scholarly journals Feed Efficiency and Serobiochemical Profile of Wistar Rats Fed With Spirulina As Functional Food

2016 ◽  
Vol 4 (2) ◽  
pp. 135-140 ◽  
Author(s):  
K Manjula ◽  
M Raj ◽  
Ramya Krishna
Keyword(s):  
Sea Water ◽  
Arthrospira Platensis ◽  
Feed Consumption ◽  
Albino Rats ◽  
Test Results ◽  
Model Study ◽  
Study Test ◽  
Serum Biochemical ◽  
Serum Biochemical Profile ◽  
Wistar Albino Rats

Spirulina is an algae that grow in fresh and sea water and itself known to the human community with its unique Neutraceuticals properties, generally produced from the species named Arthrospira platensis, and Arthrospira maxima. Arthrospira species were cultivated throughout the world to fulfil the need of human dietary supplementation. An experimental study was planned to know the effect of spirulina supplementation on serum biochemical profile of Wistar albino rats as model study. Test results clearly denoted that diet planned with spirulina fed rats showed better serobiochemical profile when compared with stock diet and rice based diet. The protein and albumin values were significantly higher in spirulina fed rats. Feed consumption rate is very low in spirulina diet but gained more weight when compared to stock and rice diets, this might be due to high biological value protein in spirulina.

scholarly journals Assessment of the nutritive value of toasted castor seed cake-based diets as a reflect on blood profile of weanling wistar albino rats

2021 ◽  
Vol 44 (3) ◽  
Author(s):  
A. F Agboola
Keyword(s):  
Blood Cell ◽  
Castor Seed ◽  
Albino Rats ◽  
Blood Profile ◽  
Seed Cake ◽  
Soyabean Meal ◽  
Serum Biochemical ◽  
Wistar Albino Rats ◽  
Biochemical Indices ◽  
Dietary Treatments

Since the cost of feed is increasing due to the keen competition between humans and animals, there is a need to critically seek for a matching alternative. Castor seed cake, a residue after the extraction of oil from nutrients-rich castor seed constitutes a waste which can be converted into livestock feed. Thus, the study was carried out to investigate the effect of graded levels of castor seed cake diets on haematological and serum biochemical indices of weanling albino rats in an experiment that lasted 21 days. Thirty weanling Wistar albino rats were weighed individually and randomly assigned to 5 dietary treatments with 3 replicates of two rats in a completely randomized design. Diet 1 was a nitrogen-free diet (NFD), while diets 2, 3, 4, and 5 had 0% (without castor seed cake inclusion), 2, 4 and 6% castor seed cake replacing soyabean meal respectively. At day 21, blood samples were obtained from two rats per replicate for haematological and serum analysis. There were no significant differences (P>0.05) observed in all the parameters (packed cell volume, haemaglobin, red blood cell, white blood cell, lymphocyte, neutrophil, monocyte, eosinophil and platelet) measured. Similarly, diet had no effect on the serum biochemical indices (creatinine, urea, total protein and globulin) measured. Significant difference (P<0.05) was however observed in albumin (2.62 – 3.18g/dL) of rats on the different experimental diets. The albumin concentrations of weanling albino rats on dietary treatments were similar to those on the control diet but significantly (P<0.05) higher (3.09 – 3.18g/dL) than those on the nitrogen free diet. It can be concluded that castor seed cake can replace soyabean meal up to 6% inclusion level without eliciting detrimental effect on blood profile of weanling wistar albino rats.

scholarly journals Tubular Necrosis, Acid-Base and Electrolyte Abnormalities Associated with Gasoline Vapour-induced Nephrotoxicity

2020 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Renal Function ◽  
Biochemical Markers ◽  
Histopathological Examination ◽  
Albino Rats ◽  
Renal Vasculature ◽  
Tubular Necrosis ◽  
Serum Biochemical ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Electrolyte Abnormalities

Introduction: This study aimed to assess the effect of exposure to gasoline vapor (GV) on the histomorphology and biochemical markers of renal function in rats. Methods: Twenty-four mature Wistar Albino rats weighing 180–200 g were randomly divided into two groups (n = 12 per group). Animals in group 1 (G1) served as unexposed controls, while animals in group 2 (G2) were exposed to GV for 35 days. At the end of the exposure, the animals were sacrificed, and blood samples were collected for biochemical analysis while the kidneys were removed and processed for histopathological evaluation. Results: Serum biochemical markers of renal function in the exposed group differed significantly (p< 0.05) from the unexposed group in urea (45.16 ± 1.00mg/dl versus(vs) 13.20 ± 0.69 mg/dl), creatinine (1.16 ± 0.27mg/dl vs 0.38 ± 0.10mg/dl), uric acid (3.66 ± 0.82mmol/L vs 1.96 ± 0.08mmol/L), potassium (6.90 ± 0.27mmol/L vs 3.57 ± 0.26mmol/L), sodium (182.60 ± 3.21mmol/L vs 141.33 ± 10.46mmol/L), chloride (119.00 ± 1.58mmol/L vs 103.33 ± 2.07mmol/L), pH (6.82 ± 0.22 vs 7.38 ± 0.25), bicarbonate (16.60 ± 5.03mmol/L vs 26.50 ± 3.45mmol/L), and glucose (125.60 ± 16.23mg/ dl vs 83.33 ± 4.46mg/dl). Histopathological examination of kidney sections revealed areas of degenerative and necrotic changes in the glomerulus, tubules, and renal vasculature, particularly in the cortical portion of the kidney. Conclusion: Chronic exposure to gasoline compounds may be associated with significant structural and biochemical derangements in kidney function.

scholarly journals EFFECT OF ARTHROSPIRA PLATENSIS AS A FOOD SUPPLEMENT AGAINST SODIUM FLUORIDEINDUCED INTOXICATION ON SOFT TISSUES OF MALE WISTAR ALBINO RATS

2017 ◽  
Vol 10 (11) ◽  
pp. 133
Author(s):  
Ravindra Reddy Kandula ◽  
Narasimha Jayaveera Korlakunta ◽  
Raghavendra Mitta
Keyword(s):  
Body Weight ◽  
Soft Tissues ◽  
Radical Scavenging ◽  
Arthrospira Platensis ◽  
Albino Rats ◽  
Hydroalcoholic Extract ◽  
Group I ◽  
Liver And Kidney ◽  
Wistar Albino Rats

  Objective: The objective of the present study was to explore the in vitro antioxidant and effect of hydroalcoholic extract of Arthrospira platensis (ASP) against sodium fluoride (NaF)-induced toxic effects on soft tissues (heart, liver, and kidney).Methods: In vitro antioxidant activity was assessed using 1,1-diphenyl-2-picrylhydrazyl radical scavenging, 2,2’-azino-bis(3-ethylbenzothiazoline- 6-sulphonic acid) radical scavenging, metal chelation, total antioxidant and reducing power assays, and total flavonoid and phenol content. In this study, 36 male Wistar albino rats were divided into six groups of six animals each. Animals were served as Group I - normal control, Group II - toxic control, and Groups III, IV, and V - treatment groups, which received hydroalcoholic extract of ASP at doses of 100, 200, and 400 mg/kg body weight (p.o), respectively. Group VI served as plant control received hydroalcoholic extract of ASP at a dose of 400 mg/kg body weight (p.o). All groups except Groups I and VI received NaF (100 ppm) through drinking water for 30 days.Results: Results showed that intoxication of NaF caused significant elevation of serum biomarkers of the heart, liver, and kidney and altered tissue oxidative stress markers’ levels. Administration of hydroalcoholic extract of ASP significantly normalized elevated serum levels of heart (p<0.001), liver (p<0.001, p<0.05), and kidney biomarkers (p<0.001). Decrease in lipid peroxidation and increase in reduced glutathione and catalase enzyme levels in a dose-dependent manner were observed in soft tissues (p<0.001, p<0.01, and p<0.05).Conclusion: The study revealed that ASP has good antioxidant and mitigative action against NaF intoxication on soft tissues.

scholarly journals Examination of the Ovarian Reserve after Generation of Unilateral Rudimentary Uterine Horns in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Hasan Toyganözü ◽  
Hakan Nazik ◽  
Raziye Narin ◽  
Deniz Satar ◽  
Mehmet Ali Narin ◽  
...  
Keyword(s):  
Rat Model ◽  
Statistical Significance ◽  
Albino Rats ◽  
Negative Effects ◽  
Primordial Follicles ◽  
Rudimentary Horn ◽  
Model Study ◽  
Experimental Rat Model ◽  
Wistar Albino Rats ◽  
The Right

Objective. The purpose of this experimental rat model study is to evaluate the changes in the ovarian environment after excision of the rudimentary horn.Methods. Ten female Wistar albino rats were used in this study. One cm of right uterine horn length was excised in the first operation. Two months after the first operation, all animals were sacrificed to obtain ovaries for histological examination. Mann-WhitneyUtest and Student'st-test were used for statistical analysis purposes. Statistical significance was defined asP<0.005.Results. The number of primordial follicles (P=0.415), primary follicles (P=0.959), preantral follicles (P=0.645), antral follicles (P=0.328), and Graafian follicles (P=0.721) was decreased and the number of atretic follicles (P=0.374) increased in the right ovarian side. Howeve,r this difference was not found to be statistically significant.Conclusion. The results of this experimental rat model study suggest that the excision of rudimentary horn could have negative effects on ipsilateral ovarian functions.

The Effect of Pentoxifylline and Hyperbaric Oxygen on Achilles Osteotendinous Junction İnjury: An experimental animal model study

2019 ◽  
Vol 21 (6) ◽  
pp. 437-446
Author(s):  
Mehmet Taner Palabıyık ◽  
Yavuz Akalın ◽  
Ömer Yalçın ◽  
İsmail Gökhan Şahin ◽  
Nazan Çevik ◽  
...  
Keyword(s):  
Animal Model ◽  
Hyperbaric Oxygen ◽  
Experimental Studies ◽  
Control Group ◽  
Albino Rats ◽  
Positive Effects ◽  
Model Study ◽  
Animal Model Study ◽  
Wistar Albino Rats ◽  
Biomechanical Tests

Background. To investigate the effects of hyperbaric oxygen (HBO) and pentoxifylline (PTX) treatment on osteotendinous junction healing of Achilles tendon in an animal model. Materials and methods. Thirty-six adult female Wistar-albino rats were randomly divided into three groups as control, PTX and HBO groups with a total of 12 rats per group. Under general anesthesia, the Achilles tendons were cut at the level of the osteotendinous junction and repaired. After the surgery, no treatment was given to the control group. Fifty mg/kg intraperitoneal PTX was administered to the PTX group daily for 1 week. The HBO group was exposed to 2,5 atmospheric pressure, 100% oxygen for 2 hours daily for 1 week. All animals were sacrificed at the end of sixth week. Biomechanical tests and histological examinations were performed. Results. Energy absorption was significantly higher in the PTX group than that in the control group after biomechanical tests (p=0.010). Histopathological evaluation results revealed no difference between the groups: however, hyalinization level was relatively better in the HBO group than that in the control group (p=0.026). Conclusions. 1. We concluded that PTX has a positive effect on the treatment of osteotendinous junction injuries based on our results. 2. Although HBO therapy did not provide statistically significant differences, it might have some positive effects on these injuries. 3. Further experimental studies and clinical trials should be conducted.

scholarly journals Effects of Sub-acute Oral Administration of Ethanolic Leaf Extract of Byrsocarpus coccineus on Haematology and Serum Biochemical Parameters of Wistar Albino Rats.

2020 ◽  
Vol 2 (2) ◽  
pp. 97-104
Author(s):  
G. M. Oladele
Keyword(s):  
Leaf Extract ◽  
Serum Biochemistry ◽  
Control Group ◽  
Albino Rats ◽  
Anaesthetized Rats ◽  
Serum Biochemical ◽  
High Doses ◽  
Wistar Albino Rats ◽  
Group D ◽  
Ethanolic Leaf Extract

Byrsocarpus coccineus is an indigenous herb widely dispersed in tropical Africa and commonly known as Crimson thyme. The leaf and root of the plant is noted to possess medicinal benefits in traditional medicine of the Western part of Nigeria. The plant has been reported to possess analgesic, antiplasmodial, inflammatory, antidiarrhic and antipyretic activities. The present study was therefore aimed at determining the sub-acute toxicity of ethanolic leaf extract of Byrsocarpus coccineus. The ethanolic leaf extract of the plant was administered orally at 250, 500, and 1000 mg/kg to three groups A, B and C of Wistar rats respectively for 14 days while the control group D was administered orally with 3ml/kg of distilled water. Blood samples were then obtained from the anaesthetized rats for haematology and serum biochemistry. The result obtained from serum analyses showed a significant increase (p<0.05) in the levels of blood urea nitrogen and creatinine levels while the increase in alkaline phosphatase is not significant for the treated groups B and C compared with the control. It was therefore concluded that high doses of the extract may have untoward effects on the kidney and therefore, the use of the plant extract in high doses should be discouraged.

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