OPTIMIZATION OF GD AND B CONTAINING COMPOSITION FOR APPLICATION IN EXTREME CONDITION

2011 ◽  
Author(s):  
Nikoloz Chikhradze
Keyword(s):  
Extreme Condition

Analysis of Oncogene Protein Structure Using Small World Network Concept

2020 ◽  
Vol 15 (7) ◽  
pp. 732-740
Author(s):  
Neetu Kumari ◽  
Anshul Verma
Keyword(s):  
Amino Acids ◽  
Protein Structure ◽  
Degree Distribution ◽  
Protein Structures ◽  
Small World ◽  
Extreme Condition ◽  
Centrality Measures ◽  
Small World Network ◽  
Network Concept ◽  
Oncogene Protein

Background: The basic building block of a body is protein which is a complex system whose structure plays a key role in activation, catalysis, messaging and disease states. Therefore, careful investigation of protein structure is necessary for the diagnosis of diseases and for the drug designing. Protein structures are described at their different levels of complexity: primary (chain), secondary (helical), tertiary (3D), and quaternary structure. Analyzing complex 3D structure of protein is a difficult task but it can be analyzed as a network of interconnection between its component, where amino acids are considered as nodes and interconnection between them are edges. Objective: Many literature works have proven that the small world network concept provides many new opportunities to investigate network of biological systems. The objective of this paper is analyzing the protein structure using small world concept. Methods: Protein is analyzed using small world network concept, specifically where extreme condition is having a degree distribution which follows power law. For the correct verification of the proposed approach, dataset of the Oncogene protein structure is analyzed using Python programming. Results: Protein structure is plotted as network of amino acids (Residue Interaction Graph (RIG)) using distance matrix of nodes with given threshold, then various centrality measures (i.e., degree distribution, Degree-Betweenness correlation, and Betweenness-Closeness correlation) are calculated for 1323 nodes and graphs are plotted. Conclusion: Ultimately, it is concluded that there exist hubs with higher centrality degree but less in number, and they are expected to be robust toward harmful effects of mutations with new functions.

Sub-millikelvin station at Synergetic Extreme Condition User Facility

2018 ◽  
Vol 27 (7) ◽  
pp. 070702
Author(s):  
Zhi Gang Cheng ◽  
Jie Fan ◽  
Xiunian Jing ◽  
Li Lu
Keyword(s):  
Extreme Condition ◽  
User Facility

Design and dynamic analysis of landing gear system in vertical takeoff and vertical landing reusable launch vehicle

2018 ◽  
Vol 233 (10) ◽  
pp. 3700-3713
Author(s):  
Ming Zhang ◽  
Dafu Xu ◽  
Shuai Yue ◽  
Haifeng Tao
Keyword(s):  
General Scheme ◽  
Surface Friction ◽  
Launch Vehicle ◽  
Landing Gear ◽  
Gear System ◽  
Extreme Condition ◽  
Response Characteristics ◽  
Reusable Launch Vehicle ◽  
Vertical Landing ◽  
Vertical Takeoff

Landing gear system is a key part of the implementation of reusable vertical takeoff and vertical landing launch vehicle, where its buffing performance is directly related to the vehicle whether it can land safely or stably. According to the reusable launch vehicle general scheme, outrigger landing legs are designed, and the hydraulic absorber is used for the landing gear system. Meanwhile, a scaling principle prototype of landing gear system is developed, and the landing impact test is carried out. A dynamic simulation model of the landing vehicle has been set up, researching the influence of parameters, such as the horizontal velocity, initial inclination, surface friction coefficient, and pitch angular velocity on the landing performance. Four kinds of extreme conditions are identified, and dynamic response characteristics of landing system under each extreme condition are conducted. The simulation results are in good agreement with the experimental data. The buffing performance of the vehicle meets the design requirements, which provides a reference for the design of landing gear system of the vehicle.

Extreme Wave Condition at Doggerbank

2016 ◽  
Vol 138 (4) ◽  
Author(s):  
Espen Engebretsen ◽  
Sverre K. Haver ◽  
Dag Myrhaug
Keyword(s):  
Wind Turbines ◽  
Wind Farm ◽  
Offshore Wind ◽  
Extreme Condition ◽  
Exceedance Probability ◽  
Extreme Wave ◽  
Sea State ◽  
Wave Condition ◽  
The North ◽  
Wave Conditions

In design of offshore wind turbines, extreme wave conditions are of interest. Usually, the design wave condition is taken as the sea state corresponding to an annual exceedance probability of 2 × 10−2, i.e., a return period of 50 years. A possible location for a future wind farm, consisting of bottom fixed wind turbines, is the Doggerbank area. The water depth in this area varies from about 60 m in the north to about 20 m in the south. The hindcast database NORA10 provides sea state characteristics from 1957 to present over a domain covering Doggerbank. Regarding the deeper areas just north of Doggerbank, this hindcast model is found to be of good quality. Larger uncertainties are associated with the hindcast results as we approach shallower water further south. The purpose of the present study is to compare sea state evolution over Doggerbank as reflected by NORA10 with the results of the commonly used shallow water hindcast model SWAN. The adequacy of the default parameters of SWAN for reflecting changes in wave conditions over a sloping bottom is investigated by comparison with model test results. Extreme wave conditions for two locations 102.5 km apart in a north–south direction are established using NORA10. This is done using both, an all sea states approach and a peak over threshold (POT) approach. Assuming the extremes for the northern position to represent good estimates, the wave evolution southward is analyzed using SWAN. The extreme condition obtained from NORA10 in the northern position is used as input to SWAN and the results from the two hindcast models are compared in the southern position. SWAN seems to suggest a somewhat faster decay over Doggerbank compared to NORA10.

scholarly journals Advanced Modelling of KF Implemented Flying Wing

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Widanalage Dakshina ◽  
Thiwanka Fernando
Keyword(s):  
Extreme Condition ◽  
Flow Conditions ◽  
Ongoing Research ◽  
Stability And Control ◽  
Advanced Phase ◽  
Landing Gears ◽  
Two Phases ◽  
The Stability ◽  
And Control ◽  
Base Design

This research carries out the advanced phase in correlation with the previous published design of KF Implemented Flying Wing. At the primary stage the basic design was considered under omission of non-static components and turbulent conditions. At this stage the simulations have taken a step ahead with improved flow conditions and advanced modeling of the design. As per the design aspects the engines, pylons, landing gears and shape improvements were done with solid modeling. Due to the computational limitations this was divided in to two phases as cruising conditions with non-static components and further studies to be carried out in Takeoff and Landing conditions with extended landing gears. Under the stability and control conditions a separate research is being carried out in achieving the optimum capability. Propfan engine selected for extreme condition evaluations. The implementations were made without disrupting the base design which was presented in phase one basic simulation carried out prior to this. The simulation results deemed to be promising for the first stage as well as the effect of new components. The secondary target areas are to be carried out in further ongoing research as well

scholarly journals 50 YEARS OF THE DEPARTMENT OF TRAUMATOLOGY, ORTHOPEDICS AND EXTREME CONDITION SURGERY OF KAZAN STATE MEDICAL UNIVERSITY VYACHESLAV F.

2017 ◽  
Vol 10 (4) ◽  
pp. 102-104
Author(s):  
VYACHESLAV F. CHIKAEV ◽  
◽  
GULNARA M. FAIZRAKHMANOVA ◽  
ALEXEY L. EMELIN ◽  
◽  
...  
Keyword(s):  
Extreme Condition ◽  
Medical University

scholarly journals Phosphorus dynamics during early soil development in extreme environment

2021 ◽  
Author(s):  
Zuzana Frkova ◽  
Chiara Pistocchi ◽  
Yuliya Vystavna ◽  
Katerina Capkova ◽  
Jiri Dolezal ◽  
...  
Keyword(s):  
Isotopic Composition ◽  
Soil Development ◽  
Parent Material ◽  
Available P ◽  
Extreme Condition ◽  
Organic P ◽  
Soil P ◽  
Early Stages ◽  
P Pools ◽  
Microbial P

Abstract. At the early stages of pedogenesis, the dynamics of phosphorus (P) in soils are controlled by microbial communities, the physicochemical properties of the soil and the environmental conditions. While various microorganisms involved in carrying out biogeochemical processes have been identified, little is known about the actual contribution of microbial processes, such as organic P hydrolysis and microbial P turnover, to P cycling. We thus focused on processes driven by microbes and how they affect the size and cycling of organic and inorganic soil P pools along a soil chronosequence in the Chamser Kangri glacier forefield (Western Himalayas). The rapid retreat of the glacier allowed us to study the early stages of soil formation under cold arid climate. Biological P transformations were studied with the help of the isotopic composition of oxygen (O) in phosphate (δ18OP) coupled to sequential P fractionation performed on soil samples from four sites of different age spanning 0 to 100–150 years. The mineral P, i.e. 1M HCl-extractable P, represented still 95 % of the total P stock after approximately 100 years of soil development. Its isotopic composition was similar to the parent material also at the most developed site. Primary phosphate minerals, therefore, mostly composed this pool. The δ18OP of the available P and the P bound to Fe and Al oxides instead differed from that of the parent material, suggesting that these pools underwent biological turnover. The isotopic composition of O in of the available P was mostly controlled by the microbial P, suggesting fast exchanges occurred between these two pools possibly fostered by repeated freezing-thawing and drying-rewetting cycles. The release of P from organic P become increasingly important with soil age, constituting one third of the P flux to available P at the oldest site. Accordingly, the lighter isotopic composition of the P bound to Fe and Al oxides at the oldest site indicated that this pool contained phosphate released by organic P mineralization. Compared to previous studies on early pedogenesis under alpine or cold climate, our findings suggest a much slower decrease of the P-bearing primary minerals during the first 100 years of soil development under extreme condition. However, they provide evidence that, by driving short-term P dynamics, microbes play an important role in controlling the redistribution of primary P into inorganic and organic soil P pools.

scholarly journals Recent Progress in Multi-Extreme Condition by Miniature High-Pressure Cell

2012 ◽  
Vol 22 (3) ◽  
pp. 206-213 ◽  
Author(s):  
Kazuyuki MATSUBAYASHI ◽  
Akihiko HISADA ◽  
Tatsuya KAWAE ◽  
Yoshiya UWATOKO
Keyword(s):  
High Pressure ◽  
Recent Progress ◽  
Extreme Condition ◽  
High Pressure Cell ◽  
Pressure Cell

scholarly journals Bulimia Nervosa: A Psychological Eating Disorder

2020 ◽  
pp. 2-2
Author(s):  
Aneeza Tausesf ◽  
Sara Hayee
Keyword(s):  
Eating Disorders ◽  
Eating Disorder ◽  
Bulimia Nervosa ◽  
Mental Health Problems ◽  
Healthy Lifestyle ◽  
Health Problems ◽  
Extreme Condition ◽  
Home Exercise ◽  
Young Generation ◽  
Short Period

Eating disorders are multifaceted mental health problems which require medical treatments and counseling from a psychological expert.In extreme condition,these eating disorders can cause serious health problems and may be lethal if these are not diagnosed and treated timely.Eating Disorder Hope organization has conducted a survey which revealed thatalmost 40% of teen age girls were suffering from at least one kind of eating disorder while91% of young females do dieting to reduce their weight. It has been estimated that about one million males and ten million females suffer from various types of eating disorders.  Bulimia nervosa is one of the eating disorders. It oftens develops in teenage or early adulthood.It is common in women than men. In bulimia nervosa, a person usually eats a lot in a short period of time. It seems that the personcannot control himself fromeating food. It happens until they are painfully full and then they will purge to end their discomfort and to compensate their calories. They will purge by forced vomitinglaxatives,diuretics or excessive exercise.Frequent self-induced vomiting can contribute to inflammation of parotidgland and can result in hand calluses. It is more common in families appearing in generations.There are many risk factors for this disease like being overweight/obesity, socio-cultural pressures to have a well tonned body, psychological impacts resulting in stress and poor self-esteem. Dieting has become a part of our culture. There are manysymptoms of bulimia. For example, patients live in a fear of gaining weight, they go through the repeated episodes of abnormal eating large amounts of food in single sitting. There is a feeling which develops in patients that they cannot control what they eat and what type of food they eat, and after bingering they are forcing themselves to vomit and do more exercise to stop weight gain. If we leave bulimia untreated it will cause kidney problems, irregular heart rhythms, digestive issues and dental problems etc. In time treatment and diagnosis of bulimia helps the person to recover well and quick and the person can get rid of this disorder completely otherwise it can be life threatening. A person experiences bulimia to manage the emotional pain he is undergoing but it only worsens the condition and the response may be to ramp up obsessive thoughts and compulsive behaviors. Nearly half of bulimia patients have a co-occuring mood disorder and more than half of bulimia patients have co-occuring anxiety disorders. Self-harm is a common condition affecting 34% of those with bulimia. Recent studies on bulimia show that in 10-15% of male members of our society who are living with this disorder, risk of suicide has increased. Statistics show that relapse of this disorder isvery common.Relapse is occurring in about30-50% of the cases, and it isleading to common cause of death in suicide.For treatment of bulimia nervosa, you may need to go for several types. Bulimia can be reduced by taking anti-depressants or psychotherapy, but using both in combination is more fruitful to overcome this disorder. Psychotherapy is very important for patients, in which the person goes to the psychiatrist to discuss the issues related to bulimia. Educating the patient on nutrition also helps in this regard. Anutritionist can prescribe the food by which a person will feel the cravings for food to a lesser extent. In severe conditions,the patient can be admitted to a hospital because sometimes there is a need fortreatment in a hospital. In many cases it is not possible to eradicate it completely.But before the situation goes wrong, we can guide a person to lead a healthier life with the help of professionally used treatments. Since we are living in an era where everyone is busy, it is important to guide and educate the children about a healthy lifestyle. There is a need to give them confidence about their physical appearance, no matter what their weight, size and shape is. Enjoyable family meals should be arranged on daily basis or regularly. Talks on physical appearances, body weight and dieting should be discouraged at home. Exercise, walk, activities like sports and swimming can help young generation to adopt a healthy lifestyle and streamline their daily life. If you observe that someone in your friends or relatives is having issues related to food which is indicating thathe or she can possibly has an eating disorder, you should talk to the person supportively and discuss the issue and help them in any way you can before the situation gets worse.

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