Overview of Automated Immunohistochemistry

2014 ◽  
Vol 138 (12) ◽  
pp. 1578-1582 ◽  
Author(s):  
Jeffrey W. Prichard
Keyword(s):  
Literature Review ◽  
Immunohistochemical Staining ◽  
Turnaround Time ◽  
Clinical Diagnostics ◽  
Data Sources ◽  
Strategic Design ◽  
Advantages And Disadvantages ◽  
Practice Experience ◽  
Increasing Demand

Context The increasing demand for immunohistochemistry for clinical diagnostics, in combination with an ongoing shortage of staff in the histology laboratory, has brought about a need for automation in immunohistochemistry. The current automated staining platforms vary significantly in their design and capabilities. Objective To review how technology has been applied to automating the process of immunohistochemical staining. Data Sources Literature review, vendor interviews, and personal practice experience. Conclusions Each of the commercially available, automated immunohistochemistry platforms has strategic design differences that produce advantages and disadvantages. Understanding those differences can help match the demands of testing volumes, turnaround time, standardization, and labor savings to the appropriate automated instrumentation.

scholarly journals Review and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors

2015 ◽  
Vol 139 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Shaobo Zhu ◽  
Conrad Schuerch ◽  
Jennifer Hunt
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Literature Review ◽  
Head And Neck ◽  
Head And Neck Tumors ◽  
Data Sources ◽  
Diverse Group ◽  
Immunohistochemical Markers ◽  
Neck Tumors ◽  
Practice Experience

Context Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors. Objective To review immunohistochemical markers, which can aid in the diagnosis of selected salivary gland and head and neck tumors. Data Sources Literature review and authors' personal practice experience. Conclusions Salivary gland and head and neck tumors include a large diverse group of tumors with complex and overlapping histologic features. Immunohistochemistry plays an important role in resolving the differential diagnosis of some salivary gland and head and neck tumors and can provide information for the prognosis of certain tumors.

Immunohistochemistry in Undifferentiated Neoplasm/Tumor of Uncertain Origin

2014 ◽  
Vol 138 (12) ◽  
pp. 1583-1610 ◽  
Author(s):  
Fan Lin ◽  
Haiyan Liu
Keyword(s):  
Literature Review ◽  
Diagnostic Accuracy ◽  
Diagnostic Errors ◽  
Research Data ◽  
Data Sources ◽  
Tissue Specific ◽  
Ancillary Study ◽  
Practice Experience ◽  
Therapeutic Decisions

Context Immunohistochemistry has become an indispensable ancillary study in the identification and classification of undifferentiated neoplasms/tumors of uncertain origin. The diagnostic accuracy has significantly improved because of the continuous discoveries of tissue-specific biomarkers and the development of effective immunohistochemical panels. Objectives To identify and classify undifferentiated neoplasms/tumors of uncertain origin by immunohistochemistry. Data Sources Literature review and authors' research data and personal practice experience were used. Conclusions To better guide therapeutic decisions and predict prognostic outcomes, it is crucial to differentiate the specific lineage of an undifferentiated neoplasm. Application of appropriate immunohistochemical panels enables the accurate classification of most undifferentiated neoplasms. Knowing the utilities and pitfalls of each tissue-specific biomarker is essential for avoiding potential diagnostic errors because an absolutely tissue-specific biomarker is exceptionally rare. We review frequently used tissue-specific biomarkers, provide effective panels, and recommend diagnostic algorithms as a standard approach to undifferentiated neoplasms.

scholarly journals Practical Applications in Immunohistochemistry: Carcinomas of Unknown Primary Site

2015 ◽  
Vol 140 (6) ◽  
pp. 508-523 ◽  
Author(s):  
Patricia L. Kandalaft ◽  
Allen M. Gown
Keyword(s):  
Literature Review ◽  
Primary Site ◽  
Data Sources ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Carcinoma Of Unknown Primary ◽  
Practical Applications ◽  
Practice Experience ◽  
Practical Guidance ◽  
The Many

Context.—Identification of the site of origin of carcinoma of unknown primary using immunohistochemistry is a frequent requirement of anatomic pathologists. Diagnostic accuracy is crucial, particularly in the current era of targeted therapies and smaller sample sizes. Objectives.—To provide practical guidance and suggestions for classifying carcinoma of unknown primary using both proven and new antibodies, as well as targeting panels based on integration of morphologic and clinical features. Data Sources.—Literature review, the authors' practice experience, and authors' research. Conclusions.—With well-performed and interpreted immunohistochemistry panels, anatomic pathologists can successfully identify the site of origin of carcinoma of unknown primary. It is crucial to understand not only the diagnostic uses of the many available antibodies but also the potential limits and pitfalls.

Quality in Surgical Pathology Communication and Reporting

2011 ◽  
Vol 135 (11) ◽  
pp. 1394-1397 ◽  
Author(s):  
Raouf E. Nakhleh
Keyword(s):  
Literature Review ◽  
Effective Communication ◽  
Turnaround Time ◽  
Surgical Pathology ◽  
Data Sources ◽  
Final Report

Context.—Communication in surgical pathology is complex and includes multiple facets. Objective.—To discuss different aspects of pathology practice that represent quality communication in surgical pathology. Data Sources.—Literature review. Conclusions.—Achieving quality communication in surgical pathology is dependent on pathologists addressing multiple situations including managing physicians' expectations for turnaround time and ancillary testing, understanding what information is needed to manage the patient at intraoperative consultation and in the final report, assuring adequate report content with the use of synoptic checklist reports, and using report formatting suggestions that aid report comprehension. Finally, the pathologists' availability to answer questions and discuss cases is an important factor in effective communication, including their willingness to verbally report urgent and significant unexpected diagnoses to ensure that important diagnoses are not overlooked.

scholarly journals Swarm Robotic Interactions in an Open and Cluttered Environment: A Survey

Designs ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 37
Author(s):  
Maxime Vaidis ◽  
Martin J.-D. Otis
Keyword(s):  
Literature Review ◽  
Research Trends ◽  
Cluttered Environment ◽  
Advantages And Disadvantages ◽  
Population Migrations ◽  
New Research ◽  
Interaction Strategy ◽  
Crowded Environment

Recent population migrations have led to numerous accidents and deaths. Little research has been done to help migrants in their journey. For this reason, a literature review of the latest research conducted in previous years is required to identify new research trends in human-swarm interaction. This article presents a review of techniques that can be used in a robots swarm to find, locate, protect and help migrants in hazardous environment such as militarized zone. The paper presents a swarm interaction taxonomy including a detailed study on the control of swarm with and without interaction. As the interaction mainly occurs in cluttered or crowded environment (with obstacles) the paper discussed the algorithms related to navigation that can be included with an interaction strategy. It focused on comparing algorithms and their advantages and disadvantages.

scholarly journals A Systematic Literature Review of Multi-Criteria Decision-Making Methods for Sustainable Selection of Insulation Materials in Buildings

2021 ◽  
Vol 13 (2) ◽  
pp. 737
Author(s):  
Indre Siksnelyte-Butkiene ◽  
Dalia Streimikiene ◽  
Tomas Balezentis ◽  
Virgilijus Skulskis
Keyword(s):  
Decision Making ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Energy Demand ◽  
Energy Performance ◽  
Future Research ◽  
Multi Criteria Decision Making ◽  
Insulation Materials ◽  
Advantages And Disadvantages ◽  
Selection Of

The European Commission has recently adopted the Renovation Wave Strategy, aiming at the improvement of the energy performance of buildings. The strategy aims to at least double renovation rates in the next ten years and make sure that renovations lead to higher energy and resource efficiency. The choice of appropriate thermal insulation materials is one of the simplest and, at the same time, the most popular strategies that effectively reduce the energy demand of buildings. Today, the spectrum of insulation materials is quite wide, and each material has its own specific characteristics. It is recognized that the selection of materials is one of the most challenging and difficult steps of a building project. This paper aims to give an in-depth view of existing multi-criteria decision-making (MCDM) applications for the selection of insulation materials and to provide major insights in order to simplify the process of methods and criteria selection for future research. A systematic literature review is performed based on the Search, Appraisal, Synthesis and Analysis (SALSA) framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In order to determine which MCDM method is the most appropriate for different questions, the main advantages and disadvantages of different methods are provided.

Forestry Working Groups/Groupes du travail

1989 ◽  
Vol 65 (3) ◽  
pp. 220-224
Author(s):  
J. J. E. Dosne
Keyword(s):  
Developing Countries ◽  
Natural Resources ◽  
Burkina Faso ◽  
New Caledonia ◽  
International Organisations ◽  
Tropical Forestry ◽  
Advantages And Disadvantages ◽  
Working Groups ◽  
Increasing Demand ◽  
Definition Of

The advantages and disadvantages of working in developing countries are reviewed. The definition of a developing country and the aid it receives from Canada are analysed. Projects in these countries do not harm the Canadian industry. The development of natural resources is a priority of international organisations, after health, sanitation and education. Organisations interested in this development are listed. A few notes of forestry projects in Turkey, Jamaica, Honduras, Burkina Faso, Haiti, Costa Rica are enclosed; as well as an ideal project in New Caledonia where they have assumed their own responsibility. A message: all Canadian faculties of forestry, should give a few courses on tropical forestry because of its need and the increasing demand for Canadian foresters in this field. All who have worked overseas agree that there is a certain satisfaction in having contributed to the advancement of developing countries.

Standardization of Diagnostic Immunohistochemistry: Literature Review and Geisinger Experience

2014 ◽  
Vol 138 (12) ◽  
pp. 1564-1577 ◽  
Author(s):  
Fan Lin ◽  
Zongming Chen
Keyword(s):  
Quality Management ◽  
Literature Review ◽  
Best Practices ◽  
Critical Points ◽  
Medical Center ◽  
Management Program ◽  
Review Article ◽  
Data Sources ◽  
Test Results ◽  
Antibody Validation

Context Immunohistochemistry has become an indispensable ancillary technique in anatomic pathology laboratories. Standardization of every step in preanalytic, analytic, and postanalytic phases is crucial to achieve reproducible and reliable immunohistochemistry test results. Objective To standardize immunohistochemistry tests from preanalytic, analytic, to postanalytic phases. Data Sources Literature review and Geisinger (Geisinger Medical Center, Danville, Pennsylvania) experience. Conclusions This review article delineates some critical points in preanalytic, analytic, and postanalytic phases; reiterates some important questions, which may or may not have a consensus at this time; and updates the newly proposed guidelines on antibody validation from the College of American Pathologists Pathology and Laboratory Quality Center. Additionally, the article intends to share Geisinger's experience with (1) testing/optimizing a new antibody and troubleshooting; (2) interpreting and reporting immunohistochemistry assay results; (3) improving and implementing a total immunohistochemistry quality management program; and (4) developing best practices in immunohistochemistry.

Current CITE-ings from the popular and trade computing press: telework and telecommuting

2016 ◽  
Vol 33 (1) ◽  
pp. 21-22 ◽  
Author(s):  
Martin Kesselman
Keyword(s):  
Literature Review ◽  
Design Methodology ◽  
Virtual Reference ◽  
Content Type ◽  
Advantages And Disadvantages ◽  
Better Than

Purpose – This article examines Current CITE-ings from the Popular and Trade Computing Press, Telework and Telecommuting Design/methodology/approach – The methodology adopted is a literature review. Findings – Readily available technologies now allow librarians to perform most of their work-offsite. Some traditional building-based services such as reference, have been taken over by virtual reference and now even instruction offers options on par with or even better than classroombased questions such as a webinar that can be viewed and reviewed at any time or by having librarians embedded into various courseware packages. Researchlimitations/implications – Librarians no longer need be limited to a single library; groups of subject librarians can work together in the cloud to provide services to multiple universities. Originality/value – This article collates some articles from the non-library literature that mayprovide some ideas and review advantages and disadvantages for both the library and employee

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