Retrospective evaluation of the cases with neonatal sepsis and antibiotic resistance of the causing microorganisms

2016 ◽  
pp. 319-24 ◽  
Author(s):  
Abdurrahman Avar Özdemir ◽  
Yusuf Elgörmüş
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
Retrospective Evaluation

scholarly journals Antimicrobial Resistance among Neonates with Bacterial Sepsis and Their Clinical Outcomes in a Tertiary Hospital in Kathmandu Valley, Nepal

2021 ◽  
Vol 6 (2) ◽  
pp. 56
Author(s):  
Bijendra Raj Raghubanshi ◽  
Karuna D. Sagili ◽  
Wai Wai Han ◽  
Henish Shakya ◽  
Priyanka Shrestha ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
Bacterial Culture ◽  
Bacterial Species ◽  
Antibiotic Sensitivity ◽  
College Teaching ◽  
Hospital Treatment ◽  
Resistant Bacteria ◽  
Coagulase Negative Staphylococcus ◽  
Cross Sectional

Globally, antibiotic resistance in bacteria isolated from neonatal sepsis is increasing. In this cross-sectional study conducted at a medical college teaching hospital in Nepal, we assessed the antibiotic resistance levels in bacteria cultured from neonates with sepsis and their in-hospital treatment outcomes. We extracted data of neonates with sepsis admitted for in-patient care from June 2018 to December 2019 by reviewing hospital records of the neonatal intensive care unit and microbiology department. A total of 308 neonates with sepsis were admitted of which, blood bacterial culture antibiotic sensitivity reports were available for 298 neonates. Twenty neonates (7%) had bacteriologic culture-confirmed neonatal sepsis. The most common bacterial species isolated were Staphylococcus aureus (8), followed by coagulase-negative Staphylococcus (5). Most of these bacteria were resistant to at least one first-line antibiotic used to manage neonatal sepsis. Overall, there were 7 (2%) deaths among the 308 neonates (none of them from the bacterial culture-positive group), and 53 (17%) neonates had left the hospital against medical advice (LAMA). Improving hospital procedures to isolate bacteria in neonates with sepsis, undertaking measures to prevent the spread of antibiotic-resistant bacteria, and addressing LAMA’s reasons are urgently needed.

scholarly journals Bacteriological profile and sensitivity pattern of neonatal sepsis

2017 ◽  
Vol 8 (1) ◽  
pp. 174-177
Author(s):  
Rowshan Jahan Akhter ◽  
Md Mahbubul Hoque ◽  
BH Nazma Yasmeen ◽  
MAK Azad Chowdhury
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Neonatal Morbidity ◽  
Diffusion Method ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Haematological Profile ◽  
Resistance Patterns ◽  
Antibiotic Resistance Patterns

Introduction : Neonatal sepsis remains an important cause of neonatal morbidity and mortality in NICU setup and a major challenge for the neonatologists. The prevalent organisms and their antibiotic resistance patterns evolve with time and with the usage of antimicrobials.Aims and Objectives : To analyze the bacteriological profile and antibiotic resistance patterns of proven neonatal sepsis cases in Dhaka Shishu Hospital.Materials and Methods : The study was Prospective observational study. All the clinically suspected cases of Neonatal Sepsis admitted to the Neonatal word from January 2015 to December 2015 were included in the study. Clinically suspected cases of neonatal sepsis further evaluated with blood cultures and antibiotic susceptibility testing using the Kirby Bauer disc diffusion method. Data was collected for the following variables: Demographic profile, haematological profile, blood culture result and antibiotic sensitivity patterns.Results : Total 96 cases clinically suspected neonatal sepsis were included in the study. Among them 29 cases (30.21%) was culture positive septicemia. Klebsiella pneumoniae was the most common isolate accounting for 31.03% cases followed by Escherichia coli 27.59%. In Klebsiella infection most common sensitivity were Imipenum and Ciprofloxacin which were 77.78 and 33.33% respectively. In E.coli common sensitive drugs were Imipenum and Amikacin. In serratia common sensitive drugs were Imipenum, Netlmicin and Ciprofloxacin.Conclusion : K. pneumoniae was the most common pathogen. Most common sensitivity was Imipenum, Amikacin, Ciprofloxacin, Gentamicin, Netlmicin, and Ceftazidime,.Northern International Medical College Journal Vol.8(1) July 2016: 174-177

scholarly journals Microbial profile of neonatal sepsis and antibiotic resistance from a tertiary care hospital in South India

2019 ◽  
Vol 6 (1) ◽  
pp. 57-60
Author(s):  
Kalaivani Ramakrishnan ◽  
◽  
Arunava Kali ◽  
Pravin Charles M. V ◽  
Sreenivasan Srirangaraj ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
South India ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Microbial Profile

scholarly journals The Relationship of Birth Weight Infant with Bacteriological Profile and Antibiotic Resistance of Neonatal Sepsis

2019 ◽  
Vol 7 (5) ◽  
Author(s):  
Nisrina Asysyifa ◽  
Husjain Djajaningrat ◽  
Diah Lestari
Keyword(s):  
Antibiotic Resistance ◽  
Birth Weight ◽  
Blood Culture ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
P Value ◽  
Klebsiella Pneumonia ◽  
Bacteriological Profile ◽  
Relationship Of ◽  
The Relationship

Neonatal sepsis is a major issue on neonatal-care field. This incident occurs by many factors, one of the factor is infant with a low birth weight. Blood culture is used as the gold standard for diagnosis. The spectrum of bacteria which caused neonatal sepsis is constantly change and vary due to antibiotic resistance phenomenon. This study aimed to determine the relationship of birth weight infant with bacteriological profile and antibiotic resistance of neonatal sepsis in RSAB Harapan Kita Jakarta. This study used observational method with cross sectional design and purposive sampling method which is analyzed by chisquare test. Medical record data and blood culture and antibiotic resistance test from all subjects in Januari until December 2018 were reviewed. The sample in this research is neonatal sepsis patients who met inclusion criteria were 51 patients. From 51 (55,43%) subjects, there were 39 (76,47%) neonatal sepsis in low birth weight infant. Klebsiella pneumonia spp (41,17%) and Staphylococcus epidermidis (19,60%) were the predominant pathogens. Amikacin (62,74%), and meropenem (50,98%) were the most susceptible antibiotic towards bacteria. Maximum resistance among organisms was seen in cefotaxime (84,31%), ceftazidime (78,43%), and amoxicillin (70,58%).  The result of the analysis found there is a relationship between birth weight infant and bacteriological profile (p-value = 0,035), but there is no relationship between birth weight infant and antibiotic resistance of neonatal sepsis (p-value =0,092; 0,066; and 0,521). There is a relationship between birth weight infant and bacteriological profile , but there is no relationship between birth weight infant and antibiotic resistance of neonatal sepsis.

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Homayoon Behmadi ◽  
Abasalt Borji ◽  
Azadeh Taghavi-Rad ◽  
Leyla Soghandi ◽  
Reza Behmadi
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis

scholarly journals AETIOLOGY, ANTIBIOTIC RESISTANCE AND RISK FACTORS FOR NEONATAL SEPSIS IN A LARGE REFERRAL CENTRE IN ZAMBIA

2017 ◽  
Vol 2 (Suppl 2) ◽  
pp. A51.1-A51
Author(s):  
Mwila Kabwe ◽  
John Tembo ◽  
Lophina Chilukutu ◽  
Moses Chilufya ◽  
Francis Ngulube ◽  
...  
Keyword(s):  
Risk Factors ◽  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
Referral Centre

Etiology of early-onset neonatal sepsis and antibiotic resistance in Bukavu, Democratic Republic of the Congo

2021 ◽  
Author(s):  
Guy M Mulinganya ◽  
Maud Claeys ◽  
Serge Z Balolebwami ◽  
Bertrand A Bamuleke ◽  
Jules I Mongane ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Democratic Republic ◽  
Enterobacter Cloacae ◽  
Antimicrobial Treatment ◽  
Diffusion Method ◽  
First Line ◽  
Disk Diffusion Method ◽  
Republic Of The Congo

Abstract Background The Democratic Republic of the Congo (DRC) ranks among the countries with the highest neonatal death rates (between 14 and 28‰). In the DRC, neonatal sepsis causes 15.6% of this mortality, but data on the bacterial etiology and associated drug susceptibility are lacking. Methods Hemocultures of 150 neonates with possible early onset neonatal sepsis (pEOS) were obtained at the Hôpital Provincial Général de Référence de Bukavu (HPGRB, Bukavu, DRC). The newborns with pEOS received an empirical first-line antimicrobial treatment (ampicillin, cefotaxime and gentamicin), based on the synopsis of international guidelines for the management of EOS which are in line with WHO recommendations. Isolates were identified by matrix-assisted laser desorption ionization - time of flight mass spectrophotometry (MALDI-TOF MS). Antibiotic resistance was assessed using the disk diffusion method. Results A total of 50 strains was obtained from 48 patients and identified. The three most prevalent species were Enterobacter cloacae complex (42%), Klebsiella pneumoniae (18%) and Serratia marcescens (12%). Enterobacter cloacae isolates were resistant to all first-line antibiotics. All K. pneumoniae and S. marcescens isolates were resistant to ampicillin, and the majority of the K. pneumoniae and half of the S. marcescens isolates were resistant to both cefotaxime and gentamicin. All E. cloacae complex strains, 89% of the K. pneumoniae and half of S. marcescens had an extended-spectrum ß-lactamase (ESBL) phenotype. Conclusions The most prevalent pathogens causing EOS in Bukavu were E. cloacae complex, K. pneumoniae and S. marcescens. Most of these isolates were resistant to the WHO recommended antibiotics.

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