Standardization of Diagnostic Immunohistochemistry: Literature Review and Geisinger Experience

2014 ◽  
Vol 138 (12) ◽  
pp. 1564-1577 ◽  
Author(s):  
Fan Lin ◽  
Zongming Chen
Keyword(s):  
Quality Management ◽  
Literature Review ◽  
Best Practices ◽  
Critical Points ◽  
Medical Center ◽  
Management Program ◽  
Review Article ◽  
Data Sources ◽  
Test Results ◽  
Antibody Validation

Context Immunohistochemistry has become an indispensable ancillary technique in anatomic pathology laboratories. Standardization of every step in preanalytic, analytic, and postanalytic phases is crucial to achieve reproducible and reliable immunohistochemistry test results. Objective To standardize immunohistochemistry tests from preanalytic, analytic, to postanalytic phases. Data Sources Literature review and Geisinger (Geisinger Medical Center, Danville, Pennsylvania) experience. Conclusions This review article delineates some critical points in preanalytic, analytic, and postanalytic phases; reiterates some important questions, which may or may not have a consensus at this time; and updates the newly proposed guidelines on antibody validation from the College of American Pathologists Pathology and Laboratory Quality Center. Additionally, the article intends to share Geisinger's experience with (1) testing/optimizing a new antibody and troubleshooting; (2) interpreting and reporting immunohistochemistry assay results; (3) improving and implementing a total immunohistochemistry quality management program; and (4) developing best practices in immunohistochemistry.

scholarly journals BLENDED LEARNING: SUPPORTING STUDENTS’ LEARNING AND ENHANCING THEIR EXPERIENCE — A LITERATURE REVIEW

2019 ◽  
pp. 45-51
Author(s):  
Gulbaxor ABDUKADIROVA ◽  
Gulrukh KHAMROEVA
Keyword(s):  
Literature Review ◽  
Best Practices ◽  
Online Education ◽  
Blended Learning ◽  
Teaching And Learning ◽  
Review Article ◽  
Journal Articles ◽  
Effectiveness And Efficiency ◽  
Broad Generalization ◽  
Innovative Concept

This review article provides an analysis of the researches conducted during the last two decades on the topic of blended learning in teaching and learning process. Some studies which highlighted the benefits of blended learning had been analyzed in order to develop new features of effectiveness and efficiency of this innovative concept. As a result, 15 journal articles, 6 published books and several commentaries were identified, read, evaluated, and synthesized. Some general principles regarding best practices in online education and blended learning will be shared with cautions against broad generalization. Маколада сўнгги йигирма йилда таълим ва ўкув жараёнида аралашган таълим мавзуси бўйича ўтказилган тадқиқотлар таҳлили тақдим этилган. Ушбу инновацион концепциянинг самарадорлиги ва самарадорликнинг янги хусусиятларини ишлаб чикиш мақсадида аралаш таълим тадқиқ этилган бир қанча илмий ишлар ўрганилган. Ўн бешта илмий мақола, олтита китоб ва кўплаб тақризлар ўрганилди, баҳоланди ва умумий хулосалар чиқарилди. Онлайн таълим ва аралаш таълимнинг шу пайтгача маълум бўлган энг яхши амалиётларига оид айрим умумий принциплар кенг умумлаштиришдан ҳоли тарзда изоҳланди. В данной обзорной статье приводится анализ исследований, проведенных в течение последних двух десятилетий по теме смешанного обучения в процессе преподавания. Некоторые исследования, в которых подчеркивалось преимущество смешанного обучения, были проанализированы с целью разработки новых характеристик эффективности и действенности этой инновационной концепции. В результате было проанализировано 15 журнальных статей, 6 опубликованных книг и несколько комментариев. Некоторые общие принципы, касающиеся практики в области онлайн-образования и смешанного обучения, будут изложены с предостережением от широкого обобщения.

scholarly journals Application of Immunohistochemistry in the Diagnosis of Pulmonary and Pleural Neoplasms

2017 ◽  
Vol 141 (9) ◽  
pp. 1195-1213 ◽  
Author(s):  
Jennifer S. Woo ◽  
Opal L. Reddy ◽  
Matthew Koo ◽  
Yan Xiong ◽  
Faqian Li ◽  
...  
Keyword(s):  
Literature Review ◽  
Diagnostic Tool ◽  
Personal Experience ◽  
Review Article ◽  
Data Sources ◽  
Practical Approach ◽  
Valuable Diagnostic Tool ◽  
Histologic Evaluation ◽  
Selection Of ◽  
Pleural Neoplasms

Context.— A vast majority of neoplasms arising from lung or pleura are initially diagnosed based on the histologic evaluation of small transbronchial, endobronchial, or needle core biopsies. Although most diagnoses can be determined by morphology alone, immunohistochemistry can be a valuable diagnostic tool in the workup of problematic cases. Objective.— To provide a practical approach in the interpretation and immunohistochemical selection of lung/pleura–based neoplasms obtained from small biopsy samples. Data Sources.— A literature review of previously published articles and the personal experience of the authors were used in this review article. Conclusion.— Immunohistochemistry is a useful diagnostic tool in the workup of small biopsies from the lung and pleura sampled by small biopsy techniques.

scholarly journals PERAN PERAWAT TENTANG INSIDEN NYARIS CEDERA PADA PASIEN DI RUMAH SAKIT

2020 ◽  
Author(s):  
Lidya Andriani Sihombing
Keyword(s):  
Patient Safety ◽  
Quality Management ◽  
Literature Review ◽  
World Health Organization ◽  
Fundamental Principle ◽  
Management Program ◽  
World Health ◽  
Critical Component ◽  
Text Book ◽  
Health Organization

Insiden keselamatan pasien menjadi salah satu indikator mutu pelayanan di rumah sakit. Monitoring variasi insiden sebagai kontrol dalam melakukan upaya perbaikan mutu dan keselamatan pasien. Keselamatan pasien merupakan sebuah prioritas utama yang harus diprogramkan dan dilaksanakan oleh rumah sakit, yang bertujuan untuk melindungi pasien dari setiap kejadian tak terduga yang tak diharapkan. Pada tahun 2004, World Health Organization (WHO) mencanangkan Safety Is a Fundamental Principle of Patient Care and a Critical Component of Quality Management, program tersebut merupakan program bersama dengan berbagai negara untuk meningkatkan keselamatan pasien di rumah sakit. Keselamatan pasien (patient safety) saat ini telah menjadi isu global dan nasional bagi Rumah Sakit. Rumah sakit tidak hanya berorientasi terhadap laba semata, namun harus tetap memperhatikan kualitas layanan terhadap para konsumen terutama berkenaan dengan isu keselamatan pasien (patient safety). Tujuan: Tujuan dari pengkajian ini untuk meningkatkan kualitas keselamatan pasien di Rumah Sakit, meningkatkan standar layanan kesehatan terhadap pasien dan masyarakat serta mencegah menurunya kualitas atau kejadian yang tidak diharapkan. Metode: Metode yang digunakan dalam membahas ini yakni literature review dengan cara menggunakan analisis data dari beberapa sumber seperti jurnal atau text book. Metode ini menggambarkan penerapan standar sasaran keselamatan pasien di Rumah Sakit melalui literature. Hasil: Kejadian Nyaris Cedera (KNC) dan Kejadian Tidak Cedera (KTD) masih terjadi di Rumah Sakit. mengingat insiden yang berkaitan dengan keselamatan pasien sangat erat kaitannya dengan mutu pelayanan fasilitas kesehatan dan hukum. Perawat juga harus memahami tindakan yang akan diambil dengan melakukan laporan Insiden Keselamatan Pasien KKP-RS merupakan suatu pelaporan anonim dan tertulis ke KKP-RS setiap KTD atau KNC yang terjadi pada pasien yang kemudian dilakukan analisis penyebab, rekomendasi dan solusinya, terhadap bagaimana alur pelaporan yang dimiliki oleh rumah sakit.

A Systematic Literature Review of the EFQM Excellence Model from 1991 to 2019

1970 ◽  
Vol 2 (2) ◽  
pp. 11-15
Author(s):  
Muhammad Yousaf ◽  
Petr Bris
Keyword(s):  
Quality Management ◽  
Data Collection ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Quantitative Research ◽  
Web Of Science ◽  
State Of The Art ◽  
Future Research ◽  
European Foundation ◽  
The Subject

A systematic literature review (SLR) from 1991 to 2019 is carried out about EFQM (European Foundation for Quality Management) excellence model in this paper. The aim of the paper is to present state of the art in quantitative research on the EFQM excellence model that will guide future research lines in this field. The articles were searched with the help of six strings and these six strings were executed in three popular databases i.e. Scopus, Web of Science, and Science Direct. Around 584 peer-reviewed articles examined, which are directly linked with the subject of quantitative research on the EFQM excellence model. About 108 papers were chosen finally, then the purpose, data collection, conclusion, contributions, and type of quantitative of the selected papers are discussed and analyzed briefly in this study. Thus, this study identifies the focus areas of the researchers and knowledge gaps in empirical quantitative literature on the EFQM excellence model. This article also presents the lines of future research.

Best Practices for Data Visualization: Creating and Evaluating a Report for an Evidence-Based Fall Prevention Program (Preprint)

2018 ◽  
Author(s):  
Srijesa Khasnabish ◽  
Zoe Burns ◽  
Madeline Couch ◽  
Mary Mullin ◽  
Randall Newmark ◽  
...  
Keyword(s):  
Literature Review ◽  
Best Practices ◽  
Implementation Science ◽  
Data Visualization ◽  
Systematic Literature Review ◽  
Fall Prevention ◽  
Prevention Program ◽  
Evidence Based ◽  
Data Display ◽  
Fall Prevention Program

BACKGROUND Data visualization experts have identified core principles to follow when creating visual displays of data that facilitate comprehension. Such principles can be applied to creating effective reports for clinicians that display compliance with quality improvement protocols. A basic tenet of implementation science is continuous monitoring and feedback. Applying best practices for data visualization to reports for clinicians can catalyze implementation and sustainment of new protocols. OBJECTIVE To apply best practices for data visualization to create reports that clinicians find clear and useful. METHODS First, we conducted a systematic literature review to identify best practices for data visualization. We applied these findings and feedback collected via a questionnaire to improve the Fall TIPS Monthly Report (FTMR), which shows compliance with an evidence-based fall prevention program, Fall TIPS (Tailoring Interventions for Patient Safety). This questionnaire was based on the requirements for effective data display suggested by expert Stephen Few. We then evaluated usability of the FTMR using a 15-item Health Information Technology Usability Evaluation Scale (Health-ITUES). Items were rated on a 5-point Likert scale from strongly disagree (1) to strongly agree (5). RESULTS The results of the systematic literature review emphasized that the ideal data display maximizes the information communicated while minimizing the cognitive efforts involved with data interpretation. Factors to consider include selecting the correct type of display (e.g. line vs bar graph) and creating simplistic reports. The qualitative and quantitative evaluations of the original and final FTMR revealed improved perceptions of the visual display of the reports and their usability. Themes that emerged from the staff interviews emphasized the value of simplified reports, meaningful data, and usefulness to clinicians. The mean (SD) rating on the Health-ITUES scale when evaluating the original FTMR was 3.86 (0.19) and increased to 4.29 (0.11) when evaluating the revised FTMR (Mann Whitney U Test, z=-12.25, P<0.001). CONCLUSIONS Best practices identified through a systematic review can be applied to create effective reports for clinician use. The lessons learned from evaluating FTMR perceptions and measuring usability can be applied to creating effective reports for clinician use in the context of other implementation science projects.

scholarly journals Cholesterol Granuloma of the Maxillary Sinus—A Case Report and Literature Review

2021 ◽  
Vol 12 ◽  
pp. 215265672098478
Author(s):  
Abdulrahman Alghulikah ◽  
Norah Musallam ◽  
Ibrahim Sumaily ◽  
Amany Fathaddin ◽  
Surayie Aldossary
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Maxillary Sinus ◽  
Review Article ◽  
Unusual Presentation ◽  
Differential Diagnoses ◽  
Anatomical Site ◽  
Cholesterol Granuloma ◽  
Comprehensive Literature Review

Cholesterol Granulomas of the Maxillary Sinus, considered an unusual presentation at this anatomical site. Over last 2 decades, only few cases are reported in the literature (English) and no available comprehensive reviews or studies on this entity. Herein in this article we present a comprehensive literature review of the available reports of 16 cases along with reporting a new case which we managed, aided with its histopathological pictures. This review article can be a reference for practitioners in the field of otorhinolaryngology who may encounter these cases. Also, it attracts the attention to consider this pathology among the differential diagnoses of nasal masses. Moreover, including a described pathological imaging may help young pathologist to identify this pathology.

scholarly journals The Wild West of Emergency Use Authorizations for SARS-CoV-2 Testing: What Could Be the True Sensitivity?

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S142-S143
Author(s):  
S Dalal ◽  
S Patel ◽  
J M Petersen ◽  
D Jhala
Keyword(s):  
Medical Center ◽  
Initial Result ◽  
Reference Laboratory ◽  
Test Results ◽  
Rt Pcr ◽  
Repeat Testing ◽  
Parallel Testing ◽  
Percent Agreement ◽  
Instructions For Use ◽  
Multiple Reference

Abstract Introduction/Objective SARS-CoV-2 is a pandemic that has required mobilization to meet urgent needs. In this mobilization, emergency use authorizations (EUA) have been issued by the FDA to expedite the deployment of these tests. This has led to a situation whereby sensitivity has not been rigorously studied for any of the assays with EUAs. Estimates can be extrapolated from the limited samples documented by the company in their instructions for use (IFU). Although the nationwide shortage of testing reagents prevent parallel testing of multiple platforms on all specimens, observations of repeat specimens at the Veteran Affairs Medical Center (VAMC) provides the first study in the literature of more complete data for SARS-CoV-2 nucleic acid (RT-PCR) assay on sensitivity on the Abbott (Abbott Park Ill) and Cepheid (Sunnyvale CA) assays. Methods A retrospective search was performed for all test results for SARS-CoV-2 by RT-PCR from 3/1/2020 to 4/14/2020 at Corporal Michael J. Crescenz Medical Center, in order to evaluate the sensitivity on Abbott m2000 and Cepheid platforms. Results across multiple reference laboratories and in-house testing platforms were collated in a table with all patients clinically requiring repeat testing recorded. Results 114/863 patients had repeat testing. The tests were performed initially by outside reference laboratories (25 patients), on the Abbott m2000 (63 patients), and Cepheid Infinity (26 patients). 15/114 (13%) had discordant results on repeat testing. This included 1 test initially done by a reference laboratory. 8 days after the initial result from the reference lab, a positive for the same patient was identified on the Abbott platform. 11 initial Abbott results were discordant on further repeat testing on two platforms - Abbott (6 patients) and Cepheid (5 patients) 1-6 days later. In addition, 3 initial Cepheid were discordant on further repeat testing by the same Cepheid platform (1-16 days later). Conclusion While the instructions for use for both platforms suggest 100% sensitivity and specificity (due to the 100% positive and negative percent agreement in limited specimens), the true sensitivity is less than 100%, particularly early in the course of the infection. In our study, the positive percent agreement (surrogate for sensitivity) was 83% for initial Abbott tests, 88% for initial Cepheid tests, and 95% by Reference laboratory platform.

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