scholarly journals Potential Drugs for Treating COVID-19 Infection

2020 ◽  
Vol 7 (4) ◽  
Author(s):  
Mehrdad Mohammadi ◽  
Tim Sandle ◽  
Sajad Rajabi ◽  
Ahmad Khorshidi ◽  
Ahmad Piroozmand
Keyword(s):  
Respiratory Disease ◽  
Therapeutic Agents ◽  
Hubei Province ◽  
Antiviral Drugs ◽  
Review Article ◽  
Interferon Α ◽  
The Novel ◽  
Efficacy And Safety ◽  
Chinese Herbal ◽  
Novel Coronavirus

: The novel Coronavirus Disease 2019 (COVID-19) appeared as an emerging respiratory disease in December 2019 in Wuhan, Hubei province, China, and then spread rapidly worldwide, being declared a pandemic on March 11, 2020. Researchers are attempting to discover specifically designed antiviral treatments for COVID-19. Several therapeutic agents such as Interferon-α, Lopinavir/Ritonavir, Ribavirin, Chloroquine, Chloroquine phosphate, Hydroxychloroquine, Arbidol, Favipiravir, Remdesivir, Darunavir, Imatinib, Teicoplanin, Azithromycin, COVID-19 convalescent plasma, other potential antiviral drugs, and Chinese herbal agents are now being clinically studied to examine both pharmaceutical efficacy and safety for COVID-19 treatment in several countries. Some favorable results from these studies have been obtained to date. This review article summarizes and reiterates drugs that are potentially efficient against COVID-19.

scholarly journals A perspective review of deadly viral diseases: An era of viruses

2021 ◽  
Vol 10 (8) ◽  
pp. 1038
Author(s):  
Abhishek Sharma ◽  
Sarita J. Bhyan ◽  
Abdul Malik
Keyword(s):  
Mortality Rate ◽  
West Africa ◽  
Health Risk ◽  
Viral Infections ◽  
Antiviral Drugs ◽  
Review Article ◽  
Viral Diseases ◽  
The Novel ◽  
Novel Coronavirus ◽  
Scarcity Of Resources

This review article overviewed briefly about the era of deadly viruses. Humans have been combating viruses since before our species had even evolved into its recent form. In some cases of viral infections, vaccines and antiviral drugs have allowed us to treat infections from spreading broadly, and have facilitated to patient recover. But it is far from over to fight the viruses. In recent decades, a number of viruses have sprung from animals to humans and have caused massive outbreaks, claiming thousands of lives such as the virus that led to the 2014-2016 Ebola outbreak in West Africa kills up to 90% of the population, making it the deadliest member of the Ebola family. But there are some viruses that are equally deadly, and some are even more deadly. Some viruses, including the novel coronavirus currently undergoing global outbreaks, have a low mortality rate but still pose a serious health risk as we have no means of access to the health facilities and scarcity of resources and infrastructure. Here we are reporting such type of ten deadly viruses. those have infected humans within last 50 years.

scholarly journals Coronavirus Disease 2019 (COVID-19): Future Challenges and Recommendations for Dental Settings

2021 ◽  
Vol 4 (11) ◽  
pp. RV1-RV5
Author(s):  
Najmus Sahar ◽  
Pradeep Tangade ◽  
Vikas Singh ◽  
Surbhi Priyadarshini ◽  
Debashis Roy
Keyword(s):  
Health Care Workers ◽  
Preventive Measures ◽  
Clinical Manifestations ◽  
Virus Transmission ◽  
Review Article ◽  
The Novel ◽  
Medical Practitioners ◽  
Care Workers ◽  
Future Challenges ◽  
Novel Coronavirus

The novel coronavirus outbreak is a contagious disease affecting the countries around the world. The quick advancing nature of pandemic has gripped the entire community making it a public health emergency. Infection control preventive measures are necessary to prevent it from further spreading. Medical practitioners, health care workers and Dentists are at high risk of acquiring and transmission of infection. The virus transmission occurs through respiratory tract, aerosols and droplets. Clinical manifestations of virus vary from mild to severe sickness. This review article mainly emphasizes on all the information collected to date on the virus, and future recommendations for dental settings to manage the further spread of this virus.

scholarly journals The clinical characteristics and treatment approaches of COVID-19: a concise review

2021 ◽  
Author(s):  
Sajjad Eslamkhah ◽  
Nazila Alizadeh ◽  
Khalil Hajiasgharzadeh ◽  
Masoud Eslamkhah ◽  
Ahad Mokhtarzadeh ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Web Of Science ◽  
Close Contact ◽  
Review Article ◽  
Main Concern ◽  
The Novel ◽  
Concise Review ◽  
Potential Benefits ◽  
Characteristic Features ◽  
Novel Coronavirus

A series of cases of pneumonia occurred in China in late 2019. For this type of coronavirus, the WHO formally identified the condition as a coronavirus disease 2019 (COVID-19). They announced that this disease is the recent main concern of health problems in the world. Transfer of this novel coronavirus (nCoV) from human to human exists predominantly among family members, who have close contact with each other. This review article is provided based on the recent findings of COVID-19, which were retrieved by searching PubMed, Google Scholar, Scopus, and Web of Science until December 2020. Here, we highlighted the coronaviruses types, COVID-19 symptoms, epidemiology of the disease, transmission ways, and nCoV related pneumonia pathogenesis and continue with characteristic features and treatment methods. While no approved treatments are available for this type of infection therapy but several drugs may have potential benefits. It seems that identifying the detailed characteristics of the novel coronavirus disease offers the foundation for further research into the production of effective anti-COVID-19 drugs and vaccines.

scholarly journals The Role of Herbal and Nutritional Treatments in the Fight against COVID-19 and Other Respiratory Tract Infections

2021 ◽  
Vol 18 (22) ◽  
pp. 12001
Author(s):  
Aline El Zakhem ◽  
May Annie Chalhoub ◽  
Maya Bassil
Keyword(s):  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
The Novel ◽  
Medical Treatments ◽  
Nutritional Interventions ◽  
Chinese Herbal ◽  
Upper Respiratory ◽  
Novel Coronavirus ◽  
Tract Infections

With the growing spread of COVID-19 worldwide, the appeal to alternative and nutritional therapies in conjunction with medical therapies has been heightened. This article aims to review studies assessing the roles of Chinese traditional medicine and nutrition in upper respiratory infections, including COVID-19. Various Chinese herbal protocols have been shown to fight respiratory infections, with several having been tested on the novel coronavirus. Additionally, promising findings have been reported when medical treatments were complemented with nutritional interventions. Supplementation with vitamins C and D, Zinc and Selenium are discussed, in addition to certain phytochemicals and food that also possess immunoregulatory and antiviral properties. Further clinical studies are needed to establish these alternative treatments as part of the management of emerging respiratory infections.

scholarly journals COVID-19: Diagnosis, Management and Response

2021 ◽  
pp. 161-170
Author(s):  
Ashwini Shalikrao Mhaske ◽  
Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Hubei Province ◽  
Positive Patient ◽  
The Novel ◽  
Wuhan City ◽  
Corona Virus ◽  
Early Reaction ◽  
Novel Coronavirus ◽  
Predetermined Number

Background: COVID infection 2019 (COVID-19) is identified as a disease caused by Corona virus formally known as severe acute respiratory syndrome (SARS-CoV-2), which was first detected in Wuhan City, Hubei Province, China, amidst of an outbreak of respiratory sickness cases. Summary: As there is no affirmed total course of treatment for the Novel Coronavirus, the best way to handle it is by playing it safe, its administration and early reaction. Segregation and disinfection go inseparably with regards to dealing with a COVID positive patient. In any case, the predetermined number of clinical office accessible is blocking the cycle of control and anticipation for a particularly number of infected patients. Conclusion: As the pandemic is advancing, more examinations and exploration is needed to effectively deal with the spread of the novel Corona virus. Foundation improvement and arrangement of clinical office and gear is the preeminent prerequisite for early reaction and treatment.

scholarly journals COVID-19: A Critical Review on Viral Biochemistry, Environmental Transmission, Therapeutics and Safety Measures

2020 ◽  
Vol 1 (6) ◽  
Author(s):  
Roshni Kumari ◽  
Kumari Pragati Nanda ◽  
Hena Firdaus ◽  
Soumen Dey
Keyword(s):  
Specific Treatment ◽  
Scattered Data ◽  
Review Article ◽  
World Health ◽  
The Novel ◽  
Safety Measures ◽  
Current Scenario ◽  
Novel Coronavirus ◽  
Health Organization

The outbreak of coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is declared pandemic by World Health Organization (WHO) keeping in view its infection rate and toxicity level. The entire world is struggling hard to survive the prevailing health emergency. The authors realise the urgent need of contributing an overview of the present scenario to the researchers who are breathlessly trying to combat this pandemic situation. This review aimed at binding all the scattered data and research available till now on COVID-19 disease starting from its origin to transmission and spread through environmental factors till treatment and the safety measures that should be implemented. This article would possibly help the readers by providing an outlook of current scenario on various perspectives of COVID-19 disease at a single glance. The types, origin and toxicity caused are discussed in brief. The role of contaminated aerosols (viral-laden smoke from tobacco, cigarettes), wastewater, fomites, human and faecal matter are important in spreading the novel coronavirus in the environment. There is no specific treatment till date but clinical trials and diagnosis on several known drugs are on-going. The precaution and safety measures could hopefully reduce number of infections and mortality. The number of infected cases confirmed till 2 August 2020 was 17660523 with 680894 deaths in the world. We tried in this review article to summarize the scattered data available on biochemistry of SARS-CoV-2, environmental spread of virus and the safety measures to combat COVID-19 pandemic.

scholarly journals Nanotechnology against the novel coronavirus (severe acute respiratory syndrome coronavirus 2): diagnosis, treatment, therapy and future perspectives

Nanomedicine ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. 497-516
Author(s):  
Hamid Rashidzadeh ◽  
Hossein Danafar ◽  
Hossein Rahimi ◽  
Faezeh Mozafari ◽  
Marziyeh Salehiabar ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Therapeutic Agents ◽  
Rapid Diagnosis ◽  
Socioeconomic Impact ◽  
The Novel ◽  
Future Perspectives ◽  
Mortality And Morbidity ◽  
Self Assembling ◽  
Novel Coronavirus ◽  
Significant Mortality

COVID-19, as an emerging infectious disease, has caused significant mortality and morbidity along with socioeconomic impact. No effective treatment or vaccine has been approved yet for this pandemic disease. Cutting-edge tools, especially nanotechnology, should be strongly considered to tackle this virus. This review aims to propose several strategies to design and fabricate effective diagnostic and therapeutic agents against COVID-19 by the aid of nanotechnology. Polymeric, inorganic self-assembling materials and peptide-based nanoparticles are promising tools for battling COVID-19 as well as its rapid diagnosis. This review summarizes all of the exciting advances nanomaterials are making toward COVID-19 prevention, diagnosis and therapy.

scholarly journals REVIEW ON PANDEMIC OUTBREAK OF CORONAVIRUS (COVID-19): VIROLOGY, AVAILABLE TREATMENT, PREVENTION, AND FUTURE PROJECTION

2020 ◽  
pp. 1-6
Author(s):  
Abhijit Mohan Kanavaje ◽  
Vipul Ajit Sansare
Keyword(s):  
Early Stage ◽  
Scale Up ◽  
Therapeutic Agents ◽  
Family Welfare ◽  
The Novel ◽  
Future Projection ◽  
Potential Threat ◽  
Treatment Regimens ◽  
Treatment And Prevention ◽  
Novel Coronavirus

Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, this disease has spread rapidly around the globe. On 11 March 2020, WHO declared Novel Coronavirus Disease (COVID-19) outbreak as a pandemic and reiterated the call for countries to take immediate actions and scale up the response to treat, detect and reduce transmission to save people’s lives. As of 3 April 2020, according to the Ministry of Health & Family Welfare (MoHFW), a total of 2301 COVID-19 cases (including 55 foreign nationals) have been reported in 29 states/union territories. These include 156 who have been cured/discharged,1 who has migrated, and 56 deaths in India. Considering the potential threat of a pandemic, scientists and physicians have been racing to understand this new virus and the pathophysiology of this disease to uncover possible treatment regimens and discover effective therapeutic agents and vaccines. The objective of this review article was to have a preliminary opinion about the disease, the ways of treatment, and prevention in this early stage of this outbreak.

scholarly journals Review of the efficacy of HEPA filtered air to control coronavirus risks in cleanrooms

2020 ◽  
Author(s):  
Tim Sandle
Keyword(s):  
Immune System ◽  
Respiratory Disease ◽  
Large Family ◽  
High Energy ◽  
Viral Transmission ◽  
The Body ◽  
The Novel ◽  
Enveloped Viruses ◽  
Novel Coronavirus ◽  
Outer Coating

The risk of viral transmission in the built environment is a matter of concern in the era of the novel coronavirus pandemic, for most of society, given that humans spent the majority of their time indoors. For pharmaceuticals and healthcare, there is an additional concern about working in cleanrooms and the degree to which protective measures are appropriate. With cleanrooms, an important concern is with the efficacy of HEPA filters. This article looks at the risks stemming from SARS-CoV-2 and applies these to the cleanroom context. The article concludes that the cleanroom environment does not contribute to the risk of viral transmission, and certain design aspects can, in fact, reduce the risk compared with other built environments. Characteristics of the novel coronavirus Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and SARS-CoV). Coronaviruses are zoonotic, meaning they can be transmitted between animals and people ¹. Coronaviruses are classified as RNA ‘enveloped’ viruses, whereas viruses such as rotavirus, or poliovirus are termed non-enveloped. Enveloped viruses have an envelope or outer coating which is needed by the virus to help it attach to the host cell. If this outer coating is destroyed, for example by a disinfectant, the virus cannot survive. The mode of transmission for enveloped viruses is characterized by the specific virus; however, the most common routes are via indirect or direct contact of infectious virus particles, contact with or inhalation of respiratory droplets ². The specific coronavirus of concern is SARS-CoV-2, with SARS standing for ‘severe acute respiratory syndrome’ and CoV representing ‘coronavirus’. The associated respiratory disease is termed COVID-19 (to represent ‘coronavirus disease 2019). This particular virus can cause severe respiratory disease because cells in the lung are damaged and no longer able to transport oxygen into the bloodstream. Some symptoms of disease such as fever and fatigue result from the activities of the immune system trying to eliminate the infection from the body. Heat (fever) inactivates viruses and fatigue results from the high energy demands of the immune system fighting the virus ³.

Sign in / Sign up

Export Citation Format

Share Document