scholarly journals Evaluating Factors Affecting the Time Interval Between Propofol Injection and Induction of Electro-convulsion and Relationship Between These Factors and Duration of Convulsion

2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Alireza Haji Seyed Javadi ◽  
Ehsan Najafian ◽  
Hamid Kayalha ◽  
Ali Akbar Shafikhani
Keyword(s):  
Clinical Severity ◽  
Seizure Threshold ◽  
Current Evidence ◽  
P Value ◽  
Time Interval ◽  
Short Term ◽  
Seizure Duration ◽  
Factors Affecting ◽  
The Relationship

Background: Current evidence on the effect of anesthetic-ECT time interval (AETI) is controversial. This study aimed to investigate the factors affecting the time interval between propofol injection and electro-convulsion induction and the relationship between these factors and the duration of convulsion. Methods: In this study, 102 patients (616 sessions of ECT) were studied. Demographic and clinical data (age, gender, receiving or not receiving medications that affected the seizure threshold, the total number of ECT sessions, clinical severity of admission scores, clinical diagnosis, propofol dose, seizure duration, and AETI) were collected in special forms and analyzed by appropriate statistical methods. Results: Sessions with long-term AETI had longer seizure time than sessions with short-term AETI (33.47 ± 8.46 vs. 28.68 ± 9.74, P value < 0.05). The duration of seizures was significantly longer in the group with long AETI in sessions 1, 2, and 4 than in the other group (P value < 0.05). There was a significant relationship between the duration of seizures and propofol dose, AETI, and receiving drugs effective in the seizure threshold (P value < 0.05). Conclusions: The results showed that increasing AETI and injecting a lower dose of propofol to induce anesthesia would increase the duration of seizures. Also, taking medications that would affect the seizure threshold reduces the duration of seizures.

scholarly journals ANALYSIS OF FACTORS AFFECTING THE INDONESIAN SYARIAH STOCK INDEX (ISSI) ON THE INDONESIAN STOCK EXCHANGE (IDX)

2019 ◽  
Vol 8 (2) ◽  
pp. 26
Author(s):  
Siska Angriani Hasibuan ◽  
Armin Rahmansyah
Keyword(s):  
Exchange Rate ◽  
Stock Exchange ◽  
Stock Index ◽  
Variable Amount ◽  
Short Term ◽  
Correction Model ◽  
Factors Affecting ◽  
Independent Variables ◽  
The Relationship

The Indonesian Syariah Stock Index (ISSI) is an indicator that can be used by investors to know the movements of the sharia stock market. This research aims to analyze the effect of the Indonesian Syariah Stock Index (ISSI) on the Indonesian Stock Exchange (IDX). The analysis uses equations by the method of Error Correction Model (ECM). This study analyzed the relationship between the dependent and independent variables in both the short term and long term. Estimation results show that in the long term and the short term, the variable amount of the inflation was a positif and significant in the short term but not significant in the long term affect the Indonesian Syariah Stock Index (ISSI). The variable amount of the BI rate and exchange rate was a negative and significant in the short term but not significant in the long term affect the Indonesian Syariah Stock Index (ISSI). These results show that inflation, BI rate and exchange rate was significant in the short term affect the Indonesian Syariah Stock Index (ISSI) on the Indonesian Stock Exchange (IDX).

scholarly journals ANALYSIS OF FACTORS AFFECTING THE INDONESIAN SYARIAH STOCK INDEX (ISSI) ON THE INDONESIAN STOCK EXCHANGE (IDX)

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Siska Angriani Hasibuan
Keyword(s):  
Exchange Rate ◽  
Stock Exchange ◽  
Stock Index ◽  
Variable Amount ◽  
Short Term ◽  
Correction Model ◽  
Factors Affecting ◽  
Independent Variables ◽  
The Relationship

The Indonesian Syariah Stock Index (ISSI) is an indicator that can be used by investors to know the movements of the sharia stock market. This research aims to analyze the effect of the Indonesian Syariah Stock Index (ISSI) on the Indonesian Stock Exchange (IDX). The analysis uses equations by the method of Error Correction Model (ECM). This study analyzed the relationship between the dependent and independent variables in both the short term and long term. Estimation results show that in the long term and the short term, the variable amount of the inflation was a positif and significant in the short term but not significant in the long term affect the Indonesian Syariah Stock Index (ISSI). The variable amount of the BI rate and exchange rate was a negative and significant in the short term but not significant in the long term affect the Indonesian Syariah Stock Index (ISSI). These results show that inflation, BI rate and exchange rate was significant in the short term affect the Indonesian Syariah Stock Index (ISSI) on the Indonesian Stock Exchange (IDX).

scholarly journals Factors Affecting ESG towards Impact on Investment: A Structural Approach

2021 ◽  
Vol 13 (19) ◽  
pp. 10868
Author(s):  
Satyabrata Aich ◽  
Ayusha Thakur ◽  
Deepanjan Nanda ◽  
Sushanta Tripathy ◽  
Hee-Cheol Kim
Keyword(s):  
Social Impact ◽  
Short Term ◽  
Interpretive Structural Modeling ◽  
Factors Affecting ◽  
Investment Returns ◽  
Research Gap ◽  
Investment Process ◽  
The Impact ◽  
The Relationship

Recent disasters have emphasized the need for further action to protect businesses and society from long-term sustainability threats. We believe that the crisis is hastening nascent ESG trends, and that the increased focus on a company’s environmental and social impact will last long after crises have passed. We refined three fundamental concepts that guide our thinking on investing based on environmental, social, and governance factors as our approach to sustainable investing has evolved. The ESG factor assessments are more of an inherent aspect of a sound investment process than a separate investment discipline. When ESG variables are considered, the focus is on long-term risk adjusted investment returns. Investors should choose the strategy that best matches with their goals and interests. ESG investing is not a simple yes or no answer. The research gap extracted from the previous studies is to determine the relationship among the influencing factors of ESG and its priority with their driving and dependence capabilities. We used an ISM Approach to uncover the interrelationships and influencing behavior among the elements for considering ESG in investment after conducting a thorough literature research and consulting with experts. Here interpretive structural modeling (ISM) was used to explore the links among such extracted factors and its interdependencies. There was also focus on the short-term and long-term factors to achieve our desired objective. Our research will assist businesses in attracting and obtaining finance. The results of this analysis will be helpful for leaders to understand the impact of ESG on the investment aspects of an organization.

Molecular biology of enzyme adaptations in higher eukaryotes

Genome ◽  
1989 ◽  
Vol 31 (1) ◽  
pp. 272-283 ◽  
Author(s):  
Donal A. Hickey ◽  
Bernhard F. Benkel ◽  
Charalambos Magoulas
Keyword(s):  
Molecular Biology ◽  
Tissue Specificity ◽  
Enzyme System ◽  
Direct Interaction ◽  
Evolutionary Genetics ◽  
Short Term ◽  
Eukaryotic Genes ◽  
Higher Eukaryotes ◽  
The Relationship

Multicellular eukaryotes have evolved complex homeostatic mechanisms that buffer the majority of their cells from direct interaction with the external environment. Thus, in these organisms long-term adaptations are generally achieved by modulating the developmental profile and tissue specificity of gene expression. Nevertheless, a subset of eukaryotic genes are still involved in direct responses to environmental fluctuations. It is the adaptative responses in the expression of these genes that buffers many other genes from direct environmental effects. Both microevolutionary and macroevolutionary patterns of change in the structure and regulation of such genes are illustrated by the sequences encoding α-amylases. The molecular biology and evolution of α-amylases in Drosophila and other higher eukaryotes are presented. The amylase system illustrates the effects of both long-term and short-term natural selection, acting on both the structural and regulatory components of a gene–enzyme system. This system offers an opportunity for linking evolutionary genetics to molecular biology, and it allows us to explore the relationship between short-term microevolutionary changes and long-term adaptations.Key words: gene regulation, molecular evolution, eukaryotes, Drosophila, amylase.

scholarly journals Time Interval to Biochemical Failure as a Surrogate End Point in Locally Advanced Prostate Cancer: Analysis of Randomized Trial NRG/RTOG 9202

2019 ◽  
Vol 37 (3) ◽  
pp. 213-221 ◽  
Author(s):  
James J. Dignam ◽  
Daniel A. Hamstra ◽  
Herbert Lepor ◽  
David Grignon ◽  
Harmar Brereton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomized Trial ◽  
Locally Advanced ◽  
Biochemical Failure ◽  
Mediating Effect ◽  
Time Interval ◽  
Short Term ◽  
End Points ◽  
End Point

Background In prostate cancer, end points that reliably portend prognosis and treatment benefit (surrogate end points) can accelerate therapy development. Although surrogate end point candidates have been evaluated in the context of radiotherapy and short-term androgen deprivation (AD), potential surrogates under long-term (24 month) AD, a proven therapy in high-risk localized disease, have not been investigated. Materials and Methods In the NRG/RTOG 9202 randomized trial (N = 1,520) of short-term AD (4 months) versus long-term AD (LTAD; 28 months), the time interval free of biochemical failure (IBF) was evaluated in relation to clinical end points of prostate cancer–specific survival (PCSS) and overall survival (OS). Survival modeling and landmark analysis methods were applied to evaluate LTAD benefit on IBF and clinical end points, association between IBF and clinical end points, and the mediating effect of IBF on LTAD clinical end point benefits. Results LTAD was superior to short-term AD for both biochemical failure (BF) and the clinical end points. Men remaining free of BF for 3 years had relative risk reductions of 39% for OS and 73% for PCSS. Accounting for 3-year IBF status reduced the LTAD OS benefit from 12% (hazard ratio [HR], 0.88; 95% CI, 0.79 to 0.98) to 6% (HR, 0.94; 95% CI, 0.83 to 1.07). For PCSS, the LTAD benefit was reduced from 30% (HR, 0.70; 95% CI, 0.52 to 0.82) to 6% (HR, 0.94; 95% CI, 0.72 to 1.22). Among men with BF, by 3 years, 50% of subsequent deaths were attributed to prostate cancer, compared with 19% among men free of BF through 3 years. Conclusion The IBF satisfied surrogacy criteria and identified the benefit of LTAD on disease-specific survival and OS. The IBF may serve as a valid end point in clinical trials and may also aid in risk monitoring after initial treatment.

scholarly journals BANK PROFITABILITY AND MACROECONOMY: EVIDENCE FROM LITHUANIA

2017 ◽  
Vol 24 (2) ◽  
pp. 383-405 ◽  
Author(s):  
Laurynas NARUŠEVIČIUS
Keyword(s):  
Banking Sector ◽  
Short Term ◽  
Empirical Examination ◽  
Bank Profitability ◽  
Pooled Mean Group ◽  
Real Gdp ◽  
Income Statement ◽  
Main Determinants ◽  
The Relationship

The purpose of this paper is to investigate the relationship between profitability of the Lithuanian banking sector and its internal and external determinants. We use the panel error correc­tion model to assess long-term and short-term determinants of items from bank income statements (net interest income, net fee and commission income and operating expenses). The results of the pooled mean group estimator show that bank size and real GDP are the main determinants in the long-term. Meanwhile, empirical examination suggests various variables as short-term determinants of income statement items. The pooled mean group estimation technique and the analysis of sepa­rate income statement items enable us to have a better insight into the Lithuanian banking sector and determinants of its revenue and expenses.

scholarly journals HUBUNGAN PENGGUNAAN DIAPERS DENGAN KEMAMPUAN TOILETING PADA ANAK

2018 ◽  
Vol 2 (1) ◽  
pp. 117
Author(s):  
Rendika Baharudin Abror ◽  
Cholik Harun Rosjidi ◽  
Rika Maya Sari
Keyword(s):  
Data Collection ◽  
Toilet Training ◽  
P Value ◽  
Developmental Tasks ◽  
Chi Square ◽  
Cross Sectional ◽  
Large Sample ◽  
Relationship Of ◽  
The Relationship

AbstractEach child has a task that must be passed well, especially at the age of the child (12-36 months). One of the developmental tasks in toddlers is toilet training. Long-term use of diapers can cause toilet effects. This study aims to determine the relationship between diapers with the ability of toileting in children.The design of this research is Correlation with cross sectional approach. Large sample of 70 respondents. Sampling of the study using total sampling, data collection using questionnaires and calculations using Chi-square Correlation test using SPSS 16.0 error α 0.05.The results of the research variables The use of diapers in children interpreted most of the 47 children of respondents (67.1%) Did not use and almost half of the 23 respondents (32.9%) use. The ability of toileting in children is interpreted by most of the 42 respondents (60.0%) fulfilled, and almost half of 28 respondents (40.0%) are not met.Based on the calculation of Chi-square SPSS statistic shows that p value 0,000 <0,05) means that there is relationship of diaper usage with the ability of toileting in children with the closeness of cc relationship of 0.479 enough category.The results of this study concluded that almost half of them use diapers, and almost half of them do not meet the ability of toileting, the researcher suggests in the research place to put a picture or leaflet about the effect of Diaper Usage on Toileting Ability so that the wise mother in using Diapers.Keywords: diapers, toileting, children AbstrakSetiap anak mempunyai tugas perkembangan yang harus dilewati dengan baik, terlebih pada usia toddler (12-36 bulan). Salah satu tugas perkembangan pada anak usia toddler adalah toilet training. Pemakaian diapers dalam jangka panjang dapat menimbulkan efek yang berbahaya serta bisa menghambat kemampuan toilet training anak. Penelitian ini bertujuan untuk mengetahui Hubungan Penggunaan diapers dengan kemampuan toileting pada anakDesain penelitian ini adalah Korelasi dengan pendekatan cross sectional. Besar sampel 70 responden. Sampling penelitian menggunakan Total sampling, pengumpulan data menggunakan kuesioner dan perhitungan menggunakan uji Korelasi Chi-square dengan menggunakan SPSS 16.0 kesalahan α 0,05.Hasil penelitian variabel Penggunaan diapers pada anak diinterpretasikan sebagian besar 47 anak responden (67,1%) Tidak menggunakan dan hampir setengahnya 23 responden (32,9%) menggunakan. Pada kemampuan toileting pada anak diinterpretasikan sebagian besar 42 responden (60,0%) tercapai, dan hampir setengahnya 28 responden (40,0%) belum tercapai.Berdasarkan perhitungan uji statistik Chi-square SPSS menunjukkan p value 0,000< 0,05) artinya ada hubungan penggunaan diapers dengan kemampuan toileting pada anak dengan keeratan hubungan cc sebesar 0,479 kategori cukupHasil penelitian disimpulkan hampir setengahnya menggunakan diapers, dan hampir setengahnya belum tercapai kemampuan toileting maka peneliti menyarankan pada tempat penelitian untuk memasang gambar atau leaflet tentang dampak Penggunaan Diapers Terhadap Kemampuan Toileting, sehingga ibu bijak dalam menggunakan Diapers.Kata kunci: Diapers, Toileting, Anak.

scholarly journals Early and long-term complications following transanal pull through Soave technique in infants with Hirschsprung's diseaseric infants with Hirschsprung's disease

2019 ◽  
Author(s):  
Manoochehr Ghorbanpour ◽  
Mohammad Ali Seyfrabie ◽  
Babak Yousefi
Keyword(s):  
Intestinal Obstruction ◽  
Hirschsprung's Disease ◽  
Hirschsprung’S Disease ◽  
Statistical Tests ◽  
Case Series ◽  
P Value ◽  
Short Term ◽  
Case Series Study ◽  
The Mean

Objective. Patients undergoing Soave surgery for Hirschsprung's disease are at risk for some complications. The aim of this study was to investigate such short-term and long-term complications and evaluate the outcome of the operation in these patients. Methods. A case series study was carried out during the last 12 years, during 2007 to 2018 in Besat hospital of Hamadan. Data collection conducted using a checklist includes questions about demographic information, clinical features, and short-term and long-term complications, and consequences of post-operative surgery. The findings of the study were analyzed using SPSS software version 20 and appropriate statistical tests. P-value less than 0.05 was considered statistically significant. Results. A total of 55 children underwent Soave surgery during the last 12 years in Besat Hospital Hamadan, Iran. The mean age of the patients was 38±10 days during surgery, of which 56.4% were female. The mean hospital stay was 7.3 days. Also, the mean weight of children at birth was 2970±447 gr. Most of the patients were born as NVD (52.7%) and term (74.5%). The most common comorbidity was congenital heart disease. The most common short-term complication was intestinal obstruction in 14 patients (25.5%) and the most frequent long-term complication was intestinal obstruction and constipation (27.3% each cases). The mortality rate of patients in this study was 14.5% in total. Conclusions. One stage surgical procedure in Hirschsprung's disease is a safe and effective method, but care should be taken in choosing patients and patients should be monitored for possible complications, so that they can be considered and implemented for proper treatment.

scholarly journals Scorpion Envenomation of Lactating Rats Decreases the Seizure Threshold in Offspring

Toxins ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 853
Author(s):  
Marina de Oliveira Rodrigues Barbosa ◽  
Maria Eliza F. do Val de Paulo ◽  
Ana Leonor Abrahão Nencioni
Keyword(s):  
Perinatal Period ◽  
Postnatal Period ◽  
Seizure Threshold ◽  
Long Term Effects ◽  
Crude Venom ◽  
Long Time ◽  
Few Data ◽  
The Relationship ◽  
Convulsive Threshold

Few data are available in the literature describing the long-term effects of envenoming in the perinatal period. In this study, the relationship between envenoming of lactating rats and possible behavioral changes in the mother and in her offspring were investigated. Lactating Wistar rats received a single dose of T. serrulatus crude venom on postnatal days 2 (V2), 10 (V10) or 16 (V16), and had their maternal behavior evaluated. The seizure threshold was evaluated in adulthood offspring. A decrease in maternal care during envenoming was observed in V2 and V10 groups. The retrieval behavior was absent in the V2 group, and a lower seizure threshold in the adult offspring of all groups was observed. During envenoming, mothers stayed away from their offspring for a relatively long time. Maternal deprivation during the early postnatal period is one of the most potent stressors for pups and could be responsible, at least in part, for the decrease in the convulsive threshold of the offspring since stress is pointed to as a risk factor for epileptogenesis. Furthermore, the scorpionic accident generates an intense immune response, and inflammation in neonates increases the susceptibility to seizures in adulthood. Therefore, maternal envenoming during lactation can have adverse effects on offspring in adulthood.

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