Expression of interleukin 4 receptors in bronchial asthma patients who underwent specific immunotherapy

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with still not enough known pathogenesis despite the development of genetics, immunological and microbiological research. The number of patients with CRS has been constantly growing. The coexistence of CRS, bronchial asthma and aspirin intolerance (aspirin triad) is an adverse prognostic factor with higher risk of recurrences. The aim of study was to compare the severity of CRSwNP depending of coexistence of bronchial asthma and/or aspirin intolerance. The research was performed in the group of 204 patients operated 2009-2013 with 5 years follow-up. Higher nasal polyps growth in groups of patients with aspirin triad and CRSwNP and bronchial asthma in endoscopic examination (p=0,0005 and p=0,0030 respectively) and CT-scan according to Lund-Mackay point scale (p<0,0001 and p=0,0009) was showed. Also, these patients presented increased severity of nasal symptoms before surgical treatment according to VAS scale (p=0,0126 for CRSwNP with bronchial asthma; p=0,0390 for aspirin triad). Similarly, 6 months after surgery the same groups of patients presented higher severity of the disease symptoms (p<0,0001 for aspirin triad’ patients; p=0,0174 for CRSwNP and bronchial asthma’ patients) . Patients with aspirin triad had also statistically more surgeries in past (p=0,001), what proves that recurrences in this group are very likely to be observed in spite of the use of proper conservative treatment. No such differences have been shown in the group of patients with CRSwNP and isolated aspirin intolerance (without bronchial asthma). Allergy to inhaled allergens, hypersensitivity to aspirin are factors significantly worsening the course of CRSwNP. It would be advisable to consider, despite a lack of history of aspirin intolerance, a hypersensititvity to aspirin test in patients with particularly severe CRSwNP, especially those associated with bronchial asthma. It also seems reasonable to carry out such a test on every patient with newly diagnosed CRSwNP and bronchial asthma in order to be able to plan further treatment in this group of patients accordingly including biological treatment with antimonoclonal therapy against interleukin 4, 5 or13.

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MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

Annals of the Russian academy of medical sciences ◽

10.15690/vramn.v68i7.714 ◽

2013 ◽

Vol 68 (7) ◽

pp. 57-60

Author(s):

O. A. Sharavii ◽

S. V. Smirnova

Keyword(s):

Immune Response ◽

Chlamydia Trachomatis ◽

Blood Serum ◽

Bronchial Asthma ◽

Mycoplasma Hominis ◽

Acute Stage ◽

Control Group ◽

Clinical Markers ◽

Chlamydophila Psittaci ◽

Asthma Patients

Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results. We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum.

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Design of a pivotal phase III trial of allergen specific immunotherapy (AIT) using a high-dose house dust mite (HDM) allergoid in patients with allergic bronchial asthma

10.26226/morressier.5acc8ad4d462b8028d89b144 ◽

2018 ◽

Author(s):

Michael Rudert ◽

Viola Gödicke

Keyword(s):

Bronchial Asthma ◽

House Dust ◽

House Dust Mite ◽

Specific Immunotherapy ◽

Phase Iii ◽

High Dose ◽

Pivotal Phase ◽

Allergen Specific Immunotherapy ◽

Phase Iii Trial ◽

Dust Mite

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Incresed IL-33 expression in atopic bronchial asthma patients with confirmed viral respiratory infection

10.26226/morressier.5acdc660d462b8029238e077 ◽

2018 ◽

Author(s):

Mariola Galitskaya

Keyword(s):

Bronchial Asthma ◽

Respiratory Infection ◽

Atopic Bronchial Asthma ◽

Asthma Patients ◽

Viral Respiratory Infection ◽

Viral Respiratory

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Comparison between Compliance of Fluticasone Propionate Diskhaler and of Fluticasone Propionate Diskus in Adult Bronchial Asthma Patients

Respiration ◽

10.1159/000095313 ◽

2006 ◽

Vol 73 (5) ◽

pp. 680-684 ◽

Cited By ~ 1

Author(s):

Takashi Hasegawa ◽

Eiichi Suzuki ◽

Katsuya Fujimori ◽

Takuro Sakagami ◽

Shinichi Toyabe ◽

...

Keyword(s):

Fluticasone Propionate ◽

Bronchial Asthma ◽

Asthma Patients

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GASTROESOPHAGEAL REFLUX DISEASE AND BRONCHIAL ASTHMA: MECHANISMS OF COMORBID FORMATION AND COURSE.

EUREKA Health Sciences ◽

10.21303/2504-5679.2020.001199 ◽

2020 ◽

Vol 2 ◽

pp. 3-7

Author(s):

Aleksey Oparin ◽

Givi Akhvlediani ◽

Anatoliy Oparin ◽

Sergei Pavlov

Keyword(s):

Bronchial Asthma ◽

Interleukin 4 ◽

Enzyme Linked Immunosorbent Assay ◽

Clear Correlation ◽

The Third ◽

Gender And Age ◽

Galectin 3 ◽

Degree Of Certainty ◽

Anti Inflammatory

The aim of the study: To estimate the level of Galectin-3 with the parallel tracing of the content of pro- and anti-inflammatory cytokines Interleukin-6 (IL-6) and Interleukin-4 (IL-4) for patients with GERD and BA both in case of separate nosologies, and in case of their combined course during the period of exacerbation of the diseases. Methods. The study was conducted in three groups of patients, homogeneous by gender and age. The first group included 18 patients with GERD. The second group included 19 patients with intermittent or persistent-mild bronchial asthma. The third group included 22 patients suffering from GERD with concomitant BA intermittent or persistent-mild severity. Determination of the level of galectin-3 and interleukins (IL-4 and IL-6) in the blood serum was carried out by enzyme-linked immunosorbent assay. Results. Analyzing the results of the study, we found that the level of galectin - 3 was increased on average in both groups of patients with isolated GERD (and in patients with BA). In patients of the third group with comorbid pathology, the level of galectin-3 was statistically significantly higher than not only the norm, but also the average of patients with isolated BA and GERD. At the same time, we found the rise in the level of pro-inflammatory (IL-6) and anti-inflammatory (IL-4) cytokines. Moreover, in patients with GERD, the level of IL-6 was increased with a higher degree of reliability, and the level of IL-4 was increased with a lower degree of reliability. In patients with BA, on the contrary, the level of IL-4 was determined more often and higher, and the level of IL-6 was lower. Conclusions. Analyzing result of the study, a clear correlation and features of changes in the level of galectin-3, IL-4, IL-6 in patients with isolated GERD, BA, as well as with the comorbidity of these diseases, were revealed. In patients with BA, the level of galectin-3 increases with the same degree of certainty as in the group of patients with GERD. In the cytokine system, on the contrary, the level of anti-inflammatory (IL-4) cytokines increases with a greater degree of certainty than the level of pro-inflammatory (IL-6) cytokines. In patients with GERD with concomitant BA, the level of galectin-3 increases with a greater degree of certainty. It is observed also a higher rising of pro-inflammatory (IL-6) cytokines and a slightly pronounced increasing of the level of anti-inflammatory (IL-4) cytokines in comparison with the group of patients with isolated GERD.

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Prevalence and Predictors of Metabolic Syndrome among Patients with Bronchial Asthma: A Cross Sectional Study

The Open Respiratory Medicine Journal ◽

10.2174/1874306402115010014 ◽

2021 ◽

Vol 15 (1) ◽

pp. 14-18

Author(s):

Abdellah H.K. Ali

Keyword(s):

Metabolic Syndrome ◽

Blood Sugar ◽

Bronchial Asthma ◽

Density Lipoprotein ◽

Patient Characteristics ◽

Cross Sectional Study ◽

Metabolic Abnormality ◽

Fasting Blood Sugar ◽

Cross Sectional ◽

Asthma Patients

Background: Recent studies have reported the epidemiological link between Metabolic Syndrome (MS) and asthma, but it has rarely been studied in Egypt. The study aimed to investigate the prevalence of MS and its predictors among asthma patients in Egypt. Methods: In total, 320 patients with bronchial asthma were included. The following were assessed: spirometric evaluation, anthropometric indices, blood pressure, fasting blood sugar and serum lipid profile. We analyzed the correlation between metabolic scores and patient characteristics. Predictors of MS were identified using logistic regression analysis. Results: The prevalence of MS was 57.5% in asthma patients. For asthma patients, low High-Density Lipoprotein (HDL) and abdominal obesity were the commonest metabolic abnormality. Waist circumference, Fasting Blood Sugar (FBS) and triglyceride correlated significantly with asthma (P ‹ 0.05). FBS and DBP were the best predictors of MS. Conclusion: MS is frequent in asthma patients in Egypt. Obesity and lipid abnormalities were the commonest metabolic abnormality. Screening of these patients for components of metabolic syndrome should be a part of routine workup.

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Periodontal clinical features of bronchial asthma patient using inhalation drugs

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol33no3.29739 ◽

2021 ◽

Vol 33 (3) ◽

pp. 217

Author(s):

Maria Efrinta Ginting ◽

Rosiliwati Wihardja ◽

Dyah Nindita Carolina

Keyword(s):

Periodontal Disease ◽

Clinical Features ◽

Bronchial Asthma ◽

Periodontal Pocket ◽

Periodontal Status ◽

Asthmatic Patients ◽

Gingival Bleeding ◽

Periodontal Index ◽

Asthma Patients ◽

One Year

Introduction: Bronchial asthma patients use inhalation drugs as therapy to achieve a controlled asthma state. Inhaled corticosteroids and β2 agonists are the medication that is being used in this case. Prolonged use of inhalation drugs will affect the health of periodontal tissue. The effect of these drugs can reduce the periodontal defense mechanism and increase the risk of periodontal disease. This study aims to determine the periodontal clinical features of bronchial asthma patients using inhalation drugs. Method: This research was a descriptive study. The sample of the study were 22 females and 8 males bronchial asthma patients at the Community Lung Health Center of Bandung (Balai Besar Kesehatan Paru Masyarakat Bandung/BBKPM Bandung) who had been using inhalation drugs for at least one year. The periodontal clinical feature was assessed by employing a Community Periodontal Index (CPI) modified with probing the gingival sulcus to assess the presence of gingival bleeding, periodontal pocket, and loss of clinical attachment where then a periodontal status was obtained. The periodontal status data were then processed using the periodontitis case definitions from the Centers for Disease Control and Prevention/American Academy of Periodontology (CDC/AAP) to determine periodontal disease in asthmatics patients. Results: Clinical features of gingival bleeding were found in 26 asthmatic patients (86.7%), periodontal pockets in 18 asthmatic patients (60%), and loss of clinical attachment in 27 asthmatic patients (90%). Based on the CDC/AAP case definition, 23 asthmatic patients (76.7%) had periodontitis. Bronchial asthma patients who used inhalation drugs had a risk of periodontitis.Conclusion: Bronchial asthma patients who used inhalation drugs for at least one year had gingival bleeding and loss of clinical attachment and periodontal pocket.

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Opistorchis felineus invasion influence on immunity in bronchial asthma

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2010-3-85-90 ◽

2010 ◽

Vol 9 (3) ◽

pp. 85-90

Author(s):

L. M. Ogorodova ◽

M. B. Freidin ◽

A. E. Sazonov ◽

O. S. Fyodorova ◽

I. A. Deyev ◽

...

Keyword(s):

Experimental Study ◽

Immune Response ◽

Bronchial Asthma ◽

Cell Cultures ◽

Molecular Mechanisms ◽

Opisthorchis Felineus ◽

Genes Expression ◽

Asthma Patients ◽

Human Immune Response ◽

Human Immune

To investigate the molecular mechanisms of human immune response modification by Opisthorchis felineus antigens in bronchial asthma. The experimental study was performed with cell cultures from patients with bronchial asthma, patients with opisthorchiasis, and patients with BA and opisthorchiasis co-occurred. A proposed down-regulation of immune response by higher level of IL10 and TGFB genes expression in patients with opisthorchiasis was revealed.

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