scholarly journals Differences in Platelet Glycoprotein Expression During Menstruation Cycle and Ovulatory Phase

2019 ◽  
Vol 11 (3) ◽  
pp. 83
Author(s):  
Faisal M. Alzahrani ◽  
Fathelrahman M. Hassan
Keyword(s):  
Menstrual Cycle ◽  
Reproductive Age ◽  
Hormonal Contraceptives ◽  
Platelet Glycoprotein ◽  
Arab Women ◽  
Platelet Activity ◽  
Reproductive Age Women ◽  
Physiological Properties ◽  
Significant Difference ◽  
Integrin Gene

INTRODUCTION: The variations in the physiological properties of female platelets during menstrual cycle phases, pregnancy and postmenopausal women to interactions with platelet CD49b, CD42b, CD41a and CD61 expression glycoprotein receptors were not well understood. Therefore, the aim of the present study was to evaluate the expression of these glycoprotein receptors during menstruation and ovulatory phase of menstrual cycle in reproductive age women. METHODS: It is across section study including 44 healthy young non‑hormonal contraceptives taking women aged between 19-44 years to determine the effect of estrogen on the expression level of platelet glycoprotein receptors (GPIb, GPIIa, GPIIb and GPIIIa) in its resting state in women in reproductive age. RESULTS: No significant difference in the expression of CD42b, CD41a and CD61 between menstruation and ovulatory phases in resting platelets in all subjects. However, this study showed a significant difference in CD49b expression in none-Arab ethnic subjects compared to Arab women. CONCLUSION & RECOMMENDATIONS: This study suggested CD49b glycoprotein receptor used to be the commonly expression on the surface of platelet at some stage in menstruation and ovulatory segment of menstrual cycle in reproductive age women in turn extended platelet activity. Further studies including large number of subjects, platelet integrin gene polymorphisms and progesterone factors changes in platelet clotting associated to menstrual cycle should be conducted.

The effect of menstrual cycle on platelet aggregation in reproductive-age women

Platelets ◽  
2010 ◽  
Vol 21 (5) ◽  
pp. 343-347 ◽  
Author(s):  
Nir Melamed ◽  
Yariv Yogev ◽  
Tal Bouganim ◽  
Eran Altman ◽  
Andreas Calatzis ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Menstrual Cycle ◽  
Reproductive Age ◽  
Reproductive Age Women

scholarly journals PENGGUNAAN KONTRASEPSI HORMONAL DAN OBESITAS PADA WANITA USIA SUBUR DI INDONESIA: ANALISIS DATA IFLS 5 TAHUN 2014

2020 ◽  
Vol 10 (2) ◽  
pp. 101-110
Author(s):  
Yusri Kartika ◽  
Sudarto Ronoatmodjo
Keyword(s):  
Contraceptive Use ◽  
Cox Regression ◽  
Hormonal Contraception ◽  
Hormonal Contraceptive ◽  
Reproductive Age ◽  
Hormonal Contraceptives ◽  
Bivariate Analysis ◽  
P Value ◽  
Cross Sectional ◽  
Reproductive Age Women

Abstract Background: Prevalence of obesity in adult females in Indonesia is 32,9% in 2013. Hormonal contraceptives (pills, injections and implants) are widely used by reproductive-age women in Indonesia, and the prevalence is 45%. Objective: The aim of this study is to identify whether reproductive-age women who use hormonal contraceptives are at risk of developing obesity compared to WUS who do not use hormonal contraceptives. Method: The design of this study is a cross sectional study using secondary data (5th Indonesia Family Life Survey, and the sample is reproductive-age women (15-49 years old) consisting of 6045 respondents. The variables of this study are obesity, hormonal contraceptive use, age, education, occupation, and duration of contraceptive use. Data were analysed by using Cox Regression. Result: The results of bivariate analysis showed that hormonal contaceptive use, age, education, occupation, and duration of contraceptive use were associated with obesity among reproductive-age womenand statistically significant (P-Value <0,05). Multivariate analysis showed that hormonal contraceptive use did not increase the risk of obesity among reproductive-age women in Indonesia (PR 0.939; CI 95% 0.869 - 1.013). Conclusion: The use of hormonal contraception did not increase the risk of obesity among reproductive-age women. Key words: Hormonal Contraception; Obesity; Reproductive Age-Women Abstrak Latar belakang : Prevalensi obesitas pada perempuan dewasa di Indonesia sebesar 32,9 persen pada tahun 2013. Kontrasepsi hormonal (pil, suntikan dan implan) merupakan jenis kontrasepsi yang paling banyak digunakan oleh wanita usia subur (WUS) di Indonesia, dengan prevalensi sebesar 45%. Tujuan : untuk mengetahui apakah wanita usia subur (WUS) yang menggunakan kontrasepsi hormonal berisiko mengalami obesitas dibandingkan WUS yang tidak menggunakan kontrasepsi hormonal.  Metode : Desain penelitian ini adalah studi cross- sectional dengan menggunakan data sekunder IFLS 5 tahun 2014. Sampel adalah WUS (15-49 tahun) sebanyak 6.045 responden. Variabel dalam penilitian ini adalah obesitas pada WUS, penggunaan kontrasepsi hormonal, umur, pendidikan, pekerjaan, serta lama penggunaan kontrasepsi. Analisis data yang digunakan adalah Cox Regression. Hasil : Hasil analisis bivariat menunjukkan bahwa variabel penggunaan kontrasepsi hormonal, umur, pendidikan dan status pekerjaan, serta  lama penggunaan kontrasepsi berhubungan dengan obesitas pada WUS (p-value <0,05). Analisis multivariat menunjukkan bahwa penggunaan kontrasepsi hormonal tidak meningkatkan risiko obesitas secara bermakna pada WUS di Indonesia (PR 0,939; CI 95% 0,869 – 1,013). Kesimpulan: Penggunaan kontrasepsi hormonal tidak meningkatkan risiko WUS untuk mengalami obesitas.   Kata kunci: Kontrasepsi Hormonal; Obesitas; Wanita Usia Subur

scholarly journals Hormonal contraception and the risk of severe asthma exacerbation: 17-year population-based cohort study

Thorax ◽  
2020 ◽  
pp. thoraxjnl-2020-215540
Author(s):  
Bright I Nwaru ◽  
Holly Tibble ◽  
Syed A Shah ◽  
Rebecca Pillinger ◽  
Susannah McLean ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Severe Asthma ◽  
Asthma Exacerbation ◽  
Population Based ◽  
Emergency Department Visits ◽  
Reproductive Age ◽  
Hormonal Contraceptives ◽  
Reproductive Age Women ◽  
Severe Asthma Exacerbation

BackgroundLongitudinal studies investigating impact of exogenous sex steroids on clinical outcomes of asthma in women are lacking. We investigated the association between use of hormonal contraceptives and risk of severe asthma exacerbation in reproductive-age women with asthma.MethodsWe used the Optimum Patient Care Research Database, a population-based, longitudinal, anonymised primary care database in the UK, to construct a 17-year (1 January 2000–31 December 2016) retrospective cohort of reproductive-age (16–45 years, n=83 084) women with asthma. Using Read codes, we defined use, subtypes and duration of use of hormonal contraceptives. Severe asthma exacerbation was defined according to recommendations of the European Respiratory Society/American Thoracic Society as asthma-related hospitalisation, accident and emergency department visits due to asthma and/or oral corticosteroid prescriptions. Analyses were done using multilevel mixed-effects Poisson regression with QR decomposition.ResultsThe 17-year follow-up resulted in 456 803 person-years of follow-up time. At baseline, 34% of women were using any hormonal contraceptives, 25% combined (oestrogen/progestogen) and 9% progestogen-only contraceptives. Previous (incidence rate ratio (IRR) 0.94, 95% CI 0.92 to 0.97) and current (IRR 0.96, 95% CI 0.94 to 0.98) use of any, previous (IRR 0.92, 95% CI 0.87 to 0.97) and current use of combined (IRR 0.93, 95% CI 0.91 to 0.96) and longer duration of use (3–4 years: IRR 0.94, 95% CI 0.92 to 0.97; 5+ years: IRR 0.91, 95% CI 0.89 to 0.93) of hormonal contraceptives, but not progestogen-only contraceptives, were associated with reduced risk of severe asthma exacerbation compared with non-use.ConclusionsUse of hormonal contraceptives may reduce the risk of severe asthma exacerbation in reproductive-age women. Mechanistic studies investigating the biological basis for the influence of hormonal contraceptives on clinical outcomes of asthma in women are required.Protocol registration numberEuropean Union electronic Register of Post-Authorisation Studies (EUPAS22967).

scholarly journals Menstrual Cycle and Detectable Human Papillomavirus in Reproductive-age Women: A Time Series Study

2013 ◽  
Vol 208 (9) ◽  
pp. 1404-1415 ◽  
Author(s):  
Su-Hsun Liu ◽  
Rebecca M. Brotman ◽  
Jonathan M. Zenilman ◽  
Patti E. Gravitt ◽  
Derek A. T. Cummings
Keyword(s):  
Time Series ◽  
Human Papillomavirus ◽  
Menstrual Cycle ◽  
Reproductive Age ◽  
Time Series Study ◽  
Reproductive Age Women ◽  
Series Study

Menarche and Menstruation in Various Ethnic Groups in Israel

1971 ◽  
Vol 20 (4) ◽  
pp. 384-391 ◽  
Author(s):  
I. Halbrecht ◽  
E. Sklorowski ◽  
J. Tsafrir
Keyword(s):  
Public Health ◽  
Menstrual Cycle ◽  
Socioeconomic Factors ◽  
Sexual Development ◽  
Significant Relationship ◽  
Genetic Factors ◽  
Arab Women ◽  
Geographic Factors ◽  
Significant Difference ◽  
Age Of Menarche

SUMMARYSexual development may be influenced by geographic factors (temperature, humidity, altitude, light), socioeconomic factors (nutrition, public health, family size), and genetic factors (population, familial heredity). Most of them are largely interrelated and difficult to define.An anamnestic study has been carried out in Israel on Ashkenazi, non-Ashkenazi, and Arab women aged 19 to 60. The age of menarche appeared to be significantly different for Ashkenazi vs. non-Ashkenazi, while no significant difference was found between Arabs and either of the two Jewish groups. Highly significant differences were found for the length of the menstrual cycle, although this finding should be considered with caution. No significant relationship was found between age of menarche and length of the menstrual cycle.

scholarly journals Use of combined hormonal contraceptives among women with systemic lupus erythematosus with and without medical contraindications to oestrogen

Rheumatology ◽  
2019 ◽  
Vol 58 (7) ◽  
pp. 1259-1267 ◽  
Author(s):  
Arielle Mendel ◽  
Sasha Bernatsky ◽  
Christian A Pineau ◽  
Yvan St-Pierre ◽  
John G Hanly ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Premenopausal Women ◽  
Reproductive Age ◽  
World Health ◽  
Hormonal Contraceptives ◽  
Factors Associated ◽  
Reproductive Age Women ◽  
Observational Cohort ◽  
Health Organization ◽  
Combined Hormonal Contraceptives

Abstract Objectives To assess the prevalence of combined hormonal contraceptives (CHCs) in reproductive-age women with SLE with and without possible contraindications and to determine factors associated with their use in the presence of possible contraindications. Methods This observational cohort study included premenopausal women ages 18–45 years enrolled in the SLICC Registry ⩽15 months after SLE onset, with annual assessments spanning 2000–2017. World Health Organization Category 3 or 4 contraindications to CHCs (e.g. hypertension, aPL) were assessed at each study visit. High disease activity (SLEDAI score >12 or use of >0.5 mg/kg/day of prednisone) was considered a relative contraindication. Results A total of 927 SLE women contributed 6315 visits, of which 3811 (60%) occurred in the presence of one or more possible contraindication to CHCs. Women used CHCs during 512 (8%) visits, of which 281 (55%) took place in the setting of one or more possible contraindication. The most frequently observed contraindications were aPL (52%), hypertension (34%) and migraine with aura (22%). Women with one or more contraindication were slightly less likely to be taking CHCs [7% of visits (95% CI 7, 8)] than women with no contraindications [9% (95% CI 8, 10)]. Conclusion CHC use was low compared with general population estimates (>35%) and more than half of CHC users had at least one possible contraindication. Many yet unmeasured factors, including patient preferences, may have contributed to these observations. Further work should also aim to clarify outcomes associated with this exposure.

scholarly journals Modulation of Platelet Functions Assessment during Menstruation and Ovulatory Phases

2019 ◽  
Vol 12 (3) ◽  
pp. 296-300
Author(s):  
Faisal Alzahrani ◽  
◽  
◽  
Fathelrahman Hassan ◽  
Keyword(s):  
Menstrual Cycle ◽  
Platelet Function ◽  
Luteal Phase ◽  
Thrombus Formation ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Platelet Activity ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Platelet Functions

During menstruation, endometrial hemostasis is achieved by platelet aggregation, fibrin deposition, and thrombus formation that interact with local endocrine and immunological factors which cause termination of menstrual bleeding. Interactions between steroidal sex hormones and platelet functions are not well understood. The aim of this study was to evaluate the effect of platelet function during the menstrual cycle and luteal phase in women of reproductive age. The cross-sectional study on women of reproductive age included 44 healthy women. Platelet function was assessed by PFA-100TM analyzer with collagen/epinephrine and collagen/ADP cartridges during the menstrual cycle and luteal phase. There were no significant differences in platelet function between menstruation and ovulatory phase. Platelet activity in Arab collagen/epinephrine cartridge increased during menstruation compared to non-Arab ethnic subjects and no significant differences in platelet function were found when using collagen/ADP cartridge. This study suggested modulation in platelet functions during menstruation and luteal phase in women of reproductive age. Further studies, including a large number of subjects, platelet genetic and progesterone factors change in platelet clotting associated to menstrual cycle should be conducted.

scholarly journals The role of hysteroresectoscopy in the diagnosis and treatment of reproductive age women with uterine leiomyoma

2021 ◽  
Vol 5 ◽  
pp. 61-64
Author(s):  
M.A. Flaksemberg
Keyword(s):  
Menstrual Cycle ◽  
Histological Examination ◽  
Uterine Leiomyoma ◽  
Endometrial Hyperplasia ◽  
Ultrasound Examination ◽  
Uterine Cavity ◽  
Reproductive Age ◽  
Chronic Endometritis ◽  
Reproductive Age Women ◽  
Ultrasound Findings

The objective: to investigate the features of hysteroscopic picture of the uterine cavity and endometrium condition in women with uterine leiomyoma (UL) and the possibility of using the results to choose a treatment method.Materials and methods. A total amount of reproductive age women with uterine leiomyoma that was examined is 216. Among them 118 women underwent surgical treatment for UL and 98 patients treated with conservative therapy. In addition to general clinical methods, ultrasound examination, hysterorectoscopy, and histological examination of the obtained material was performed, followed by a comparative analysis of the findings.Results. According to hysteroresectoscopy, the uterine cavity in women with UL was more frequently characterized by irregular wall relief (47.7%) and irregular shape (43.1%) due to submucosal (14.4%) and intramural nodes with centripetal growth (30.6% ), which was significantly more frequent compared to ultrasound findings (13.9%, p<0.05). Endometrial polyps predominated among endometrial pathology (55.6%), which was consistent with the histological finding (59.7%) and was twice as frequent as ultrasound findings (23.1%, p<0.05). And endometrial hyperplasia (14.8%), which was consistent with ultrasound findings (18.1%) but was twice as rare compared to histological examination (36.6%, p<0.05). Chronic endometritis was detected at hysteroscopy in less than 1% of subjects, whereas at histological examination, it was 26.4%, p<0.05. Ultrasound examination revealed no endometrial transformation during the cycle in 30.1% of women, which was consistent with a mismatch in endometrial development to the chronological day of the menstrual cycle according to histological examination (23.1%).Conclusion. Hysteroresectoscopy is an important stage in the examination of women with UL, which helps to assess the condition of the uterine cavity, in particular, the degree of deformation of leiomatous nodules, which determines the clinical course of the disease and is a contributing factor to infertility, and affects the choice of treatment tactics in this cohort of patients. Hysteroresectoscopy when combined with ultrasound and histological examination of the endometrium, a more comprehensive characterisation of the endometrial condition (chronic endometritis, mismatch of the day of the menstrual cycle) and the presence of associated pathological processes (polyps and endometrial hyperplasia) that require correction can be obtained.

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