Assessing the Relationship Between 25-Hydroxy Vitamin D3 Deficiency with Forearm Fracture in 2 to 15 Year-Old Children

Introduction: The International Diabetes Federation (IDF) Announces 415 million people around the world are suffering from diabetes. There is a high proportion of UDM (undiagnosed diabetes) at the level of the world and particularly in developing countries. The number of people with UDM in Iran in 2015 are 2197.96 per 1000. Vitamin D3 deficiency is associated with increased risk of type 2 diabetes and for a long time, been recognized as a risk factor for glucose intolerance. Salivary composition, as the mirror of oral health, its use as a diagnostic tool is increasing and diabetes is also can be effective on the flow rate of saliva and its compounds. Analysis of saliva can be used as part of the evaluation of endocrine function. Material and Methods: In this case-control study in 2016 in Hamadan, we selected 57 newly diagnosed patients with type 2 diabetes mellitus with mean aged 47.73 years and 57 healthy controls with mean aged 45.36 years. By using Spitting method, 5ml of completely unstimulated saliva samples were collected from diabetic patients and control subjects. The serum and saliva 25(OH)Vit.Dconcentrations were measured by ELISA. The results are analyzed by SPSS 16.Results: Significant difference was found in serum concentrations between the two groups (p<0.001). But in unstimulated whole salivary 1, 25(OH) 2D3 concentrations between the two groups, difference was not significant and the relationship, was reversed. There was a significant correlation (P=0.013) between serum and saliva 1, 25(OH) 2D3concentrations in the control group. In other words, the correlation was approximately 0.33. Correlation between serum and saliva 1, 25(OH) 2D3 concentrations in case group was not significant. Serum levels of 1, 25(OH) 2D3 in 21.1% of control group, showed the inadequate level (Vit.D3= 20-29ng/ml) and in the case group, showed the critical situation and overall 91.2% of the newly diagnosed diabetics, suffered from lack of vitamin D3. According to the salivary levels of 1, 25(OH) 2D3, in general, a total of 58% of the case group, have deficiency of vitamin D3.Conclusion: The results was confirmed vitamin D3 deficiency in participating in the study population (both case and control). The findings showed that there is lower concentration of 1, 25(OH) 2D3 in serum and after that in saliva in diabetic patients that newly diagnosed. Saliva would play a helpful diagnostic role in the early detection, the monitoring and progression of diabetes, but still serum is the better method for detecting vit.D3 levels and more research needs to be done on saliva for detecting Vit.D3 concentrations.

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Relationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease in China

Journal of International Medical Research ◽

10.1177/03000605211012231 ◽

2021 ◽

Vol 49 (5) ◽

pp. 030006052110122

Author(s):

Meng Li ◽

Jun Xu ◽

Qin Wan ◽

Qiang He ◽

Yan Ma ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Vitamin D3 ◽

Serum Vitamin ◽

Factors Associated ◽

Severe Deficiency ◽

Group A ◽

Deficiency Group ◽

The Relationship ◽

Vitamin D3 Deficiency

Objective In the present study, we aimed to investigate the relationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease (CKD) in China, to assist understanding of the effects of vitamin D treatment in such patients. Methods A total of 225 patients with CKD were enrolled and a range of laboratory parameters were measured. The participants were allocated to three groups, according to their serum 25-hydroxyvitamin D3 concentration: a severe deficiency group, a deficiency group, and a sufficiency group. The prevalences of anaemia in the three groups were assessed, and the factors associated with anaemia in patients with CKD were analysed using logistic regression. Results The prevalences of anaemia were 79.5% in the severe deficiency group, 63.5% in the deficiency group, and 48.0% in the sufficiency group. The prevalence of anaemia gradually increased with the severity of vitamin D3 deficiency. The prevalences of anaemia in participants with stages 1 to 5 CKD were 21.1%, 30.4%, 39.5%, 78.7%, and 94.6%, respectively. Conclusion Vitamin D3 deficiency may increase the risk of anaemia in patients with CKD.

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Association of Single Nucleotide Polymorphisms in the VDR and CYP27B1 Genes with Risk of Developing Vitamin D3 Deficiency

Journal of Pure and Applied Microbiology ◽

10.22207/jpam.15.1.15 ◽

2021 ◽

Vol 15 (1) ◽

pp. 201-211

Author(s):

Hormoz Selahvarzi ◽

Milad Kamdideh ◽

Mehrnoosh Vahabi ◽

Ali Dezhgir ◽

Massoud Houshmand ◽

...

Keyword(s):

Vitamin D ◽

Single Nucleotide Polymorphisms ◽

Vitamin D3 ◽

Odds Ratio ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Increased Risk ◽

Significant Difference ◽

The Relationship ◽

Vitamin D3 Deficiency

This study was carried out to investigate the relationship between common variants in two vitamin D pathway genes (VDR and CYP27B1) and vitamin D3 serum levels. In this study, serum vitamin D metabolite levels were measured in the blood samples of 200 patients with alopecia areata. Then, single nucleotide polymorphisms (SNPs) in VDR and CYP27B1 were analyzed using polymerase chain reaction (PCR)-sequencing. Sixty-three variations were observed in these genes (42 variations in CYP27B1 and 21 variations in VDR). A significant difference in Rs1544410 (odds ratio: 7, P < 0.0005) and rs4646536 (odds ratio: 4.043, P < 0.0005) variants was found between the patients and controls. The study showed the relationship between the two polymorphisms, Rs1544410 (odds ratio: 7, 95% CI, 1–8) and rs4646536 (odds ratio: 4.043, 95% CI, 3–14.038) on the genes VDR and CYP27B1, respectively, with increased risk of developing vitamin D3 insufficiency in the Iranian population. Therefore, SNPs in the VDR and CYP27B1 genes can be considered as prognostic biomarkers of the risk of developing vitamin D3 deficiency.

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Influence of Vitamin D3 Deficiency on the Development of Malocclusions

10.21203/rs.3.rs-109312/v1 ◽

2020 ◽

Author(s):

Anna Leszczyszyn ◽

Marzena Dominiak ◽

Sylwia Hnitecka

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Venous Blood ◽

Skeletal Malocclusion ◽

Skeletal Defect ◽

Number Of Patients ◽

Skeletal Defects ◽

The Impact ◽

The Relationship ◽

Vitamin D3 Deficiency

Abstract Background: Insufficient or excessive growth of the craniofacial bone leads to skeletal and dental defects, which in turn result in the presence of malocclusions. To date, all causes of malocclusion have not been fully explained. In the development of skeletal abnormalities, attention is often paid to general deficiencies - including vitamin D3 deficiency, which causes rickets in growing people. It is suspected that its chronic deficiency may also affect the development of skeletal malocclusion. The aim of the study was to prospectively assess the impact of vitamin D deficiency on the development of malocclusions.Methods: The examination consisted of three parts - (1) medical interview, (2) orthodontic examination along with an alginate impression and radiological imaging, (3) taking a venous blood sample for vitamin D3 level testing.Results: In about 42,1% patients the presence of a skeletal defect was found. In 46,5% of patients presence of dentoalveolar malocclusion occurred. The most common skeletal defect was jaw narrowing in turn, among malocclusions most often retrogenia was diagnosed.Conclusions: A relatively small number of patients in the study group was diagnosed with skeletal malocclusion. Due to effects of vitamin D on the development and metabolism of bones, including jawbones, and the relationship with, for example, rickets, we believe that it would be worthwhile to conduct a study fully focused on the group of patients with skeletal defects.

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Vitamin D3 Deficiency and COVID-19.

Coronaviruses ◽

10.2174/2666796701999200914112352 ◽

2020 ◽

Vol 01 ◽

Author(s):

Olen R. Brown ◽

Martin R. Hullender

Keyword(s):

Vitamin D3 ◽

Vitamin D3 Deficiency

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Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3

Vitamin D ◽

10.1515/9783110882513-136 ◽

1994 ◽

pp. 414-415

Keyword(s):

Vitamin D3 ◽

Endocrine Pancreas ◽

Dihydroxyvitamin D3 ◽

1,25 Dihydroxyvitamin D3 ◽

Calbindin D28k ◽

Vitamin D3 Deficiency

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A Quantitative Point-of-Need Assay for the Assessment of Vitamin D3 Deficiency

Scientific Reports ◽

10.1038/s41598-017-13044-5 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 8

Author(s):

S. Vemulapati ◽

E. Rey ◽

D. O’Dell ◽

S. Mehta ◽

D. Erickson

Keyword(s):

Vitamin D3 ◽

Vitamin D3 Deficiency

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Abstract 121: Vitamin D Deficiency Study in Postural Orthostatic Tachycardia Syndrome

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.8.suppl_2.121 ◽

2015 ◽

Vol 8 (suppl_2) ◽

Author(s):

Chandralekha Ashangari ◽

Amer Suleman

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Electronic Medical Records ◽

Vitamin D3 ◽

Medical Records ◽

Postural Orthostatic Tachycardia Syndrome ◽

Vitamin D Levels ◽

The World ◽

25 Oh Vitamin D ◽

Vitamin D3 Deficiency

Objectives The aim of this study is to assess vitamin D levels, including the prevalence of vitamin D deficiency/insufficiency in Postural Orthostatic Tachycardia Syndrome (POTS) patients. Background : The Postural Orthostatic Tachycardia Syndrome (POTS) affects primarily young women. POTS is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. We frequently find vitamin D deficiency in patients who present with POTS Methods: 180 patients were selected randomly from our clinic with POTS. Patients Vitamin D levels charts were reviewed from electronic medical records, 25-OH vitamin D (Vitamin D3 ) status was defined as Normal (>30 ng/mL), Insufficient (20.0-29.9 ng/mL), and deficient (<20 ng/mL). Results: Out of 180 patients, 170 patients are female (94%, n=170, age 31.88±10.36), 10 patients are male (6% ,age 25.83±6.19). 79 patients had vitamin D3 level >30 ng/ml, 10 patients had vitamin D3 level range >20.0 to 29.9 ng/mL, 91 patients had vitamin D3 level < 20ng/mL. Conclusion: Our research results demonstrated that Postural Orthostatic Tachycardia Syndrome (POTS) patients have a higher rate of vitamin D3 deficiency (51% have Vitamin D3 less than 20 ng/mL). Vitamin D3 levels are low in more than half of POTS patients (56% had less than 30 ng/mL )

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Evaluation of vitamin D3 in patients of polycystic ovary syndrome and their correlation

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20171967 ◽

2017 ◽

Vol 6 (5) ◽

pp. 2010

Author(s):

Rooplekha Chauhan ◽

Sonal Sahani ◽

Ankita Garg

Keyword(s):

Polycystic Ovary Syndrome ◽

Vitamin D3 ◽

Polycystic Ovary ◽

Serum Vitamin ◽

Reproductive Age ◽

Ovary Syndrome ◽

Chi Square ◽

Exact Test ◽

Young Females ◽

Vitamin D3 Deficiency

Background: Polycystic ovary syndrome (PCOS) is enigma faced by young females since the onset of urbanization. As on day, PCOS is the most common endocrine disorder in the women of reproductive age affecting 4-10%. This study done to measure serum vitamin D3 levels of PCOS patients and to identify its association with factors associated with various symptoms and signs in PCOS.Methods: Institutional based prospective observational study conducted on 70 patients of PCOS, both suspected and already diagnosed, attending gynecology OPD of Department of obstetrics and gynecology of NSCB Medical College Jabalpur from 1 March 2015 to 31 August 2016. Diagnosis of PCOS was made by Rotterdam 2003 criteria. A detailed assessment was done and preformed proforma was filled. Serum Vitamin D3 levels were estimated by standard lab technique ‘Liquid Chromatography Tandem Mass Spectrometry’ and categorized into vitamin D3 sufficient >30ng/dl, insufficient 20-29ng/dl and deficient <20ng/dl. Categorical data was coded numerically before the analysis. For comparison of frequency distribution chi square test or fisher’s exact test were applied as appropriate.Results: Prevalence of Vitamin D3 deficiency in patients of PCOS was found to be 84.3%.Conclusions: The present study concludes that there is correlation between vitamin D3 and PCOS, screening and correction of vitamin D3 deficiency may prevent PCOS and its manifestations. Hence, it is speculated that improvement of vitamin D3 levels at a younger age can contribute to prevention of PCOS.

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