PREPARATION OF POLYHERBAL DISPERSIBLE TABLET AND EVALUATION BY RP-HPLC

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (04) ◽  
pp. 32-39
Author(s):  
Divya Hegde ◽  
◽  
Kirankumar Hullatti ◽  
Vishakha Parab Gaonkar ◽  
Uday Kumar Bolmal
Keyword(s):  
Raw Materials ◽  
Chemical Properties ◽  
Hplc Method ◽  
Piper Nigrum ◽  
Piper Longum ◽  
Rp Hplc ◽  
Physico Chemical ◽  
Poor Patient Compliance ◽  
Dispersible Tablet ◽  
Acceptance Range

The aim of the present study was to convert an Ayurvedic formulation, “trikatu churna”, into a polyherbal dispersible tablet. Standardization parameters were performed for raw materials, trikatu churna and its extract. The standardized extract was further used for formulation of the dispersible tablet. The evaluation of raw materials, trikatu churna, trikatu extract and dispersible tablet was done using preliminary phytochemical and physico-chemical tests. The pre- and post-compression parameters for polyherbal dispersible tablet formulation were within the acceptance range. The piperine content in Piper nigrum, Piper longum, trikatu extract and formulation was found to be 2.884mg/mL, 0.515mg/gm, 0.303mg/gm and 0.357mg/gm, respectively. The developed RP-HPLC method was found to be precise, accurate and reproducible for the estimation of piperine in raw materials and dispersible tablet. It can be concluded that the prepared dispersible tablet has overcome the disadvantages of churna, such as poor patient compliance and pungent taste, without altering its dose and chemical properties.

scholarly journals RP - HPLC Method for Determination of Piperine fromPiper longumLinn. andPiper nigrumLinn

2005 ◽  
Vol 2 (2) ◽  
pp. 131-135 ◽  
Author(s):  
M. K. Santosh ◽  
D. Shaila ◽  
I. Rajyalakshmi ◽  
I. Sanjeeva Rao
Keyword(s):  
Mobile Phase ◽  
Control Method ◽  
Hplc Method ◽  
Piper Nigrum ◽  
Detector Response ◽  
Piper Longum ◽  
Rp Hplc ◽  
Quality Control Method ◽  
Detection And Quantification

Piper longumLinn. andPiper nigrumLinn. are used as spices and medicines. Quantitative determination of piperine was undertaken to provide an easy and simple analytical method, which can be used as a routine quality control method. RP-HPLC was performed using methanol and water as mobile phase. The detection and quantification was performed at a wavelength of 345 nm. Linearity of detector response for piperine was between the concentrations 0.005% to 0.1%. The correlation coefficient obtained for the linearity was 0.998. The assay value of piperine for fruit and root ofP. longumwas found to be 0.879% and 0.31%. The assay value of piperine for fruit ofP. nigrumwas 4.5%. The recovery value of standard piperine was 99.4%. Low value of standard deviation and coefficient of variation are indicative of high precision of the method.

Research of Physical and Chemical Properties of Powder Cellulose from Various Type of Raw Materials

2020 ◽  
Vol 992 ◽  
pp. 791-795
Author(s):  
K.S. Momzyakova ◽  
T.R. Deberdeev ◽  
Z.T. Valishina ◽  
R.Ya. Deberdeev ◽  
A.V. Ibragimov ◽  
...  
Keyword(s):  
Raw Materials ◽  
Chemical Activation ◽  
Chemical Properties ◽  
Alkaline Treatment ◽  
Hammer Mill ◽  
Plant Materials ◽  
Physico Chemical ◽  
Powder Cellulose ◽  
Oat Straw ◽  
Physical And Chemical

The features of obtaining powder cellulose from non-woody plant materials, excluding the stages of acid and / or enzymatic hydrolysis using the original technological approach at atmospheric pressure and temperature, were studied 90-100 degree of Celsius. The feedstock after alkaline treatment, according to the proposed technology, is subjected to physico-chemical activation using a modified extrusion unit, providing intensive grinding and defibrillation of the fibers, washing, drying, grinding on a hammer mill. Physicochemical and structural studies of the obtained powder pulp from lucerne, oat straw and cotton powder pulp were carried out. The efficiency and prospects of the proposed process are shown.

Research Methods of Making Glass and its Physico-Chemical Properties

2019 ◽  
Vol 968 ◽  
pp. 168-175
Author(s):  
Lilia I. Baranova-Shishkova ◽  
Karina S. Simpolskaya ◽  
Elena Zvonareva ◽  
Vladimir V. Goncharenko
Keyword(s):  
Energy Consumption ◽  
Research Methods ◽  
Raw Materials ◽  
Wide Spectrum ◽  
Chemical Properties ◽  
Technological Processes ◽  
Silicate Formation ◽  
Glass Forming ◽  
Physico Chemical ◽  
Modern Methods

This article discusses the modern methods of physico-chemical properties of glass manufacturing, through the use of a wide spectrum of glass-forming. Description of the implementation of the staged methods of chemical-technological processes of silicate formation, implying the lowest energy consumption, in connection with the transition to the processing of secondary raw materials.

scholarly journals Characteristics of biochar pellets from corn straw under different pyrolysis temperatures

2018 ◽  
Vol 5 (8) ◽  
pp. 172346 ◽  
Author(s):  
Xianjun Xing ◽  
Fangyu Fan ◽  
Wen Jiang
Keyword(s):  
Raw Materials ◽  
Chemical Properties ◽  
Clean Energy ◽  
Proximate Analysis ◽  
Mechanical Resistance ◽  
Corn Straw ◽  
Heating Value ◽  
Physico Chemical ◽  
Different Temperatures ◽  
Biomass Resources

Biomass resources have the potential to produce clean-energy. However, their physico-chemical properties are inferior to those of coal, and thus, biomass resources are not regarded as ideal feedstock for industrial application. In the present study, the pyrolysis of corn (maize) straw pellets was performed under different temperatures (400, 450, 500, 550 and 600°C) at a 10°C min −1 heating rate and 30 min residence time, and the characteristics of biochar pellets were carefully investigated, particularly their elemental composition, hydrophobicity and mechanical resistance. Fourier transform infrared, proximate analysis and scanning electron microscopy were performed. Results indicated that the mass and energy yields of the biochar pellets decreased from 35.46 to 28.65% and from 50.17 to 45.52%, respectively, at increased temperature. Meanwhile, the higher heating value of the biochar pellets increased from 15.45 MJ kg −1 in the raw materials to 21.86 and 24.55 MJ kg −1 in the biochar produced at 400 and 600°C, respectively. In addition, biochar pellets showed good hydrophobicity, which benefited their storage and transportation, though mechanical resistance decreased. The pellets had compact structures, regular shapes and weakened or no functional groups in contrast with raw pellets, and these properties played important roles in the improvements.

scholarly journals REFRACTORY CLAY RAW MATERIALS OF REPUBLIC OF BELARUS FOR PRODUCTION OF THE PORCELAIN TILE

2019 ◽  
Vol 62 (12) ◽  
pp. 39-44
Author(s):  
Hanna N. Shymanskaya ◽  
Evgeniya M. Dyatlova ◽  
Rostislav Yu. Popov
Keyword(s):  
Raw Materials ◽  
Import Substitution ◽  
Chemical Properties ◽  
Xrd Analysis ◽  
Sem Analysis ◽  
Refractory Clay ◽  
Production Costs ◽  
Operational Characteristics ◽  
Physico Chemical ◽  
Porcelain Tiles

The possibility of replacing imported refractory clays and kaolines, which are part of porcelain stoneware mix, with refractory clay materials of the Republic of Belarus, in particular quartz-pyrophyllite-kaolinite rock and kaolin of “Dedovka” and “Sitnitsa” deposits, was explored. Porcelainised stoneware body formulations of JSC “Keramin” (Minsk, Republic of Belarus) was taken as the basis. It was found that physico-chemical properties and operational characteristics of porcelain tiles comply with the requirements of EN 14411: 2014, when adding 2.5–15.0 wt.% quartz-pyrophyllite-kaolinite rock. Incorporation of quartz-pyrophyllite-kaolinite rock in percentage higher than 15.0 wt.% resulted in reduction in the total amount of the vitreous phase of porcelain stoneware, thus increasing water absorption, apparent porosity as well as reduces flexural strength and bulk density. The main crystalline phases in the synthesized materials were quartz and mullite. It was also revealed that imported kaolines could be completely replaced by kaolines of “Dedovka” and “Sitnitsa” deposits. In this, required physico-chemical properties and operational characteristics of porcelain tiles was maintained. SEM analysis revealed that specimens synthesized using considered kaolines show quite dense microstructures, with a high degree of vitrification. The gas phase in these materials was practically absent, the presence of only individual small irregular pores was found. XRD analysis indicated that the major phases were mullite, quartz, microcline and hematite. It was hematite that gives the obtained porcelain stoneware samples a dark gray color scheme. Thus, the use of domestic refractory clay raw materials provides import substitution and declining production costs.

scholarly journals A VALIDATED RP-HPLC METHOD FOR IMPURITY PROFILING OF SODIUM NITROPRUSSIDE IN INJECTION DOSAGE FORM

2021 ◽  
pp. 160-169
Author(s):  
MURALI KRISHNAM RAJU P. ◽  
VENKATA NARAYANA B. ◽  
SHYAMALA P. ◽  
SRINIVASU KONDRA ◽  
HSN RAJU DANTULURI
Keyword(s):  
Sodium Nitroprusside ◽  
High Performance ◽  
Research Work ◽  
Hplc Method ◽  
Isocratic Elution ◽  
Reverse Phase ◽  
Impurity Profiling ◽  
Rp Hplc ◽  
Acceptance Range ◽  
Nitrite Nitrate

Objective: The main objective of this research work is to develop and validate a single reverse-phase high-performance liquid chromatography (RP-HPLC) method. This method should becapable of quantifying all the known, as well as other possible degradation impurities of sodium nitroprusside (SNP) in its injection formulation. Methods: Of allmethod development trails, we have observed better separations between known and degradation impuritiesin Inert sustain C18, (250 x 4.6) mm, 5 µm column at 30 °C temperature. Isocratic elution was carried out by using pH 8.6 phosphate buffer and acetonitrile in the ratio of 65:35 %v/v with a flow rate of 0.8 ml/min. The detection was carried out at 220 nm, with an injection volume of 10 µl. Results: In the proposed method, SNP was eluted at 22.5 min. Nitrite, nitrate, and ferrocyanide were linear from 0.25 to 37 μg/ml, ferricyanide was linear from 1.0 to 37 μg/ml, and SNP was linear from 0.75 to 37 μg/ml. The % RSD for six spiked samples (precision)was found to be less than 0.5 %. Accuracy was performed for known impurities from LOQ to 150 % for a 0.5 % specification level. The resultswere found to be in the acceptance range of 90-110 %. The LOQ concentration of nitrite, nitrate, and ferrocyanide was 0.25 μg/ml each,LOQ offerricyanide and SNP was found to be 1.0 μg/ml and 0.75 μg/ml, respectively. The SNP injection samples were exposed to different degradation conditions, and the results were found specific in the proposed methodology. Conclusion: The proposed RP-HPLC method is specific, precise, accurate, linear, stable, and robust for quantification of known and other possible degradation impurities in SNP injection formulation.

scholarly journals EFFECT OF COMPOST DOSES ON SOIL RESILIENCE IN PALU VALLEY

2020 ◽  
Vol 7 (2) ◽  
pp. 99-105
Author(s):  
Danang Widjajanto ◽  
Uswah Hasanah ◽  
Imam Wahyudi ◽  
St Sukmawati ◽  
Sufyan Sufyan
Keyword(s):  
Organic Carbon ◽  
Total Nitrogen ◽  
Raw Materials ◽  
Block Design ◽  
Chemical Properties ◽  
Soil Surface ◽  
Total Porosity ◽  
Field Capacity ◽  
Physico Chemical ◽  
Soil Resilience

Applying organic matter to the soil surface is an effective effort to increase soil resilience in the Palu valley, which is classified as low. This study aimed to determine: 1) the effect of several doses of compost on the physico-chemical properties of the soil, 2) the correlation between the percentage of organic carbon and total nitrogen in the soil to several physico-chemical properties of the soil. The research was based on a randomized block design in a greenhouse of the Faculty of Agriculture, Tadulako University, Palu. Compost uses raw materials for plantain stems (Musa textilia) and leaves of Gamal (Gliricidia sepium). The compost doses used in the experiment consisted of 0%, 1%, 2%, 3%, 4%, and 5% of the weight of air-dry soil, respectively. The treatment was repeated three times. The results showed that compost application significantly affected soil content weight, total porosity, saturated hydraulic conductivity, field capacity moisture content, percentage of organic carbon, total nitrogen, and cation exchange capacity. The correlation test results showed a powerful relationship between the percentage of organic carbon or total soil nitrogen to other soil physico-chemical properties observed in the experiment.

scholarly journals Physico-chemical characterization of clay mineral mixtures from Boyacá-Colombia

DYNA ◽  
2020 ◽  
Vol 87 (213) ◽  
pp. 116-122
Author(s):  
Iván Supelano García ◽  
Carlos Andrés Palacio Gómez ◽  
Julieth Alexandra Mejía Gómez ◽  
Carlos Arturo Parra Vargas
Keyword(s):  
Clay Minerals ◽  
Raw Materials ◽  
Chemical Properties ◽  
Chemical Characterization ◽  
X Rays ◽  
Scanning Calorimetry ◽  
Positron Annihilation Lifetime ◽  
Physico Chemical ◽  
Technological Tool ◽  
And Control

An adequate identification of physico-chemical properties of clay minerals is an important step to develop technological applications. In Colombia, a common issue is that the evaluation of raw materials with the preparation of the final product depend on empirical knowledge, it is common not to use any kind of technological tool to conduct any analysis. In contrast, the clay mixtures for this study were prepared and characterized by following a careful procedure to evaluate and control the qualities such as color of the final product. For this purpose, differential scanning calorimetry, magnetization, scanning electron microscopy, X-rays analysis, and positron annihilation lifetime spectroscopy techniques were applied. It is possible to conclude that the implementation scientific techniques in the sector of clay minerals may serve as a powerful tool, since preparing samples in an empirical way have been proved to lead to different qualities in the final product.

scholarly journals Antitumor Features of Vegetal Protein-Based Nanotherapeutics

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 65 ◽  
Author(s):  
Silvia Voci ◽  
Agnese Gagliardi ◽  
Massimo Fresta ◽  
Donato Cosco
Keyword(s):  
Raw Materials ◽  
Polymeric Nanoparticles ◽  
Chemical Properties ◽  
The Novel ◽  
Colloidal Systems ◽  
Preparation Methods ◽  
Renewable Raw Materials ◽  
Pharmaceutical Application ◽  
Physico Chemical ◽  
Body Compartments

The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of plant-derived proteins as innovative, safe and renewable raw materials to be used for the development of polymeric nanoparticles unlocked a new scenario in the drug delivery field. In particular, the reduced size of the colloidal systems combined with the peculiar properties of non-immunogenic polymers favored the characterization and evaluation of the pharmacological activity of the novel nanoformulations. The aim of this review is to describe the physico-chemical properties of nanoparticles composed of vegetal proteins used to retain and deliver anticancer drugs, together with the most important preparation methods and the pharmacological features of these potential nanomedicines.

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