scholarly journals Comparison of the Effect of Propofol and Dexmedetomidine on Hemodynamic Parameters and Stress Response Hormones During Laparoscopic Cholecystectomy Surgery

2021 ◽  
Vol 11 (5) ◽  
Author(s):  
Ali Ghomeishi ◽  
Ahmad Reza Mohtadi ◽  
Kaveh Behaeen ◽  
Sholeh Nesioonpour ◽  
Nima Bakhtiari ◽  
...  
Keyword(s):  
Heart Rate ◽  
Laparoscopic Cholecystectomy ◽  
Stress Hormones ◽  
Endocrine System ◽  
Atrial Pressure ◽  
Hemodynamic Parameters ◽  
Hemodynamic Variables ◽  
Anesthetic Drugs ◽  
Epinephrine Level ◽  
Significant Difference

Background: General anesthesia induces endocrine, immunologic, and metabolic responses. Anesthetic drugs affect the endocrine system by changing the level of stress hormones and hemodynamic variables of the patient. Objectives: The purpose of this study was to compare the effects of propofol and dexmedetomidine on hemodynamic parameters and stress-induced hormones in laparoscopic cholecystectomy (LC) surgery. Methods: Seventy patients of elective LC were included in this study. The patients were randomly assigned into two equal groups of propofol (75 µg/kg/min) and dexmedetomidine (0.5 µg/kg/hour) as anesthesia maintenance. Hemodynamic parameters (heart rate and mean atrial pressure), blood sugar, and serum epinephrine level were monitored and recorded from pre-anesthesia period to 10 min after entry to post-anesthesia care unit (PACU) according to a planned method. Results: Heart rate and mean atrial pressure changes were significantly lower in dexmedetomidine group in all stages compared to propofol group (P < 0.001). Also, the rises in blood glucose and serum epinephrine levels in the dexmedetomidine group were significantly higher than in the propofol group (P < 0.001). Conclusions: Anesthesia maintenance by dexmedetomidine showed a significant difference in hemodynamic parameters in comparison with propofol. While dexmedetomidine had better effects on controlling hemodynamic parameters, propofol showed better effects on decreasing stress hormones, and it can be suggested for LC surgery.

A Non-inferiority Trial: Safety and Efficacy of Topical 1:1000 versus 1:10 000 Epinephrine in Sino-nasal Surgeries

2020 ◽  
pp. 000348942096282
Author(s):  
Cassie L. Dow ◽  
Anders W. Sideris ◽  
Ravjit Singh ◽  
Mitchell H. Giles ◽  
Catherine Banks ◽  
...  
Keyword(s):  
Heart Rate ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Nasal Passage ◽  
Hemodynamic Parameters ◽  
Hemodynamic Stability ◽  
Absolute Change ◽  
Significant Difference ◽  
Blood Pressures ◽  
Surgical Conditions

Objective: This study aimed to test the non-inferiority of topical 1:1000 epinephrine compared to topical 1:10 000 with regard to intraoperative hemodynamic stability, and to determine whether it produced superior visibility conditions. Methods: A single-blinded, prospective, cross-over non-inferiority trial was performed. Topical 1:1000 or topical 1:10 000 was placed in 1 nasal passage. Hemodynamic parameters (heart rate, systolic and diastolic blood pressures, and mean arterial pressure) were measured prior to insertion then every minute for 10 minutes. This was repeated in the contralateral nasal passage of the same patient with the alternate concentration. The surgeon graded the visualization of each passage using the Boezaart Scale. The medians of the greatest absolute change in parameters were compared using a Wilcoxon Rank-Signed test and confidence intervals were calculated using a Hodges-Lehman test. The non-inferiority margin was pre-determined at 10 bpm for heart rate and 10 mmHg for blood pressures. A Wilcoxon Rank-Signed test was used to assess superiority in visualization. Results: Thirty-two patients were enrolled and after exclusions, nineteen were assessed (mean age = 35.63 ± 12.49). Differences in means of greatest absolute change between the 2 concentrations were calculated (heart rate = 2.49 ± 1.20; systolic = −1.51 ± 2.16; diastolic = 2.47 ± 1.47; mean arterial pressure = 0.07 ± 1.83). In analyses of medians, 1:1000 was non-inferior to the 1:10 000. There was a significant difference (–0.58 ± 0.84; P = .012) in visualization in favor of topical 1:1000. Conclusion: Topical 1:1000 epinephrine provides no worse intraoperative hemodynamic stability compared to topical 1:10 000 but affords superior visualization and should be used to optimize surgical conditions.

scholarly journals The Effects of Different Pressure Pneumoperitoneum on the Pulmonary Mechanics and Surgical Satisfaction in the Laparoscopic Cholecystectomy

2021 ◽  
Vol 17 (6) ◽  
pp. 33-41
Author(s):  
B. Küçüköztaş ◽  
L. İyilikçi ◽  
S. Ozbilgin ◽  
M. Ozbilgin ◽  
T. Ünek ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Minute Ventilation ◽  
Peak Inspiratory Pressure ◽  
Low Pressure ◽  
Pulmonary Mechanics ◽  
Abdominal Pressure ◽  
Hemodynamic Parameters ◽  
Peripheral Oxygen Saturation ◽  
Significant Difference ◽  
Standard Pressure

Objectives. Inspiratory, hemodynamic and metabolic changes occur in laparoscopic surgery depending on pneumoperitoneum and patient position. This study aims to evaluate the effects of intra-abdominal pressure increase based on CO2 pneumoperitoneum in laparoscopic operations on hemodynamic parameters and respiratory dynamics and satisfaction of surgeon and operative view.Materials and Methods. A total of 116 consecutive, prospective, ASA class I–III cases aged 18–70 years undergoing laparoscopic cholecystectomy were enrolled in this study. Data of 104 patients were analysed. Patients were divided into two groups as the group Low Pressure (<12 mmHg) (Group LP) (n=53) and the group Standard Pressure (>13 mmHg) (Group SP) (n=51). In this study administration of general anesthesia used total intravenous anaesthesia in both groups. All groups had standard and TOF monitorization applied. The anaesthesia methods used in both groups were recorded. Before, during and after peritoneal insufflation, the peroperative ventilation parameters and hemodynamic parameters were recorded. The adequacy of pneumoperitoneum, gastric and the operative view were evaluated by the operating surgeon and recorded.Results. The peripheral oxygen saturation showed no significant difference between the low and standard pressure pneumoperitoneum in view of tidal volume, respiratory rate, end tidal CO2, mean and peak inspiratory pressure, and minute ventilation values. In terms of hemodynamics, when values just after intubation and before extubation were compared, it was observed that in the LP group systolic, diastolic and mean blood pressure values were higher. In terms of heart rate, no significant difference was observed in determined periods between groups. There was no significant difference between the groups in terms of surgical satisfaction and vision.Conclusion. Low pressure pneumoperitoneum provides effective respiratory mechanics and stable hemodynamics for laparoscopic cholecystectomy. It also provides the surgeon with sufficient space for hand manipulations. Anaesthetic method, TIVA and neuromuscular blockage provided good surgery vision with low pressure pneumoperitoneum.

scholarly journals Effects of intravenous Dexmedetomidine on Intraoperative Hemodynamic Parameters in the Patients Undergoing Laparoscopic Cholecystectomy

2020 ◽  
Vol 9 (2) ◽  
pp. 6-7
Author(s):  
Arjun Singh ◽  
Ravi Singh Dogra ◽  
Poonam ◽  
Reva Thakur
Keyword(s):  
Heart Rate ◽  
Laparoscopic Cholecystectomy ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Tracheal Extubation ◽  
Anesthesia Induction ◽  
Hemodynamic Parameters ◽  
Time Points

Background: Dexmedetomidine, in addition to sympatholytic effect, diminishes intraoperative requirement of anesthetics including propofol. The present study was conducted to evaluate the effects of intravenous dexmedetomidine on intraoperative hemodynamics in laparoscopic cholecystectomy. Subjects and Methods: Five patients undergoing laparoscopic cholecystectomy received dexmedetomidine. Dexmedeto- midine was loaded (1 µg/kg) before anesthesia induction and infused (0.6 µg/kg/h) during surgery. Anesthesia was induced with propofol. Mean arterial pressure (MAP) and heart rate (HR) were recorded at baseline and at various time points from the loading of drugs to just after tracheal extubation. Results: Both HR and MAPdecreased till insufflation and then increased at extubation. Conclusion: During propofol-based anesthesia for laparoscopic cholecystectomy, dexmedetomidine provides stable intraoperative hemodynamics.

Effect of physical exercises on anthropometric parameters, blood pressure and heart rate of young people and adults in Matola city–Mozambique

2020 ◽  
Vol 9 (4) ◽  
pp. 139-144
Author(s):  
José Luís Sousa Manjate ◽  
Félix Salvador Chavane ◽  
Leonardo Lúcio Nhantumbo
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Physical Inactivity ◽  
Wilcoxon Test ◽  
Hemodynamic Parameters ◽  
Anthropometric Parameters ◽  
Hemodynamic Variables ◽  
Physical Exercises ◽  
Age Range ◽  
Anthropometric Assessment

Introduction: physical inactivity is a risk factor for chronic non-communicable diseases, causing morbidity and mortality and weight gain in the economy of nations. Objective: to analyze the effect of combined physical exercises on anthropometric and hemodynamic parameters in young and adults people in Cidade da Matola. Methodology: 22 subjects from 23 to 60 years old (8 female and 14 male) were randomly selected in 2017. The anthropometric assessment consisted of weight, height, BMI and waist circumference. Hemodynamic variables were evaluated with an Omron M3-HEM-7131-E tensiometer. The sample performed combined physical exercises for three consecutive months. Using SPSS, 20.0, at 95% CI, the non-parametric WILCOXON test was applied to examine the effect of physical exercises on the variables of interest. Results: globally, weight and BMI increased over the course of the intervention, however without statistical differences, on the other hand, height, WP, SBP, DBP and HR differed statistically: P=(0.019; 0.008; 0.048; 0.006; 0.000) respectively. After analyzing the sex, only male individuals registered statistically significant differences for WP, DBP and HR: P=(0.023; 0.006; 0.000) respectively. The age range of individuals aged ≥ 36 years revealed a significant effect of the intervention on the variables WP, DBP and HR: P=(0.022; 0.042; 0.001) respectively. Conclusions: although the sample size was small, globally, the effect of the intervention on the variables of interest was notorious, especially in Blood Pressure, Heart Rate and Waist Perimeter.

scholarly journals Myocardial load at 30% and 50% of Maximal Voluntary Isometric Contraction in healthy individuals with Active and Sedentary Lifestyle

2020 ◽  
Vol 4 (1) ◽  
pp. 7-11
Author(s):  
Samrudhi Singh ◽  
◽  
Mariya Jiandani ◽  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Isometric Contraction ◽  
Sedentary Lifestyle ◽  
Rate Pressure Product ◽  
Care Hospital ◽  
Hemodynamic Parameters ◽  
Maximal Voluntary Isometric Contraction ◽  
Significant Difference

Background: Activities of daily living consists of isometric & isotonic contraction. Isometric contraction is a static contraction that exerts pressure overload on the heart. Studies have been carried out demonstrating hemodynamic effects of isotonic exercises however limited studies are available on myocardial load with isometric exercises. Aims and Objectives: To study the myocardial load at 30% and 50% of maximal voluntary isometric contraction (MVIC) in individuals with active and sedentary lifestyle. Study design and setting: Observational cross-sectional study was carried out in a tertiary care hospital. Materials and Methods: 140 healthy subjects (70 each in active & sedentary group) were recruited for the study. Baseline demographics of both groups were comparable. Hemodynamic parameters were taken at rest. Subject performed 30% and 50% MVIC and hemodynamic parameters were recorded during and post contraction. Statistical Analysis: Paired t test was used to compare the myocardial load between 30% and 50% MVIC in both groups. Repeated measures ANOVA was used to compare the myocardial load between active & sedentary groups at 30% and 50% MVIC. Result: There was a statistically significant difference in heart rate, systolic blood pressure &rate pressure product between 30% and 50% in active as well as sedentary groups. There was statistically no significant difference in heart rate, systolic blood pressure & rate pressure product between active & sedentary groups at 30% and 50% MVIC. Conclusion: The myocardial load during activities at submaximal intensities (<50%) is within the physiological limits and can be performed safely in individuals with active and sedentary lifestyle.

scholarly journals Evaluation of nicotine patch in pain control of patients undergoing laparoscopic cholecystectomy

2018 ◽  
Vol 45 (3) ◽  
Author(s):  
EUCLIDES DIAS MARTINS FILHO ◽  
CÉSAR FREIRE DE MELO VASCONCELOS ◽  
FERNANDO DE SANTA CRUZ OLIVEIRA ◽  
ADRIANO DA FONSECA PEREIRA ◽  
ÁLVARO ANTÔNIO BANDEIRA FERRAZ
Keyword(s):  
Blood Pressure ◽  
Laparoscopic Cholecystectomy ◽  
Oxygen Saturation ◽  
Pain Control ◽  
Nicotine Patch ◽  
Test Group ◽  
Control Group ◽  
Hemodynamic Parameters ◽  
Significant Difference ◽  
The Mean

ABSTRACT Objective: to analyze the effects of nicotine patch on pain control, occurrence of nausea and its hemodynamic repercussions in laparoscopic cholecystectomy procedures. Methods: we conducted an analytical, prospective, randomized, triple-blinded, clinical study between January and July 2017. The sample consisted of 17 patients who underwent laparoscopic cholecystectomy for the treatment of cholelithiasis. Nine patients used nicotine patch, and eight, placebo patch. The studied variables were pain, nausea, patient satisfaction, blood pressure, heart rate, oximetry and morphine rescue. Results: taking into account the pain and nausea parameters, there was no statistically significant difference between the groups (p>0.05). Also, the evaluation of rescue medication, both opioids and prokinetics, did not show any significant statistical difference between the groups. Among the hemodynamic parameters, there was only one statistically significant difference in the analysis of oxygen saturation and systolic blood pressure (SBP) six hours after surgery: the mean oxygen saturation was higher in the Test group (97.89 x 95.88) and the mean SBP was higher in the Control group (123.89 x 110.0). Conclusion: although pain levels were lower for nicotine within 24 hours, the action of nicotine and the need for rescue opioids in pain control were not statistically significant between the groups and at the time intervals studied. There was no clinical repercussion in the hemodynamic parameters.

The influence of osteopathic correction on the rate of various rhythms of the body

2019 ◽  
pp. 64-71 ◽  
Author(s):  
A. E. Chernikova ◽  
Yu. P. Potekhina
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Age Groups ◽  
Biomechanical Properties ◽  
Dispersion Analysis ◽  
The Body ◽  
Body Tissues ◽  
Age Related ◽  
Significant Difference ◽  
Before And After

Introduction. An osteopathic examination determines the rate, the amplitude and the strength of the main rhythms (cardiac, respiratory and cranial). However, there are relatively few studies in the available literature dedicated to the influence of osteopathic correction (OC) on the characteristics of these rhythms.Goal of research — to study the influence of OC on the rate characteristics of various rhythms of the human body.Materials and methods. 88 adult osteopathic patients aged from 18 to 81 years were examined, among them 30 men and 58 women. All patients received general osteopathic examination. The rate of the cranial rhythm (RCR), respiratory rate (RR) heart rate (HR), the mobility of the nervous processes (MNP) and the connective tissue mobility (CTM) were assessed before and after the OC session.Results. Since age varied greatly in the examined group, a correlation analysis of age-related changes of the assessed rhythms was carried out. Only the CTM correlated with age (r=–0,28; p<0,05) in a statistically significant way. The rank dispersion analysis of Kruskal–Wallis also showed statistically significant difference in this indicator in different age groups (p=0,043). With the increase of years, the CTM decreases gradually. After the OC, the CTM, increased in a statistically significant way (p<0,0001). The RCR varied from 5 to 12 cycles/min in the examined group, which corresponded to the norm. After the OC, the RCR has increased in a statistically significant way (p<0,0001), the MNP has also increased (p<0,0001). The initial heart rate in the subjects varied from 56 to 94 beats/min, and in 15 % it exceeded the norm. After the OC the heart rate corresponded to the norm in all patients. The heart rate and the respiratory rate significantly decreased after the OC (р<0,0001).Conclusion. The described biorhythm changes after the OC session may be indicative of the improvement of the nervous regulation, of the normalization of the autonomic balance, of the improvement of the biomechanical properties of body tissues and of the increase of their mobility. The assessed parameters can be measured quickly without any additional equipment and can be used in order to study the results of the OC.

scholarly journals Caffeine improves biochemical and specific performance after judo training: a double-blind crossover study in a real judo training situation

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Kelvin Euton Oliveira Carmo ◽  
Diego Ignácio Valenzuela Pérez ◽  
Charles Nardelli Valido ◽  
Jymmys Lopes dos Santos ◽  
Bianca Miarka ◽  
...  
Keyword(s):  
Heart Rate ◽  
Uric Acid ◽  
Body Mass ◽  
Perceived Exertion ◽  
Rating Of Perceived Exertion ◽  
Power Performance ◽  
Double Blind ◽  
Biochemical Effect ◽  
Plasma Uric Acid ◽  
Hemodynamic Variables

Abstract Background Nutritional ergogenic aids are foods or nutrients that can improve physical performance. Among these foods with ergogenic properties, caffeine has shown that it can increase the fat catabolism, strength, and improve the cognition and time reaction of an athlete, therefore, it is hoped that it can improve the performance of judokas. This study through a double-blind crossover (supplement X placebo) protocol, investigated the effects caffeine supplementation (single capsule containing 5 mg/kg body mass intake 60 min before the session) on biochemical, anthropometrical, physical, subjective and hemodynamic variables measured before, during and after two typical judo trainingcxs sessions (120-min: 40-min of gymnastics; 40-min of specific technics and; 40-min of judo combat). Methods 8 high-level athletes (21.4 ± 2.0 years; 83.6 ± 15.2 kg; 1.8 ± 0.1 m; 17.9 ± 7.0 Fat%) were evaluated before and after each training for body mass, hydration, upper and lower limb power, performance in the special judo fitness test (SJFT), free fatty acids (FFA) in plasma, uric acid, glucose, lactate, heart rate, and pain. In addition, heart rate, FFA in plasma, uric acid, glucose, lactate, rating of perceived exertion and pain were assessed during the training. Results At 120 min, supplementation resulted in a higher concentration of plasma FFA (1.5 ± 0.5 vs. 1.0 ± 0.3 mmol/L; p = 0.047) and lactate (4.9 ± 1.8 vs. 3.0 ± 1.2 mmol/L; p = 0.047), and a lower concentration of uric acid (5.4 ± 0.9 vs. 7.0 ± 1.5 mg/dL; p = 0.04). Supplementation also resulted in performance maintenance (fatigue index) in the SJFT (Δ0.3 ± 2.0 vs Δ1.7 ± 2.5, for caffeine and placebo respectively, p = 0.046). No adverse effects were observed. Conclusion Based on the applied dose, intake time, and sample of this study, we can conclude that caffeine produces an ergogenic biochemical effect, and improves performance in judo athletes.

scholarly journals Can Residential Greenspace Exposure Improve Pain Experience? A Comparison between Physical Visit and Image Viewing

Healthcare ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 918
Author(s):  
Hansen Li ◽  
Xing Zhang ◽  
Shilin Bi ◽  
Yang Cao ◽  
Guodong Zhang
Keyword(s):  
Heart Rate ◽  
State Anxiety ◽  
Pain Threshold ◽  
Pain Perception ◽  
The State ◽  
Subjective Stress ◽  
Pain Experience ◽  
Scenic Beauty ◽  
Significant Difference ◽  
Pain Stimuli

Reducing the burden of pain via greenspace exposure is a rising research topic. However, insufficient evidence has been found in relation to the environmental effect itself. Residential greenspace, as a convenient but limited natural environment for urban dwellers, has benefits and services yet to be discovered. Therefore, the current study recruited 24 young adults to evaluate the effects of physical visit to, or image viewing of, residential greenspace on pain perception and related psychophysiological outcomes, via simulated pain. Pain threshold and tolerance were recorded via the level of pain stimuli, and pain intensity was evaluated using the Visual Analog Scale (VAS). The state scale of the State–Trait Anxiety Inventory (STAI-S) and two adjective pairs were employed to measure the state anxiety and subjective stress, respectively. Meanwhile, heart rate (HR), heart rate variability (HRV), and blood pressure (BP) were measured to investigate physiological responses. Besides, Scenic Beauty Estimation (SBE) was also employed to assess participants’ preference regarding the experimental environments. The results revealed that visiting the greenspace significantly increased the pain threshold and tolerance, while no significant effect was observed for image viewing. On the other hand, no significant difference was observed in pain-related psychophysiological indices between the experimental settings, but significantly negative associations were found between the scores of SBE and subjective stress and state anxiety. In conclusion, the current study brings experimental evidence of improving pain experience via residential greenspace exposure, while the related psychophysiological benefits require further investigation.

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