scholarly journals Mortality reduction with levosimendan in patients with heart failure: Current evidence is underpowered

2021 ◽  
Author(s):  
Filippo Sanfilippo ◽  
Luigi La Via ◽  
Federica Merola ◽  
Marinella Astuto
Keyword(s):  
Heart Failure ◽  
Current Evidence ◽  
Mortality Reduction ◽  
Patients With Heart Failure

scholarly journals Value of MitraClip in Reducing Functional Mitral Regurgitation

2019 ◽  
Vol 13 (1) ◽  
pp. 30-34
Author(s):  
Mehmet Ali Elbey ◽  
Luis Augusto Palma Dallan ◽  
Guilherme Ferragut Attizzani ◽  
Keyword(s):  
Heart Failure ◽  
Mitral Regurgitation ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Functional Mitral Regurgitation ◽  
Current Evidence ◽  
Successful Implementation ◽  
Severe Mitral Regurgitation ◽  
Percutaneous Mitral Valve Repair ◽  
Patients With Heart Failure

Patients with heart failure who have secondary severe mitral regurgitation due to left ventricular dysfunction have a poor prognosis, with high rates of rehospitalization and mortality. Percutaneous mitral valve repair using the MitraClip (Abbott) has been shown to be safe and effective in secondary severe mitral regurgitation with heart failure. The number of MitraClip procedures performed has increased significantly, as recently published large, randomized clinical studies have shown. However, these studies have drawn different conclusions. This review aims to summarize the current evidence for the MitraClip procedure and provide information for its safe and successful implementation, comparing the studies that examined the use of MitraClip versus medical therapy alone or surgical repair for severe secondary mitral regurgitation.

scholarly journals The prevalence of malnutrition and its effects on the all-cause mortality among patients with heart failure: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259300
Author(s):  
Shubin Lv ◽  
Songchao Ru
Keyword(s):  
Heart Failure ◽  
Cohort Studies ◽  
Data Extraction ◽  
Meta Analysis ◽  
Current Evidence ◽  
Cochrane Library ◽  
Cross Sectional ◽  
Total Prevalence ◽  
Patients With Heart Failure ◽  
All Cause Mortality

Objective Malnutrition has a high occurrence in patients with chronic heart failure (CHF). The prevalence of malnutrition and its impact on all-cause mortality in patients with CHF were assessed using a meta-analysis. Methods PubMed, Embase, the Cochrane Library, Web of Science, Medline, CBM, CNKI, WANFANG DATA, and VIP databases were searched to collect cross-sectional and cohort studies on malnutrition, and the prevalence and all-cause mortality of patients with CHF were determined. The time of retrieval was from the database establishment to May 2021. Two researchers independently performed screening of the literature, data extraction and assessed the risk of bias in the included studies. Then Stata 16.0 software was used for meta-analysis. Results A total of 10 cross-sectional and 21 cohort studies were included, including 12537 patients with CHF. A meta-analysis demonstrated that the total prevalence of malnutrition in patients with heart failure was 46% (95% confidence interval [CI]: 0.43, 0.49). Compared to patients with non-malnutrition, malnutrition increased the risk of all-cause mortality in patients with CHF (hazard ratio = 2.15, 95% CI [1.89, 2.45], P < 0.05). Discussion Current evidence suggests that the prevalence of malnutrition is high among patients with CHF. The risk of all-cause mortality in such patients can be increased by malnutrition. Therefore, the risk of malnutrition in patients with CHF should be considered to reduce the occurrence of adverse clinical outcomes.

Mind–Body Interventions in Patients With Heart Failure: State of the Science

2021 ◽  
pp. 073346482110530
Author(s):  
Wanich Suksatan ◽  
Thitipong Tankumpuan
Keyword(s):  
Heart Failure ◽  
Tai Chi ◽  
Psychological Symptoms ◽  
Behavioral Outcomes ◽  
Current Evidence ◽  
Future Research ◽  
Failure State ◽  
Patients With Heart Failure ◽  
Mental Wellness ◽  
State Of The Science

Complementary and alternative medicine are broadly considered mind–body interventions (MBIs) that support physical and mental wellness in patients with heart failure (HF). The aims of this review were to integrate and summarize current evidence from MBIs in patients with HF and to identify gaps for future research. We used PRISMA guideline and conducted a literature search through six databases. Fifteen publications met the criteria, published between 2013 and 2021. This review stipulated that MBIs included yoga, Tai Chi, meditation, reflexology, massage, relaxation, and breathing interventions. The findings emphasized that MBIs could reduce physical and psychological symptoms and improve health outcomes in patients with HF. MBIs had encouraging results for patients with HF on selected physiological and behavioral outcomes. Despite the early state of the evidence in this field, it seems that MBIs will play an essential role in the future for alleviating the symptoms of patients with HF.

Depression and Rehospitalization in Patients With Heart Failure After Discharge From Hospital to Home: An Integrative Review

2021 ◽  
pp. 108482232098696
Author(s):  
Wanich Suksatan ◽  
Thitipong Tankumpuan
Keyword(s):  
Heart Failure ◽  
Healthcare Providers ◽  
Cost Of Care ◽  
Current Evidence ◽  
Adverse Health Outcomes ◽  
Adherence To Medication ◽  
Effective Interventions ◽  
Patients With Heart Failure ◽  
Meta Analyses ◽  
The Relationship

Patients with heart failure are known to be particularly vulnerable to depression resulting in adverse health outcomes. However, there has been no literature review on current evidence regarding the relationship between depression and rehospitalization. This review aims to explore the relationship between depression and rehospitalization in patients with heart failure. A systematic review employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines included articles published between 2001 and 2019 taken from Scopus, PubMed, CINAHL, and PsycINFO databases. We identified 12 relevant studies with participants ranging from 115 to 160,169 patients. Heart failure patients with depression were more likely to be rehospitalized than those without. To explain this, few reasons have been proposed. First, depression could disrupt the regulation of autonomic nervous system, neurohormonal activation, and body’s natural rhythm. Second, depressed patients tend to have poor adherence to medication. Healthcare providers should not only focus on drug and dietary management but also on implementing effective interventions to manage depression, in order to reduce the risk of rehospitalization. Moreover, palliative care should start at the stage of heart failure diagnosis to improve quality of life, better outcomes, and lower cost of care for the patients.

Measures of Engagement with mHealth Interventions in Patients with Heart Failure: A Scoping Review (Preprint)

2021 ◽  
Author(s):  
Ifeanyi Madujibeya ◽  
Terry Lennie ◽  
Adaeze Aroh ◽  
Misook L Chung ◽  
Debra Moser
Keyword(s):  
Heart Failure ◽  
Patient Engagement ◽  
English Language ◽  
Exercise Adherence ◽  
Qualitative Studies ◽  
Current Evidence ◽  
Structured Interviews ◽  
System Usage ◽  
Patients With Heart Failure ◽  
Usage Data

BACKGROUND The computing and communication features of mobile devices are increasingly leveraged in mHealth interventions to provide comprehensive and tailored support that may have positive outcomes in patients with heart failure (HF). However, examination of mHealth intervention effectiveness has provided mixed findings. Considering that patient engagement is a prerequisite for the effectiveness of interventions, understanding how patients engage with mHealth interventions, and the effects of patient engagement on HF outcomes may explain the mixed findings. OBJECTIVE Our aim was to synthesize current evidence on measures of patient engagement with mHealth interventions, and the effects of engagement on HF outcomes METHODS A comprehensive search of the literature was conducted in 7 databases for relevant studies published in the English Language from 2009 to September 2021. Descriptive characteristics of studies were reported. Content analysis was conducted to identify themes that described patient engagement with mHealth in the qualitative studies included in the review. RESULTS We synthesized 32 studies that operationalized engagement with mHealth interventions in 4771 patients with HF (67.9% male), ranging from a sample of 7 to 1571, with a median of 53.3 patients. Patient engagement with mHealth interventions was measured only quantitatively based on system usage data (71.8%, 23/32), only qualitatively based on data from semi-structured interviews and focus groups (6.3%, 2/32), and by a combination of both quantitative and qualitative data (21.9%, 7/32). System usage data were evaluated using 6 metrics of engagement: (1) number of physiological parameters transmitted (63.3%, 19/30); (2) number of HF questionnaires completed (6.7%, 2/30); (3) numbers of logins (13.3%, 4/30); (4) number of short message service (SMS) responses (3.3%, 1/30); (5) time spent (16.7%, 5/30); (6) number of features accessed/screen viewed (9.5%, 4/30). There was a lack of consistency in how system usage metrics were reported across the studies. Eighty percent of the studies reported only the descriptive characteristics of the system usage data. Emotional, cognitive, and behavioral domains of patient engagement were identified in qualitative studies. Patient engagement levels ranged from 45% to 100% and decreased over time. The effects of engagement on HF knowledge, self-care, exercise adherence, and HF hospitalizations were inconclusive. CONCLUSIONS The operational definitions of patient engagement with mHealth interventions are underreported and lack consistency. The application of inferential analytical methods to engagement data is extremely limited. More research focused on developing optimal and standardized measures of patient engagement that may be applied across different study designs is warranted.

scholarly journals Pulmonary Hypertension in Heart Failure Patients

2020 ◽  
Vol 6 ◽  
Author(s):  
Sriram D Rao ◽  
Srinath Adusumalli ◽  
Jeremy A Mazurek
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Left Ventricular ◽  
Current Evidence ◽  
Assist Device ◽  
Ventricular Assist ◽  
Left Ventricular Assist ◽  
Patients With Heart Failure ◽  
Definition Of

The development of pulmonary hypertension (PH) in patients with heart failure is associated with increased morbidity and mortality. In this article, the authors examine recent changes to the definition of PH in the setting of left heart disease (PH-LHD), and discuss its epidemiology, pathophysiology and prognosis. They also explore the complexities of diagnosing PH-LHD and the current evidence for the use of medical therapies, promising clinical trials and the role of left ventricular assist device and transplantation.

scholarly journals Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

2021 ◽  
Author(s):  
Ali A. Al-Mubarak ◽  
Peter van der Meer ◽  
Nils Bomer
Keyword(s):  
Heart Failure ◽  
Current Knowledge ◽  
Left Ventricular ◽  
Selenium Supplementation ◽  
Future Perspective ◽  
Left Ventricular Ejection ◽  
Current Evidence ◽  
Keshan Disease ◽  
Ventricular Ejection Fraction ◽  
Patients With Heart Failure

Abstract Purpose of Review (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30–50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins. Recent Findings Suboptimal selenium levels (<100 μg/L) are prevalent in more than 70% of patients with heart failure and were associated with lower exercise capacity, lower quality of life, and worse prognosis. Small clinical trials assessing selenium supplementation in patients with HF showed improvement of clinical symptoms (NYHA class), left ventricular ejection fraction, and lipid profile, while governmental interventional programs in endemic areas have significantly decreased the incidence of Keshan disease. In addition, several selenoproteins are found impaired in suboptimal selenium conditions, potentially aggravating underlying mechanisms like oxidative stress, inflammation, and thyroid hormone insufficiency. Summary While the current evidence is not sufficient to advocate selenium supplementation in patients with heart failure, there is a clear need for high level evidence to show whether treatment with selenium has a place in the contemporary treatment of patients with HF to improve meaningful clinical endpoints. Graphical abstract

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