Effect of unilateral electrolytic lesion of fastigial nucleus on behavior, learning and memory of Wistar albino rats

2014 ◽  
Vol 1 (3) ◽  
pp. 54
Author(s):  
Loganathan Sundareswaran ◽  
Rathinasamy Sheeladevi
Author(s):  
KEERTHI PRIYA CS ◽  
MALATHI S ◽  
RAVINDRAN RAJAN

Objective: The aim of the present study is to investigate the effect of paradoxical sleep deprivation (SD) on learning and memory impairment and anxiety-like behavior in female Wistar albino rats. Methods: Eight-arm radial maze, open-field test, and light and dark test were used to assess the animals learning and memory and anxiety-like behavior. Results: SD associated with weaker learning and memory and increased anxiety- and depressive-like behavior in animals. Conclusion: Animals were exposed to SD showed learning and memory impairment and also exhibited increased anxiety- and depressive-like behavior when compared to control animals.


Author(s):  
Pojala Kumar ◽  
Krishnakanth K. ◽  
Jagadeesh Alla

Background: The objective was to study the effect of Aegle marmelos methanolic extracts of leaf (LE) and fruit pulp extract (FE) on learning and memory in albino rats. 40 healthy wistar albino rats of either sex were randomly divided into 10 groups of 4 each (n=4), weighing about 150 to 200 gm were selected for the study. The extracts i.e. 1ml of 1% carboxy methyl cellulose, LE and FE at doses of 100 mg/kg and 200 mg/kg were administered per oral one hour before the experiment.Methods: Learning and memory was assessed by elevated plus maze and Hebb William maze. Latency time and number of entries were assessed by elevated plus maze whereas only latency was assessed by Hebb William maze.Results: Plant extracts of LE and FE at doses 100 mg/kg and 200 mg/kg have shown significant percentage reduction in latency time in elevated plus maze and Hebb William maze (p<0.05) and reduction in the number of entries in elevated plus maze.Conclusions: LE and FE at doses 200 mg/kg have shown significant effect on learning and memory.


Author(s):  
JEYAKUMARI P ◽  
RAVINDRAN RAJAN

Objective: The aim of the study is to investigate the impact of noise-induced stress and electroencephalogram (EEG) with behavioral alteration in male Wistar albino Rats. Methods: Adult albino rats were randomly divided into three groups. Each group contains six animals. Rats exposed to acute and sub-acute noise, stress (100 dB/4 h) were compared with control animals and assessed for learning and memory using an Eight-arm radial maze, Y-maze, T-maze and also monitoring of brain electrical activity showed by the electro encephalography. Results: The reference memory and working memory error increases, in acute and sub-acute noise stress. The amplitude and frequency also increase in frontal and occipital lobar when compared to control animals. Conclusion: Animals were exposed to noise stress showed learning and memory impairment and also changes in EEG wave pattern.


Author(s):  
Pradeep Deshmukh ◽  
Tanaji Nandgude ◽  
Mahendra Singh Rathode ◽  
Anil Midha ◽  
Nitin Jaiswal

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).


2020 ◽  
Vol 19 (2) ◽  
pp. 217-221
Author(s):  
Maria Jesús Lisbona-González ◽  
Candela Reyes-Botella ◽  
Esther Muñoz-Soto ◽  
Maria Victoria Olmedo-Gaya, ◽  
Jorge Moreno-Fernandez ◽  
...  

Adipose tissue is an endocrine organ and has central role in interaction with other organs or tissues while propolis can induce lipolysis. Therefore, the aim of this study is to provide detailed information about adipose tissue homeostasis modifications and body composition during propolis supplement consumption. Twenty male Wistar albino rats (8 weeks) were divided into two groups of 10 animals each and fed for 90 days with two different types of diets: standard for the control group (diet C) and standard diet + 2% propolis (diet P). Thyroid hormones did not show differences, while ghrelin and adiponectin decreased in the group that was fed propolis. Insulin, leptin, and non-esterified fatty acids also increased along with reduced body weight and fat, in addition to increased lean mass when propolis was in the diet. We conclude that propolis could decrease ghrelin and adiponectin but increase non-esterified fatty acids and insulin secretion, which improves body composition.


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