scholarly journals Estudo Da Atividade Antioxidante Do Óleo Essencial De Alecrim (Rosmarinus Officinalis L) No Tratamento Ao Estresse Oxidativo Na Doença De Alzheimer

2022 ◽  
Vol 2 (3) ◽  
pp. 238-246
Author(s):  
Letícia Grejo de Oliveira ◽  
Mary Leiva de Faria ◽  
Elaine Soares Amorim
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Essential Oil ◽  
Antioxidant Capacity ◽  
Antioxidant Action ◽  
Radical Method ◽  
Rosmarinus Officinalis L ◽  
Hydrolysis Of ◽  
Reduction Capacity ◽  
Rosemary Essential Oil

O óleo essencial de alecrim (Rosmarinus offininalis L) pode ser utilizado na prevenção do Alzheimer em decorrência da sua composição química, especialmente compostos terpênicos que atuam pela sua ação antioxidante ou pela inibição da acetilcolinesterase (AChE), que retarda a hidrólise catabólica da acetilcolina com o intuito de compensar a escassez da mesma nos terminas sinápticos. Esse trabalho teve o objetivo de extrair e determinar a atividade antioxidante do óleo essencial de alecrim. Primeiramente extraiu-se o óleo essencial do material botânico de alecrim por hidrodestilação em destilador do tipo Clevenger. A determinação da capacidade antioxidante foi realizada em triplicata pelo método de radical livre utilizando o reagente 2,2-difenil-1-picril hidrazil (DPPH). O rendimento obtido na extração do óleo essencial de alecrim foi de 0,42%. O resultado obtido para a atividade antioxidante do óleo essencial de alecrim foi satisfatório, sendo a capacidade de redução de DPPH em 30 minutos de 87,21%±0,25. Os resultados obtidos indicam que o óleo essencial de alecrim pode ser utilizado no tratamento da doença de Alzheimer, visto que o mesmo pode atuar inibindo o stress oxidativo, a principal causa para o desenvolvimento de doenças neurodegenerativas. Deve-se considerar, entretanto, a composição do óleo essencial visto que os fatores ambientais e de cultivo podem influenciar na capacidade antioxidante do mesmo.   Rosemary essential oil (Rosmarinus offininalis L) can be used in the prevention of Alzheimer's due to its chemical composition, especially terpenic compounds that act by its antioxidant action or by the inhibition of acetylcholinesterase (AChE), which delays the catabolic hydrolysis of acetylcholine in order to compensate the lack of it in the synaptic terminals. This work aimed to extract and determine the antioxidant activity of rosemary essential oil. First, the essential oil was extracted from the rosemary botanical material by hydrodistillation in a Clevenger distiller. The antioxidant capacity was determined in triplicate by the free radical method using the reagent 2,2-diphenyl-1-picryl hydrazyl (DPPH). The yield obtained from the extraction of rosemary essential oil was 0.42%. The result obtained for the antioxidant activity of rosemary essential oil was satisfactory, and the DPPH reduction capacity in 30 minutes was 87.21%±0.25. The results obtained indicate that rosemary essential oil can be used in the treatment of Alzheimer's disease, since it can act by inhibiting oxidative stress, the main cause for the development of neurodegenerative diseases. However, the composition of the essential oil should be considered, since environmental and cultivation factors can influence its antioxidant capacity.  

scholarly journals Rosmarinus officinalis L.: Chemical Modifications of the Essential oil and Evaluation of Antioxidant and Antimicrobial Activity

2009 ◽  
Vol 4 (12) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Giorgio Pintore ◽  
Mauro Marchetti ◽  
Mario Chessa ◽  
Barbara Sechi ◽  
Nadia Scanu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Rosmarinus Officinalis ◽  
Hydrocarbon Fraction ◽  
Bornyl Acetate ◽  
Minimal Bactericidal Concentration ◽  
Aeromonas Sobria ◽  
Antioxidant And Antimicrobial Activity ◽  
Rosmarinus Officinalis L ◽  
Micro Organisms

Rosmarinus officinalis essential oil was separated into its hydrocarbon and oxygenated fractions. The major compounds in the hydrocarbon fraction were α-pinene (44.2%), camphene (24.5%), and limonene (11.7%), while in the oxygenated fraction they were 1,8-cineole (37.6%), camphor (16.5%), and bornyl acetate (21.4%). The hydrocarbon fraction was submitted to a hydroformylation process and the antioxidant activity of the product was screened by the DPPH and β-carotene/linoleic acid tests. The hydroformylated fraction maintained the antioxidant activity of the whole oil. The MIC (minimal inhibitory concentration) and the MBC (minimal bactericidal concentration) of the essential oil, hydrocarbon, oxygenated and hydroformylated fractions were also tested on several microorganisms. Aeromonas sobria and Candida strains were the most susceptible micro-organisms. The hydroformylated fraction exhibited a MBC against Candida strains resistant to the other fractions.

scholarly journals Artificial Intelligence (AI) to the Rescue: Deploying Machine Learning to Bridge the Biorelevance Gap in Antioxidant Assays

2020 ◽  
pp. 247263032096271
Author(s):  
Sunday Olakunle Idowu ◽  
Amos Akintayo Fatokun
Keyword(s):  
Oxidative Stress ◽  
Artificial Intelligence ◽  
Machine Learning ◽  
Antioxidant Capacity ◽  
Unmet Need ◽  
Hydrogen Atom Transfer ◽  
Support Vector ◽  
Antioxidant Action ◽  
Predictive Tool

Oxidative stress induced by excessive levels of reactive oxygen species (ROS) underlies several diseases. Therapeutic strategies to combat oxidative damage are, therefore, a subject of intense scientific investigation to prevent and treat such diseases, with the use of phytochemical antioxidants, especially polyphenols, being a major part. Polyphenols, however, exhibit structural diversity that determines different mechanisms of antioxidant action, such as hydrogen atom transfer (HAT) and single-electron transfer (SET). They also suffer from inadequate in vivo bioavailability, with their antioxidant bioactivity governed by permeability, gut-wall and first-pass metabolism, and HAT-based ROS trapping. Unfortunately, no current antioxidant assay captures these multiple dimensions to be sufficiently “biorelevant,” because the assays tend to be unidimensional, whereas biorelevance requires integration of several inputs. Finding a method to reliably evaluate the antioxidant capacity of these phytochemicals, therefore, remains an unmet need. To address this deficiency, we propose using artificial intelligence (AI)-based machine learning (ML) to relate a polyphenol’s antioxidant action as the output variable to molecular descriptors (factors governing in vivo antioxidant activity) as input variables, in the context of a biomarker selectively produced by lipid peroxidation (a consequence of oxidative stress), for example F2-isoprostanes. Support vector machines, artificial neural networks, and Bayesian probabilistic learning are some key algorithms that could be deployed. Such a model will represent a robust predictive tool in assessing biorelevant antioxidant capacity of polyphenols, and thus facilitate the identification or design of antioxidant molecules. The approach will also help to fulfill the principles of the 3Rs (replacement, reduction, and refinement) in using animals in biomedical research.

scholarly journals 266 ANTIOXIDANT CAPACITY OF BOAR SEMINAL PLASMA

2005 ◽  
Vol 17 (2) ◽  
pp. 283 ◽  
Author(s):  
M. Hernandez ◽  
A. Cano ◽  
M.B. Arnao ◽  
X. Lucas ◽  
J.M. Vazquez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Antioxidant Capacity ◽  
Seminal Plasma ◽  
Total Antioxidant Capacity ◽  
Room Temperature ◽  
Color Characteristics ◽  
Nylon Mesh ◽  
Total Antioxidant ◽  
Lipophilic Antioxidant

It has been established that antioxidants in seminal plasma play an important role in protecting the spermatozoa against oxidative stress-induced damage. This study was conducted to measure the total antioxidant capacity (TAC) of boar seminal plasma. Fifty-four ejaculates were collected from 17 mature boars of proven fertility by the gloved-hand technique. Ejaculates were collected separately in different fractions (pre-sperm, sperm-rich, and post-sperm) according to their macroscopic (color) characteristics. After centrifugation (2400g for 3 min), the sperm pellet was discarded; the supernatant was recentrifuged and filtered through a 10-μm nylon mesh filter to remove debris or clumped spermatozoa. The seminal plasma was frozen at -20°C until further use. After thawing at room temperature, seminal plasma aliquots of 5 μL were immediately assessed for total antioxidant capacity. TAC was measured using the ABTS/H2O2/HRP decoloration method (Cano A et al. 2000 Redox Report 5, 365–370) which allows differentiation between hydrophilic and lipophilic antioxidant activity capacity. TAC units were expressed as micromolar (μM) Trolox equivalents. Data were analyzed using ANOVA. Only the hydrophilic activity was measurable, with the lipophilic activity being undetected. The overall TAC of seminal samples (mean ± SEM) was 1623.7 ± 56.28 μM, ranging from 674 to 2428 μM. Different TACs were observed among males (P < 0.05) and between ejaculates of the same male (P < 0.05). Ejaculate fraction had a significant effect (P < 0.001) on the TAC levels. The post-sperm fraction had a significantly lower TAC level (1104.09 ± 57.66 μM) than the pre-sperm and sperm-rich fractions (1611.95 ± 153.68 μM and 1356.136 ± 72.47 μM, respectively, P < 0.001). In conclusion, hydrophilic antioxidant activity represented the main contribution to the TAC in boar seminal plasma, showing differences among males, between ejaculates of the same male, and also between the different ejaculate fractions. This work was supported by CICYT (AGF98-0533; AGL01-0471) and INIA (RZ01-019).

Antifungal and antiaflatoxigenic activity of rosemary essential oil (Rosmarinus officinalis L.) against Aspergillus flavus

2019 ◽  
Vol 37 (1) ◽  
pp. 153-161 ◽  
Author(s):  
Natália da Silva Bomfim ◽  
Cássia Yumie Kohiyama ◽  
Lydiana Pollis Nakasugi ◽  
Samuel Botião Nerilo ◽  
Simone Aparecida Galerani Mossini ◽  
...  
Keyword(s):  
Essential Oil ◽  
Aspergillus Flavus ◽  
Rosmarinus Officinalis ◽  
Rosmarinus Officinalis L ◽  
Rosemary Essential Oil

Green tea polyphenol epigallocatechin-3-gallate improves the antioxidant capacity of eggs

2020 ◽  
Vol 11 (1) ◽  
pp. 534-543 ◽  
Author(s):  
Jianping Wang ◽  
Ru Jia ◽  
Pietro Celi ◽  
Xuemei Ding ◽  
Shiping Bai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Antioxidant Capacity ◽  
Green Tea ◽  
Dietary Supplementation ◽  
Tea Polyphenol ◽  
Chemical Substances ◽  
Green Tea Polyphenol

Dietary supplementation with EGCG led to an increase in egg antioxidant activity and antioxidant chemical substances, tryptophan and carotenoid. This may be associated with its increasing effect on the oxidative stress related regulators expression (P38MAPK, Nrf2 and HO-1).

scholarly journals Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Aleksandar Rašković ◽  
Isidora Milanović ◽  
Nebojša Pavlović ◽  
Tatjana Ćebović ◽  
Saša Vukmirović ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Rosmarinus Officinalis ◽  
Rosmarinus Officinalis L

scholarly journals Changes in the essential oil content and terpene composition of rosemary (Rosmarinus officinalis L.) by using plant biostimulants

2016 ◽  
Vol 107 (1) ◽  
pp. 147 ◽  
Author(s):  
Amir FOROUTAN NIA ◽  
Hassanali NAGHDI BADI ◽  
Ali MEHRAFARIN ◽  
Sanaz BAHMAN ◽  
Mehdi SEIF SAHANDI
Keyword(s):  
Amino Acids ◽  
Essential Oil ◽  
Oil Content ◽  
Control Treatment ◽  
Bornyl Acetate ◽  
Rosmarinus Officinalis L ◽  
Complete Fertilizer ◽  
Maximum Content ◽  
Rosemary Essential Oil

Plant biostimulants can stimulate the increase of growth, metabolism and the biosynthesis of metabolites in plants. This study investigated the changes of rosemary essential oil and its components composition under use of biostimulants for the possible reduction in use of chemical fertilizers. Treatments included biostimulants based on amino acids in four formulations, Aminolforte, Kadostim, Humiforte, and Fosnutren (each of them at 0.75 and 1.5 L ha<sup>-1</sup>), and application of N.P.K fertilizer as a control treatment (by applied complete fertilizer at 100 kg per hectar with proportion of 15:8:15 percentage of N:P:K in the fertilizer). Results showed that the essential oil content and its components were significantly affected by biostimulants application. The maximum content of essential oil was obtained at 1.5 L ha<sup>-1 </sup>Humiforte and both concentrations of Aminolforte. While, the highest content of <em>α</em>-pinene, 1,8-cineole, and camphor as major components of rosemary essential oil were obtained at 1.5 L ha<sup>-1 </sup>Fosnutren. In addition, the maximum content of linalool, <em>z</em>-pinocamphone, bornyl acetate, and caryophyllene oxide were observed at 1.5 L ha<sup>-1</sup> Fosnutren.Although, the highest content of myrcene and verbenone was obtained in the treatment with N.P.K fertilizer, but the maximum contents of <em>β</em>-pinene, camphene, borneol, and <em>α</em>-terpineol were related to the both concentrations of Aminolforte.We can conclude that biostimulants based on amino acids can be an effective alternative in reducing the use of chemical fertilizer and increasing the quantity and quality of rosemary essential oil.

scholarly journals Histological study for the biological effect of Rosemary Rosmarinus officinalis L. essential oil on liver and kidney tissues

2013 ◽  
Vol 7 (1) ◽  
pp. 48-53
Author(s):  
Yasamin T. Qadori ◽  
Khaleel I. Rashid ◽  
Ibtihal I. Madhloom ◽  
Mahera N. Al-Shaikh
Keyword(s):  
Essential Oil ◽  
Biological Effect ◽  
Biological Activities ◽  
Histological Study ◽  
Living Matter ◽  
Liver And Kidney ◽  
Rosmarinus Officinalis L ◽  
Different Doses ◽  
Normal Architecture ◽  
Rosemary Essential Oil

Many herbs and plant extracts are added to the diet not only for their aromatic properties but they possess an important biological activity. The aim of the present investigation is to examine the biological activities (describes the beneficial or adverse effects of a drug and materials on living matter) of rosemary essential oil on liver and kidney tissues. The tissues treated with different doses of essential oil of rosemary (100, 200, 300, 400) ml. Histological examination of liver tissue treated with 400 ml of rosemary revealed normal architecture with rate of stimulating cells more than the other concentrations, without dilated and congested of portal vein.

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