Metastatic Patterns of Cancers: Results From a Large Autopsy Study

2008 ◽  
Vol 132 (6) ◽  
pp. 931-939 ◽  
Author(s):  
Guy diSibio ◽  
Samuel W. French
Keyword(s):  
Quantitative Description ◽  
Primary Cancer ◽  
Autopsy Study ◽  
Regional Lymph Nodes ◽  
Design Review ◽  
Medical Centers ◽  
Metastatic Patterns ◽  
Quantitative Analyses ◽  
Metastatic Sites ◽  
Do So

Abstract Context.—Many studies have addressed metastatic patterns seen among various cancers. No recent studies, however, provide quantitative analyses of such patterns arising from a broad range of cancers based primarily on postmortem tissue analyses. Objective.—To provide a quantitative description of metastatic patterns among different primary cancers based on data obtained from a large, focused autopsy study. Design.—Review of data from 3827 autopsies, performed between 1914 and 1943 on patients from 5 affiliated medical centers, comprising 41 different primary cancers and 30 different metastatic sites. Results.—Testicular cancers were most likely to metastasize (5.8 metastases per primary cancer), whereas duodenal cancers were least likely to do so (0.6 metastases per primary cancer). Preferred metastatic sites varied among the primary cancers analyzed. Overall, regional lymph nodes were the most common metastatic target (20.6% of total), whereas testes were the least common (0.1% of total). Conclusions.—Not surprisingly, different primary cancers tended to metastasize, with differing frequencies, to different sites. These varying metastatic patterns might be helpful in deducing the origins of cancers whose primary sites are unclear at presentation.

Testing for long memory in the presence of a general trend

2001 ◽  
Vol 38 (04) ◽  
pp. 1033-1054 ◽  
Author(s):  
Liudas Giraitis ◽  
Piotr Kokoszka ◽  
Remigijus Leipus
Keyword(s):  
Long Memory ◽  
Change Point ◽  
General Trend ◽  
Quantitative Description ◽  
Stationary Sequence ◽  
Change Points ◽  
Asymptotic Size ◽  
Short Memory ◽  
The Impact ◽  
Do So

The paper studies the impact of a broadly understood trend, which includes a change point in mean and monotonic trends studied by Bhattacharyaet al.(1983), on the asymptotic behaviour of a class of tests designed to detect long memory in a stationary sequence. Our results pertain to a family of tests which are similar to Lo's (1991) modifiedR/Stest. We show that both long memory and nonstationarity (presence of trend or change points) can lead to rejection of the null hypothesis of short memory, so that further testing is needed to discriminate between long memory and some forms of nonstationarity. We provide quantitative description of trends which do or do not fool theR/S-type long memory tests. We show, in particular, that a shift in mean of a magnitude larger thanN-½, whereNis the sample size, affects the asymptotic size of the tests, whereas smaller shifts do not do so.

scholarly journals The Social Functions of Questions in Embodied Collaborative Work

2021 ◽  
Author(s):  
Lucas M Bietti ◽  
Federico U. Bietti
Keyword(s):  
Group Performance ◽  
Collaborative Work ◽  
Performance Outcomes ◽  
Similar Distribution ◽  
Social Functions ◽  
Group Productivity ◽  
Qualitative And Quantitative ◽  
The Social ◽  
Quantitative Analyses ◽  
Do So

Researchers have been interested in the investigation of the social functions of questions in conversational contexts. However, limited research has been conducted on the social functions of questions in embodied collaborative work, i.e. work that involves the manipulation of physical objects. The aim of this study was to identify the social functions of questions in embodied collaborative work and to determine whether such functions correlate with performance outcomes. To do so, we conducted qualitative and quantitative analyses of a dataset of 1751 question-answer sequences collected from an experimental study where pairs of participants (N=134) completed a collaborative food preparation task. Qualitative analysis enabled us to identify three functions of questions: Anticipation questions, exploration questions and confirmation questions. Quantitative analyses revealed that there was no correlation between the types of questions and group performance. However, they showed that groups that contributed the most to performance presented a similar distribution of question types. The identification of such patterns is a first step towards the design and implementation of interaction-focused interventions aimed at increasing group productivity in embodied collaborative work.

scholarly journals THE EFFECT OF TEMPERATURE AND OF LYSIN CONCENTRATION ON THE ACCELERATION OF HEMOLYSIS

1941 ◽  
Vol 25 (2) ◽  
pp. 247-261
Author(s):  
Eric Ponder
Keyword(s):  
Cell Surface ◽  
Quantitative Description ◽  
Negative Temperature ◽  
Effect Of Temperature ◽  
Membrane Component ◽  
Temperature Coefficients ◽  
Rate Of Escape ◽  
Point To Point ◽  
Special Case ◽  
Do So

The acceleration of saponin hemolysis by benzene, indol, and nonyl alcohol has been investigated as a function of temperature, and it has been found that these accelerators have negative temperature coefficients. This points to their being concentrated at the cell surface, and to the surface being the seat of their accelerating action. It is shown that the accelerating power of indol (used as a typical accelerator) is constant so long as the lysin in the system is capable of producing lysis per se, but that the acceleration falls off when only sublytic concentrations are present. The relations are expressed in a series of equations, and explained in terms of the reactions among the accelerator, the lysin, and the membrane component, which breaks down in spots, rather than uniformly, when lysis occurs. The argument involves a consideration of the idea that a monolayer of lysin at the cell surface is necessary for hemolysis, of Abramson's hypothesis of "key spots" on the surface, of the rate of escape of hemoglobin from the hemolyzing cell, and of the results of electrophoretic and impedance measurements. The existing theory of the kinetics is extended by introducing the idea of a variation in resistance from point to point in the cell membrane; in this form it describes the situation so far as is at present known, and shows that the results of the various methods of investigation are consistent with each other. The only idea discussed which seems to have little foundation is that lysis is determined by the formation of a monolayer of lysin at the cell surface; when this occurs, it must do so only as a special case. Finally, a semi-quantitative description of the frequency distribution of the resistances in the membrane is derived from existing data. The variation in resistance which it is necessary to assume is quite small, as might be expected in the case of a membrane with a regular ultra-structure.

Hidradenocarcinomas: A Brief Review and Future Directions

2010 ◽  
Vol 134 (5) ◽  
pp. 781-785 ◽  
Author(s):  
Steven Gauerke ◽  
James J. Driscoll
Keyword(s):  
Clear Cell ◽  
De Novo ◽  
Regional Lymph Nodes ◽  
Future Directions ◽  
Future Studies ◽  
Molecular Events ◽  
Variable Morphology ◽  
Metastatic Sites ◽  
Multiple Recurrences ◽  
Adnexal Tumors

Abstract Hidradenocarcinomas are rare, aggressive skin adnexal tumors of sweat gland origin that demonstrate a high potential for local recurrence, metastasis, and poor outcome. These neoplasms can derive from preexisting clear cell hidradenomas but more commonly appear de novo, with the molecular events responsible for the pathogenesis currently unknown. Historically, diagnosis has been difficult because of the few cases, inconsistent nomenclature, variable morphology of cells that compose the neoplasm, and confusion with other visceral metastatic tumors. Presentation is generally benign with an indolent clinical course that typically includes local and multiple recurrences. Despite wide-excision surgery, disease at regional lymph nodes and metastatic sites is common and linked to decreased survival. Currently, molecular markers of pathogenesis as well as effective forms of adjuvant chemotherapy are lacking. Future studies are required to identify the histopathologic and immunohistochemical features, which may facilitate diagnosis and foster development of molecularly targeted forms of adjuvant therapy.

A cohort compassionate-use program with cabazitaxel plus prednisone for patients with metastatic castration-resistant prostate cancer: Interim results.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15112-e15112
Author(s):  
Sevil E. Bavbek ◽  
Zafar I Malik ◽  
Giuseppe Di Lorenzo ◽  
Hans-Jorg Scholz ◽  
Inge M van Oort ◽  
...  
Keyword(s):  
Disease Progression ◽  
Safety Data ◽  
Dose Intensity ◽  
Castration Resistant Prostate Cancer ◽  
Compassionate Use ◽  
Regional Lymph Nodes ◽  
Prior Therapy ◽  
Neutropenic Sepsis ◽  
Metastatic Sites ◽  
Ecog Ps

e15112 Background: In the TROPIC trial (NCT00417079), treatment with CbzP produced a statistically significant improvement in overall survival vs mitoxantrone + prednisone (MP) in patients (pts) with mCRPC previously treated with a docetaxel (D)-containing regimen (HR 0.70; p< 0.0001). These results supported the establishment of 2 programs (based on local regulations): a compassionate use (CUP) and an early access program (EAP; NCT01254279). Methods: The aims of the CUP/EAP are to provide drug to pts with mCRPC who may benefit from CbzP prior to commercial availability and further assess CbzP safety profile. Total enrollment for both programs is estimated at 1600 pts from 250 centers globally. Eligible pts receive CbzP (25 mg/m2 Q3W + prednisone 10 mg PO QD) until disease progression, death, unacceptable toxicity or physician/pt decision. Results: Baseline characteristics and safety data are available for the first 399 pts: median age was 68 yrs (range 43–89), with 90.2% ECOG PS 0–1. The median cumulative dose of prior D was 675 mg/m2; prior therapy with MP was permitted. For pts whose disease progressed following D, median time from last dose of D to progression was 4 months; 53.3% of pts experienced disease progression either during or < 3 months after D. 61% of pts had ≥ 2 metastatic sites; the most common were bone (93.2%) and regional lymph nodes (34.4%). At the time of analysis, a median of 4 cycles of CbzP had been administered; 4 pts received ≥ 10 cycles. Median relative dose intensity was 99.2% (range 80.1–104.9). G-CSF was administered to 34.3% of pts in Cycle 1 (6.3% therapeutic, 26.6% prophylactic). Overall, 71.4% of pts had adverse events (AEs; all grades). Most common grade 3-4 AEs were neutropenia 11.3%, febrile neutropenia 6.3%, anemia 2.8%, fatigue 2%, neutropenic sepsis 1.8%, vomiting 1.3% and diarrhea 1%. Eight (2%) treatment-related deaths were reported. Conclusions: The CUP/EAP provides additional safety data for CbzP in a routine clinical practice pt population with heavily pre-treated mCRPC. Treatment with CbzP was tolerable, with a predictable and manageable toxicity profile consistent with data reported for TROPIC and the product labeling.

Testing for long memory in the presence of a general trend

2001 ◽  
Vol 38 (4) ◽  
pp. 1033-1054 ◽  
Author(s):  
Liudas Giraitis ◽  
Piotr Kokoszka ◽  
Remigijus Leipus
Keyword(s):  
Long Memory ◽  
Change Point ◽  
General Trend ◽  
Quantitative Description ◽  
Stationary Sequence ◽  
Change Points ◽  
Asymptotic Size ◽  
Short Memory ◽  
The Impact ◽  
Do So

The paper studies the impact of a broadly understood trend, which includes a change point in mean and monotonic trends studied by Bhattacharyaet al.(1983), on the asymptotic behaviour of a class of tests designed to detect long memory in a stationary sequence. Our results pertain to a family of tests which are similar to Lo's (1991) modifiedR/Stest. We show that both long memory and nonstationarity (presence of trend or change points) can lead to rejection of the null hypothesis of short memory, so that further testing is needed to discriminate between long memory and some forms of nonstationarity. We provide quantitative description of trends which do or do not fool theR/S-type long memory tests. We show, in particular, that a shift in mean of a magnitude larger thanN-½, whereNis the sample size, affects the asymptotic size of the tests, whereas smaller shifts do not do so.

Canine Gastric Adenocarcinoma

1978 ◽  
Vol 15 (5) ◽  
pp. 600-607 ◽  
Author(s):  
A. K. Patnaik ◽  
A. I. Hurvitz ◽  
G. F. Johnson
Keyword(s):  
Distant Metastases ◽  
Gastric Epithelium ◽  
Intestinal Type ◽  
Diffuse Type ◽  
Regional Lymph Nodes ◽  
Female Ratio ◽  
Desmoplastic Reaction ◽  
Glandular Structures ◽  
Metastatic Sites ◽  
Male To Female

In a retrospective study of 26 gastric adenocarcinomas of the dog, 17 were found to have histologic features of the diffuse type and nine of the intestinal type similar to those of the same tumor in man. The intestinal type was characterized by distinct glandular structures lined with well polarized cells at the primary and metastatic sites and mild desmoplastic reaction. Three subtypes with distinct histologic features (papillary, five; acinar, three; solid, one) were recognized in this group. Fourteen of the diffuse adenocarcinomas were characterized by random infiltration by neoplastic cells, singly or in clusters, often with signet ring cells and severe desmoplastic reaction. The remaining three diffuse adenocarcinomas also had recognizable acinar structures and were considered to be glandular subtypes of the diffuse type. In eight dogs there was a 7:1 male to female ratio for dogs with the intestinal type and in 16 dogs a 2:1 male to female ratio for dogs with the diffuse type. Two of the nine intestinal type of adenocarcinomas, but none of the diffuse tumors, had intraluminal growths. Metaplasia of gastric epithelium was seen in nearly half the tumors; this was more common in the intestinal type (six of nine). Different degrees of carcinomatosis were seen in 24 of 26 dogs. Regional lymph nodes were involved in the 20 dogs whose nodes were available for examination. Distant metastases were seen in 19 of 26 dogs; liver, lungs and adrenal glands were the most common sites. Various degrees of lymphoid cell infiltration, suggesting the antigenic quality of the neoplasms, were seen in 15 dogs. Additional neoplasms were seen in eight dogs.

A link between municipal spending on housing and other factors explaining housing conditions in a country

2021 ◽  
Author(s):  
Barbora Raková
Keyword(s):  
Housing Conditions ◽  
Correlation Matrices ◽  
Policy Makers ◽  
National Budget ◽  
Housing Costs ◽  
Important Field ◽  
Quantitative Analyses ◽  
Linear Regressions ◽  
Do So ◽  
Budget Expenditure

Housing policy has been for years pronounced as an important field for urban development. However, cities are rather reluctant to join in, explaining their position mainly by financial scarcity and low competence. This however does have social implications on life of the citizens. The aim of this study is to conduct a basic prove of a link between proportion of municipal spending on Housing and other factors explaining Housing conditions in a country. In other words, the goal of this brief study is to analyse what aspects of housing may be linked with the level of municipal spending on Housing and how. To do so, data about 21 countries from OECD Housing Database have been used for basic quantitative analyses (correlation matrices and linear regressions). The outputs suggest that the level of municipal spending on Housing is positively linked with the proportion of national budget designated for Housing and the GDP level of the country. It has also been found that housing costs of people, who have a mortgage, are higher in places, where municipal budget expenditure is on a higher level. Finally, the results indicate, that where proportion of municipal budget spending on Housing is higher, there the construction of new dwellings is slower and the relative expenditure of households on Housing is lower. Although the results may have interesting value for policy makers, they need to be proved by a further analysis. This study is only a brief baseline for further analysis, because of low number of observations and because further factors related to housing may need to be added.

Mitral value anomalies in tricuspid atresia: an autopsy study of 54 hearts

1997 ◽  
Vol 7 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Robin J. Pinto ◽  
Jaya Deshpande ◽  
Bharat V Dalvi
Keyword(s):  
Pulmonary Hypertension ◽  
Mitral Valve ◽  
Cardiac Failure ◽  
Septal Defect ◽  
Tricuspid Atresia ◽  
Contributory Factor ◽  
Anatomic Study ◽  
Autopsy Study ◽  
Perioperative Mortality ◽  
Do So

AbstractAnatomic study of 54 autopsied cases of tricuspid atresia revealed mitral valvar anomalies in 9 (16.7%). The morphologic findings in these 9 cases are presented and compared with 45 cases having a normal mitral valvar apparatus. The anomalies included a cleft valve in 2, parachute valve in 2, straddling valve in 3, and a valve with dual orifice in 2.Two of these cases had more than one anomaly. Data from echocardiography and cardiac catheterisation, when available, had failed to diagnose the anomalies during life. The anomalies were more commonly associated with discordant ventriculo-arterial connections (33.3% versus 13.3%, p < 0.01), were associated significantly with a large ventricular septal defect (33.3% versus 4.4%, p < 0.01), and with pulmonary hypertension (33.3% versus 2.2%, p < 0.01). Two of 3 post operative deaths among the 9 were due to hemodynamic consequences arising from the uncorrected mitral valvar anomaly (parachute valve in both ). Diagnosis of these anomalies prior to surgical correction is imperative, as their presence may necessitate repair or replacement of the mitral valve. Failure to do so may result in increased perioperative mortality, congestive cardiac failure and arrhythmias at a later date. Mitral valvar anomalies may be a contributory factor to the early onset of cardiac failure seen in patients with tricuspid atresia undergoing palliative shunts.

Metastatic Patterns of Salivary Gland Neoplasms

1982 ◽  
Vol 91 (4) ◽  
pp. 465-466 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Salivary Gland ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Regional Lymph Nodes ◽  
Adenoid Cystic ◽  
Salivary Gland Carcinomas ◽  
Long Term Follow Up ◽  
Metastatic Patterns

Long-term follow-up of salivary gland carcinomas allows a better evaluation of their biologic malignancy than the traditional five-year period. Metastases (distant and local) are possible over the entire lifetime of a patient and are dependent upon histologic grade, persistence of neoplasm and clinical stage. Distant metastases to bone and lungs are manifested by nearly every carcinoma. Metastases to regional lymph nodes vary according to histologic type and it appears that the adenoid cystic carcinoma has the lowest incidence of that event.

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