scholarly journals Interpretation of Clinical and Laboratory Findings of Patients with Lupus Nephritis According to the Results of Biopsy

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Parviz Soufivand ◽  
Abdolrahman Rostamian ◽  
Mohammad Reza Abbasi ◽  
Fatemeh Shahbazi
Keyword(s):  
Lupus Nephritis ◽  
Clinical Manifestations ◽  
Study Groups ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Laboratory Findings ◽  
Exact Test ◽  
Limb Edema ◽  
Severity Of The Disease ◽  
Compare Study

Background: There are controversies regarding the diagnosis of lupus nephritis. Also, its clinical manifestations and severity are different from one patient to another. Objectives: The current study aimed to interpret clinical and laboratory features of lupus nephritis according to the results of the biopsy. Methods: Following a retrospective design, 30 patients with lupus, who were candidates for renal biopsy and undergoing kidney biopsy, were studied. Clinical findings (blood pressure and limb edema) and laboratory findings (Cr, ESR, CRP, BUN, C3, C4, CH50, Anti-ds DNA, and hematuria) were gathered. Finally, the diagnostic value of clinical and laboratory findings was interpreted according to the biopsies and the staging of samples in the pathology. Data were analyzed using SPSS. Quantitative variables are displayed using mean and quartiles. Fisher’s exact test was used to compare study groups. Also, independent samples t-test and Levene’s test were used to evaluate variances of quantitative variables. Results: Of 30 cases, 5 had a biopsy of 3 and FSGN. Also, 8 cases were on stages 3 and 4, 9 had a stage of 4 biopsy, and 8 cases were on stage 4 - 5, 5, and 5 - 6. The association between age, Limp edema, ESR, and biopsy was statistically significant (P < 0.05). Conclusions: This study demonstrated the usefulness of clinical and laboratory findings to determine the severity of the disease in the shortest time, mainly due to its easy, non-invasive access and early preparation of the results, which will facilitate the initiation of treatment.

Follow-up of Osteomyelitis of Infants with Systemic Serum Parameters and Bone Scintigraphy

1996 ◽  
Vol 35 (04) ◽  
pp. 116-121 ◽  
Author(s):  
G. E Fueger ◽  
M. Vejda ◽  
R. M. Aigner
Keyword(s):  
Bone Scintigraphy ◽  
Antibiotic Treatment ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Laboratory Findings ◽  
Radiographic Findings ◽  
Serum Parameters ◽  
Wbc Count ◽  
Differential White Blood Cell

Summary Aim: To prevent orthopedic sequelae in acute hematogenous pyogenic osteomyelitis (AHPO) of infants early diagnosis, recognition of recurrence and effective therapy is needed. This retrospective study of 47 infants with bacteriologically confirmed AHPO concerned with an analysis of the diagnostic value of systemic serum parameters compared to bone scintigraphy (BSC). Methods: AHPO was characterized initially and during the course of disease by clinical findings, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total and differential white blood cell (WBC) count, BSC, and plain radiography. Results: CRP was the most effective serum parameter for follow- up of disease. The first sign of BSC to signal adequate response to antibiotic treatment was the decrease or normalization of hyperperfusion. Escape from therapy or poor prognosis, even when the serum parameters were normalized, was signaled by the recurrence of focal hyperperfusion and the persistent or increasing local uptake ratios on the 3-h-image over 6 weeks during a course of antibiotic treatment. Conclusion: Antibiotic treatment masks the clinical presentation, and the radiographic findings, causes non-characteristic laboratory findings, but do not prevent the scintigraphic visualization; BSC and serum parameters used in the right completion are the most successful and efficient modalities for follow-up of AHPO. Maintenance of antibiotic therapy should be done until BSC findings have reverted to normal.

scholarly journals Seizure increases electroencephalographic abnormalities in children with tuberculous meningitis

2016 ◽  
Vol 34 (3) ◽  
pp. 161 ◽  
Author(s):  
Prastiya Indra Gunawan ◽  
Darto Saharso
Keyword(s):  
Tuberculous Meningitis ◽  
Clinical Manifestations ◽  
Clinical Findings ◽  
Altered Consciousness ◽  
Cross Sectional ◽  
Exact Test ◽  
Eeg Abnormalities ◽  
Cross Sectional Design ◽  
Abnormal Eegs ◽  
Eeg Pattern

Background<br />Tuberculous meningitis (TBM) is a severe intracranial infection with fatal outcomes, permanent disabilities, and electroencephalographic (EEG) abnormalities. Seizures may occur in TBM. The EEG findings in TBM vary according to the site of the inflammatory process. There are few studies describing the EEG patterns and clinical manifestations of TBM. The objective of this study was to investigate the correlation between clinical findings and EEG patterns in children with TBM. <br /><br />Methods<br />A study of cross-sectional design using medical records was conducted on 12 children with TBM, with their EEG patterns classified as abnormal and normal. Clinical manifestations such as seizures, altered consciousness, headache or fever were collected. A positive cerebrospinal fluids Mycobacterium tuberculosis culture was considered to indicate definitive TBM. Abnormal EEG descriptions were classified into abnormal I, II or III. Correlation between EEG pattern and clinical manifestation were analyzed with Fisher’s exact test. <br /><br />Results<br />The study found cases of 12 children with TBM, the majority presenting with seizures, decreased consciousness and fever. Abnormal EEGs were found in 75% of children and 77% of them showed epileptogenic activities. The EEG results mostly described epileptogenic potentials in the frontotemporal region. There was a significant correlation between EEG abnormality and seizures in children with TBM (p&lt;0.05).<br /><br />Conclusions<br />The EEG pattern in children with TBM varies, and EEG abnormalities were more frequently localized in the frontotemporal region. Seizures were associated with EEG abnormalities in children with TBM. EEG abnormalities occurring simultaneously with seizures may predict the occurrence of seizures.

scholarly journals Immune-Related Urine Biomarkers for the Diagnosis of Lupus Nephritis

2021 ◽  
Vol 22 (13) ◽  
pp. 7143
Author(s):  
María Morell ◽  
Francisco Pérez-Cózar ◽  
Concepción Marañón
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Diagnostic Value ◽  
Attractive Alternative ◽  
Non Invasive ◽  
Disease Systemic Lupus Erythematosus ◽  
Renal Biopsies ◽  
Inflammatory State ◽  
Severity Of The Disease

The kidney is one of the main organs affected by the autoimmune disease systemic lupus erythematosus. Lupus nephritis (LN) concerns 30–60% of adult SLE patients and it is significantly associated with an increase in the morbidity and mortality. The definitive diagnosis of LN can only be achieved by histological analysis of renal biopsies, but the invasiveness of this technique is an obstacle for early diagnosis of renal involvement and a proper follow-up of LN patients under treatment. The use of urine for the discovery of non-invasive biomarkers for renal disease in SLE patients is an attractive alternative to repeated renal biopsies, as several studies have described surrogate urinary cells or analytes reflecting the inflammatory state of the kidney, and/or the severity of the disease. Herein, we review the main findings in the field of urine immune-related biomarkers for LN patients, and discuss their prognostic and diagnostic value. This manuscript is focused on the complement system, antibodies and autoantibodies, chemokines, cytokines, and leukocytes, as they are the main effectors of LN pathogenesis.

scholarly journals Clinical and laboratory findings versus results of renal biopsy: Evaluation the diagnostic value in patients with lupus nephritis

2020 ◽  
Vol 5 (3) ◽  
pp. 111-114
Author(s):  
Shila Aghayani ◽  
Mohammad Reza Abbasi ◽  
Seyed Reza Najafizadeh ◽  
Shafieh Movaseghi ◽  
Abdolrahman Rostamian
Keyword(s):  
Lupus Nephritis ◽  
Renal Biopsy ◽  
Diagnostic Value ◽  
Laboratory Findings

scholarly journals Cryptosporidium Sp. Findings and Its Symptomatology among Immunocompromised Patients

2019 ◽  
Vol 7 (10) ◽  
pp. 1567-1571
Author(s):  
Dewi Masyithah Darlan ◽  
Muhammad Fakhrur Rozi ◽  
Yunilda Andriyani ◽  
Hemma Yulfi ◽  
Restuti Hidayani Saragih ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Numerical Data ◽  
Nausea And Vomiting ◽  
Categorical Variables ◽  
High Risk Population ◽  
Fisher Exact Test ◽  
Tertiary Referral Hospital ◽  
Laboratory Findings ◽  
Cd4 Cell Count ◽  
Exact Test

BACKGROUND: Cryptosporidium sp. is an apicomplexan protozoa, and it is related to an immunocompromised state. As it develops diverse clinical manifestations, mild to life-threatening conditions, administration of anti-parasitic medication and its management remain problematic. AIM: The study aimed to provide Cryptosporidiosis symptomatology and its prevalence among HIV-infected patients in a tertiary referral hospital, Haji Adam Malik General Hospital, Medan, Indonesia. MATERIAL AND METHODS: Symptomatology was noted using short-questionnaire, and laboratory findings were obtained from the hospital medical record registry on the same day of admission. We enrolled 24 patients were suffered from HIV infection for a certain period and more than one-week diarrhoea including 18 males and 6 females. Routine faeces examination using wet mount, Kinyoun-gabet, and trichrome staining was performed for all samples in Parasitology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia. Numerical data were evaluated using the Mann-Whitney test while Fisher Exact test was used to determine any association between categorical variables. RESULTS: Our study found that 8 of 24 patients were positive with Cryptosporidium sp. while its symptomatology including abdominal cramp (66.7%), nausea and vomiting (70.8%), and fever (62.5%) is prevalent from our study. We obtained significant association between CD4 cell count (p = 0.006), diarrhea duration (p = 0.007), abdominal pain (p = 0.005), and nausea and vomiting (p = 0.021) with cryptosporidiosis. CONCLUSION: High consideration of several symptoms related to cryptosporidiosis leads a clinician to initiate prompt management particularly in a high-risk population.

scholarly journals Early Detection Of Deep Vein Thrombosis In Patients With Coronavirus Disease 2019: Who to Screen and Who not to with Doppler Ultrasound?

2020 ◽  
Author(s):  
Anna Maria Ierardi ◽  
Andrea Coppola ◽  
Stefano Fusco ◽  
Elvira Stellato ◽  
Stefano Aliberti ◽  
...  
Keyword(s):  
Doppler Ultrasound ◽  
High Rate ◽  
World Health ◽  
Continuous Variables ◽  
Roc Curve Analysis ◽  
Chi Square ◽  
Laboratory Findings ◽  
Exact Test ◽  
Heparin Administration ◽  
Severity Of The Disease

Abstract BACKGROUND. Aim of the study is to evaluate the incidence of DVT in COVID-19 patients and its correlation with the severity of the disease and with clinical and laboratory findings.METHODS. 234 symptomatic patients with COVID-19, diagnosed according to the World Health Organization guidelines, were included in the study. The severity of the disease was classified as moderate, severe and critical. Doppler ultrasound (DUS) was performed in all patients. DUS findings, clinical, laboratory’s and therapeutic variables were investigated by contingency tables, Pearson chi square test and by Student T test and Fisher's exact test. ROC curve analysis was applied to study significant continuous variables.RESULTS. Overall incidence of DVT was 10.7% (25/234): 1.6% (1/60) among moderate cases, 13.8% (24/174) in severely and critically ill patients. Prolonged bedrest and intensive care unit admission were significantly associated with the presence of DVT (19.7%). Fraction of inspired oxygen, P/F ratio, respiratory rate, heparin administration, D-dimer, IL-6, ferritin and CRP showed correlation with DVT. CONCLUSIONS. DUS may be considered a useful and valid tool for early identification of DVT. In less severely affected patients, DUS as screening of DVT might be unnecessary. High rate of DVT found in severe patients and its correlation with respiratory parameters and some significant laboratory findings suggests that these can be used as a screening tool for patients who should be getting DUS.

scholarly journals A comparative study of biochemical parameters in mild and severe cases of COVID-19

2021 ◽  
Vol 9 (11) ◽  
pp. 3402
Author(s):  
Gouri A. Gulavani ◽  
Smita V. Wali ◽  
Sanjyoti A. Panchbudhe
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Biochemical Parameters ◽  
Clinical Manifestations ◽  
Severe Form ◽  
Nasopharyngeal Swab ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
The Difference ◽  
Severity Of The Disease

Background: COVID-19 has a range of clinical manifestations, including cough, fever, breathlessness, diarrhoea.    Diagnosis of COVID-19 is commonly made through detection of SARS-CoV-2 RNA by PCR testing of a nasopharyngeal swab or other specimens. Evaluation and management of COVID-19 depend on the severity of the disease. This study was done to analyses the difference in the laboratory findings of the mild and severe cases in patients with COVID-19.Methods: In this study biochemical parameters of the patients with mild and those admitted in intensive care unit (ICU) of SKNMCGH, Pune were studied. Total 60 patients were included in this study. Standard deviation and mean were calculated from the values of biochemical parameters of COVID-19 patients in intensive care unit (ICU) and ward patients.Conclusions: We found levels of lactate dehydrogenase (LDH), C-reactive protein (CRP), Aspartate aminotransferase (AST), alanine aminotransferase (ALT), ferritin were significantly elevated in severely ill ICU admitted patients than mild patients. This may be useful for predicting progression towards a more severe form of COVID-19. 

scholarly journals Clinical Manifestations, Epidemiology, and Laboratory Diagnosis of Human Monocytotropic Ehrlichiosis in a Commercial Laboratory Setting

2003 ◽  
Vol 10 (5) ◽  
pp. 891-896 ◽  
Author(s):  
Juan P. Olano ◽  
Wayne Hogrefe ◽  
Brent Seaton ◽  
David H. Walker
Keyword(s):  
Clinical Manifestations ◽  
Severity Of Illness ◽  
Laboratory Diagnosis ◽  
Clinical Findings ◽  
Reference Laboratory ◽  
Laboratory Setting ◽  
Retrospective Case ◽  
Laboratory Findings ◽  
Commercial Laboratory ◽  
Doxycycline Treatment

ABSTRACT Clinical, epidemiological, and laboratory diagnostic issues of human monocytotropic ehrlichiosis (HME) were investigated in a retrospective case study conducted at a national reference laboratory (Focus Technologies, formerly MRL Reference Laboratory), and at the University of Texas Medical Branch at Galveston, Texas, during 1997 and 1998. Standard questionnaires were sent to physicians for each laboratory-diagnosed patient 2 days to 2 weeks after immunofluorescent antibody assay results were available. Among the 41 cases for which data were obtained, 32 (78%) were definite cases of HME, and 9 (22%) were probable cases of HME. Tick bite or exposure to ticks was recorded in more than 97% of cases. The most prominent clinical findings were fever, abdominal tenderness, and regional lymphadenopathy. There was an association between age and severity of illness. The main laboratory findings included leukopenia, thrombocytopenia, and elevated aspartate aminotransferase and alanine aminotransferase. Clinical and laboratory findings were nonspecific and were not good predictors of the severity of illness. The 90% of patients who received doxycycline treatment underwent rapid clinical improvement with a favorable outcome. The usual duration of effective treatment with doxycycline was 7 to 10 days. This retrospective study is unique because it was based in a commercial reference laboratory setting that receives specimens from different geographic locations. The clinical and laboratory information from 41 patients provides insight into the epidemiological, clinical, and laboratory characteristics of HME.

scholarly journals Serum estradiol levels in infertile men with non-obstructive azoospermia

2020 ◽  
Vol 14 ◽  
pp. 263349412092834
Author(s):  
Nader Salama ◽  
Saeed Blgozah
Keyword(s):  
Wide Spectrum ◽  
Semen Analysis ◽  
Study Groups ◽  
Clinical Findings ◽  
Obstructive Azoospermia ◽  
Serum Estradiol ◽  
Laboratory Findings ◽  
Infertile Men ◽  
Number Of Patients ◽  
Estradiol Levels

Purpose: To report the different patterns of estradiol levels in infertile men with non-obstructive azoospermia and correlate these levels with their clinical and laboratory findings. Materials and methods: A retrospective study was launched, and a retrieval of data for infertile men with non-obstructive azoospermia ( n = 166) and fertile controls ( n = 40) was performed. The retrieved data included demographics, clinical findings, scrotal duplex, semen analysis, and hormonal assay (testosterone, follicle-stimulating hormone, luteinizing hormone, prolactin, and estradiol). Results: Our findings showed a wide spectrum of estradiol concentrations. The patients were arranged into three groups (high, normal, and low estradiol groups). The normal estradiol group was the most prevalent (71.1%). Testosterone, gonadotrophins, testicular volumes, and the number of patients with jobs in polluted workplaces showed significant differences among the study groups ( p = 0.001, <0.001, <0.001, and 0.004, respectively). Age, body mass index, varicocele prevalence, prolactin, and smoking habits did not show any significant differences among the groups. Obesity was lacking in the low estradiol group, but it had significantly higher prevalence in the normal ( p = 0.013) or high group ( p = 0.023) compared with the controls. Conclusion: Serum estradiol, in infertile men with non-obstructive azoospermia, may be present at different levels. It is recommended that estradiol be measured in infertile men with non-obstructive azoospermia when there is an alteration in testosterone concentration, obesity, a polluted workplace occupation, or before trying hormonal therapy. Extended studies are highly recommended to provide a clear clue whether alterations in estradiol concentrations in men with non-obstructive azoospermia are the cause or a consequence of the condition.

scholarly journals Microthrombotic renal involvement in an SLE patient with concomitant catastrophic antiphospholipid syndrome: the beneficial effect of rituximab treatment

Lupus ◽  
2018 ◽  
Vol 27 (9) ◽  
pp. 1552-1558 ◽  
Author(s):  
Á Diószegi ◽  
T Tarr ◽  
M Nagy-Vincze ◽  
M Nánásy-Vass ◽  
R Veisz ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Renal Function ◽  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Clinical Manifestations ◽  
Clinical Findings ◽  
Severe Thrombocytopenia ◽  
Catastrophic Antiphospholipid Syndrome ◽  
Laboratory Findings

Antiphospholipid syndrome is characterized by multiple arterial and/or venous thrombotic events, recurrent fetal losses in the presence of antiphospholipid antibodies (aPL). Catastrophic antiphospholipid syndrome is a life-threatening, rare subset of antiphospholipid syndrome when the thrombotic events affect at least three organs, and clinical manifestations develop simultaneously or within a week. Diagnostically, small vessel occlusions can be detected by histopathology in the presence of aPL. Our case report describes an 18-year-old man who has been treated for antiphospholipid syndrome associated with systemic lupus erythematosus (SLE) since 2011. The clinical findings were dominated by recurrent deep vein thrombosis, and severe proteinuria caused by lupus nephritis, accompanied by mild serological and laboratory findings. The patient was hospitalized in March 2014 because of severe thrombocytopenia and infective diarrhoea. At this time the renal functions deteriorated rapidly. Simultaneously, left upper extremity paresis was observed; computed tomography showed ischaemic lesions in the territory of the middle cerebral artery. Abdominal discomfort and pain occurred. On computed tomography scan ischaemic lesions were seen in the spleen, the right kidney and the coeliac trunk. Laboratory and serological findings verified the presence of aPL and anti-DNA antibodies, anaemia and thrombocytopenia. Based on the above-mentioned clinical and laboratory findings, the diagnosis of catastrophic antiphospholipid syndrome was established. Anticoagulation, corticosteroids and plasma exchange treatment, as well as haemodiafiltration were initiated. Although the thrombotic cascade decelerated following these interventions, we could not see an improvement in the renal function. Rituximab treatment was started, leading to a significant improvement in renal function. After 5 weeks of treatment the patient was discharged from hospital.

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