Canine Gastric Adenocarcinoma

In a retrospective study of 26 gastric adenocarcinomas of the dog, 17 were found to have histologic features of the diffuse type and nine of the intestinal type similar to those of the same tumor in man. The intestinal type was characterized by distinct glandular structures lined with well polarized cells at the primary and metastatic sites and mild desmoplastic reaction. Three subtypes with distinct histologic features (papillary, five; acinar, three; solid, one) were recognized in this group. Fourteen of the diffuse adenocarcinomas were characterized by random infiltration by neoplastic cells, singly or in clusters, often with signet ring cells and severe desmoplastic reaction. The remaining three diffuse adenocarcinomas also had recognizable acinar structures and were considered to be glandular subtypes of the diffuse type. In eight dogs there was a 7:1 male to female ratio for dogs with the intestinal type and in 16 dogs a 2:1 male to female ratio for dogs with the diffuse type. Two of the nine intestinal type of adenocarcinomas, but none of the diffuse tumors, had intraluminal growths. Metaplasia of gastric epithelium was seen in nearly half the tumors; this was more common in the intestinal type (six of nine). Different degrees of carcinomatosis were seen in 24 of 26 dogs. Regional lymph nodes were involved in the 20 dogs whose nodes were available for examination. Distant metastases were seen in 19 of 26 dogs; liver, lungs and adrenal glands were the most common sites. Various degrees of lymphoid cell infiltration, suggesting the antigenic quality of the neoplasms, were seen in 15 dogs. Additional neoplasms were seen in eight dogs.

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Oral carcinoma epidemiology in Paraná State, Southern Brazil

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2009000200018 ◽

2009 ◽

Vol 25 (2) ◽

pp. 393-400 ◽

Cited By ~ 18

Author(s):

Roberta Losi-Guembarovski ◽

Rodrigo Paes de Menezes ◽

Fernando Poliseli ◽

Vivian Nappi Chaves ◽

Hellen Kuasne ◽

...

Keyword(s):

Distant Metastases ◽

Lymph Node Involvement ◽

Oral Carcinoma ◽

Female Ratio ◽

Anatomical Distribution ◽

Floor Of Mouth ◽

Male Female Ratio ◽

Node Involvement ◽

Histological Characteristics ◽

Male To Female

Oral carcinoma is the sixth most frequent type of cancer in the world and the seventh most common in Brazil (the country with the highest incidence in Latin America). Mean five-year survival remains one of the lowest among the main cancers, thus justifying studies that contribute to the development of preventive strategies. The aim of this study was to compare the epidemiological, clinical, and histological characteristics of 91 patients with oral carcinoma. Mean age was 58.62 ± 10.46 years, and male-to-female ratio was 6.6:1.0 (79 men and 12 women). European descendants predominated with 79 patients (86.8%). Eighty-five individuals (93.4%) smoked and 70 (76.9%) consumed alcohol regularly. Anatomical distribution of tumors was: 27 (29.7%) tongue; 18 (19.8%) floor of mouth; 11 (12.1%) oropharynx; and 11 (12.1%) oral mucosa. Fifty-seven patients (62.6%) presented lymph node involvement and three (3.3%) had distant metastases. Surgery and radiotherapy were used in 43.2% of patients. With the exception of the male/female ratio (which was higher), our data are consistent with previous studies on oral carcinoma patients.

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Pathobiological Characteristics of Intestinal and Diffuse-Type of Gastric Carcinoma-Retrospective Study of Gastric Cancers

International Journal of Medical and Dental Sciences ◽

10.18311/ijmds/2017/18833 ◽

2017 ◽

Vol 6 (2) ◽

pp. 1462

Author(s):

M. Priyadharshini ◽

R. Narmadha ◽

S. Dhanalakshmi ◽

Rajesh Natarajan ◽

S. Subitha ◽

...

Keyword(s):

Gastric Cancer ◽

Retrospective Study ◽

Gastric Carcinoma ◽

Nodal Metastasis ◽

Intestinal Type ◽

Diffuse Type ◽

Cell Type ◽

Gastric Cancers ◽

Microscopic Features ◽

Glandular Structures

Background: Gastric carcinomas have various pathological features. Based on patterns of growth and invasiveness, however, they fall into two types: diffuse type and intestinal type. These two types of carcinoma appear to be different in their histogenetic origins.Objectives: To analyse various types of gastric cancer reported in last five years. To compare the features of intestinal and diffuse type gastric carcinoma including gross appearance, staging, grading of tumor.Materials and Methods: This was a retrospective study of 324 gastric cancer which were surgically resected and received over 5 years. The tumors were divided into groups according to their gross and microscopic patterns. Gross appearance was classified based on Borrmann classification. Microscopic features evaluated include tumor cell type, extent of invasion, degree of maturation, formation of glandular structures, nodal metastasis.Results: Totally 320 cases of gastric cancer were received of which 218(68%) were male, 102(32%) were female. Gastric cancers are rare below the age of 30 years. Comparing the type of gastric cancer intestinal type were 269(84%), diffuse type were 24(7.5%) and other type of gastric cancer including GIST, lymphoma, mucinous adenocarcinoma were 27(8.5%). Younger patients have higher stage of lymph node metastasis in diffuse type, but not for the intestinal type.Conclusion: Gastric cancer more common in male (M:F= 2:1) and most frequently seen in 5th decade. Intestinal type constitutes the most common type of gastric tumor. Gross appearance of diffuse type was predominantly infiltrative (79%).

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Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients

Scientific Reports ◽

10.1038/s41598-021-89844-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Qiaozhu Zeng ◽

Jingyuan Gao ◽

Xinyu Zhang ◽

Aichun Liu ◽

Zhenfan Wang ◽

...

Keyword(s):

Kidney Disease ◽

Clinical Laboratory ◽

Imaging Finding ◽

Age At Onset ◽

Female Ratio ◽

Related Disease ◽

Igg4 Related Disease ◽

Peking University ◽

Chinese Cohort ◽

Male To Female

AbstractWe aimed to compare the demographic, clinical and laboratory characteristics between IgG4-related kidney disease (IgG4-RKD+) and extrarenal IgG4-related disease (IgG4-RKD−) in a large Chinese cohort, as well as describing the radiological and pathological features of IgG4-RKD+. We retrospectively analyzed the medical records of 470 IgG4-related disease (IgG4-RD) patients at Peking University People’s Hospital from January 2004 to January 2020. The demographic, clinical, laboratory, radiological and pathological characteristics between IgG4-RKD+ and IgG4-RKD− were compared. Twenty IgG4-RD patients who had definite etiology of renal impairment including diabetes, hypertension and etc. were excluded. Among the remained 450 IgG4-RD patients, 53 were diagnosed with IgG4-RKD+ . IgG4-RKD+ patients had older age at onset and at diagnosis. Male to female ratio of IgG4-RKD+ patients is significantly higher. In the IgG4-RKD+ group, the most commonly involved organs were salivary gland, lymph nodes and pancreas. It was found that renal function was impaired in approximately 40% of IgG4-RKD+ patients. The most common imaging finding is multiple, often bilateral, hypodense lesions. Male sex, more than three organs involved, and low serum C3 level were risk factors for IgG4-RKD+ in IgG4-RD patients. These findings indicate potential differences in pathogenesis of these two phenotypes.

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P129 The utility of routine operative swab culture in uncomplicated peri-anal abscesses

BJS Open ◽

10.1093/bjsopen/zrab032.128 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

Author(s):

Apoorva Khajuria ◽

Tuba Rahim ◽

Mariam Baig ◽

Kai Leong ◽

Apoorva Khajuria

Keyword(s):

Inflammatory Bowel Disease ◽

Perianal Abscess ◽

Female Ratio ◽

Incision And Drainage ◽

Common Presentation ◽

History Of ◽

Inflammatory Bowel ◽

Operative Findings ◽

The Cost ◽

Male To Female

Abstract Introduction Despite perianal abscess being a common presentation, certain aspects of its management remain controversial, especially the routine use of intra-operative swab cultures. Methods A retrospective review of patients that underwent incision and drainage procedures for a perianal abscess over a six-month period was undertaken. Results Over 6 months, 50 patients were identified. The male to female ratio was 3:1 and median ASA score was 1. Only 6/50 patients presented with recurrent abscess and 1 patient had history of inflammatory bowel disease. On the basis of operative findings, 39 patients (78%) had uncomplicated abscess (not associated with cellulitis, sinus or fistula); swab cultures were performed in 26 (67%) of these patients. All patients were discharged on the same day; microbiology reports did not impact the treatment and no patients were followed up in clinic post-operatively or presented with recurrence. The number of unnecessary microbiology swabs undertaken in this cohort equates to approximately 52 unnecessary swabs a year. The cost of one swab is £10.10p, which means £520 could potentially be saved annually. Conclusion Routine intra-operative swab cultures do not impact management decisions, add to unnecessary costs and therefore should not be undertaken in uncomplicated or first presentation of peri-anal abscesses.

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High rates of gastroesophageal cancers in patients with dyspepsia undergoing upper gastrointestinal endoscopy in Uganda

Endoscopy International Open ◽

10.1055/a-1480-7231 ◽

2021 ◽

Vol 09 (07) ◽

pp. E997-E1000

Author(s):

Ronald Mbiine ◽

Cephas Nakanwagi ◽

Olivia Kituuka

Keyword(s):

Positive Association ◽

Referral Hospital ◽

Outcome Variable ◽

Mulago Hospital ◽

Upper Gastrointestinal Endoscopy ◽

Female Ratio ◽

Mulago National Referral Hospital ◽

Male To Female ◽

Upper Gastrointestinal ◽

National Referral Hospital

Abstract Background and study aims Dyspepsia is the most common presenting symptom in the gastrointestinal clinic of Mulago National Referral hospital. The etiology is essentially not fully described in our patient population. This study was therefore conducted to establish the causes of dyspepsia based on endoscopic diagnosis among patients with dyspepsia seeking care at the National Referral hospital of Uganda. Patients and methods This retrospective study conducted in the endoscopy unit of Mulago hospital reviewed 356 patient endoscopy reports spanning January 2018 to July 2020 with a focus on those with a referral indication of dyspepsia. Age and sex were the independent variables of interest while the endoscopy findings as reported by the endoscopist were the outcome variable of interest. Results Of the 356 endoscopy reports reviewed, 159 met the inclusion criterion of dyspepsia as the indication. Participant mean age was 47.7 years (± 16.53) with the majority (25.79 %) in the fifth decade while the male to female ratio was 1. The majority of patients had organic dyspepsia (90.57 %) while the commonest finding was gastritis 69 (43.4 %). Gastroesophageal cancers represented (18) 11.32 % of all findings. There was a positive association between age > 50 years with gastroesophageal cancers (7.639) as well as age < 50 years and functional dyspepsia (2.794); however, all these were not statistically significant (P = 0.006 and (P = 0.095, respectively). Conclusions Organic/structural dyspepsia comprises over 90 % of investigated dyspepsia with 11 % comprising cancer among patients seeking endoscopy at the National Referral Hospital of Uganda.

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Astrocytomas of the spinal cord in children and adolescents

Journal of Neurosurgery ◽

10.3171/jns.1985.63.5.0669 ◽

1985 ◽

Vol 63 (5) ◽

pp. 669-675 ◽

Cited By ~ 135

Author(s):

Ronald Reimer ◽

Burton M. Onofrio

Keyword(s):

Spinal Cord ◽

Histological Grade ◽

Extended Period ◽

Spinal Deformities ◽

Duration Of Symptoms ◽

Female Ratio ◽

Content Type ◽

Orthopedic Procedure ◽

Male To Female ◽

Fine Print

✓ The authors review 32 cases of spinal cord astrocytoma in patients under 20 years of age who were treated at the Mayo Clinic between 1955 and 1980. There was a 1.3:1 male to female ratio. Twenty patients were between 6 and 15 years of age at the time of diagnosis. The duration of symptoms prior to definitive diagnosis varied from 5 days to 9 years, with an average of 24 months. The most common symptoms were pain (62.5%), gait disturbance (43.7%), numbness (18.8%), and sphincteric dysfunction (18.8%). The most common neurological findings were a Babinski response (50.0%), posterior column sensory dysfunction (40.6%), and paraparesis (37.5%). A median follow-up period of 8.6 years (range 0.8 to 25.5 years) revealed that the survival time diminished with increased histological grade of the astrocytoma (p < 0.001). The development of postlaminectomy spinal deformities represented a serious postoperative complication. This occurred in 13 patients and was first recognized between 8 and 90 months postoperatively. Six deformities occurred following cervical laminectomy, and eight patients required at least one orthopedic procedure. It is crucial to follow these patients for an extended period of time to watch for postoperative spinal deformities.

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Clinicohematological Study of Thrombocytosis in Children

ISRN Hematology ◽

10.1155/2014/389257 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 9

Author(s):

Nathiya Subramaniam ◽

Suneel Mundkur ◽

Pushpa Kini ◽

Nalini Bhaskaranand ◽

Shrikiran Aroor

Keyword(s):

Platelet Count ◽

Myeloid Leukemia ◽

Prospective Observational Study ◽

Myelogenous Leukemia ◽

Distribution Width ◽

Female Ratio ◽

Reactive Thrombocytosis ◽

Acute Myelogenous ◽

Male To Female ◽

Primary Thrombocytosis

Introduction. Primary thrombocytosis is very rare in children; reactive thrombocytosis is frequently observed in children with infections, anemia, and many other causes. Aims and Objectives. To identify the etiology of thrombocytosis in children and to analyze platelet indices (MPV, PDW, and PCT) in children with thrombocytosis. Study Design. A prospective observational study. Material and Methods. A total of 1000 patients with thrombocytosis (platelet > 400×109/L) were studied over a period of 2 years. Platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT) were noted. Results. Of 1000 patients, 99.8% had secondary thrombocytosis and only two children had primary thrombocytosis (chronic myeloid leukemia and acute myelogenous leukemia, M7). The majority of the children belonged to the age group of 1month to 2 years (39.7%) and male to female ratio was 1.6 : 1. Infection with anemia (48.3%) was the most common cause of secondary thrombocytosis followed by iron deficiency alone (17.2%) and infection alone (16.2%). Respiratory infection (28.3%) was the predominant infectious cause observed. Thrombocytosis was commonly associated with IDA among all causes of anemia and severity of thrombocytosis increased with severity of anemia (P=0.021). With increasing platelet count, there was a decrease in MPV (<0.001). Platelet count and mean PDW among children with infection and anemia were significantly higher than those among children with infection alone and anemia alone. None were observed to have thromboembolic manifestations. Conclusions. Primary thrombocytosis is extremely rare in children than secondary thrombocytosis. Infections in association with anemia are most commonly associated with reactive thrombocytosis and severity of thrombocytosis increases with severity of anemia.

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Follow-up of the air pollution and the human male-to-female ratio analysis in São Paulo, Brazil: a times series study

BMJ Open ◽

10.1136/bmjopen-2013-002552 ◽

2013 ◽

Vol 3 (7) ◽

pp. e002552 ◽

Cited By ~ 8

Author(s):

Simone Georges El Khouri Miraglia ◽

Mariana Matera Veras ◽

Luis Fernando Amato-Lourenço ◽

Fernando Rodrigues-Silva ◽

Paulo Hilário Nascimento Saldiva

Keyword(s):

Air Pollution ◽

Sao Paulo ◽

Ratio Analysis ◽

São Paulo ◽

Female Ratio ◽

Times Series ◽

Human Male ◽

Male To Female ◽

Series Study

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DEMOGRAPHIC PROFILE OF ACUTE FEBRILE ENCEPHALOPATHY CASES IN PEDIATRIC AGE GROUP PATIENTS: A STUDY FROM WESTERN RAJASTHAN

10.36106/ijsr/1302690 ◽

2021 ◽

pp. 72-73

Author(s):

Laxmi Rathore ◽

P. K. Khatri ◽

Saroj K. Meena ◽

Archana Bora ◽

Suneel Bhooshan

Keyword(s):

Lower Class ◽

Mental States ◽

Clinical Feature ◽

Female Ratio ◽

Pediatric Age Group ◽

History Of ◽

Laboratory Investigations ◽

Demographic Distribution ◽

Viral Etiologies ◽

Male To Female

Acute Febrile Encephalopathy is a clinical term used to describe patients presenting with short febrile illnesses with altered mental states. Demographic distribution plays an essential role in the diagnosis of viral etiologies. One hundred ve suspected AFE cases were enrolled in the study. A detailed history by predesigned performa and laboratory investigations was obtained for data collection. Viral etiology was diagnosed in 32 (30.48%) cases. The male to female ratio was 1.39:1. Total 56.25% of positive cases were from the lower class, 28.13% from the middle class, and 15.63% from the upper class. 24 (75%) cases from rural, while only 8 (25%) of the urban population showed viral etiologies. In 19 (59.4%) cases were either history of incomplete vaccination or not vaccinated, 13 (40.6%) cases had a history of complete immunization among positive cases. The predominant clinical feature was fever (100%) followed by seizures 66(62.86%), vomiting 37(35.24%), headache 14(13.33%), paresis in 16(15.24%) and altered sensorium in 29(27.62%), respectively. To conclude, the etiologic panorama of AFE varies with several factors such as time and demographical location, age, and immunization status. There is an urgent need to conduct more studies to prole the viral etiologies according to their prevalence in geographical areas so the treatment can be tailored accordingly and prophylaxis treatment or immunization can be boosted in the population at risk of getting the disease.

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COMPARISON OF CLINICO-SOCIAL PROFILE OF PULMONARY AND EXTRA PULMONARY TUBERCULOSIS IN TERTIARY CARE HOSPITAL IN A RURALAREA: A RETROSPECTIVE STUDY

10.36106/ijsr/4605295 ◽

2021 ◽

pp. 70-72

Author(s):

Gaurav Santosh Nemade ◽

Sumit Nitin Dhus ◽

Arushi Ramesh Shetty ◽

Neha Dhananjay Firake

Keyword(s):

Tertiary Care ◽

Care Hospital ◽

Female Ratio ◽

Extra Pulmonary Tuberculosis ◽

Younger Age ◽

Tobacco Addiction ◽

History Of ◽

Early Case ◽

Male To Female ◽

Clinical Characteristic

BACKGROUND AND OBJECTIVES: The burden of tuberculosis (TB) in India is the highest accounting for 26% of the global incidence. A total of 1.4 million people died from TB in 2019 (including 208 000 people with HIV). India accounts for a fourth of the global burden of TB and 29% of global mortality. Therefore, we carried out this study to compare demographic, lifestyle and clinical characteristic between pulmonary TB (PTB) and extrapulmonary TB (EPTB). MATERIALS AND METHODOLOGY:Aretrospective analysis was carried of 348 patients diagnosed in DOTS centre, Pravara Rural Hospital, Loni. Characteristics of demographic and clinical characteristics were obtained from medical case records. RESULTS:Among the 348 cases, 71.3% were PTB and 28.7% were EPTB including, pleural (36%), meningeal (27%) and lymphatic (20%) cases. The male to female ratio in PTB and EPTB are 1.99 and 1.22 respectively. EPTB was more common at younger age (<25 years). Tobacco addiction (10.9%), diabetes mellitus (4.03%), HIV positivity (12.1%) and history of contact with Tb patients (17.7%) were more likely to be associated with PTB. CONCLUSION:Increased awareness of the risk factors may facilitate early case nding and better management outcomes for these patients.

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