scholarly journals The relationship between carbonic anhydrase-III expression and oxidative stress in brown adipose tissue

2018 ◽  
pp. 361-368 ◽  
Author(s):  
Cemil Kahraman ◽  
Ahmet Alver ◽  
Ayşe Şentürk ◽  
İmran İnce Akça
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Carbonic Anhydrase ◽  
Brown Adipose Tissue ◽  
Carbonic Anhydrase Iii ◽  
Brown Adipose ◽  
The Relationship ◽  
And Oxidative Stress

scholarly journals The Effects of Quercetin on High Fat Diet-Induced Inflammation and Oxidative Stress in Brown Adipose Tissue

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1669-1669
Author(s):  
Ya Pei ◽  
Hye Won Kang
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
High Fat Diet ◽  
The Body ◽  
Low Grade ◽  
Related Factor ◽  
High Fat ◽  
Brown Adipose ◽  
And Oxidative Stress

Abstract Objectives Under obesity state, adipose tissue derived inflammatory mediators circulate all over the body and induce low-grade chronic inflammation, which is the main cause for the development of metabolic diseases. Moreover, inflammation-induced reactive oxygen species (ROS) cause oxidative stress, a process in damaging cellular structure and functions. Recently, microRNAs (miRNAs) were found to potentially regulate inflammation and its associated diseases. Brown adipose tissue (BAT) protects against obesity through thermogenic activity to increase energy expenditure. However, high levels of inflammation, ROS generation and aberrant level of miRNAs result in the dysfunction of BAT. Previously, quercetin showed anti-obesity effect through BAT activation. Thus, the purpose of this study was sought to investigate the effect of quercetin on high fat diet (HFD)-induced inflammation and oxidative stress in BAT. Methods C57BL/6 male mice were fed with a HFD or HFD supplemented with 1% quercetin (HFDQ) for 16 weeks. Total RNA was isolated from BAT to measure the expression of target mRNAs such as tumor necrosis factor alpha (TNFa), interleukin (IL) 1b, IL6, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX) 2, NADPH oxidase (NOX) 2, nuclear factor E2-related factor (NRF) 2, superoxide dismutase (SOD) 2, SOD3, and catalase that are involved in regulation of inflammation and oxidative stress, and microRNA (miRNA)-155, a master regulator of inflammation, using a quantitative PCR. Results BAT of HFDQ-fed mice exhibited decreased expression of COX2, TNFa, IL1b, IL6, and iNOS compared to that of HFD-induced obese mice. NOX2 gene encoding an enzyme that generates ROS was also decreased in BAT of HFDQ-fed mice. The genes such as SOD2, SOD3, NRF2, and catalase that are involved in regulation of antioxidant enzymes were significantly increased. As the cognate gene of TNFa, miRNA-155 levels were downregulated. Conclusions Quercetin ameliorates HFD-induced inflammation and oxidative stress in BAT by regulating miRNA-155. Intake of quercetin may improve obese conditions by regulating BAT function through anti-inflammatory and antioxidant effects. Funding Sources This work was supported by USDA.

scholarly journals The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

2011 ◽  
Vol 10 (1) ◽  
pp. 238 ◽  
Author(s):  
Yung-Cheng Huang ◽  
Tai-Been Chen ◽  
Chien-Chin Hsu ◽  
Shau-Hsuan Li ◽  
Pei-Wen Wang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Brown Adipose Tissue Activity ◽  
Fdg Pet Ct ◽  
The Tropics ◽  
The Relationship

The Relationship between Oxidative Stress and Obesity in Prostate Disease

2012 ◽  
Vol 79 (2) ◽  
pp. 156-158 ◽  
Author(s):  
Anna Scavuzzo ◽  
Vincenzo Favilla ◽  
Sebastiano Cimino ◽  
Massimo Madonia ◽  
Giovanni Li Volti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Adipose Tissue ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Bioactive Substances ◽  
Prostatic Disease ◽  
Prostate Disease ◽  
The Relationship ◽  
And Oxidative Stress

Recent data suggest that chronic increment of reactive oxygen species (ROS) may be involved in the development and progression of chronic prostatic disease, such as BPH and PCa; adipose tissue produces bioactive substances called adipokines, also involved in the production of ROS. Our study aims to evaluate the relationship between obesity and oxidative stress in prostate disease.

scholarly journals Brown adipose tissue and its modulation by a mitochondria-targeted peptide in rat burn injury-induced hypermetabolism

2013 ◽  
Vol 304 (4) ◽  
pp. E331-E341 ◽  
Author(s):  
Kikuo Yo ◽  
Yong-Ming Yu ◽  
Gaofeng Zhao ◽  
Ali A. Bonab ◽  
Naoki Aikawa ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Burn Injury ◽  
Morphological Changes ◽  
Resting Metabolic Rate ◽  
Injury Model ◽  
Brown Adipose ◽  
Ucp1 Expression ◽  
The Relationship

Hypermetabolism is a prominent feature of burn injury, and altered mitochondria function is presumed to contribute to this state. Recently, brown adipose tissue (BAT) was found to be present not only in rodents but also in humans, and its activity is associated with resting metabolic rate. In this report, we elucidate the relationship between burn injury-induced hypermetabolism and BAT activity and the possible role of the mitochondria-targeted peptide SS31 in attenuating burn injury-induced hypermetabolism by using a rat burn injury model. We demonstrate that burn injury induces morphological changes in interscapular BAT (iBAT). Burn injury was associated with iBAT activation, and this effect was positively correlated with increased energy expenditure. BAT activation was associated with augmentation of mitochondria biogenesis, and UCP1 expression in the isolated iBAT mitochondria. In addition, the mitochondria-targeted peptide SS31 attenuated burn injury-induced hypermetabolism, which was accompanied by suppression of UCP1 expression in isolated mitochondria. Our results suggest that BAT plays an important role in burn injury-induced hypermetabolism through its morphological changes and expression of UCP1.

Sex Differences in Seasonal Changes of Brown Adipose Tissue and Activity of the Australian Vespertilionid Bat Eptesicus vulturnus

1982 ◽  
Vol 30 (1) ◽  
pp. 15 ◽  
Author(s):  
CR Tidemann
Keyword(s):  
Body Weight ◽  
Sex Differences ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Seasonal Changes ◽  
Wild Population ◽  
Tissue Weight ◽  
Adipose Tissue Weight ◽  
Brown Adipose ◽  
The Relationship

Information on seasonal changes in activity, body weight and brown adipose tissue weight was collected from a wild population of a small Australian vespertilionid, Eptesicus vulturnus. Both sexes, but especially females, became less active during the colder months of the year. Males maintained body weight and brown adipose tissue weight during winter, as do non-hibernating mammals. Females lost brown adipose tissue and body weight during winter, as do hibernators. The relationship between the sex differences in overwintering behaviour and the reproductive cycle is discussed.

scholarly journals Ellagic Acid Affects Metabolic and Transcriptomic Profiles and Attenuates Features of Metabolic Syndrome in Adult Male Rats

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 804
Author(s):  
Adéla Kábelová ◽  
Hana Malínská ◽  
Irena Marková ◽  
Olena Oliyarnyk ◽  
Blanka Chylíková ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Ellagic Acid ◽  
High Fat Diet ◽  
Male Rats ◽  
High Fat ◽  
Brown Adipose

Ellagic acid, a natural substance found in various fruits and nuts, was previously shown to exhibit beneficial effects towards metabolic syndrome. In this study, using a genetic rat model of metabolic syndrome, we aimed to further specify metabolic and transcriptomic responses to ellagic acid treatment. Adult male rats of the SHR-Zbtb16Lx/k.o. strain were fed a high-fat diet accompanied by daily intragastric gavage of ellagic acid (50 mg/kg body weight; high-fat diet–ellagic acid (HFD-EA) rats) or vehicle only (high-fat diet–control (HFD-CTL) rats). Morphometric and metabolic parameters, along with transcriptomic profile of liver and brown and epididymal adipose tissues, were assessed. HFD-EA rats showed higher relative weight of brown adipose tissue (BAT) and decreased weight of epididymal adipose tissue, although no change in total body weight was observed. Glucose area under the curve, serum insulin, and cholesterol levels, as well as the level of oxidative stress, were significantly lower in HFD-EA rats. The most differentially expressed transcripts reflecting the shift induced by ellagic acid were detected in BAT, showing downregulation of BAT activation markers Dio2 and Nr4a1 and upregulation of insulin-sensitizing gene Pla2g2a. Ellagic acid may provide a useful nutritional supplement to ameliorate features of metabolic syndrome, possibly by suppressing oxidative stress and its effects on brown adipose tissue.

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