Analysis of the impact of bronchial asthma and hypersensitivity to aspirin on the clinical course of chronic sinusitis with nasal polyps

2019 ◽  
Vol 73 (5) ◽  
pp. 1-5
Author(s):  
Marta Podwysocka ◽  
Katarzyna Dąbrowska-Monti ◽  
Wojciech Fendler ◽  
Konrad Pagacz ◽  
Wioletta Pietruszewska
Keyword(s):  
Bronchial Asthma ◽  
Nasal Polyps ◽  
Endoscopic Examination ◽  
Interleukin 4 ◽  
Number Of Patients ◽  
Asthma Patients ◽  
Aspirin Triad ◽  
Aspirin Intolerance ◽  
Severity Of The Disease ◽  
The Impact

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with still not enough known pathogenesis despite the development of genetics, immunological and microbiological research. The number of patients with CRS has been constantly growing. The coexistence of CRS, bronchial asthma and aspirin intolerance (aspirin triad) is an adverse prognostic factor with higher risk of recurrences. The aim of study was to compare the severity of CRSwNP depending of coexistence of bronchial asthma and/or aspirin intolerance. The research was performed in the group of 204 patients operated 2009-2013 with 5 years follow-up. Higher nasal polyps growth in groups of patients with aspirin triad and CRSwNP and bronchial asthma in endoscopic examination (p=0,0005 and p=0,0030 respectively) and CT-scan according to Lund-Mackay point scale (p<0,0001 and p=0,0009) was showed. Also, these patients presented increased severity of nasal symptoms before surgical treatment according to VAS scale (p=0,0126 for CRSwNP with bronchial asthma; p=0,0390 for aspirin triad). Similarly, 6 months after surgery the same groups of patients presented higher severity of the disease symptoms (p<0,0001 for aspirin triad’ patients; p=0,0174 for CRSwNP and bronchial asthma’ patients) . Patients with aspirin triad had also statistically more surgeries in past (p=0,001), what proves that recurrences in this group are very likely to be observed in spite of the use of proper conservative treatment. No such differences have been shown in the group of patients with CRSwNP and isolated aspirin intolerance (without bronchial asthma). Allergy to inhaled allergens, hypersensitivity to aspirin are factors significantly worsening the course of CRSwNP. It would be advisable to consider, despite a lack of history of aspirin intolerance, a hypersensititvity to aspirin test in patients with particularly severe CRSwNP, especially those associated with bronchial asthma. It also seems reasonable to carry out such a test on every patient with newly diagnosed CRSwNP and bronchial asthma in order to be able to plan further treatment in this group of patients accordingly including biological treatment with antimonoclonal therapy against interleukin 4, 5 or13.

Expression of interleukin 4 receptors in bronchial asthma patients who underwent specific immunotherapy

2004 ◽  
Vol 93 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Krzysztof Kowal ◽  
Joanna Osada ◽  
Sebastian Zukowski ◽  
Milena Dabrowska ◽  
Lawrence DuBuske ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Specific Immunotherapy ◽  
Interleukin 4 ◽  
Asthma Patients

scholarly journals CURRENT ISSUES OF BRONCHIAL ASTHMA 2021: WORLD ASTHMA DAY AND THE IMPACT OF THE COVID-19 PANDEMIC

2021 ◽  
Vol 2021 (2) ◽  
pp. 21-26
Author(s):  
G. L. Gumeniuk ◽  
◽  
V. I. Ignatieva ◽  
S. G. Opimakh
Keyword(s):  
Bronchial Asthma ◽  
Viral Entry ◽  
High Performance ◽  
Inhaled Corticosteroids ◽  
Inhaled Steroids ◽  
Key Words Bronchial Asthma ◽  
Asthma Patients ◽  
Transmembrane Serine Protease ◽  
The Impact

This year’s World Asthma Day has the theme “Uncovering Asthma Misconceptions”. This position calls for action and action to clarify common myths and misconceptions about asthma that prevent asthma sufferers from receiving optimal benefits from major success in treating the condition. According to GINA experts, the most common mistakes in the world about asthma are as follows: 1. Myth: asthma is a childhood disease; people “outgrow” it as they age. True: asthma can occur at any age. 2. Myth: Asthma is an infectious disease. Truth: asthma is not contagious disease. 3. Myth: People with asthma should not exercise. Truth: When asthma is well controlled, individuals with asthma can exercise and achieve high performance in sports. 4. Myth: asthma can only be controlled with high doses of steroids. Truth: Most often, asthma is controlled with low doses of inhaled steroids. To a large extent, these theses refer to one of the most important challenges of our time — the management of patients with bronchial asthma in the context of the COVID-19 pandemic. Patients with asthma have a lower susceptibility to COVID-19, a less severe course, and a lower risk of hospitalizations due to COVID-19. Allergic asthma or its eosinophilic phenotype, intake of inhaled corticosteroids (ICS) have a positive effect on the course of the COVID-19 disease, since in such patients the lower expression level of ACE 2 receptors in the upper and lower respiratory tract, which are input receptors for SARS-CoV-2 virus. ICS such as budesonide or ciclesonide are capable of inhibiting the replication of genomic SARS-CoV-2 RNA due to the influence of viral endonuclease NSP15 and TMPRSS2 (transmembrane serine protease 2), a protease involved in viral entry into the cell. Some ICS (including budesonide) reduce or block SARS-CoV-2 replication in vitro. Experts from international asthma groups note that in the face of the COVID-19 pandemic, asthma patients should continue to take basic therapy, including corticosteroids. And in current studies, ICS budesonide in COVID-19 patients reduces the risk of hospitalization or emergency care by 91 % and significantly improves clinical recovery. Key words: bronchial asthma, COVID-19, inhaled corticosteroids, World Asthma Day.

scholarly journals Correlations between symptoms, nasal endoscopy and computed tomography findings in patients with chronic rhinosinusitis without nasal polyps

2020 ◽  
Vol 77 (1) ◽  
pp. 41-46
Author(s):  
Slobodan Savovic ◽  
Natasa Dragnic ◽  
Vladimir Kljajic ◽  
Ljiljana Jovancevic ◽  
Maja Buljcik-Cupic ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Facial Pain ◽  
Nasal Polyps ◽  
Nasal Congestion ◽  
Endoscopic Examination ◽  
Nasal Endoscopy ◽  
Nasal Discharge ◽  
Strongly Correlated ◽  
Moderate Correlation ◽  
Severity Of The Disease

Background/Aim. Chronic rhinosinusitis (CRS) is one of the most common chronic conditions that is diagnosed on the basis of the condition symptoms, nasal endoscopy and computed tomograhpy (CT) of the nose and paranasal sinuses. There are two forms of CRS: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). The aim of this paper was to determine if there is a correlation between the symptoms, nasal endoscopy and CT in patients with CRSsNP. Methods. The study included 110 patients with CRSsNP. The intensity of the symptoms assessed on the visual analogue scale (VAS) and the condition of nasal mucosa and the presence of nasal secretion was estimated by endoscopic examination of the nose while CT was used to determine the Lund-Mackay (LM) score values. Pearson?s coefficient of correlation was used for statistic data processing. Results. The severity of the disease as a whole (r = 0.509) and nasal discharge (r = 0.562) moderately correlated with CT. Nasal congestion (r = 0.354) and the reduction of loss of smell (r = 0.324) mildly correlated with CT, while facial pain/pressure (r = 0.218) had a very weak correlation with CT. The severity of the disease as a whole (r = 0.717) and nasal discharge (r = 0.821) strongly correlated with nasal endoscopy. Nasal congestion (r = 0.525) had a moderate correlation with nasal endoscopy while facial pain/pressure (r = 0.345) and the reduction of the loss of smell (r= 0.394) had a mild correlation with nasal endoscopy. A moderate correlation was found between nasal endoscopy and CT (r = 0.630). Conclusion. The severity of the disease as a whole and nasal discharge have more significant correlations both with nasal endoscopy and CT in relation to the correlations between other symptoms and nasal endoscopy, as well as CT. More significant correlations between the symptoms and nasal endoscopy in relation to the correlations between the symptoms and CT and the existence of a moderate correlation between nasal endoscopy and CT, enable a lesser use of CT diagnostics and only in precisely defined situatiations.

Nasal polyposis in patients with asthma and allergic rhinitis

2012 ◽  
Vol 126 (8) ◽  
pp. 780-783 ◽  
Author(s):  
A Ahmadiafshar ◽  
H R Farjd ◽  
F Moezzi ◽  
N Mousavinasab
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Concomitant Treatment ◽  
Cross Sectional ◽  
High Prevalence ◽  
The Impact

AbstractObjective:This study aimed to determine the prevalence of nasal polyps in patients with allergic rhinitis and with asthma, and also to assess the impact of this condition on these disorders.Study design:Cross-sectional study.Methods:The presence of nasal polyps was assessed by rhinoscopy and endoscopic examination.Results:Nasal polyps were detected in 60 out of 250 patients (24 per cent) with documented asthma or allergic rhinitis. There was a statistically significant correlation between asthma severity and nasal polyposis prevalence (p = 0.007), but not between allergic rhinitis severity and nasal polyposis prevalence (p = 0.081). The prevalence of nasal polyps increased significantly with increasing patient age and rhinitis or asthma duration.Conclusion:The prevalence of nasal polyps in patients with allergic rhinitis or asthma was higher than previously reported. Given this high prevalence of nasal polyposis, nasal examination and concomitant treatment of this disorder are recommended.

scholarly journals Oropharyngeal microbiota features in patients with bronchial asthma, depending on the severity of the disease and the level of control

2015 ◽  
Vol 12 (2) ◽  
pp. 29-36
Author(s):  
S V Fedosenko ◽  
L M Ogorodova ◽  
A S Popenko ◽  
V A Petrov ◽  
A V Tyacht ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Bronchial Asthma ◽  
Taxonomic Composition ◽  
Taxonomic Identification ◽  
Uncontrolled Asthma ◽  
Stable Period ◽  
Systemic Antibiotic Therapy ◽  
Rrna Sequencing ◽  
Asthma Patients ◽  
Severity Of The Disease

This paper presents the results of the comparative analysis of the taxonomic composition of oropharyngeal microbiota obtained by swab from the back of the throat of the 2 groups of patients with bronchial asthma: patients with mild persistent controlled or partially controlled asthma, and patients with severe uncontrolled asthma. The swab collecting procedure was performed in a stable period of the disease without exacerbations episodes and systemic antibiotic therapy courses within the previous 4 weeks or more. Taxonomic identification of the microbiota was performed using conserved regions of bacterial 16S rRNA sequencing. The study revealed a number of differences in the representation of the identified microorganisms that make up the oropharyngeal microbiota in patients with asthma, depending on the severity of asthma, the level of control, other clinical and anamnestic features.

scholarly journals THE AIRWAYS MICROBIAL COMMUNITY COMPOSITION IN HEALTHY INDIVIDUALS AND BRONCHIAL ASTHMA PATIENTS

2015 ◽  
Vol 69 (3-4) ◽  
pp. 71-76
Author(s):  
S. V. Fedosenko ◽  
L. M. Ogorodova ◽  
M. A. Karnaushkina ◽  
E. S. Kulikov ◽  
I. A. Deev ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Bronchial Asthma ◽  
Molecular Genetic ◽  
Microbial Community Composition ◽  
Healthy Individuals ◽  
Phylogenetic Groups ◽  
Healthy Human ◽  
Microbial Identification ◽  
Asthma Patients ◽  
The Impact

This review summarizes the results of studies on the composition of microbial communities in the airways of healthy individuals and patients with asthma. Modern molecular genetic technology of the microbial identification, which are based on a sequence determination of encoding proteins genes conserved regions. These regions form the 16s-subunit ribosomal RNA in microorganisms of different species. These genes are detected by sequencing markers characteristic of individual microorganisms and their phylogenetic groups, and allow to perform a deep analysis of the microbiota in healthy volunteers and patients with chronic bronchoobstructive diseases. So, apparently healthy human bronchial tree is characterized by low bacterial contamination (most typical representatives here are the genera Pseudomonas, Streptococcus, Prevotella, Fusobacteria and Veilonella, much less potentially pathogenic Haemophilus and Neisseria are represented). In bronchial asthma patients the lower respiratory tract microbiota undergoes a qualitative transformation: as compared to healthy individuals the number of Proteobacteria increases and the number of Bacteroidetes decreases. Severe asthma in children is associated with significant respiratory tract Staphylococcus spp. insemination. Association between the asthma developing higher risk in young children and organisms such as Haemophilus, Moraxella and Neisseria spp. It is of considerable interest to determine the role of the microbiome in the development of human diseases of the bronchopulmonary system, and to understand the impact of the microbes communities as a course of disease and the important factor for the development of resistance to therapy.

scholarly journals Clinical and functional featuresof respiratory heat exchange and cold airway hyperresponsiveness in patients with bronchial asthma and chronic polypous rhinosinusitis

2008 ◽  
pp. 59-62
Author(s):  
E. V. Zakharova
Keyword(s):  
Heat Exchange ◽  
Bronchial Asthma ◽  
Airway Hyperresponsiveness ◽  
Nasal Polyps ◽  
Quiet Breathing ◽  
Exhaled Air ◽  
Asthma Patients ◽  
Nasal Function ◽  
Respiratory Heat Exchange ◽  
Healthy Persons

The aim of the study was to investigate airway conditioning function and cold hyperresponsiveness in patients with bronchial asthma (BA) and nasal polyps. One hundred and eleven asthma patients with or without chronic polypous rhinosinusitis (CPR) were examined. Respiratory heat exchange and cold airway hyperresponsiveness were assessed using thermometry of expired air during quiet breathing and isocapnic hyperventilation with cold air in comparison with a group of healthy persons. The conditioning nasal function was worsened in BA patients with CPRS. Disorders of nasal heat exchange led to decreased temperature of the exhaled air during quiet breathing and cold hyperventilation. These disorders were closely related to increased frequency and severity of cold airway hyperresponsiveness.

Successful treatment of nasal polyps with low dose aspirin for asipirin sensitive patients

2020 ◽  
Vol 24 (8) ◽  
pp. 581-584
Author(s):  
Agnė Savonytė ◽  
Justas Arasimavičius ◽  
Darius Rauba ◽  
Violeta Kvedarienė
Keyword(s):  
Bronchial Asthma ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Severe Form ◽  
Alternative Methods ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Aspirin Intolerance ◽  
Methods Of Treatment

Aspirin-exacerbated respiratory disease (AERD) represents a severe form of chronic rhinosinusitis (CRS) characterized by nasal polyposis, bronchial asthma and aspirin intolerance. The following syndrome is difficult to manage. In this report, we present a case of hypersensitivity to acetylsalicylic acid (AsA) together with bronchial asthma and nasal polyps. This case proves that desensitization for aspirin is one of the alternative methods of treatment for nasal polyps and aspirin-induced asthma for people hypersensitive to aspirin.

MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

2013 ◽  
Vol 68 (7) ◽  
pp. 57-60
Author(s):  
O. A. Sharavii ◽  
S. V. Smirnova
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Mycoplasma Hominis ◽  
Acute Stage ◽  
Control Group ◽  
Clinical Markers ◽  
Chlamydophila Psittaci ◽  
Asthma Patients

 Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results.  We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum. 

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