scholarly journals Is there an effect of folic acid supplementation on the coagulation factors and C-reactive protein concentrations in subjects with atherosclerosis risk factors?

2012 ◽  
Vol 66 ◽  
pp. 696-701 ◽  
Author(s):  
Artur Mierzecki ◽  
Karolina Kłoda ◽  
Maria Jastrzębska ◽  
Kornel Chełstowski ◽  
Krystyna Honczarenko ◽  
...  
Keyword(s):  
Risk Factors ◽  
Folic Acid ◽  
Coagulation Factors ◽  
Folic Acid Supplementation ◽  
C Reactive Protein ◽  
Acid Supplementation ◽  
Reactive Protein ◽  
Atherosclerosis Risk ◽  
Atherosclerosis Risk Factors

No effect of folic acid supplementation in the course of 1 year on haemostasis markers and C-reactive protein in older adults

2005 ◽  
Vol 94 (07) ◽  
pp. 96-100 ◽  
Author(s):  
Mariska Klerk ◽  
Jane Durga ◽  
Evert G. Schouten ◽  
Cornelis Kluft ◽  
Frans J. Kok ◽  
...  
Keyword(s):  
Older Adults ◽  
Folic Acid ◽  
Disease Risk ◽  
Controlled Trial ◽  
Folic Acid Supplementation ◽  
Serum Folate ◽  
Tissue Type ◽  
C Reactive Protein ◽  
Acid Supplementation ◽  
Reactive Protein

SummaryElevated homocysteine levels are associated with an increased cardiovascular disease (CVD) risk, but the underlying mechanism is still unclear. High homocysteine might affect the endothelium, and consequently lead to impaired haemostasis. In a randomized placebo controlled trial among 276 older adults with plasma total homocysteine concentrations above 13 mM at screening, we investigated the effect of homocysteine lowering by folic acid supplementation (0.8 mg/day) for 1 year on markers of endothelial function (vonWillebrand factor), coagulation (tissue factor, factor VIIa, fragments 1+2), and fibrinolysis (fibrin degradation products, tissue-type plasminogen activator), and inflammation (C-reactive protein). Despite a 24% reduction in plasma homocysteine concentration and four-fold increase in serum folate concentration in the folic acid group compared to the placebo group, there was no clear change in any of the haemostasis markers, nor CRP. Although homocysteine is associated with vascular disease risk in the general population, marked lowering of slightly elevated homocysteine concentrations by one-year folic acid supplementation does not influence haemostasis markers.

scholarly journals Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects

2004 ◽  
Vol 106 (4) ◽  
pp. 353-358 ◽  
Author(s):  
Richard J. WOODMAN ◽  
David E. CELERMAJER ◽  
Peter L. THOMPSON ◽  
Joseph HUNG
Keyword(s):  
Risk Factors ◽  
Folic Acid ◽  
Endothelial Function ◽  
Healthy Subjects ◽  
Folic Acid Supplementation ◽  
Double Blind ◽  
Acid Supplementation ◽  
Flow Mediated Dilatation ◽  
Artery Disease ◽  
Cad Risk

Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we assessed whether endothelial function is impaired in healthy subjects with hyperhomocysteinaemia but without other CAD risk factors and whether folic acid supplementation improves endothelial function in these subjects. Flow-mediated dilatation (FMD) of the brachial artery was performed on 26 healthy subjects, age 49±2 years (mean±S.E.M.), with high tHcy (15.6±1.5 µmol/l) and 16 healthy age-matched subjects with low tHcy (7.9±0.6 µmol/l; P<0.001). Subjects with high tHcy were then randomized to receive 5 mg/day of folic acid or placebo for 8 weeks in a double-blind cross-over trial with a 4-week washout. FMD was not associated with tHcy and was not different between high and low tHcy groups (7.0±0.6% compared with 6.6±1.2%, P=0.76). Treatment with folic acid decreased tHcy by 34% in hyperhomocysteinaemic subjects (P=0.02 compared with placebo), but had no effect on FMD (+0.5±0.6% compared with -0.7±0.5%; P=0.17 compared with placebo). In healthy subjects with hyperhomocysteinaemia, but without additional cardiovascular risk, endothelial function is unimpaired and folic acid supplementation has no additional effect.

scholarly journals Ischemia-modified albumin in migraine patients during interictal period

2016 ◽  
Vol 85 (4) ◽  
pp. 231-237
Author(s):  
Slawomir Michalak ◽  
Krystyna Osztynowicz ◽  
Alicja Płóciniczak ◽  
Waldemar Myszka ◽  
Marcin Nowicki ◽  
...  
Keyword(s):  
Cobalt Chloride ◽  
Hdl Cholesterol ◽  
Cardiovascular Complications ◽  
Control Group ◽  
C Reactive Protein ◽  
Ischemia Modified Albumin ◽  
Homocysteine Concentration ◽  
Reactive Protein ◽  
Atherosclerosis Risk ◽  
Atherosclerosis Risk Factors

Aim. Ischemia-modified albumin (IMA) is a marker of myocardial ischemia and may be affected by ischemia occurring in other tissues. Migraine has been reported as a risk factor of ischemic stroke or cardiovascular events. Dysfunction of endothelial cells, as well as association with arteriopathies was evidenced in migraine patients. The aim of this study was to evaluate interictal IMA in migraine patients.Material and Methods. Fifty migraineurs aged 38 ± 9 years were included in the study. The control group consisted of 25 healthy volunteers aged 37 ± 8 years. In all subjects neurological examination was carried on, as well as clinimetric evaluation with the use of: MIDAS, MIGSEV, QVM, VAS and VRS. Ischemia-modified albumin was evaluated by means of spectrophotometric method with the use of cobalt chloride. The concentrations of total cholesterol, HDL- and LDL-cholesterol, triglycerides, homocysteine, C-reactive protein and Lp(a) were analyzed with routine spectrophotometric methods.Results. IMA was significantly (P = 0.0108) higher in migraine patients (0.101; 0.00–0.327 O.D.) than in controls (0.00; 0.00–0.102 O.D.; median; interquartile range). Migraineurs with aura have also higher IMA than controls. IMA correlated (rS = 0.383, P = 0.0073) with VAS and with homocysteine concentration (rS = 0.430, P = 0.0026). Multiple regression analysis of IMA and atherosclerosis risk factors showed significant correlation (P = 0.0247) with HDL cholesterol (R = 0.2958) and triglycerides concentrations (R = 0.3285).Conclusions. IMA formation in migraine patients, as a marker of oxidative stress even during interictal period in patients with hyperhomocysteinemia and/or hypertriacylglyceridemia can reflect a milieu of factors which further increases the risk for cardiovascular complications.

scholarly journals Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Khenata Forci ◽  
El Arbi Bouaiti ◽  
Mohamed Hassan Alami ◽  
Asmaa Mdaghri Alaoui ◽  
Amal Thimou Izgua
Keyword(s):  
Risk Factors ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Newborn Infants ◽  
First Trimester ◽  
Folic Acid Supplementation ◽  
Medical Monitoring ◽  
Acid Supplementation ◽  
Periconceptional Period

Abstract Background Neural tube defects (NTDs) are a group of birth defects that result from a partial or complete failure of the neural tube to close during embryogenesis. Their prevalence varies between 0.5 to 2 per 1000 births in countries without folic acid supplementation. The aim of our study is to assess the NTDs incidence and describe the risk factors within Moroccan newborn infants. Method This is a descriptive study over a period of 5 and a half years including all births at “Les Orangers” Maternity and Reproductive Health Hospital of Rabat with notification of NTD cases, whether isolated or combined with other anomalies. Data were reported on pre-established sheets and on the teratovigilance registry. Statistical analysis was performed with SPSS version 18 statistical software. Results During the study period, 43,923 births were recorded including 44 cases of neural tube defects, an incidence rate of 1 per 1000 births, with a female predominance; sex ratio = 0.8. These defects included anencephaly (50%), spina bifida (38.6%) and encephalocele (11.4%). The risk factors detected during this study include consanguinity (34%), consumption of fenugreek or other plants (36%), diabetes (4.5%) and medication (2.2%). A family history of malformation was reported in 6.8% of cases and among siblings in 4.5% of cases. The average maternal age was 30.38 ± 6.88 and the average gestational age was 36.80 ± 5.11. A quarter of mothers did not benefit from any medical monitoring during pregnancy while 59% did not take folic acid supplementation during the first trimester of pregnancy and none of them took B9 vitamin during the periconceptional period. The antenatal diagnosis was performed in 63% of cases. The mortality rate was 3.8 per 10,000 and 16% of cases evolved positively. Conclusion NTDs require high intensity and multidisciplinary care which stresses the importance, in our context, of strengthening and optimizing acid folic supplementation strategies during the periconceptional period.

Ischemia‑modified albumin in migraine patients during interictal period

10.20883/170 ◽  
2016 ◽  
Vol 85 (4) ◽  
pp. 231 ◽  
Author(s):  
Slawomir Michalak ◽  
Krystyna Osztynowicz ◽  
Alicja Płóciniczak ◽  
Waldemar Myszka ◽  
Marcin Nowicki ◽  
...  
Keyword(s):  
Cobalt Chloride ◽  
Hdl Cholesterol ◽  
Cardiovascular Complications ◽  
Control Group ◽  
C Reactive Protein ◽  
Ischemia Modified Albumin ◽  
Homocysteine Concentration ◽  
Reactive Protein ◽  
Atherosclerosis Risk ◽  
Atherosclerosis Risk Factors

Aim. Ischemia‑modified albumin (IMA) is a marker of myocardial ischemia and may be affected by ischemia occurring in other tissues. Migraine has been reported as a risk factor of ischemic stroke or cardiovascular events. Dysfunction of endothelial cells, as well as association with arteriopathies was evidenced in migraine patients. The aim of this study was to evaluate interictal IMA in migraine patients.Material and Methods. Fifty migraineurs aged 38 ± 9 years were included in the study. The control group consisted of 25 healthy volunteers aged 37 ± 8 years. In all subjects neurological examination was carried on, as well as clinimetric evaluation with the use of: MIDAS, MIGSEV, QVM, VAS and VRS. Ischemia‑modified albumin was evaluated by means of spectrophotometric method with the use of cobalt chloride. The concentrations of total cholesterol, HDL- and LDL‑cholesterol, triglycerides, homocysteine, C‑reactive protein and Lp(a) were analyzed with routine spectrophotometric methods.Results. IMA was significantly (P = 0.0108) higher in migraine patients (0.101; 0.00–0.327 O.D.) than in controls (0.00; 0.00–0.102 O.D.; median; interquartile range). Migraineurs with aura have also higher IMA than controls. IMA correlated (rS = 0.383, P = 0.0073) with VAS and with homocysteine concentration (rS = 0.430, P = 0.0026). Multiple regression analysis of IMA and atherosclerosis risk factors showed significant correlation (P = 0.0247) with HDL cholesterol (R = 0.2958) and triglycerides concentrations (R = 0.3285).Conclusions. IMA formation in migraine patients, as a marker of oxidative stress even during interictal period in patients with hyperhomocysteinemia and/or hypertriacylglyceridemia can reflect a milieu of factors which further increases the risk for cardiovascular complications.

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