scholarly journals Functional property of Maillard conjugate-based nano emulsion delivery system using whey protein: a mini review

Food and Life ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. 79-85
Author(s):  
Sehee Lee ◽  
Won-Jae Lee
Keyword(s):  
Whey Protein ◽  
Delivery System ◽  
Functional Property ◽  
Protein A ◽  
Nano Emulsion

Cell-Specific, Multidrug Delivery System Using Streptavidin–Protein A Fusion Protein

1996 ◽  
Vol 58 (2) ◽  
pp. 227-233 ◽  
Author(s):  
Kouichi Ohno ◽  
Brandi Levin ◽  
Daniel Meruelo
Keyword(s):  
Fusion Protein ◽  
Delivery System ◽  
Protein A

Cow's Milk Proteins Cause Infantile Colic in Breast-Fed Infants: A Double-Blind Crossover Study

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 268-271 ◽  
Author(s):  
Iréne Jakobsson ◽  
Tor Lindberg
Keyword(s):  
Whey Protein ◽  
Sequential Analysis ◽  
Protein A ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Infantile Colic ◽  
Double Blind ◽  
Milk Whey ◽  
Cow's Milk ◽  
Breast Fed

Sixty-six mothers of 66 breast-fed infants with infantile colic were put on a diet free from cow's milk. The colic disappeared in 35 infants; it reappeared on at least two challenges (cow's milk to mother) in 23 infants (35%). A double-blind crossover trial with cow's milk whey protein was performed in 16 of these 23 mothers and infants. Six infants had to be taken out of the study for various reasons; of the remaining ten infants, nine reacted with colic after their mothers' intake of whey protein-containing capsules. Sequential analysis showed a high correlation between infantile colic in breast-fed infants and their mothers' consumption of cow's milk protein. A diet free of cow's milk is suggested for the mothers as a first trial of treatment of infantile colic in breast-fed infants.

Chitosan – Whey protein as efficient delivery system for squalene: Characterization and functional food application

2019 ◽  
Vol 135 ◽  
pp. 855-863 ◽  
Author(s):  
R.G. Kumar Lekshmi ◽  
M. Rahima ◽  
N.S. Chatterjee ◽  
C.S. Tejpal ◽  
K.K. Anas ◽  
...  
Keyword(s):  
Whey Protein ◽  
Delivery System ◽  
Functional Food ◽  
Efficient Delivery

Whey protein: A functional and promising material for drug delivery systems recent developments and future prospects

2019 ◽  
Vol 30 (9) ◽  
pp. 2183-2191 ◽  
Author(s):  
Muhammad Asim Farooq ◽  
Md Aquib ◽  
Sana Ghayas ◽  
Rabia Bushra ◽  
Daulat Haleem Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Whey Protein ◽  
Drug Delivery Systems ◽  
Protein A ◽  
Delivery Systems ◽  
Promising Material ◽  
Future Prospects ◽  
Recent Developments

scholarly journals A novel whey protein synthesized only in late lactation by the mammary gland from the tammar (Macropus eugenii)

1987 ◽  
Vol 241 (3) ◽  
pp. 899-904 ◽  
Author(s):  
K R Nicholas ◽  
M Messer ◽  
C Elliott ◽  
F Maher ◽  
D C Shaw
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Whey Protein ◽  
Sequence Data ◽  
Protein A ◽  
Gel Filtration ◽  
Tammar Wallaby ◽  
Exchange Chromatography ◽  
Macropus Eugenii ◽  
Apparent Homogeneity

A major whey protein which appears in milk from the tammar wallaby (Macropus eugenii) only during the second half of lactation (late lactation protein-A, LLP-A) was purified to apparent homogeneity by ion-exchange chromatography and gel filtration. An Mr of 21,600 +/- 2000 was calculated from its amino acid composition. A computer-based comparison of the sequence of the first 69 amino acid residues with the Atlas of Protein Sequence data base showed no significant homology with known proteins. Antiserum to LLP-A was prepared in rabbits, and single radial immunodiffusion was used to measure the amounts of LLP-A in milk during the first 40 weeks of lactation. LLP-A was first detected at 26 weeks; thereafter its concentration increased abruptly, to reach a maximum of 26 g/l at approx. 36 weeks of lactation. Explants prepared from mammary gland biopsies at 20 and 35 weeks of lactation were exposed to [3H]amino acids for 8 h; immunoprecipitation of tissue extracts showed that, whereas the rate of casein synthesis was the same at both stages of lactation, LLP-A was synthesized only by the 35-week mammary gland.

Development of a Targeted Drug Delivery System: Monoclonal Antibodies Adsorption onto Bonelike Hydroxyapatite Nanocrystal Surface

2011 ◽  
Vol 409 ◽  
pp. 175-180 ◽  
Author(s):  
Elena Maria Varoni ◽  
Michele Iafisco ◽  
Lia Rimondini ◽  
Maria Prat
Keyword(s):  
Drug Delivery ◽  
Monoclonal Antibodies ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Protein A ◽  
Cancer Drug ◽  
Isothermal Adsorption ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Together with cancer biomarker advance, nanotechnology could lead to a “personalized oncology”, where early tumour detection and diagnosis are more and more specific. A nanosized drug delivery system is mainly composed of three fundamental elements: i) a drug nanocarrier (1-100 nm), ii) an anti-cancer drug; iii) an active targeting molecule, recognizing a tumour associated marker expressed at the cell surface. In our study we used: i) hydroxyapatite nanocrystals (HA-NC), for its properties of large specific surface area, hydrophilicity and biodegradability with very low toxicity and ii) monoclonal antibodies (mAb), directed against CAR-3, a mucin tumour associated surface antigen, and against the Met/HGF-R, both of which are overexpressed on human carcinomas. In our study, nanosized HA-NC, poorly aggregating and biomimetic, were synthetised and characterized. After a preliminary isothermal adsorption of human polyclonal IgG, we functionalized HA-NC, coated or not with protein A (Prot A), with the two mAbs. IgG and Prot A isothermal adsorption curves were obtained; mAb absorption was achieved and prelimary Prot A coating appeared not to improve HA-NC loading capacity. IgG conformation onto HA-NC was investigated by means of Fourier Transformed InfraRed Spectroscopy, revealing a preferential binding with the constant antibody domain, and exposition of the variable domain, involved in antigen binding, on the biomaterial surface. These immunocomplexes are confirmed to be potentially used as targeted drug delivery system.

scholarly journals Nanoemulsion Drug Delivery System: A Review

2020 ◽  
Vol 11 (SPL4) ◽  
Author(s):  
Ashish B. Budhrani ◽  
Shubhra R. Rai ◽  
Aarati S. Panchbhai ◽  
Rajshri B. Dongarwar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Water System ◽  
Physicochemical Characteristics ◽  
High Energy ◽  
Low Energy ◽  
Emulsified Water ◽  
Nano Emulsion

Nano-emulsion dosage forms have nano-sized droplets of disperse phase and are kinetically stable dosage form. Nano-emulsions are included under the category of new drug delivery system containing emulsified water in oil/oil in water system having mean globule size ranges from 10 nm to 1000 nm.  In the field of pharmacy, nano-emulsions play an essential role in the delivery of medication through various drug administration routes like parenteral, topical and oral route. Nano-emulsions are nano-sized emulsions which are used under high investigation as a drug carrier for enhancing the delivery of therapeutic agents. Nano-emulsions have enhanced functional properties as compared to standard emulsions. They are nowadays growing work for utilizing nano-sized particles in the research of pharmaceuticals, cosmetics and food products.  Mainly, intrigue has been creating simultaneously with higher emulsification techniques and mechanisms of stabilization. Nano-emulsions are formulated by both methods like high energy emulsification or low energy emulsification methods. Rapid energy emulsification technique includes high shear mixing, high-pressure homogenization or ultrasonication. In contrast, low energy emulsification technique includes the merit of the physicochemical characteristics of the system, which exploits phase transitions to obtained nano-emulsion. This review article is an effort to summarize comparative aspects like introduction, types, advantages, disadvantages, components, factors affecting, methods of preparations, methods of analysis of nano-emulsion and applications of nano-emulsion.

scholarly journals A Literature Review on Self Nanoemulsifying Drug Delivery System (SNEDDS)

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Saikumar D ◽  
Leela Prasanna J
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Solubility ◽  
Solvent Molecule ◽  
Water Soluble ◽  
Statistical Experimental Design ◽  
Characterization Methods ◽  
Nano Emulsion ◽  
Pharmacologically Active

The Lipid-based drug delivery system is extensively reported within the literature for the enhancing drug solubility, permeability, and bioavailability. A considerable majority of novel pharmacologically active constituents produced in recent drug discovery programs are lipophilic and poorly soluble, posing a significant problem for pharmaceutical researchers enhancing the oral bioavailability of such drug molecules. Self-nano emulsifying drug delivery systems (SNEDDS), are the viable oil-based approaches for drugs that exhibit low dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, researchers have been focusing on the challenges of BCS Class II and Class IV Drugs for enhancing water Solubility of poorly water-soluble drugs. SNEDDS is a Validate method for enhancing the solubility and bioavailability of lipophilic compounds. It’s the isotropic mixture of oil, surfactant, co-surfactant molecules and it also containing co-solvent molecule. which spontaneously form oil-in-water nano emulsion of approximately 200 nm or less in size upon dilution with water under gentle stirring. It’s Drug delivery system Which possess thermodynamically and kinetically stability. The physicochemical properties, drug solubilization capacity considerably regulates the selection of the SNEDDS components. The compositions of the SNEDDS are often optimized with the assistance of phase diagrams. Further to optimize SNEDDS can be done with the help of statistical experimental design. It’s a Novel drug delivery system which is applicable for the parenteral, Ophthalmic, intranasal and cosmetic drug delivery system. And therefore, the present review describes Preparation, components, mechanism of self-Nano emulsification, biopharmaceutical aspects, characterization methods and applications of Selfnanoemulsifying drug delivery system (SNEDDS).

Whey protein stabilized nanoemulsion: A potential delivery system for ginsenoside Rg3 whey protein stabilized nanoemulsion: Potential Rg3 delivery system

2019 ◽  
Vol 31 ◽  
pp. 100427 ◽  
Author(s):  
Pingping Hou ◽  
Fengling Pu ◽  
Haoyang Zou ◽  
Mengxue Diao ◽  
Changhui Zhao ◽  
...  
Keyword(s):  
Whey Protein ◽  
Delivery System ◽  
Ginsenoside Rg3
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