
Vol 24 (2) ◽  
pp. 55-66
Author(s):  
Martin Raffaele

This study explored family relationship dynamics of men with Adult Onset Epileptic Seizures (AOES) following an elective lobectomy procedure to address their frequent seizure activity. Informants were five Australian men with history of adult-onset epilepsy for which they received neurosurgery (aged 34–59 years). Thematic analysis following semi-structured interviews yielded three themes: role marginalization, role dependency and role enmeshment. All the men reported significant role marginalization in not being consulted about everyday life activities. They also reported to experience decisional role shifting towards their spouses or partners and children post-surgery. Their family role enmeshment experiences included being perceived by spouses or partners as adult–children and by their children as a parent–child. However, some of the men were accepting of these role definitions and to add rather than take away from their health-related quality of life.


2018 ◽  
Vol 36 (1) ◽  
pp. 63-76 ◽  
Author(s):  
Edoghogho Ogbeifun ◽  
Charles Mbohwa ◽  
Jan-Harm Christiaan Pretorius

Purpose All built facility begins to show signs of deterioration immediately after the facility is completed and put to use, thus necessitating routine maintenance. Increase in defects due to age, usage, and other factors, requires extensive maintenance activities known as renovation. The data used for a typical renovation plan can be collected using the condition assessment (CA) tool which depends on physical inspection of the defects or through a facility condition index which hinges on harnessing and analyzing the information in the operational history of the facility. The purpose of this paper is to examine the quality of a typical renovation plan using both tools. Design/methodology/approach The single case study of qualitative research was adopted. The data were collected through the principle of semi-structured questionnaire complemented with interviews and document analysis. The documents include periodic operational reports and a CA report used for planned renovation exercise of the Facilities Management (FM) Unit in a higher education institution in South Africa. Findings The findings revealed that although the FM Unit produces periodic reports, but there was no evidence of detailed analysis of the reports. Therefore, the programmed renovation exercises are based purely on the information from a CA. Research limitations/implications This research is a single site case study of qualitative research; the data collected are limited and not sufficient for generalization of the results. Furthermore, the lack of record of the analysis of the operational history in the periodic reports negatively affected the computation of facilities condition index (FCI). Thus it was not possible to demonstrate the strength of FCI over CA from empirical information. Originality/value The quality of a typical renovation plan is influenced by the tool used for data collection. Although the CA tool is commonly used, experience shows that the renovation exercise developed from such records is prone to many execution setbacks, such as frequent scope changes and the associated cost and time overruns. These setbacks can be minimized if the FCI is used as the tool for data collection.


1999 ◽  
Vol 6 (2) ◽  
pp. E3
Author(s):  
Marie Bourgeois ◽  
Christian Sainte-Rose ◽  
Giuseppe Cinalli ◽  
Wirginia Maixner ◽  
Conor Malucci ◽  
...  

The incidence of epilepsy among children with hydrocephalus and its relation to shunts and their complications, raised intracranial pressure (ICP), and developmental outcome are explored in a retrospective study. The authors studied a series of 802 children with hydrocephalus due to varying causes, who were treated by ventriculoperitoneal shunt placement between 1980 and 1990, with a mean follow-up period of 8 years. Patients who had tumoral hydrocephalus and those whose files lacked significant data were excluded. Data extracted from medical records, including history of the hydrocephalus and history of seizures, if any, were analyzed. Thirty-two percent of the children had epilepsy, the onset of which frequently occurred at approximately the same time that the diagnosis of hydrocephalus was made. The majority of the affected children had severe uncontrolled epilepsy. The incidence of epilepsy was significantly affected by the original cause of the hydrocephalus. The presence of radiological abnormalities was also found to be a significant predictor of epilepsy. Similarly, shunt complications predisposed to epilepsy. Episodes of raised ICP related to hydrocephalus or in association with shunt malfunction may also predispose to epileptic seizures. Furthermore, the presence of a shunt by itself seems able to promote an epileptogenic focus. Finally, epilepsy appears to be an important predictor of poor intellectual outcome in hydrocephalic children with shunts. A prospective study is needed to identify clearly and confirm avoidable factors predisposing to seizures in these children so that we can strive to reduce the incidence of these seizures and, subsequently, improve quality of life.


2021 ◽  
Author(s):  
Mariana Soares ◽  
Ana Clara Mota Gonçalo ◽  
Kaline dos Santos Kishishita Castro ◽  
Victoria de Menezes Sá Lazera

Introduction: Cannabis sativa has several therapeutic properties and has been used for millennials for healing purposes. Among its benefits are analgesic, antiemetic and tranquilizing effects, acting strongly on the nervous system. Objective: This study aims to emphasize the importance of Cannabidiol as a therapeutic purpose for epilepsy, especially in Brazil, where its use is still controlled. Method: A systematic literature review, using bibliographic searches carried out in the electronic databases LILACS, PubMed and SciELO with the descriptors “cannabidiol” and “epilepsy”. Of 1645 searches found, 06 were used in the study. Results: Epileptic seizures can be generalized or partial and are determined by the affected area. The treatment for epilepsy are drugs that decrease the arousal capacity of neural tissue and a significant percentage of individuals cannot control them with traditional drugs alone. Endocannabinoids work in response to epileptiform activity, to activate CB1 receptors for excitatory neurons, to contain excess neuronal activity, which occurs during seizures. It is proven that patients who use it do not have toxic adverse effects. Conclusions: In Brazil, Cannabis is a controlled drug and the fact that it is imported, interfere in the treatment, who is interrupted while patient waits the new dosage. The importance of cannabidiol as a target for research and studies is verified, as it has ample potential in the treatment of epilepsy and reduces brain damage caused by it. In order that patients with epilepsy, have improvements in their quality of life.


2004 ◽  
Vol 6 (3) ◽  
pp. 323 ◽  
Author(s):  
Razali Mat Zin

This empirical investigation was aimed to determine the pattern of the  relationships between the perceived presence of quality of worklife (QWL) factors and organizational commitment using samples from professional engineers in Malaysia. Engineers in private sector were selected to participate in this study. A total of 250 sets of questionnaires were sent to the selected organizations, and 152 useable questionnaire representing a response rate of 60.8% were used for statistical analysis. A QWL measure consisting of seven factors: growth and development, participation, physical environment, supervision, pay and benefit, social relevance, and workplace integration was developed based on Walton’s (1974) conception. The three-component model and measure of organizational commitment developed by Allen and Meyer (1990) was adopted in this study. Results of regression analysis indicated that only two QWL factors, growth and development and pay and benefit, were significant in explaining organizational commitment. Implication and suggestions for further research are also discussed.


2020 ◽  
Vol 21 (7) ◽  
pp. 1525-1543 ◽  
Author(s):  
Paula M. Hernandez-Diaz ◽  
Jorge-Andrés Polanco ◽  
Sandra Milena Castaño

Purpose This paper aims to know how university’s strategic managers, from botacademic and administrative systems, perceive the relationship between sustainability and accreditation as sustainability incorporation and the quality of their processes are amongst the actual challenges of universities. Design/methodology/approach This paper opted for an inductive, exploratory study using the case study approach, including 19 in-depth interviews to administrative and academic managers in a private, high-quality certified university in Colombia. The data were assessed using the content analysis methodology. The Colombian accreditation guidelines were the base to analyse the data as accreditation is part of the quality assurance system. Findings This paper provides empirical insights into how the implementation of sustainability in universities relates to the Colombian accreditation factors. The main links found were in the areas of the university’s social impact and organisational responsibility, which are highly relevant to graduates, external stakeholders and sustainability skills. Sustainable campus operation was associated with environmental management and improvement of the quality of the physical plant, with social and economic benefits in the long-term. Additionally, this research found a need for administrative and academic managers to understand and increase their commitment to sustainability. Research limitations/implications Because it was a case study, results are not generalisable. Consequently, further research on similar lines is required to universalise the mentioned observation and results. Practical implications The accreditation factors related to sustainability, inductively defined and exposed in this paper, provide an idea of how sustainability implementation could contribute to higher education quality assurance. Originality/value This paper contributes to filling the knowledge gap about embedding sustainability in Latin-American universities. This paper postulates a starting point considering accreditation standards and the link of the strategic manager’s perceptions of sustainability.


2016 ◽  
Vol 56 (5) ◽  
pp. 563-577 ◽  
Author(s):  
Ying Wang ◽  
Kevin Kam Fung So ◽  
Beverley A. Sparks

Technologies have dramatically transformed tourist experience. However, research has largely focused on traveler attitudes and technology adoption rather than their experience with travel technologies. Taking a cross-country perspective, this study examines the role of technology readiness (TR) as a personality trait in shaping travelers’ satisfaction with travel technologies, using airlines as a case study. Results of an online survey of travelers in Australia, China, and the United States revealed the moderating effects of the TR dimensions of optimism and innovativeness as well as country of residence on the relationships between perceived quality of technology-enabled services (TESs), satisfaction with TESs, overall satisfaction, and future behavior. These relationships were stronger among travelers with higher TR and varied across countries. The results suggest that tourism and hospitality service providers should incorporate measures of traveler TR and TESs’ performance into their customer-experience monitoring system.


1998 ◽  
Vol 18 ◽  
Author(s):  
R. Mandal

Mining is one of the core sector industries which plays a positive and significant role in the process of country's economic development causing some unavoidable environmental impacts. Environment has become a key issue and today have transgressed the national boundaries and have now become a part of the global concern. We need eco-friendly mining for sustained development and better quality of life with minimum negative impact on environment without any threat to the future generation. In short, a balance has to be struck between development, environment and mining. Nepal has very short history of commercial mining and existing mines are small in size, located in hilly terrain and are being mined by opencast method. The mining activities may cause serious environmental degradation if proper techniques, management policies and practices are not utilised in time. This paper presents the holistic environment promotional effects which have been introduced at Kharidhunga magnesite mine.


2021 ◽  
Vol 343 ◽  
pp. 08012
Author(s):  
Emilia Bălan ◽  
Liviu Berculescu ◽  
Răzvan-George Răcheru ◽  
Dorin Vasile Piţigoi ◽  
Lucia Adăscăliţa

In the printing industry, where production never stops, it is very important to continuously maintain machine performance. If a machine breaks down, the production will stop and it will disturb the production process. Therefore, the maintenance system must be managed efficiently to solve those problems. The paper presents the study results on continuous quality improvement of offset printing using preventive maintenance features. Offset printing is a process that involves a multitude of variables, independent and interdependent factors. The offset printing process was analyzed and the factors that have a significant influence on the quality of the process and the products made were identified. The defects that may occur during the printing process and the causes thereof have also been identified and the types of non-conformities of the end products were estabilished. The experimental method was used. The case study was conducted on Manroland 508. For the planning of preventive maintenance activities, the duration of the maintenance works necessary to ensure the proper functioning of the offset printing machines was established. Finally, maintenance activities that would guarantee and continuously improve the quality of the printing processes and the printed products were issued.


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