scholarly journals Critical Analysis of Human Exposure to Bisphenol a and its Novel Implications on Renal, Cardiovascular and Hypertensive Diseases

2021 ◽  
Author(s):  
Rafael Moreno-Gómez-Toledano ◽  
María I. Arenas ◽  
Sandra Sánchez-Esteban ◽  
Alberto Cook ◽  
Marta Saura ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Critical Analysis ◽  
Human Exposure ◽  
Endocrine Disruptor ◽  
Cytotoxic Effect ◽  
Original Data ◽  
Kidney Damage ◽  
Human Populations ◽  
Human Pharmacokinetic ◽  
Hypertensive Diseases

Bisphenol A (BPA), an endocrine disruptor involved in synthesizing numerous types of plastics, is detected in almost the entire population’s urine. The present work aims to estimate daily exposure to BPA by systematically reviewing all articles with original data related to urinary BPA concentration. This approach is based on human pharmacokinetic models, which have shown that 100% of BPA (free and metabolized form) is eliminated only in a few hours through urine. Several extensive population studies and experimental data have recently proven a significant association between urinary excretion of BPA and albuminuria, associated with renal damage. Our team’s previous work has shown that low-dose BPA can promote a cytotoxic effect on renal mouse podocytes. Moreover, BPA administration in mice promotes kidney damage and hypertension. Furthermore, preliminary studies in human renal cells in culture (podocytes) strongly suggest that BPA might also promote kidney damage. Overall, the present review analyzed BPA exposure data from mammalian cell studies, experimental animal models, and several human populations. Studying principal cohorts calculated the exposures to BPA globally, showing a high BPA exposure suggesting the need to decrease BPA exposure more effectively, emphasizing groups with higher sensitivity as kidney disease patients.

scholarly journals Bisphenol-A (BPA) in Foods commonly consumed in Southwest Nigeria and its Human Health Risk

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Adebola A. Adeyi ◽  
Babafemi A. Babalola
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Endocrine Disruptor ◽  
Adult Population ◽  
Human Health Risk ◽  
Gas Chromatography Mass Spectrometry ◽  
Routine Monitoring ◽  
Sample Extraction ◽  
Southwest Nigeria ◽  
Chicken Eggs

AbstractBisphenol-A (BPA) is a synthetic chemical ubiquitous in the environment and listed as an endocrine disruptor. It has the tendency of migrating into food stored in materials containing it. This study, therefore, determines the concentrations of BPA in foods commonly consumed in Southwest Nigeria by the adult population and also estimates the risk associated with human exposure. Eight different food categories were selected for this study. Standard QuEChERS protocol was used for sample extraction and analysed using gas chromatography-mass spectrometry (GC-MS). Vegetable oil had the highest BPA concentration (28.4 ng/g). This was followed by aquatic canned fish (26.3 ng/g), canned beef (21.3 ng/g) and crayfish (17.5 ng/g). These concentrations were below the 600 ng/g limit of the European Commission for BPA in foods. Bisphenol-A was not detected in raw beef, chicken, cheese, apple, tomatoes, beans and rice; and chicken eggs. The adult population had an average dietary intake of 30.4 ng/kg bw/day. There is no likely occurrence of harmful health effects of BPA in the selected foods with respect to the current concentrations found therein. However, routine monitoring is recommended to prevent human exposure to BPA.

Occurrence of bisphenol A and its alternatives in paired urine and indoor dust from Chinese university students: Implications for human exposure

Chemosphere ◽  
2020 ◽  
Vol 247 ◽  
pp. 125987 ◽  
Author(s):  
Hua Zhang ◽  
Qiang Quan ◽  
Mingyue Zhang ◽  
Nan Zhang ◽  
Wu Zhang ◽  
...  
Keyword(s):  
University Students ◽  
Bisphenol A ◽  
Human Exposure ◽  
Indoor Dust ◽  
Chinese University ◽  
Chinese University Students

Molecularly Imprinted Polymer-Based Electrochemical Sensor for the Determination of Endocrine Disruptor Bisphenol-A in Bovine Milk

2021 ◽  
pp. 130287
Author(s):  
Palanisamy Karthika ◽  
Saravanakumar Shanmuganathan ◽  
Subramanian Viswanathan ◽  
Cristina Delerue-Matos
Keyword(s):  
Bisphenol A ◽  
Electrochemical Sensor ◽  
Molecularly Imprinted Polymer ◽  
Endocrine Disruptor ◽  
Bovine Milk ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

scholarly journals Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 780
Author(s):  
Krystyna Makowska ◽  
Slawomir Gonkowski
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Sympathetic Innervation ◽  
Daily Intake ◽  
Everyday Objects ◽  
Living Organisms ◽  
The Impact ◽  
Heart Wall ◽  
Cholinergic Structures

Bisphenol A (BPA) contained in plastics used in the production of various everyday objects may leach from these items and contaminate food, water and air. As an endocrine disruptor, BPA negatively affects many internal organs and systems. Exposure to BPA also contributes to heart and cardiovascular system dysfunction, but many aspects connected with this activity remain unknown. Therefore, this study aimed to investigate the impact of BPA in a dose of 0.05 mg/kg body weight/day (in many countries such a dose is regarded as a tolerable daily intake–TDI dose of BPA–completely safe for living organisms) on the neurochemical characterization of nerves located in the heart wall using the immunofluorescence technique. The obtained results indicate that BPA (even in such a relatively low dose) increases the number of nerves immunoreactive to neuropeptide Y, substance P and tyrosine hydroxylase (used here as a marker of sympathetic innervation). However, BPA did not change the number of nerves immunoreactive to vesicular acetylcholine transporter (used here as a marker of cholinergic structures). These observations suggest that changes in the heart innervation may be at the root of BPA-induced circulatory disturbances, as well as arrhythmogenic and/or proinflammatory effects of this endocrine disruptor. Moreover, changes in the neurochemical characterization of nerves in the heart wall may be the first sign of exposure to BPA.

Effective adsorption of the endocrine disruptor compound bisphenol a from water on surface-modified carbon materials

2021 ◽  
Vol 552 ◽  
pp. 149513
Author(s):  
A.B. Hernández-Abreu ◽  
S. Álvarez-Torrellas ◽  
R.P. Rocha ◽  
M.F.R. Pereira ◽  
V.I. Águeda ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Carbon Materials ◽  
Surface Modified

Electrocatalyst based on Ni-MOF intercalated with amino acid-functionalized graphene nanoplatelets for the determination of endocrine disruptor bisphenol A

2021 ◽  
Vol 1150 ◽  
pp. 338228
Author(s):  
P. Arul ◽  
Sheng-Tung Huang ◽  
N.S.K. Gowthaman ◽  
G. Mani ◽  
Nithiya Jeromiyas ◽  
...  
Keyword(s):  
Amino Acid ◽  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Graphene Nanoplatelets ◽  
Functionalized Graphene

scholarly journals A novel method for rapid and quantitative detection of bisphenol A in urine

2020 ◽  
Author(s):  
Aleksandra Rutkowska ◽  
Aleksandra Olsson ◽  
Jacek Namieśnik ◽  
Andrzej Milewicz ◽  
Jan Krzysztof Ludwicki ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Hormone Receptors ◽  
Low Cost ◽  
Medical Diagnostics ◽  
Quantitative Detection ◽  
Adverse Health Effects ◽  
Increased Risk ◽  
Novel Method ◽  
Lifestyle Diseases

Bisphenol A (BPA) is classified as an endocrine disruptor (ED) and it can interact with variety of hormone receptors leading to hormonal disruption and increased risk of various adverse health effects. Reducing human exposure to BPA is one of the main challenges of public health, as it is constantly present in daily life. A low-cost and commonly applied method to enable determination of BPA in the patient's body has yet to be developed. Currently available techniques are expensive, time-consuming, and require access to highly equipped analytical chemistry laboratories. Here we describe a fast and cheap engineered lateral flow assay of our design, to detect of BPA in urine samples. The technology not only provides an opportunity to perform rapid medical diagnostics without the need for an access to the central laboratory but also a means for self-diagnosis by the patient. The addition of β-glucuronidase improves the sensitivity of detection as it releases the free BPA from glucuronide complexes in urine. This invention may become a demonstrated analytical means for lowering human exposure to BPA and probably also to other EDs and consequently, may be useful in decrease of the risk for several lifestyle diseases.

scholarly journals The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA)

2020 ◽  
Vol 257 ◽  
pp. 113516 ◽  
Author(s):  
Ramin Bahmani ◽  
DongGwan Kim ◽  
Mahsa Modareszadeh ◽  
Andrew J. Thompson ◽  
Jeong Hoon Park ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Root Growth ◽  
Growth Inhibition ◽  
Endocrine Disruptor ◽  
Root Growth Inhibition

Levels of bisphenol-A in different paper products in Guangzhou, China, and assessment of human exposure via dermal contact

2015 ◽  
Vol 17 (3) ◽  
pp. 667-673 ◽  
Author(s):  
Ruifang Fan ◽  
Biyan Zeng ◽  
Xiaosu Liu ◽  
Chao Chen ◽  
Qinwei Zhuang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Dermal Contact ◽  
Beverage Container ◽  
Food And Beverage

Bisphenol A (BPA) is a chemical widely used both in plastics production as a food and beverage container and in thermal papers as a color developer.

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